-
1
-
-
0034443957
-
Heterogeneity of therapeutic responses in asthma
-
Drazen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000; 56:1054-70.
-
(2000)
Br Med Bull
, vol.56
, pp. 1054-70
-
-
Drazen, J.M.1
Silverman, E.K.2
Lee, T.H.3
-
2
-
-
0037421590
-
Pharmacogenomics - drug deposition, drug targets, and side effects
-
Evans WE, McLeod HL. Pharmacogenomics - drug deposition, drug targets, and side effects. N Engl J Med 2003; 348:538-49.
-
(2003)
N Engl J Med
, vol.348
, pp. 538-49
-
-
Evans, W.E.1
McLeod, H.L.2
-
3
-
-
33746842930
-
Overview of the pharmacogenetics of asthma treatment
-
Weiss ST, Litonjua AA, Lange C et al. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J 2006; 6:311-26.
-
(2006)
Pharmacogenomics J
, vol.6
, pp. 311-26
-
-
Weiss, S.T.1
Litonjua, A.A.2
Lange, C.3
-
4
-
-
79551626545
-
National Heart Lung and Blood Institute; National Institute of Health. Global strategy for asthma management and prevention: Global initiative for asthma (GINA)
-
GINA. GINA, Available at (Accessed 15 March 2010).
-
GINA. National Heart Lung and Blood Institute; National Institute of Health. Global strategy for asthma management and prevention: Global initiative for asthma (GINA). GINA, 2008. Available at (Accessed 15 March 2010).
-
(2008)
-
-
-
5
-
-
5144221336
-
Can guideline-defined asthma control be achieved? The gaining optimal asthma control study
-
Bateman ED, Boushey HA, Bousquet J et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. Am J Respir Crit Care Med 2004; 170:836-44.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 836-44
-
-
Bateman, E.D.1
Boushey, H.A.2
Bousquet, J.3
-
6
-
-
33644874322
-
Long-acting beta2-agonists as in an inhaled corticosteroid-sparing agent for chronic asthma in adults and children
-
Art No.: CD005076; DOI: DOI: 10.1002/14651858.CD005076.
-
Gibson PG, Powell H, Ducharme F. Long-acting beta2-agonists as in an inhaled corticosteroid-sparing agent for chronic asthma in adults and children. Cochrane Database Syst Rev 2005, Art No.: CD005076; DOI: DOI: 10.1002/14651858.CD005076.
-
(2005)
Cochrane Database Syst Rev
-
-
Gibson, P.G.1
Powell, H.2
Ducharme, F.3
-
7
-
-
0035888721
-
Low dose inhaled budesonide and formoterol in mild persistent asthma. The optima randomized trial
-
O'Byrne PM, Barnes PJ, Rodriguez-Roisin R et al. Low dose inhaled budesonide and formoterol in mild persistent asthma. The optima randomized trial. Am J Respir Crit Care Med 2001; 164:1392-7.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1392-7
-
-
O'Byrne, P.M.1
Barnes, P.J.2
Rodriguez-Roisin, R.3
-
8
-
-
1842370350
-
Effect of inhaled formoterol and budesonide on exacerbations of asthma
-
Pauwels RA, Lofdahl CG, Postma DS et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997; 337:1405-11.
-
(1997)
N Engl J Med
, vol.337
, pp. 1405-11
-
-
Pauwels, R.A.1
Lofdahl, C.G.2
Postma, D.S.3
-
9
-
-
0025797080
-
Prescribed fenoterol and death from asthma in New Zealand, 1981-7
-
Thorax
-
Grainger J, Woodman K, Pearce N et al. Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study. Thorax 1991; 46:105-11.
-
(1991)
a further case-control study
, vol.46
, pp. 105-11
-
-
Grainger, J.1
Woodman, K.2
Pearce, N.3
-
10
-
-
0028887981
-
End of New Zealand asthma mortality epidemic
-
Pearce N, Beasley R, Crane J, Burgess C, Jackson R. End of New Zealand asthma mortality epidemic. Lancet 1995; 345:41-4.
-
(1995)
Lancet
, vol.345
, pp. 41-4
-
-
Pearce, N.1
Beasley, R.2
Crane, J.3
Burgess, C.4
Jackson, R.5
-
11
-
-
85058199898
-
Fenoterol, asthma deaths, and asthma severity
-
Pearce N, Burgess C, Crane J et al. Fenoterol, asthma deaths, and asthma severity. Chest 1997; 112:1148-50.
