Limited impact of multiple 5′ single-nucleotide polymorphisms on the transcriptional control of the human β2-adrenoceptor gene

Immunogenetics

Volumn 56, Issue 9, 2004, Pages 625-630

  Westland, Robert ^a   Van Veen, Anneke ^a   Jansen, Henk M ^a   Jonkers, Rene E ^a   Wierenga, Eddy A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Allele specific transcript quantification; Beta 2 adrenoceptor; Human; Single nucleotide polymorphisms; Transcription

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; TRANSCRIPTION FACTOR;

ALLELE; ARTICLE; ASTHMA; CONTROLLED STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETIC TRANSCRIPTION; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SINGLE NUCLEOTIDE POLYMORPHISM;

5' UNTRANSLATED REGIONS; ASTHMA; GENE EXPRESSION REGULATION; HAPLOTYPES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 11944266854     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-004-0732-8     Document Type: Article

References (20)

1. Barnes PJ (1995) Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 152:838-860
2. Bhagat R, Kalra S, Swystun VA, Cockcroft DW (1995) Rapid onset of tolerance to the bronchoprotective effect of salmeterol. Chest 108:1235-1239
3. Cheung D, Timmers MC, Zwinderman AH, Bel EH, Dijkman JH, Sterk PJ (1992) Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsive-ness in patients with mild asthma. N Engl J Med 327:1198-1203
4. Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan, Arnold K, Ruano G, Liggett SB (2000) Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 97:10483-10488
5. Emorine LJ, Marullo S, Delavier-Klutchko C, Kaveri SV, Durieu-Trautmann O, Strosberg AD (1987) Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. Proc Natl Acad Sci USA 84:6995-6999
6. Green SA, Turki J, Bejarano P, Hall IP, Liggett SB (1995) Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 13:25-33
7. Green SA, Turki J, Innis M, Liggett SB (1994) Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33:9414-9419
8. Hadcock JR, Malbon CC (1988) Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc Natl Acad Sci USA 85:5021-5025
9. Hilkens CMU, Messer G, Tesselaar K, van Rietschoten AGI, Kapsenberg ML, Wierenga EA (1996) Lack of IL-12 signaling in human allergen-specific Th2 cells. J Immunol 157:4316-4321
10. Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ (1987a) cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 84:46-50
11. Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RA, Keller P, Caron MG, Lefkowitz RJ (1987b) Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem 262:7321-7327
12. Lipworth B, Koppelman GH, Wheatley AP, Le Jeune I, Coutie W, Meurs H, Kauffman HF, Postma DS, Hall IP (2002) beta(2) adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cells. Thorax 57:61-66
13. McGraw DW, Forbes SL, Kramer LA, Liggett SB (1998) Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest 102:1927-1932
14. Nishikawa M, Mak JC, Barnes PJ (1996) Effect of short- and long-acting beta 2-adrenoceptor agonists on pulmonary beta 2-adrenoceptor expression in human lung. Eur J Pharmacol 318:123-129
15. Nishimura K, Tamaoki J, Isono K, Aoshiba K, Nagai A (2002) Beta adrenergic receptor-mediated growth of human airway epithelial cell lines. Eur Respir J 20:353-358
16. Parola AL, Kobilka BK (1994) The peptide product of a 5′ leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. J Biol Chem 269:4497-4505
17. Reihsaus E, Innis M, MacIntyre N, Liggett SB (1993) Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 8:334-339
18. Scott MG, Swan C, Wheatley AP, Hall IP (1999) Identification of novel polymorphisms within the promoter region of the human beta2 adrenergic receptor gene. Br J Pharmacol 126:841-844
19. van Veen A, Weller FR, Wierenga EA, Jansen HM, Jonkers RE (2003) A comparison of salmeterol and formoterol in attenuating airway responses to short-acting beta2-agonists. Pulm Pharmacol Ther 16:153-161
20. Yates DH, Kharitonov SA, Barnes PJ (1996) An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist. Am J Respir Crit Care Med 154:1603-1607