Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbor trout

Environmental Health Perspectives

Volumn 116, Issue 8, 2008, Pages 1047-1055

  Tilton, Susan C ^a,b,c   Orner, Gayle A ^b   Benninghoff, Abby D ^a   Carpenter, Hilary M ^a,d   Hendricks, Jerry D ^a   Pereira, Cliff B ^a   Williams, David E ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d MINNESOTA DEPARTMENT OF HEALTH   (United States)

Author keywords

Clofibrate; Dehydroepiandrosterone; Estradiol; Hepatocarcinogenesis; Microarray; Perfluorooctanoic acid; Peroxisome proliferation; Rainbow trout

Indexed keywords

AFLATOXIN B1; ALPHA TUBULIN; APOLIPOPROTEIN A1; BETA ACTIN; BETA TUBULIN; BONE MORPHOGENETIC PROTEIN; CARCINOGEN; CATALASE; CATHEPSIN D; CHAPERONE; CLOFIBRATE; COMPLEMENTARY DNA; ENVELOPE PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GROWTH HORMONE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOSIDE DIPHOSPHATE KINASE; PERFLUOROOCTANOIC ACID; PRASTERONE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STRUCTURAL PROTEIN; TATA BINDING PROTEIN; TRANSGELIN; TUMOR ANTIGEN; URIDINE PHOSPHORYLASE; VITELLOGENIN; FLUOROCARBON; OCTANOIC ACID DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVITY; ESTROGEN ACTIVITY; FATTY ACID OXIDATION; FOOD INTAKE; GENE EXPRESSION PROFILING; GENETIC REGULATION; IN VIVO STUDY; LIVER CANCER; LIVER CARCINOGENESIS; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PHENOTYPE; PRIORITY JOURNAL; RAINBOW TROUT; SIGNAL TRANSDUCTION; TOXICOGENETICS; TUMOR GROWTH; ANIMAL; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GENOMICS; LIVER TUMOR; METABOLISM;

ANIMALIA; ONCORHYNCHUS MYKISS; RODENTIA; SALMONIDAE;

AFLATOXIN B1; ANIMALS; CARCINOGENICITY TESTS; CLOFIBRATE; CLUSTER ANALYSIS; DEHYDROEPIANDROSTERONE; DISEASE MODELS, ANIMAL; ESTRADIOL; FLUOROCARBONS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMICS; LIVER NEOPLASMS; OCTANOIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCORHYNCHUS MYKISS; PEROXISOMES; SIGNAL TRANSDUCTION;

EID: 51249120558     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11190     Document Type: Article

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