Common ADRB2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Panebra, Alfredo ^a   Wang, Wayne C ^a   Malone, Molly M ^a   Pitter, Demar R G ^a   Weiss, Scott T ^b   Hawkins, Gregory A ^c   Liggett, Stephen B ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL STRAIN COS7; CELL SURFACE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSFECTION; HAPLOTYPE; MOLECULAR CLONING; PHENOTYPE; PHYLOGENETIC TREE; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STEADY STATE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CLASSIFICATION; GENETIC POLYMORPHISM; GENETICS; HUMAN; METABOLISM; PHYLOGENY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; HAPLOTYPES; HUMANS; PHENOTYPE; PHYLOGENY; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RECEPTORS, ADRENERGIC, BETA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77955608819     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011819     Document Type: Article

References (25)

1. Barnes PJ (1995) Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 152: 838-860.
2. Drazen JM, Silverman EK, Lee TH (2000) Heterogeneity of therapeutic responses in asthma. Br Med Bull 56: 1054-1070.
3. van Campen LC, Visser FC, Visser CA (1998) Ejection fraction improvement by beta-blocker treatment in patients with heart failure: an analysis of studies published in the literature. J Cardiovasc Pharmacol 32 Suppl 1: S31-S35.
4. 2-adrenergic receptor in normal and asthmatic subjects. Am J Resp Cell Mol Biol 8: 334-339.
5. Hall IP, Liggett SB (2006) Pharmacogenetics of respiratory disease. In: Hall IP, Pirmohamed M, eds. Pharmacogenetics. New York: Informa Healthcare. pp 91-111.
6. Liggett SB (2005) Genetic, molecular, and clinical characterization of adrenergic receptor polymorphisms. In: Perez D, ed. The Adrenergic Receptors: In the 21st Century. Totowa: Humana Press, Inc.pp 339-364.
7. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochem 33: 9414-9419.
8. Dorn GW, Liggett SB (2009) Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Mol Pharmacol 76: 466-480.
9. 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A 97: 10483-10488.
10. 2-adrenergic receptor regulate receptor expression. J Clin Invest 102: 1927-1932.
11. Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Klanderman B, et al. (2006) Sequence, haplotype and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med 174: 1101-1109.
12. 2-adrenergic receptor 39UTR alter expression and agonist regulation. Am J Physiol Lung Cell Mol Physiol 294: L190-L195.
13. 2-adrenergic receptor: Focus on Interactions of Agonist with Receptor. In: Pauwels R, Lofdahl CG,O'Byrne P, eds. Beta2-Agonists in Asthma Treatment. New York: Marcel Dekker, Inc.pp 19-34.
14. Wortsman J, Frank S, Cryer PE (1984) Adrenomedullary response to maximal stress in humans. Am J Med 77: 779-784.
15. 2-Adrenergic receptors desensitize in response to in vivo administered bagonist. Am J Physiol:Lung Cell Mol Physiol 13: L709-L714.
16. Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, et al. (2004) Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. The Lancet 364: 1505-1512.
17. Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, et al. (2007) Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet 370:2118-2125.
18. Bristow M (2003) Antiadrenergic therapy of chronic heart failure: surprises and new opportunities. Circ 107: 1100-1102.
19. Wang WC, Mihlbachler KA, Brunnett AC, Liggett SB (2009) Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway {beta}2-adrenergic receptor physiologic signaling. Proc Natl Acad Sci U S A 106: 15007-15012.
20. 2Cadrenergic receptors: diverse intragenic variability with haplotype-specific functional effects. Proc Natl Acad Sci 101: 13020-13025.
21. 2-adrenergic receptor routes receptors to degradation during agonist regulation. J Biol Chem 279: 38603-38607.
22. 2C-adrenergic receptor confers impaired coupling to multiple effectors. J Biol Chem 275: 23059-23064.
23. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
24. Lo K, Smale ST (1996) Generality of a functional initiator consensus sequence. Gene 182: 13-22.
25. Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, et al. (2009) Sequencing and analyses of all known human rhinovirus genomes reveals structure and evolution. Science 324: 55-59.