-
(1997)
Chest
, vol.112
, pp. 1148-50
-
-
Pearce, N.1
Burgess, C.2
Crane, J.3
-
12
-
-
0025223381
-
Regular inhaled beta-agonist treatment in bronchial asthma
-
Sears MR, Taylor DR, Print CG et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 336:1391-6.
-
(1990)
Lancet
, vol.336
, pp. 1391-6
-
-
Sears, M.R.1
Taylor, D.R.2
Print, C.G.3
-
13
-
-
0028214757
-
A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists
-
Suissa S, Ernst P, Boivin JF et al. A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists. Am J Respir Crit Care Med 1994; 149:604-10.
-
(1994)
Am J Respir Crit Care Med
, vol.149
, pp. 604-10
-
-
Suissa, S.1
Ernst, P.2
Boivin, J.F.3
-
15
-
-
33144476873
-
The salmeterol multicenter asthma research trial
-
Chest
-
Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM. The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006; 129:15-26.
-
(2006)
a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
, vol.129
, pp. 15-26
-
-
Nelson, H.S.1
Weiss, S.T.2
Bleecker, E.R.3
Yancey, S.W.4
Dorinsky, P.M.5
-
16
-
-
77955608819
-
Common ADRβ2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes
-
Panebra A, Wang WC, Malone MM et al. Common ADRβ2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes. PLoS One 2010; 5:e11819.
-
(2010)
PLoS One
, vol.5
-
-
Panebra, A.1
Wang, W.C.2
Malone, M.M.3
-
17
-
-
0032772835
-
Comparative trough effects of formoterol and salmeterol on lymphocyte beta2-adrenoceptor-regulation and bronchodilatation
-
Aziz I, McFarlane LC, Lipworth BJ. Comparative trough effects of formoterol and salmeterol on lymphocyte beta2-adrenoceptor-regulation and bronchodilatation. Eur J Clin Pharmacol 1999; 55:431-6.
-
(1999)
Eur J Clin Pharmacol
, vol.55
, pp. 431-6
-
-
Aziz, I.1
McFarlane, L.C.2
Lipworth, B.J.3
-
18
-
-
33644787781
-
Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene
-
Cho SH, Oh SY, Bahn JW et al. Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene. Clin Exp Allergy 2005; 35:1162-7.
-
(2005)
Clin Exp Allergy
, vol.35
, pp. 1162-7
-
-
Cho, S.H.1
Oh, S.Y.2
Bahn, J.W.3
-
19
-
-
6944232728
-
Use of regularly scheduled albuterol treatment in asthma
-
Lancet
-
Israel E, Chinchilli VM, Ford JG et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 2004; 364:1505-12.
-
(2004)
genotype-stratified, randomised, placebo-controlled cross-over trial
, vol.364
, pp. 1505-12
-
-
Israel, E.1
Chinchilli, V.M.2
Ford, J.G.3
-
20
-
-
0035052741
-
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma
-
Israel E, Drazen JM, Liggett SB et al. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol 2001; 124:183-6.
-
(2001)
Int Arch Allergy Immunol
, vol.124
, pp. 183-6
-
-
Israel, E.1
Drazen, J.M.2
Liggett, S.B.3
-
21
-
-
0032589460
-
Beta2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics
-
Kotani Y, Nishimura Y, Maeda H, Yokoyama M. Beta2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics. J Asthma 1999; 36:583-90.
-
(1999)
J Asthma
, vol.36
, pp. 583-90
-
-
Kotani, Y.1
Nishimura, Y.2
Maeda, H.3
Yokoyama, M.4
-
22
-
-
0345501553
-
Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics
-
Lima JJ, Thomason DB, Mohamed MH, Eberle LV, Self TH, Johnson JA. Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin Pharmacol Ther 1999; 65:519-25.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 519-25
-
-
Lima, J.J.1
Thomason, D.B.2
Mohamed, M.H.3
Eberle, L.V.4
Self, T.H.5
Johnson, J.A.6
-
23
-
-
0031466866
-
Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing
-
Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-8.
