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Volumn 6, Issue 1, 2011, Pages

PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; FATTY ACID; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOLIPID; PROTEIN KINASE C ALPHA; S6 KINASE; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

EID: 79251588105     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016215     Document Type: Article
Times cited : (37)

References (62)
  • 2
    • 38349168971 scopus 로고    scopus 로고
    • Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding
    • Yang KJ, Shin S, Piao L, Shin E, Li Y, et al. (2008) Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. J Biol Chem 283: 1480-1491.
    • (2008) J Biol Chem , vol.283 , pp. 1480-1491
    • Yang, K.J.1    Shin, S.2    Piao, L.3    Shin, E.4    Li, Y.5
  • 3
    • 33746817877 scopus 로고    scopus 로고
    • Fine tuning PDK1 activity by phosphorylation at Ser163
    • Riojas RA, Kikani CK, Wang C, Mao X, Zhou L, et al. (2006) Fine tuning PDK1 activity by phosphorylation at Ser163. J Biol Chem 281: 21588-21593.
    • (2006) J Biol Chem , vol.281 , pp. 21588-21593
    • Riojas, R.A.1    Kikani, C.K.2    Wang, C.3    Mao, X.4    Zhou, L.5
  • 4
    • 12644301164 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
    • Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, et al. (1997) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 7: 776-789.
    • (1997) Curr Biol , vol.7 , pp. 776-789
    • Alessi, D.R.1    Deak, M.2    Casamayor, A.3    Caudwell, F.B.4    Morrice, N.5
  • 5
    • 0033199841 scopus 로고    scopus 로고
    • Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo
    • Casamayor A, Morrice NA, Alessi DR (1999) Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochem J 342 (Pt 2): 287-292.
    • (1999) Biochem J , vol.342 , Issue.PART 2 , pp. 287-292
    • Casamayor, A.1    Morrice, N.A.2    Alessi, D.R.3
  • 6
    • 27944467785 scopus 로고    scopus 로고
    • New''-clear functions of PDK1: Beyond a master kinase in the cytosol
    • Kikani CK, Dong LQ, Liu F (2005) ''New''-clear functions of PDK1: beyond a master kinase in the cytosol? J Cell Biochem 96: 1157-1162.
    • (2005) J Cell Biochem , vol.96 , pp. 1157-1162
    • Kikani, C.K.1    Dong, L.Q.2    Liu, F.3
  • 7
    • 0037086609 scopus 로고    scopus 로고
    • PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism
    • Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA (2002) PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. Embo J 21: 1327-1338.
    • (2002) Embo J , vol.21 , pp. 1327-1338
    • Tian, X.1    Rusanescu, G.2    Hou, W.3    Schaffhausen, B.4    Feig, L.A.5
  • 8
    • 15944410614 scopus 로고    scopus 로고
    • PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
    • Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005) PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science 308: 114-118.
    • (2005) Science , vol.308 , pp. 114-118
    • Lee, K.Y.1    D'acquisto, F.2    Hayden, M.S.3    Shim, J.H.4    Ghosh, S.5
  • 9
    • 31444441028 scopus 로고    scopus 로고
    • 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation
    • Yin Y, Yuan H, Wang C, Pattabiraman N, Rao M, et al. (2006) 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation. Mol Endocrinol 20: 268-278.
    • (2006) Mol Endocrinol , vol.20 , pp. 268-278
    • Yin, Y.1    Yuan, H.2    Wang, C.3    Pattabiraman, N.4    Rao, M.5
  • 10
    • 0037099658 scopus 로고    scopus 로고
    • Essential role of PDK1 in regulating cell size and development in mice
    • Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, et al. (2002) Essential role of PDK1 in regulating cell size and development in mice. Embo J 21: 3728-3738.
    • (2002) Embo J , vol.21 , pp. 3728-3738
    • Lawlor, M.A.1    Mora, A.2    Ashby, P.R.3    Williams, M.R.4    Murray-Tait, V.5
  • 11
    • 0141737071 scopus 로고    scopus 로고
    • Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
    • Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, et al. (2003) Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. Embo J 22: 4666-4676.
    • (2003) Embo J , vol.22 , pp. 4666-4676
    • Mora, A.1    Davies, A.M.2    Bertrand, L.3    Sharif, I.4    Budas, G.R.5
  • 12
    • 68049117229 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma
    • Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, et al. (2009) 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res 69: 6299-6306.
    • (2009) Cancer Res , vol.69 , pp. 6299-6306
    • Maurer, M.1    Su, T.2    Saal, L.H.3    Koujak, S.4    Hopkins, B.D.5
  • 13
    • 33646581038 scopus 로고    scopus 로고
    • 3-phosphoinositidedependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    • Xie Z, Yuan H, Yin Y, Zeng X, Bai R, et al. (2006) 3-phosphoinositidedependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. BMC Cancer 6: 77.
    • (2006) BMC Cancer , vol.6 , pp. 77
    • Xie, Z.1    Yuan, H.2    Yin, Y.3    Zeng, X.4    Bai, R.5
  • 14
    • 28644435769 scopus 로고    scopus 로고
    • Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
    • Lin HJ, Hsieh FC, Song H, Lin J (2005) Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer 93: 1372-1381.
    • (2005) Br J Cancer , vol.93 , pp. 1372-1381
