Heterogeneity of therapeutic responses in asthma

British Medical Bulletin

Volumn 56, Issue 4, 2000, Pages 1054-1070

  Drazen, Jeffrey M ^a   Silverman, Edwin K ^a   Lee, Tak H ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOCORTICOID; PEPTIDOLEUKOTRIENE; TRANSCRIPTION FACTOR;

ASTHMA; DNA BINDING; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; INFLAMMATION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STATISTICAL ANALYSIS; STEROID THERAPY;

ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADRENERGIC BETA-AGONISTS; ASTHMA; BRONCHODILATOR AGENTS; CYTOKINES; GLUCOCORTICOIDS; HUMANS; LEUKOTRIENE ANTAGONISTS; MEMBRANE PROTEINS; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, GLUCOCORTICOID; TREATMENT OUTCOME;

EID: 0034443957     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1258/0007142001903535     Document Type: Review

References (48)

1. Unrepeatable repeatabilities: A common mistake
2. Spirometry in the Lung Health Study II: Determinants of short-term intra-individual variability
3. Spirometry in the Lung Health Study I: Methods and quality control
4. Mechanism and detection of glucocorticoid insensitivity in asthma
5. Steroid resistance in bronchial asthma
6. Corticosteroid resistance in chronic asthma
7. Pathogenesis of steroid-resistant asthma
8. Glucocorticoid resistance in chronic asthma - Peripheral-blood lymphocyte-T activation and comparison of the lymphocyte-T inhibitory effects of glucocorticoids and cyclosporin-A
9. Glucocorticoid resistance in chronic asthma -glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro
10. Dysregulation of interleukin-4, interleukin-5, and interferon-gamma gene-expression in steroid-resistant asthma
11. Hypothalamic-pituitary-adrenal axis in corticosteroid-resistant bronchial asthma
12. Effects of prednisolone on bone turnover in patients with corticosteroid resistant asthma
13. Prednisolone pharmacokinetics in asthmatic patients
14. Prednisolone disposition in steroid-dependent asthmatic children
15. Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid-resistant bronchial-asthma
16. Steroid-resistant asthma - Cellular mechanisms contributing to inadequate response to glucocorticoid therapy
17. Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma
18. Association of glucocordcoid insensitivity with increased expression of glucocorticoid receptor beta
19. Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma
20. Abnormal glucocorticoid receptor activator protein-I interaction in steroid-resistant asthma
21. Increased c-Fos synthesis in mononuclear-cells from patients with corticosteroid resistant asthma
22. Corticosteroid-resistant bronchial asthma is associated with increased c-Fos expression in monocytes and T lymphocytes
23. In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosphorylation of jun amino terminal kinase (JNK) and failure of prednisolone to inhibit JNK phosphorylation
24. The British guidelines on asthma management
25. Regular inhaled beta-agonist treatment in bronchial asthma
26. Asthma control during long-term treatment with regular inhaled salbutamol and salmeterol
27. 2-adrenergic receptor in normal and asthmatic subjects
28. 2-adrenoceptor polymorphisms are in linkage disequilibrium but are not associated with asthma in an adult population
29. 2-adrenergic receptor in nocturnal and non-nocturnal asthma
30. 2-adrenoceptor and response to albuterol in children with and without a history of wheezing
31. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
32. 2-agonist therapy
33. Polymorphism of the beta(2)-adrenoceptor and the response to long-term beta(2)-agonist therapy in asthma
34. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma
35. 2-adrenergic receptor on the response to regular use of albuterol in asthma
36. 2-adrenergic receptor: Focus on interactions of agonist with receptor
37. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
38. 4 from the urine of patients with airway obstruction
39. Leukotrienes and the airways
40. 4 after antigen challenge and in acute asthma and allergic rhinitis
41. 4 in humans. Effect of indomethacin
42. Naturally-occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
43. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
44. The effects of regular inhaled salbutamol on asthma control: The main result of TRUST