-
(1997)
J Clin Invest
, vol.100
, pp. 3184-8
-
-
Martinez, F.D.1
Graves, P.E.2
Baldini, M.3
Solomon, S.4
Erickson, R.5
-
24
-
-
0242719848
-
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
-
Silverman EK, Kwiatkowski DJ, Sylvia JS et al. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol 2003; 112:870-6.
-
(2003)
J Allergy Clin Immunol
, vol.112
, pp. 870-6
-
-
Silverman, E.K.1
Kwiatkowski, D.J.2
Sylvia, J.S.3
-
25
-
-
0030860288
-
Association between beta 2 adrenoceptor polymorphisms and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics
-
Tan S, Hall IP, Dewar J et al. Association between beta 2 adrenoceptor polymorphisms and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997; 350:995-9.
-
(1997)
Lancet
, vol.350
, pp. 995-9
-
-
Tan, S.1
Hall, I.P.2
Dewar, J.3
-
26
-
-
0033841788
-
Asthma exacerbations during long term beta agonist use
-
Thorax
-
Taylor DR, Drazen JM, Herbison GP, Yandava CN, Hancox RJ, Town GI. Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax 2000; 55:762-7.
-
(2000)
influence of beta(2) adrenoceptor polymorphism
, vol.55
, pp. 762-7
-
-
Taylor, D.R.1
Drazen, J.M.2
Herbison, G.P.3
Yandava, C.N.4
Hancox, R.J.5
Town, G.I.6
-
27
-
-
33645110637
-
Beta-adrenergic receptor polymorphisms and response to salmeterol
-
Wechsler ME, Lehman E, Lazarus SC et al. Beta-adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med 2006; 173:519-26.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 519-26
-
-
Wechsler, M.E.1
Lehman, E.2
Lazarus, S.C.3
-
29
-
-
29544449036
-
Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation
-
Johnson M. Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. J Allergy Clin Immunol 2006; 117:18-24.
-
(2006)
J Allergy Clin Immunol
, vol.117
, pp. 18-24
-
-
Johnson, M.1
-
30
-
-
2442549709
-
cAMP-independent mechanism is significantly involved in b2-adrenoceptor-mediated tracheal relaxation
-
Koite K, Yamashita Y, Horionouchi T, Yamaki F, Tanaka Y. cAMP-independent mechanism is significantly involved in b2-adrenoceptor-mediated tracheal relaxation. Eur J Pharmacol 2004; 492:65-70.
-
(2004)
Eur J Pharmacol
, vol.492
, pp. 65-70
-
-
Koite, K.1
Yamashita, Y.2
Horionouchi, T.3
Yamaki, F.4
Tanaka, Y.5
-
31
-
-
0034858918
-
Evidence that the anti-spasmogenic effect of the b-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cycic amp-dependent protein kinase
-
Spicuzza L, Belvisi MG, Birrell MA, Barnes PJ, Hele HJ, Spicuzza L. Evidence that the anti-spasmogenic effect of the b-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cycic amp-dependent protein kinase. Br J Pharmacol 2001; 133:1201-12.
-
(2001)
Br J Pharmacol
, vol.133
, pp. 1201-12
-
-
Spicuzza, L.1
Belvisi, M.G.2
Birrell, M.A.3
Barnes, P.J.4
Hele, H.J.5
Spicuzza, L.6
-
32
-
-
0037180086
-
Interaction between glucocorticoids and [beta]2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling
-
Roth M, Johnson PRA, Rüdiger JJ et al. Interaction between glucocorticoids and [beta]2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 2002; 360:1293-9.
-
(2002)
Lancet
, vol.360
, pp. 1293-9
-
-
Roth, M.1
Johnson, P.R.A.2
Rüdiger, J.J.3
-
34
-
-
0033943304
-
Kinetic analysis of agonist-induced downregulation of the beta(2)-adrenergic receptor in beas-2b cells reveals high- and low-affinity components
-
Williams BR, Barber R, Clark RB. Kinetic analysis of agonist-induced downregulation of the beta(2)-adrenergic receptor in beas-2b cells reveals high- and low-affinity components. Mol Pharmacol 2000; 58:421-30.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 421-30
-
-
Williams, B.R.1
Barber, R.2
Clark, R.B.3
-
35
-
-
0033036546
-
Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation
-
Moore RH, Tuffaha A, Millman EE et al. Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci 1999; 112:329-38.
