Neocortical RELN promoter methylation increases significantly after puberty

NeuroReport

Volumn 21, Issue 2, 2010, Pages 114-118

  Lintas, Carla ^a,b   Persico, Antonio M ^a,b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Autism; DNA methylation; Epigenetics; Neocortex; Neurodevelopment; Pervasive developmental disorders; Reelin; RELN; Schizophrenia

Indexed keywords

REELIN; SEX HORMONE; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; REELIN PROTEIN; SCLEROPROTEIN; SERINE PROTEINASE;

ADULTHOOD; ARTICLE; AUTISM; CPG ISLAND; DNA METHYLATION; NEOCORTEX; PREPUBERTY; PRIORITY JOURNAL; PROMOTER REGION; PUBERTY; SCHIZOPHRENIA; TEMPORAL CORTEX; ADOLESCENT; ADULT; AGING; CHILD; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC MARKER; GENETICS; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; HUMAN; MALE; METABOLISM; ONSET AGE; PATHOPHYSIOLOGY; PRESCHOOL CHILD; TEMPORAL LOBE; UPREGULATION;

ADOLESCENT; ADULT; AGE OF ONSET; AGING; AUTISTIC DISORDER; CELL ADHESION MOLECULES, NEURONAL; CHILD; CHILD, PRESCHOOL; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC MARKERS; GONADAL STEROID HORMONES; HUMANS; MALE; NEOCORTEX; NERVE TISSUE PROTEINS; PROMOTER REGIONS, GENETIC; PUBERTY; SCHIZOPHRENIA; SERINE ENDOPEPTIDASES; TEMPORAL LOBE; UP-REGULATION; YOUNG ADULT;

EID: 77649261907     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328334b343     Document Type: Article

References (24)

1. Rice DS, Curran T. Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci 2001; 24:1005-1039.
2. Huang C, D'Arcangelo G. The Reelin gene and its functions in brain development. In: Fatemi SH, editor. Reelin glycoprotein: structure, biology and roles in health and disease. New York: Springer; 2008. pp. 1-13.
3. Quattrocchi CC, Wannenes F, Persico AM, Ciafre SA, D'Arcangelo G, Farace MG, et al. Reelin is a serine protease of the extracellular matrix. J Biol Chem 2002; 277:303-309.
4. Hong SE, Shugart YY, Huang DT, Shahwan SA, Grant PE, Hourihane JO, et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat Genet 2000; 26:93-96.
5. Fatemi SH. Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry 2005; 10:251-257.
6. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, et al. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 2008; 4:e28.
7. Goes FS,Willour VL, Zandi PP, Belmonte PL, Mackinnon DF, Mondimore FM, et al. Sex-specific association of the reelin gene with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2009 [Epub ahead of print]
8. Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 2005; 134B:60-66.
9. Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A 2005; 102:9341-9346.
10. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry 2008; 63:530-533.
11. Lintas C, Persico AM. Reelin gene polymorphisms in autistic disorder. In: Fatemi SH, editor. Reelin glycoprotein: structure, biology and roles in health and disease. New York: Springer; 2008. pp. 385-399.
12. Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res 2002; 30:2930-2939.
13. Samaco RC, Hogart A, LaSalle JM. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet 2005; 14:483-492.
14. Paulin R, Grigg GW, Davey MW, Piper AA. Urea improves efficiency of bisulphite-mediated sequencing of 50-methylcytosine in genomic DNA. Nucleic Acids Res 1998; 26:5009-5010.
15. Persico AM, D'Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, et al. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol Psychiatry 2001; 6:150-159.
16. Kaminsky Z, Wang SC, Petronis A. Complex disease, gender and epigenetics. Ann Med 2006; 38:530-544.
17. Zilbovicius M, Meresse I, Chabane N, Brunelle F, Samson Y, Boddaert N. Autism, the superior temporal sulcus and social perception. Trends Neurosci 2006; 29:359-366.
18. Gillberg C, Schaumann H. Infantile autism and puberty. J Autism Dev Disord 1981; 11:365-371.
19. Kakooza-Mwesige A, Wachtel LE, Dhossche DM. Catatonia in autism: implications across the life span. Eur Child Adolesc Psychiatry 2008; 17:327-335.
20. Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, et al. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 2005; 47:567-579.
21. Sinagra M, Verrier D, Frankova D, Korwek KM, Blahos J, Weeber EJ, et al. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. J Neurosci 2005; 25:6127-6136.
22. Qiu S, Weeber EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 2007; 9:2312-2321.
23. Kaufmann WE, Moser HW. Dendritic anomalies in disorders associated with mental retardation. Cereb Cortex 2000; 10:981-991.
24. Chen Y, Kundakovic M, Agis-Balboa RC, Pinna G, Grayson DR. Induction of the reelin promoter by retinoic acid is mediated by Sp1. J Neurochem 2007; 103:650-665.