A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors

Pharmacogenetics and Genomics

Volumn 18, Issue 8, 2008, Pages 729-732

  Wang, Wayne C H ^a   Mihlbachler, Kathryn A ^a   Bleecker, Eugene R ^b   Weiss, Scott T ^c,d   Liggett, Stephen B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c CHANNING LABORATORY   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Asthma; Beta agonist; Desensitization; Kinases; Polymorphism; Tachyphylaxis

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR KINASE 5; GRK5 PROTEIN, HUMAN; ISOPRENALINE;

AFRICAN AMERICAN; ARTICLE; ASTHMA; CHINESE HAMSTER; DESENSITIZATION; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC VARIABILITY; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; CELL LINE; DRUG EFFECT; DRUG POTENTIATION; ENDOCYTOSIS; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; CELL LINE; ENDOCYTOSIS; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HUMANS; ISOPROTERENOL; PHENOTYPE; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 55749111239     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32830967e9     Document Type: Article

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