-
(1999)
J Cell Sci
, vol.112
, pp. 329-38
-
-
Moore, R.H.1
Tuffaha, A.2
Millman, E.E.3
-
37
-
-
0023194433
-
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions
-
Kobilka BK, Frielle T, Dohlman HG et al. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem 1987; 262:7321-7.
-
(1987)
J Biol Chem
, vol.262
, pp. 7321-7
-
-
Kobilka, B.K.1
Frielle, T.2
Dohlman, H.G.3
-
38
-
-
0027564307
-
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects
-
Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8:334-9.
-
(1993)
Am J Respir Cell Mol Biol
, vol.8
, pp. 334-9
-
-
Reihsaus, E.1
Innis, M.2
MacIntyre, N.3
Liggett, S.B.4
-
39
-
-
33751087760
-
Sequence, haplotype, and association analysis of adrbeta2 in a multiethnic asthma case-control study
-
Hawkins GA, Tantisira K, Meyers DA et al. Sequence, haplotype, and association analysis of adrbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med 2006; 174:1101-9.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 1101-9
-
-
Hawkins, G.A.1
Tantisira, K.2
Meyers, D.A.3
-
40
-
-
0442288082
-
Beta 2-adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma
-
Weir TD, Mallek NOA, Sandford AJ et al. Beta 2-adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 1998; 158:787-91.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 787-91
-
-
Weir, T.D.1
Mallek, N.O.A.2
Sandford, A.J.3
-
41
-
-
0032844359
-
Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals
-
Xie HG, Stein CM, Kim RB et al. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics 1999; 9:511-6.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 511-6
-
-
Xie, H.G.1
Stein, C.M.2
Kim, R.B.3
-
43
-
-
0041506933
-
Pharmacology and physiology of human adrenergic receptor polymorphisms
-
Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 2003; 43:381-411.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 381-411
-
-
Small, K.M.1
McGraw, D.W.2
Liggett, S.B.3
-
44
-
-
0034241705
-
Association of beta2-adrenergic receptor polymorphisms with severe asthma
-
Holloway JW, Dunbar PR, Riley GA et al. Association of beta2-adrenergic receptor polymorphisms with severe asthma. Clin Exp Allergy 2000; 30:1097-103.
-
(2000)
Clin Exp Allergy
, vol.30
, pp. 1097-103
-
-
Holloway, J.W.1
Dunbar, P.R.2
Riley, G.A.3
-
45
-
-
0032442150
-
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression
-
McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest 1998; 102:1927-32.
-
(1998)
J Clin Invest
, vol.102
, pp. 1927-32
-
-
McGraw, D.W.1
Forbes, S.L.2
Kramer, L.A.3
Liggett, S.B.4
-
46
-
-
0032911765
-
Identification of novel polymorphisms within the promoter region of the human β2 adrenergic receptor gene
-
Scott MG, Swan C, Wheatly AP, Hall IP. Identification of novel polymorphisms within the promoter region of the human β2 adrenergic receptor gene. Br J Pharmacol 1999; 126:841-4.
-
(1999)
Br J Pharmacol
, vol.126
, pp. 841-4
-
-
Scott, M.G.1
Swan, C.2
Wheatly, A.P.3
Hall, I.P.4
-
47
-
-
11944266854
-
Limited impact of multiple 5' single-nucleotide polymorphisms on the transcriptional control of the human beta 2-adrenoceptor gene
-
Westland R, van Veen A, Jansen HM, Jonkers RE, Wierenga EA. Limited impact of multiple 5' single-nucleotide polymorphisms on the transcriptional control of the human beta 2-adrenoceptor gene. Immunogenetics 2004; 56:625-30.
-
(2004)
Immunogenetics
, vol.56
, pp. 625-30
-
-
Westland, R.1
van Veen, A.2
Jansen, H.M.3
Jonkers, R.E.4
Wierenga, E.A.5
-
48
-
-
0034641736
-
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
-
Drysdale CM, McGraw DW, Stack CB et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000; 97:10483-8.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10483-8
-
-
Drysdale, C.M.1
McGraw, D.W.2
Stack, C.B.3
-
49
-
-
0028791628
-
Implications of genetic variability of human beta 2-adrenergic receptor structure
-
Green SA, Turki J, Hall IP, Liggett SB. Implications of genetic variability of human beta 2-adrenergic receptor structure. Pulm Pharmacol 1995; 8:1-10.
