Epigenetics in spermatogenesis

Molecular and Cellular Endocrinology

Volumn 306, Issue 1-2, 2009, Pages 33-36

  Trasler, Jacquetta M ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

DNA methylation; Epigenetics; Male germ cell; Spermatogenesis

Indexed keywords

CYTIDINE; DNA METHYLTRANSFERASE;

ARTICLE; DNA METHYLATION; EMBRYO DEVELOPMENT; EPIGENETICS; GENE CONTROL; GENE TARGETING; GENOME IMPRINTING; GERM LINE; HUMAN; NONHUMAN; OLIGOSPERMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOGENESIS; X CHROMOSOME INACTIVATION;

ANIMALS; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; MALE; METHYLTRANSFERASES; ORGAN SPECIFICITY; SPERMATOGENESIS; SPERMATOZOA;

EID: 67249153027     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.12.018     Document Type: Article

References (44)

1. Bourc'his D., and Bestor T.H. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431 (2004) 96-99
2. Chedin F., Lieber M.R., and Hsieh C.L. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc. Natl. Acad. Sci. USA 99 (2002) 16916-16921
3. Christman J.K. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21 (2002) 5483-5495
4. Cirio M.C., Martel J., Mann M., Toppings M., Bartolomei M., Trasler J., and Chaillet J.M. DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation. Dev. Biol. 324 (2008) 139-150
5. Cokus S.J., Feng S., Zhang X., et al. Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature 452 (2008) 215-219
6. Davis T.L., Trasler J.M., Moss S.B., et al. Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis. Genomics 58 (1999) 18-28
7. Davis T.L., Yang G.J., and McCarrey J.R. The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development. Hum. Mol. Genet. 9 (2000) 2885-2894
8. Doerksen T., and Trasler J.M. Developmental exposure of spermatozoa to 5-azacytidine results in abnormal preimplantation development. Biol. Reprod. 55 (1996) 1155-1162
9. Doerksen T., Benoit G., and Trasler J.M. DNA hypomethylation of male germ cells by mitotic and meiotic exposure to 5-azacytidine results in altered testicular histology. Endocrinology 141 9 (2000) 3235-3244
10. Eckhardt F., Lewin J., Cortese R., et al. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet. 38 (2006) 1378-1385
11. Egger G., Liang G., Aparicio A., and Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 (2004) 457-463
12. Geyer C.B., Kiefer C.M., Yang T.P., et al. Ontogeny of a demethylation domain and its relationship to activation of tissue-specific transcription. Biol. Reprod. 71 3 (2004) 837-844
13. Goll M.G., and Bestor T.H. Eucaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74 (2005) 481-514
14. Hajkova P., Erhardt S., Lane N., et al. Epigenetic reprogramming in mouse primordial germ cells. Mech. Dev. 117 (2002) 15-23
15. Jue K., Bestor T., and Trasler J.M. Regulated synthesis and localization of DNA methyltransferase during spermatogenesis. Biol. Reprod. 53 (1995) 561-569
16. Kaneda M., Okano M., Hata K., et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429 (2004) 900-903
17. Kato Y., Kaneda M., Hata K., et al. Role of Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet. 16 (2007) 2272-2280
18. Kelly T.L.J., Li E., and Trasler J.M. 5-Aza-2′(-Deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome. J. Androl. 24 (2003) 822-830
19. Klose R.J., and Bird A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31 (2006) 89-97
20. Kobayashi H., Sato A., Otsu E., et al. Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Hum. Mol. Genet. 16 (2007) 2542-2551
21. La Salle S., Mertineit C., Taketo T., Moens P.B., Bestor T.H., and Trasler J.M. Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev. Biol. 268 (2004) 403-415
22. La Salle S., and Trasler J.M. Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse. Dev. Biol. 296 (2006) 71-82
23. La Salle, Oakes C.C., Neaga O.R., Bourc'his D., Bestor T.H., and Trasler J.M. Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L. BMC Dev. Biol. 7 (2007) 104
24. Lee J., Kanetsu-Shinohara M., Ogonuki N., et al. Heritable imprinting defect caused by epigenetic abnormalities in mouse spermatogonial stem cells. Biol. Reprod. November 19 (2008) 10.1095/biolreprod.108.072330
25. Lister R., O'Malley R.C., Tonti-Filippini J., et al. Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell 133 (2008) 523-526
26. Lucifero D., Chaillet J.R., and Trasler J.M. Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology. Hum. Reprod. Update 10 (2004) 3-18
27. Marques C.J., Carvalho F., Sousa M., and Barros A. Genomic imprinting in disruptive spermatogenesis. Lancet 363 (2004) 1700-1702
28. Marques C.J., Costa P., Vaz B., et al. Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Mol. Hum. Reprod. 14 (2008) 67-73
29. Mertineit C.M., Yoder J., Taketo T., Laird D., Trasler J.M., and Bestor T.H. Sex-specific exons control DNA methyltransferase in germ cells. Development 125 (1998) 889-897
30. Oakes C.C., La Salle S., Smiraglia D., Robaire B., and Trasler J. Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cell development. Dev. Biol. 307 (2007) 368-379
31. Oakes C.C., La Salle S., Smiraglia D., Robaire B., and Trasler J. A unique configuration of genome-wide DNA methylation patterns in the testis. Proc. Natl. Acad. Sci. USA 104 (2007) 228-233
32. Oakes C.C., Kelly T.L.J., Robaire B., and Trasler J.M. Adverse effects of 5-aza-2′-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation. J. Pharmacol. Exp. Ther. 322 3 (2007) 1171-1180
33. Okano M., Bell D.W., Haber D.A., et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 (1999) 247-257
34. Reik W., Dean W., and Walter J. Epigenetic reprogramming in mammalian development. Science 293 (2001) 1089-1093
35. Richards E.J. Inherited epigenetic variation-revisiting soft inheritance. Nat. Rev. Genet. 7 (2006) 395-401
36. Sasaki H., and Matsui Y. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat. Rev. Genet. 9 (2008) 129-140
37. Schaefer C.B., Ooi S.K.T., Bestor T.H., and Bourc'his D. Epigenetic decisions in mammalian germ cells. Science 316 (2007) 398-399
38. Shovlin T.C., Bourc'his D., La Salle S., Trasler J.M., Bestor T.H., and Walsh C.P. Promoter switching regulates Dnmt3L expression in mouse germ cells. Hum. Reprod. 22 2 (2007) 457-467
39. Trasler J.M. Gamete imprinting: setting epigenetic patterns for the next generation. Reprod. Fert. Dev. 18 (2006) 63-69
40. Trasler J.M., Hake L.E., Johnson P.A., et al. DNA methylation and demethylation events during meiotic prophase in the mouse testis. Mol. Cell. Biol. 10 4 (1990) 1828-1834
41. Verona R.I., Mann M.R., and Bartolomei M.S. Genomic imprinting: intricacies of epigenetic regulation in clusters. Annu. Rev. Cell Dev. Biol. 19 (2003) 237-259
42. Webster K.E., O'Bryan M.K., Fletcher S., et al. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 4068-4073
43. Yoder J.A., Walsh C.P., and Bestor T.H. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13 (1997) 335-340
44. Zhu J.-K. Epigenome sequencing comes of age. Cell 133 (2008) 395-396