The Ile164 β2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

Journal of Clinical Investigation

Volumn 102, Issue 8, 1998, Pages 1534-1539

  Liggett, Stephen B ^a   Wagoner, Lynne E ^a   Craft, Laura L ^a   Hornung, Richard W ^a   Hoit, Brian D ^a   McIntosh, Tina C ^b   Walsh, Richard A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Molecular Tool Inc   (United States)

Author keywords

Adenylyl cyclase; Cardiomyopathy; Cyclic AMP; Genetics; Heart failure; Mutation; Polymorphism; adrenergic receptor

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; ISOLEUCINE;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME; ALLELE; BIOLOGICAL MODEL; CONGESTIVE CARDIOMYOPATHY; GENE FREQUENCY; GENETICS; GENOTYPE; HEART MUSCLE ISCHEMIA; MIDDLE AGED; PROSPECTIVE STUDY; SURVIVAL;

ADULT; ALLELES; CARDIOMYOPATHY, DILATED; FEMALE; GENE FREQUENCY; GENOTYPE; HEART FAILURE, CONGESTIVE; HUMANS; ISOLEUCINE; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MYOCARDIAL ISCHEMIA; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RECEPTORS, ADRENERGIC, BETA-2; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0032531426     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI4059     Document Type: Article

References (34)

1. Kannel, W.B., and A.J. Belanger. 1991. Epidemiology of heart failure. Am. Heart J. 121:951-957.
2. The SOLVD Investigators. 1991. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 325:293-302.
3. Ho, K.K., K.M. Anderson, W.B. Kannel, W. Grossman, and D. Levy. 1993. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation. 88:107-115.
4. Parmley, W.W. 1996. Cost-effective cardiology: cost-effective management of heart failure. Clin. Cardiol. 19:240-242.
5. Wagoner, L.E., and R.A. Walsh. 1996. The cellular pathophysiology of progression to heart failure. Curr. Opin. Cardiol 11:237-244.
6. 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol. Pharmacol. 35:295-303.
7. Bristow, M.R., R. Ginsburg, W. Minobe, R.S. Cubicciotti, W.S. Sageman, K. Lurie, M.E. Billingham, D.C. Harrison, and E.B. Stinson. 1982. Decreased catecholamine sensitivity and β-adrenergic-receplor density in failing human hearts. N Engl. J. Med. 307:205-211.
8. 1-receptor downregulation in heart failure. Cric. Res. 59:297-309.
9. 2-adrenergic receptor in normal and asthmatic subjects. Am. J. Resp. Cell Mol. Biol. 8:334-339.
10. 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J. Biol. Chem. 268:23116-23121.
11. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 33:9414-9419.
12. 2-adrenergic receptor polymorphism expressed in transgenic mice. Proc. Natl. Acad. Sci. USA. 10483-10488.
13. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 13:25-33.
14. 2adrenoceptor polymorphism with lower airway reactivily in asthmatic subjects. Lancet. 345:1213-1214.
15. 2adrenergic receptor in nocturnal and non-nocturnal asthma: evidence that Gly16 correlates with the nocturnal phenotype. J. Clin. Invest. 95:1635-1641.
16. 2-adrenoceptor polymorphism is associated with elevated immunoglobulin E levels in asthmatic families. J. Allergy Clin, Immunol. 100:261-265.
17. Martinez, F.D., P.E. Graves, M. Baldini, S. Solomon, and R. Erickson. 1997. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J. Clin. Invest. 100:3184-3188.
18. Tan, S., I.P. Hall, J. Dewar, E. Dow, and B. Lipworth. 1997. Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitization in moderately severe stable asthmatics. Lancet. 350:995-999.
19. Nikiforov, T.T., R.B. Rendle, P. Goelet, Y.-H. Rogers, M.L. Kotewicz, S. Anderson, G.L. Trainor, and M.R. Knapp. 1994. Genetic Bit Analysis: a solid phase method for typing single nucleotide polymorphisms. Nucleic Acids Res. 22:4167-4175.
20. Cox, D.R. 1972. Regression models and Life-tables (with discussion). J. R. Stat. Soc. 34:187-220.
21. Motulsky, H.J., E.M.S. Cunningham, A. Deblasi, and P.A. Insel. 1986. Desensitization and redistribution of beat-adrenergic receptors on human mononuclear leukocytes. Amer. J. Physiol. 250:E583-E590.
22. Insel, P.A. 1996. Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors - evolving concepts and clinical implications. N. Engl. J. Med. 334:580-585.
23. Rockman, H.A., W.J. Koch, C.A. Milano, and R.J. Lefkowitz. 1996. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. J. Mol. Med. 74:489-495.
24. Freedman, N.J., and R.J. Lefkowitz. 1996. Desensitization of G protein-coupled receptors. Recent. Prog. Horm. Res. 51:351.
25. 2-adrenergic receptor polymorphisms. News in Physiologic Sciences. 10:265-273.
26. Waagstein, F., K. Caidahl, I. Wallentin, C.H. Bergh, and A. Hjalmarson. 1989. Long-term β-blockade in dilated cardiomyopathy. Circulation. 80:551-563.
27. Packer, M., J.R. Carver, R.J. Rodeheffer, R.J. Ivanhoe, R. DiBianco, S.M. Zeldis, G.H. Hendrix, W.J. Bommer, U. Elkayam, M.L. Kukin, et al. 1991. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N. Engl. J. Med. 325:1468-1475.
28. Aass, H., T. Skomedal, and J.-B. Osnes. 1988. Increase of cyclic AMP in sub-cellular fractions of rat heart muscle after β-adrenergic stimulation: prenalterol and isoprenaline cause different distribution of bound cyclic AMP. J. Mol. Cell Cardiol. 20:847-860.
29. 2+ transients. Circ. Res. 69:1369-1379.
30. + exchange. Nature. 392:626-630.
31. Gilbert, E.M., S.L. Olsen, D.G. Renlund, and M.R. Bristow. 1993. Beta-adrenergic receptor regulation and left ventricular function in idiopathic dilated cardiomyopathy. Am. J. Cardiol. 71:23C-29C.
32. 2adrenergic receptor. Science. 264:582-586.
33. 2 adrenergic receptor cDNA. J. Clin. Invest. 101:337-343.
34. Akhter, S.A., C.A., Skaer, A.P. Kypson, P.H. McDonald, K.C. Peppel, D.D. Glower, R.J. Lefkowitz, and W.J. Koch. 1997. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci. USA. 94:12100-12105.