-
(1995)
Pulm Pharmacol
, vol.8
, pp. 1-10
-
-
Green, S.A.1
Turki, J.2
Hall, I.P.3
Liggett, S.B.4
-
50
-
-
0028068550
-
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
-
Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33:9414-9.
-
(1994)
Biochemistry
, vol.33
, pp. 9414-9
-
-
Green, S.A.1
Turki, J.2
Innis, M.3
Liggett, S.B.4
-
51
-
-
0027519404
-
A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
-
Green SA, Cole G, Jacinto M, Innis M, Liggett SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993; 268:23116-21.
-
(1993)
J Biol Chem
, vol.268
, pp. 23116-21
-
-
Green, S.A.1
Cole, G.2
Jacinto, M.3
Innis, M.4
Liggett, S.B.5
-
52
-
-
0034518904
-
Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle
-
Moore PE, Laporte JD, Abraham JH et al. Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle. Am J Respir Crit Care Med 2000; 162:2117-24.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 2117-24
-
-
Moore, P.E.1
Laporte, J.D.2
Abraham, J.H.3
-
53
-
-
33750391911
-
Is there a role of the thr164ile-[beta]2-adrenoceptor polymorphism for the outcome of chronic heart failure?
-
Leineweber K, Tenderich G, Wolf C et al. Is there a role of the thr164ile-[beta]2-adrenoceptor polymorphism for the outcome of chronic heart failure? Basic Res Cardiol 2006; 101:479-84.
-
(2006)
Basic Res Cardiol
, vol.101
, pp. 479-84
-
-
Leineweber, K.1
Tenderich, G.2
Wolf, C.3
-
54
-
-
0032531426
-
The ile164 beta2-adrenergic receptor polymorphisms adversely affects the outcome of congestive heart failure
-
Liggett S, Wagoner L, Craft L et al. The ile164 beta2-adrenergic receptor polymorphisms adversely affects the outcome of congestive heart failure. J Clin Invest 1998; 102:1534-9.
-
(1998)
J Clin Invest
, vol.102
, pp. 1534-9
-
-
Liggett, S.1
Wagoner, L.2
Craft, L.3
-
55
-
-
17444439098
-
Polymorphisms of the beta2-adrenergic receptor determine exercise capacity in patients with heart failure
-
Wagoner L, Craft L, Singh B et al. Polymorphisms of the beta2-adrenergic receptor determine exercise capacity in patients with heart failure. Circ Res 2000; 86:834-40.
-
(2000)
Circ Res
, vol.86
, pp. 834-40
-
-
Wagoner, L.1
Craft, L.2
Singh, B.3
-
56
-
-
0024344941
-
Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor
-
Strader CD, Candelore MR, Hill WS, Sigal IS, Dixon RA. Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem 1989; 264:13572-8.
-
(1989)
J Biol Chem
, vol.264
, pp. 13572-8
-
-
Strader, C.D.1
Candelore, M.R.2
Hill, W.S.3
Sigal, I.S.4
Dixon, R.A.5
-
58
-
-
0035957038
-
Blunted cardiac responses to receptor activation in subjects with thr164ile beta2-adrenoceptors
-
Brodde O, Buscher R, Tellkamp R, Radke J, Dhein S, Insel P. Blunted cardiac responses to receptor activation in subjects with thr164ile beta2-adrenoceptors. Circulation 2001; 103:1048-50.
-
(2001)
Circulation
, vol.103
, pp. 1048-50
-
-
Brodde, O.1
Buscher, R.2
Tellkamp, R.3
Radke, J.4
Dhein, S.5
Insel, P.6
-
59
-
-
0035876397
-
The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)
-
Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Eur J Pharmacol 2001; 421:141-17.
