The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs

European Journal of Pharmacology

Volumn 421, Issue 3, 2001, Pages 141-147

  Green, Stuart A ^a   Rathz, Deborah A ^a   Schuster, Amy J ^a   Liggett, Stephen B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adenylyl cyclase; G protein; Mutation

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; FORMOTEROL; ISOPRENALINE; ORCIPRENALINE; SALBUTAMOL; SALMETEROL; TERBUTALINE;

ARTICLE; ASTHMA; BINDING AFFINITY; BRONCHOSPASM; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HUMAN; PERFUSION; PHARMACOGENOMICS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HUMANS; IODINE RADIOISOTOPES; ISOPROTERENOL; ORCIPRENALINE; PINDOLOL; POLYMORPHISM, GENETIC; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-2; TERBUTALINE;

EID: 0035876397     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01049-4     Document Type: Article

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