Hypomethylation in the promoter region of POMC gene correlates with ectopic overexpression in thymic carcinoids

Journal of Endocrinology

Volumn 185, Issue 2, 2005, Pages 337-343

  Ye, Lei ^a   Li, Xiaoying ^a   Kong, Xiangyin ^a   Wang, Weiqing ^a   Bi, Yufang ^a   Hu, Landian ^a   Cui, Bin ^a   Li, Xi ^a   Ning, Guang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; CORTICOTROPIN; PROOPIOMELANOCORTIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CORRELATION ANALYSIS; CPG ISLAND; ECTOPIC CORTICOTROPIN PRODUCTION; GENE ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; LUNG CANCER; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; THYMECTOMY; THYMUS CANCER;

ACTH SYNDROME, ECTOPIC; CARCINOID TUMOR; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; PRO-OPIOMELANOCORTIN; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMUS NEOPLASMS;

EID: 18944365474     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.05963     Document Type: Article

References (16)

1. Beuschlein F & Hammer GD 2002 Ectopic pro-opiomelanocortin syndrome Endocrinology and Metabolism Clinics of North America 31 191-234.
2. Gardiner-Garden M & Frommer M 1994 Transcripts and CpG islands associated with the pro-opiomelanocortin gene and other neurally expressed genes. Journal of Molecular Endocrinology 12 365-382.
3. de Keyzer Y, Bertagna X, Luton JP & Kahn A 1989 Variable modes of proopiomelanocortin gene transcription in human tumors. Molecular Endocrinology 3 215-223.
4. de Keyzer Y, Rene P, Lenne F, Auzan C, Clauser E & Bertagna X 1997 V3 vasopressin receptor and corricotropic phenotype in pituitary and nonpituitary tumors. Hormone Research 47 259-262.
5. Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T & Bergman Y 1996 A role for nuclear NF-kappaB in B-cell-specific hypomethylation of the Ig kappa locus. Nature Genetics 13 435-441
6. Lacaze-Masmonteil T, de Keyzer Y, Luton JP, Kahn A & Bertagna X 1987 Characterization of proopiomelanocortin transcripts in human nonpituitary tissues. PNAS 84 7261-7265.
7. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN & Bird A 1998 Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 386-389.
8. Newell-Price J, King P & Clark AJ 2001 The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. Molecular Endocrinology 15 338-348.
9. Paroush Z, Keshet I, Yisraeli J & Cedar H 1990 Dynamics of hypomethylation and expression of the alpha-actin gene in myoblasts. Cell 63 1229-1237.
10. Picon A, Leblond-Francillard M, Raffin-Sanson ML, Lenne F, Bertagna X & de Keyzer Y 1995 Functional analysis of the human pro-opiomelanocortin promoter in the small cell lung carcinoma cell line DMS-79. Journal of Molecular Endocrinology 15 187-194.
11. Picon A, Bertagna X & de Keyzer Y 1999a Analysis of the human proopiomelanocortin gene promoter in a small cell lung carcinoma cell line reveals an unusual role for E2F transcription factors. Oncogene 18 2627-2633.
12. Picon A, Bertagna X & de Keyzer Y 1999b Analysis of proopiomelanocortin gene transcription mechanisms in bronchial tumour cells. Molecular Cell Endocrinology 147 93-102.
13. Popiela A, Keith G, Borzecki A, Popiela G, Manowiec M & Gabrys M 2004 The meaning of the methylation of genomic DNA in the regulation of gene expression levels. European Journal of Gynecological Oncology 25 145-149.
14. Rees DA, Hepburn PJ, McNicol AM, Francis K, Jasani B, Lewis MD, Farrell WE, Lewis BM, Scanlon MF & Ham J 2002 Loss of ACTH expression in cultured human corticotroph macroadenoma cells is consistent with loss of the POMC gene signal sequence. Molecular Cell Endocrinology 189 51-57.
15. Wang WQ, Hongyan Zhao, Ying Chen, Shouyue Sun, Bi YF, Zhengyi Tang, Yongju Zhao, Wenqiang Fang, Zhongyuan Chen, Kemin Chen, Xiaolong Jin & Guang Ning 2003 Ectopic ACTH syndromes caused by thymic carcinoid. Chinese Journal of Endocrinology and Metabolism 19 445-448.
16. Yang B, Guo M, Herman JG & Clark DP 2003 Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. American Journal of Pathology 163 1101-1107.