-
(2001)
Eur J Pharmacol
, vol.421
, pp. 141-17
-
-
Green, S.A.1
Rathz, D.A.2
Schuster, A.J.3
Liggett, S.B.4
-
60
-
-
39149091039
-
Variable-length poly-c tract polymorphisms of the beta2-adrenergic receptor 3'-utr alter expression and agonist regulation
-
Panebra A, Schwarb MR, Swift SM et al. Variable-length poly-c tract polymorphisms of the beta2-adrenergic receptor 3'-utr alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol 2008; 294:190-5.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
, pp. 190-5
-
-
Panebra, A.1
Schwarb, M.R.2
Swift, S.M.3
-
61
-
-
24944564606
-
Bronchodilator response in relation to {beta}2-adrenoceptor haplotype in patients with asthma
-
Taylor DR, Epton MJ, Kennedy MA et al. Bronchodilator response in relation to {beta}2-adrenoceptor haplotype in patients with asthma. Am J Respir Crit Care Med 2005; 172:700-3.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 700-3
-
-
Taylor, D.R.1
Epton, M.J.2
Kennedy, M.A.3
-
62
-
-
20144363204
-
Pharmacogenetic differences in response to albuterol between puerto ricans and mexicans with asthma
-
Choudhry S, Ung N, Avila PC et al. Pharmacogenetic differences in response to albuterol between puerto ricans and mexicans with asthma. Am J Respir Crit Care Med 2005; 171:563-70.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 563-70
-
-
Choudhry, S.1
Ung, N.2
Avila, P.C.3
-
63
-
-
0027417365
-
Reported asthma among Puerto Rican, Mexican-American, and Cuban children
-
Am J Public Health
-
Carter-Pokras OD, Gergen PJ. Reported asthma among Puerto Rican, Mexican-American, and Cuban children: 1982 through 1984. Am J Public Health 1993; 83:580-2.
-
(1993)
1982 through 1984
, vol.83
, pp. 580-2
-
-
Carter-Pokras, O.D.1
Gergen, P.J.2
-
64
-
-
0034011530
-
Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990-1995
-
Homa DM, Mannino DM, Lara M. Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990-1995. Am J Respir Crit Care Med 2000; 161:504-9.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 504-9
-
-
Homa, D.M.1
Mannino, D.M.2
Lara, M.3
-
65
-
-
9544253883
-
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma
-
Drazen JM, Israel E, Boushey HA et al. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med 1996; 335:841-7.
-
(1996)
N Engl J Med
, vol.335
, pp. 841-7
-
-
Drazen, J.M.1
Israel, E.2
Boushey, H.A.3
-
66
-
-
33644752735
-
[beta]-adrenoceptor responses of the airways
-
Eur J Pharmacol
-
Broadley KJ. [beta]-adrenoceptor responses of the airways: for better or worse? Eur J Pharmacol 2006; 533:15-27.
-
(2006)
for better or worse?
, vol.533
, pp. 15-27
-
-
Broadley, K.J.1
-
67
-
-
0028169718
-
The beta2-agonist controversy. Observations, explanations and relationship to asthma epidemiology
-
Sears M, Taylor D. The beta2-agonist controversy. Observations, explanations and relationship to asthma epidemiology. Drug Saf 1994; 11:259-83.
-
(1994)
Drug Saf
, vol.11
, pp. 259-83
-
-
Sears, M.1
Taylor, D.2
-
68
-
-
33845925046
-
Beta 2 Agonist enhances type 2 T-cell survival and accumulation
-
Loza M, Peters S, Foster S, Khan I, Penn R. Beta 2 Agonist enhances type 2 T-cell survival and accumulation. J Allergy Clin Immunol 2007; 119:235-44.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 235-44
-
-
Loza, M.1
Peters, S.2
Foster, S.3
Khan, I.4
Penn, R.5
-
69
-
-
60549103882
-
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model
-
Nguyen LP, Lin R, Parra S et al. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci USA 2009; 106:2435-40.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2435-40
-
-
Nguyen, L.P.1
Lin, R.2
Parra, S.3
-
70
-
-
0031597001
-
Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma
-
Hancox RJ, Sears MR, Taylor DR. Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma. Eur Respir J 1998; 11:589-93.
-
(1998)
Eur Respir J
, vol.11
, pp. 589-93
-
-
Hancox, R.J.1
Sears, M.R.2
Taylor, D.R.3
-
71
-
-
0033832449
-
Pharmacogenetics of beta-1- and beta-2-adrenergic receptors
-
Liggett SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology 2000; 61:167-73.
