Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 171, Issue 6, 2005, Pages 563-570

  Choudhry, Shweta ^b   Ung, Ngim ^b   Avila, Pedro C ^b   Ziv, Elad ^b   Nazario, Sylvette ^b   Casal, Jesus ^b   Torres, Alfonso ^b   Gorman, Jennifer D ^b   Salari, Keyan ^b   Rodriguez Santana, Jose R ^b   Toscano, Monica ^b   Sylvia, Jody Senter ^b   Alioto, MariaElena ^b   Castro, Richard A ^b   Salazar, Michael ^b   Gomez, Ivan ^b   Fagan, Joanne K ^b   Salas, Jorge ^b   Clark, Suzanne ^b   Lilly, Craig ^b   Matallana, Henry ^b   Selman, Moises ^b   Chapela, Rocio ^b   Sheppard, Dean ^b   Weiss, Scott T ^b   Ford, Jean G ^b   Boushey, Homer A ^b   Drazen, Jeffrey M ^b   Rodriguez Cintron, William ^b   Silverman, Edwin K ^b   Burchard, Esteban González ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

2 adrenergic receptor gene; Asthma genetics; Latinos; Pharmacogenetic

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BRONCHODILATING AGENT; SALBUTAMOL;

ADOLESCENT; ALLELE; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETICS; PRIORITY JOURNAL; PUERTO RICO; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ALBUTEROL; ALLELES; ASTHMA; BRONCHODILATOR AGENTS; CHILD; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; MALE; MEXICAN AMERICANS; MEXICO; POLYMORPHISM, SINGLE NUCLEOTIDE; PUERTO RICO; RECEPTORS, ADRENERGIC, BETA-2; REGRESSION ANALYSIS; RESPIRATORY FUNCTION TESTS; UNITED STATES;

EID: 20144363204     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200409-1286OC     Document Type: Article

References (28)

1. US Census Bureau U.S.DoC. United States Census 2000: United States Department of Commerce, 2000.
2. Hanis CL, Hewett-Emmett D, Bertin TK, Schull WJ. Origins of U.S. Hispanics: implications for diabetes. Diabetes Care 1991;14:618-627.
3. Carter-Pokras OD, Gergen PJ. Reported asthma among Puerto Rican, Mexican-American, and Cuban children: 1982 through 1984. Am J Public Health 1993;83:580-582.
4. Homa DM, Mannino DM, Lara M. Asthma mortality in U.S. Hispanics of Mexican. Puerto Rican, and Cuban heritage, 1990-1995. Am J Respir Crit Care Med 2000;161:504-509.
5. Nelson HS. Beta-adrenergic bronchodilators. N Engl J Med 1995;333:499-506.
6. Insel PA. Seminars in medicine of the Beth Israel Hospital, Boston: adrenergic receptors-evolving concepts and clinical implications. N Engl J Med 1996;334:580-585.
7. Ohe M, Munakata M, Hizawa N, Itoh A, Doi I, Yamaguchi E, Homma Y, Kawakami Y. Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax 1995;50:353-359.
8. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997;100:3184-3188.
9. Lima JJ, Thomason DB, Mohamed MH, Eberle LV, Self TH, Johnson JA. Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin Pharmacol Ther 1999;65:519-525.
10. Silverman EK, Kwiatkowski DJ, Sylvia JS, Lazarus R, Drazen JM, Lange C, Laird NM, Weiss ST. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol 2003;112:870-876.
11. Lipworth BJ, Hall IP, Tan S, Aziz I, Coutie W. Effects of genetic polymorphism on ex vivo and in vivo function of beta2-adrenoceptors in asthmatic patients. Chest 1999;115:324-328.
12. Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G, Liggett SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000;97:10483-10488.
13. Tan KS, McFarlane LC, Lipworth BJ. Effects of oral and inhaled corticosteroid on lymphocyte beta2- adrenoceptor function in asthmatic patients. Br J Clin Pharmacol 1997;44:565-568.
14. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM. Chinchilli VM, Cooper DM, Fahy JV, Fish JE. Ford JG, et al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000;162:75-80.
15. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516.
16. Ziv E, Burchard EG. Human population structure and genetic association studies, Pharmacogenomics 2003;4:431-441.
17. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Perez-Stable EJ, Sheppard D, Risch N. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med 2003;348:1170-1175.
18. Burchard E, Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Salari K, Rodriguez Santana J, et al. Pharmacogenetic differences in response to bronchodilators between Puerto Rican and Mexican asthmatics [abstract]. American Society of Human Genetics, Toronto, Canada, 2004. Vol. 54th Annual.
19. Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, et al. Lower bronchodilator responsiveness in Puerto Rican than in Mexican asthmatic subjects. Am J Respir Crit Care Med 2003.
20. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152:1107-1136.
21. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179-187.
22. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259-266.
23. Ott J. Analysis of human genetic linkage. In: The Johns Hopkins University Press, 3rd ed. Baltimore, 1999.
24. Laird NM, Horvath S, Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol 2000;19:S36-S42.
25. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genetic Epidemiol 2004;26(1):61-69.
26. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotypes reconstruction from population data. Am J Hum Genet 2001;68:978-989.
27. Reihsaus E. Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the β2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993;8:334-339.
28. Summerhill E, Leavitt SA, Gidley H, Parry R, Solway J, Ober C. Beta(2)-adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites. Am J Respir Crit Care Med 2000;162:599-602.