-
(2000)
Pharmacology
, vol.61
, pp. 167-73
-
-
Liggett, S.B.1
-
72
-
-
33750302641
-
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol
-
Palmer CN, Lipworth BJ, Lee S, Ismail T, Macgregor DF, Mukhopadhyay S. Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. Thorax 2006; 61:940-4.
-
(2006)
Thorax
, vol.61
, pp. 940-4
-
-
Palmer, C.N.1
Lipworth, B.J.2
Lee, S.3
Ismail, T.4
Macgregor, D.F.5
Mukhopadhyay, S.6
-
73
-
-
0035938606
-
Long-acting {beta}2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma
-
JAMA
-
Lazarus SC, Boushey HA, Fahy JV et al. Long-acting {beta}2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001; 285:2583-93.
-
(2001)
a randomized controlled trial
, vol.285
, pp. 2583-93
-
-
Lazarus, S.C.1
Boushey, H.A.2
Fahy, J.V.3
-
74
-
-
0342419450
-
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol
-
JAMA
-
Lemanske RF, Sorkness CA Jr, Mauger EA et al. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 2001; 285:2594-603.
-
(2001)
a randomized controlled trial
, vol.285
, pp. 2594-603
-
-
Lemanske, R.F.1
Sorkness Jr, C.A.2
Mauger, E.A.3
-
75
-
-
33749370049
-
Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma
-
Bleecker ER, Yancey SW, Baitinger LA et al. Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol 2006; 118:809-16.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 809-16
-
-
Bleecker, E.R.1
Yancey, S.W.2
Baitinger, L.A.3
-
76
-
-
69749128562
-
Lack of effect of promoter, coding and 3' polymorphisms of the [beta]2-adrenergic receptor (ADRB2) on the clinical response to salmeterol alone or with fluticasone propionate in subjects with asthma
-
Anderson W, Bleecker ER, Nelson H et al. Lack of effect of promoter, coding and 3' polymorphisms of the [beta]2-adrenergic receptor (ADRB2) on the clinical response to salmeterol alone or with fluticasone propionate in subjects with asthma. J Allergy Clin Immunol 2008; 121:S143.
-
(2008)
J Allergy Clin Immunol
, vol.121
-
-
Anderson, W.1
Bleecker, E.R.2
Nelson, H.3
-
77
-
-
69749128562
-
Arg16gly polymorphism of the [beta]2-adrenergic receptor gene does not modulate clinical response to salmeterol in subjects with asthma
-
Bleecker ER, Nelson H, Corren J et al. Arg16gly polymorphism of the [beta]2-adrenergic receptor gene does not modulate clinical response to salmeterol in subjects with asthma. J Allergy Clin Immunol 2008; 121:S143.
-
(2008)
J Allergy Clin Immunol
, vol.121
-
-
Bleecker, E.R.1
Nelson, H.2
Corren, J.3
-
78
-
-
37349091262
-
Effect of adrb2 polymorphisms on response to long-acting beta2-agonist therapy
-
Lancet
-
Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of adrb2 polymorphisms on response to long-acting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet 2007; 370:2118-25.
-
(2007)
a pharmacogenetic analysis of two randomised studies
, vol.370
, pp. 2118-25
-
-
Bleecker, E.R.1
Postma, D.S.2
Lawrance, R.M.3
Meyers, D.A.4
Ambrose, H.J.5
Goldman, M.6
-
79
-
-
70449652591
-
Effect of [beta]2-adrenergic receptor polymorphism on response to long-acting [beta]2 agonist in asthma (LARGE trial)
-
Lancet
-
Wechsler ME, Kunselman SJ, Chinchilli VM et al. Effect of [beta]2-adrenergic receptor polymorphism on response to long-acting [beta]2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet 2009; 374:1754-64.
-
(2009)
a genotype-stratified, randomised, placebo-controlled, crossover trial
, vol.374
, pp. 1754-64
-
-
Wechsler, M.E.1
Kunselman, S.J.2
Chinchilli, V.M.3
-
80
-
-
77951886422
-
Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate
-
Bleecker ER, Nelson HS, Kraft M et al. Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med 2010; 181:676-87.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 676-87
-
-
Bleecker, E.R.1
Nelson, H.S.2
Kraft, M.3
-
81
-
-
0031990692
-
Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2 adrenoceptor
-
January B, Seibod A, Allal C et al. Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2 adrenoceptor. Br J Clin Pharmacol 1998; 123:701-11.
-
(1998)
Br J Clin Pharmacol
, vol.123
, pp. 701-11
-
-
January, B.1
Seibod, A.2
Allal, C.3
-
82
-
-
33846895899
-
Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization
-
Moore RH, Millman EE, Godines V et al. Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol 2007; 36:254-61.
-
(2007)
Am J Respir Cell Mol Biol
, vol.36
, pp. 254-61
-
-
Moore, R.H.1
Millman, E.E.2
Godines, V.3
-
83
-
-
0347319054
-
The arginine-16 β2-adrenergic polymorphism predisposes to bronchoprotective subsensitivity in patients with formoterol and sameterol
-
Lee DKC, Currie GP, Hal IP, Lima JJ, Lipworth BJ. The arginine-16 β2-adrenergic polymorphism predisposes to bronchoprotective subsensitivity in patients with formoterol and sameterol. Br J Clin Pharmacol 2003; 57:68-75.
-
(2003)
Br J Clin Pharmacol
, vol.57
, pp. 68-75
-
-
Lee, D.K.C.1
Currie, G.P.2
Hal, I.P.3
Lima, J.J.4
Lipworth, B.J.5
-
84
-
-
33645800240
-
Tachyphylaxis to [beta]2-agonists in Spanish asthmatic patients could be modulated by [beta]2-adrenoceptor gene polymorphisms
-
Tellería JJ, Blanco-Quirós A, Muntión S et al. Tachyphylaxis to [beta]2-agonists in Spanish asthmatic patients could be modulated by [beta]2-adrenoceptor gene polymorphisms. Respir Med 2006; 100:1072-8.
-
(2006)
Respir Med
, vol.100
, pp. 1072-8
-
-
Tellería, J.J.1
Blanco-Quirós, A.2
Muntión, S.3
-
85
-
-
65949105914
-
Beta2 adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations
-
Carroll C, Stoltz P, Schramm C, Zucker A. Beta2 adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. Chest 2009; 135:1186-92.
-
(2009)
Chest
, vol.135
, pp. 1186-92
-
-
Carroll, C.1
Stoltz, P.2
Schramm, C.3
Zucker, A.4
-
86
-
-
45849121045
-
Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma
-
Martin AC, Zhang G, Rueter K et al. Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma. J Asthma 2008; 45:383-8.
-
(2008)
J Asthma
, vol.45
, pp. 383-8
-
-
Martin, A.C.1
Zhang, G.2
Rueter, K.3
-
87
-
-
2342567291
-
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
-
Mathews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004; 113:1100-8.
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 1100-8
-
-
Mathews, J.G.1
Ito, K.2
Barnes, P.J.3
Adcock, I.M.4
-
88
-
-
55749111239
-
A polymorphism of g-protein coupled receptor kinase5 alters agonist-promoted desensitization of [beta]2-adrenergic receptors
-
Wang WCH, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of g-protein coupled receptor kinase5 alters agonist-promoted desensitization of [beta]2-adrenergic receptors. Pharmacogenetics Genomics 2008; 18:729-32.
-
(2008)
Pharmacogenetics Genomics
, vol.18
, pp. 729-32
-
-
Wang, W.C.H.1
Mihlbachler, K.A.2
Bleecker, E.R.3
Weiss, S.T.4
Liggett, S.B.5
-
89
-
-
0141538183
-
An ile to met polymorphism in the catalytic domain of adenylyl cylase type 9 confers reduced beta 2 adrenergic receptor stimulation
-
Small KM, Brown KM, Theiss CT et al. An ile to met polymorphism in the catalytic domain of adenylyl cylase type 9 confers reduced beta 2 adrenergic receptor stimulation. Pharmacogenetics 2003; 13:535-41.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 535-41
-
-
Small, K.M.1
Brown, K.M.2
Theiss, C.T.3
-
90
-
-
21244503821
-
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma
-
Hum Mol Genet
-
Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between {beta}-agonist and corticosteroid pathways. Hum Mol Genet 2005; 14:1671-7.
-
(2005)
interaction between {beta}-agonist and corticosteroid pathways
, vol.14
, pp. 1671-7
-
-
Tantisira, K.G.1
Small, K.M.2
Litonjua, A.A.3
Weiss, S.T.4
Liggett, S.B.5
|