    • Lin, H.J.1    Hsieh, F.C.2    Song, H.3    Lin, J.4
  • 15
    • 0141816833 scopus 로고    scopus 로고
    • Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates betacatenin and c-Myc, and down-regulates caveolin-1
    • Xie Z, Zeng X, Waldman T, Glazer RI (2003) Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates betacatenin and c-Myc, and down-regulates caveolin-1. Cancer Res 63: 5370-5375.
    • (2003) Cancer Res , vol.63 , pp. 5370-5375
    • Xie, Z.1    Zeng, X.2    Waldman, T.3    Glazer, R.I.4
  • 16
    • 67649604297 scopus 로고    scopus 로고
    • Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells
    • Liu Y, Wang J, Wu M, Wan W, Sun R, et al. (2009) Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res 7: 944-954.
    • (2009) Mol Cancer Res , vol.7 , pp. 944-954
    • Liu, Y.1    Wang, J.2    Wu, M.3    Wan, W.4    Sun, R.5
  • 17
    • 0037096904 scopus 로고    scopus 로고
    • Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
    • Zeng X, Xu H, Glazer RI (2002) Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. Cancer Res 62: 3538-3543.
    • (2002) Cancer Res , vol.62 , pp. 3538-3543
    • Zeng, X.1    Xu, H.2    Glazer, R.I.3
  • 18
    • 33747610198 scopus 로고    scopus 로고
    • Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
    • Liang K, Lu Y, Li X, Zeng X, Glazer RI, et al. (2006) Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol 70: 1045-1052.
    • (2006) Mol Pharmacol , vol.70 , pp. 1045-1052
    • Liang, K.1    Lu, Y.2    Li, X.3    Zeng, X.4    Glazer, R.I.5
  • 20
    • 2342640982 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines
    • Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, et al. (2004) Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Res 64: 3162-3170.
    • (2004) Cancer Res , vol.64 , pp. 3162-3170
    • Stephen, R.L.1    Gustafsson, M.C.2    Jarvis, M.3    Tatoud, R.4    Marshall, B.R.5
  • 21
    • 47349115799 scopus 로고    scopus 로고
    • PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate
    • Glazer RI, Yuan H, Xie Z, Yin Y (2008) PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate. PPAR Res 2008: 247379.
    • (2008) PPAR Res , vol.2008 , pp. 247379
    • Glazer, R.I.1    Yuan, H.2    Xie, Z.3    Yin, Y.4
  • 22
    • 0037235020 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and cancers
    • Koeffler HP (2003) Peroxisome proliferator-activated receptor gamma and cancers. Clin Cancer Res 9: 1-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 1-9
    • Koeffler, H.P.1
  • 23
    • 27944434182 scopus 로고    scopus 로고
    • Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
    • Knutsen HK, Olstorn HB, Paulsen JE, Husoy T, Goverud IL, et al. (2005) Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. Anticancer Res 25: 3781-3789.
    • (2005) Anticancer Res , vol.25 , pp. 3781-3789
    • Knutsen, H.K.1    Olstorn, H.B.2    Paulsen, J.E.3    Husoy, T.4    Goverud, I.L.5
  • 24
    • 1942470331 scopus 로고    scopus 로고
    • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    • Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10: 245-247.
    • (2004) Nat Med , vol.10 , pp. 245-247
    • Gupta, R.A.1    Wang, D.2    Katkuri, S.3    Wang, H.4    Dey, S.K.5
  • 25
    • 0034779322 scopus 로고    scopus 로고
    • Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma
    • Jaeckel EC, Raja S, Tan J, Das SK, Dey SK, et al. (2001) Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 127: 1253-1259.
    • (2001) Arch Otolaryngol Head Neck Surg , vol.127 , pp. 1253-1259
    • Jaeckel, E.C.1    Raja, S.2    Tan, J.3    Das, S.K.4    Dey, S.K.5
  • 26
    • 0034485955 scopus 로고    scopus 로고
    • Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptordelta in human endometrial adenocarcinoma
    • Tong BJ, Tan J, Tajeda L, Das SK, Chapman JA, et al. (2000) Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptordelta in human endometrial adenocarcinoma. Neoplasia 2: 483-490.
    • (2000) Neoplasia , vol.2 , pp. 483-490
    • Tong, B.J.1    Tan, J.2    Tajeda, L.3    Das, S.K.4    Chapman, J.A.5
  • 27
    • 0036256981 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin
    • Suchanek KM, May FJ, Lee WJ, Holman NA, Roberts-Thomson SJ (2002) Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin. Int J Biochem Cell Biol 34: 1051-1058.
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 1051-1058
    • Suchanek, K.M.1    May, F.J.2    Lee, W.J.3    Holman, N.A.4    Roberts-Thomson, S.J.5
  • 29
    • 18144384743 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis
    • Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, et al. (2005) Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis. Cancer Res 65: 3950-3957.
    • (2005) Cancer Res , vol.65 , pp. 3950-3957
    • Yin, Y.1    Russell, R.G.2    Dettin, L.E.3    Bai, R.4    Wei, Z.L.5
  • 30
    • 79952215111 scopus 로고    scopus 로고
    • Induction of metastatic gastric cancer by peroxisome prolferator-activated receptor-delta activation
    • in press
    • Pollock CB, Rodriguez O, Martin PL, Albanese C, Li X, et al. (2010) Induction of metastatic gastric cancer by peroxisome prolferator-activated receptor-delta activation. PPAR Res, in press.
    • (2010) PPAR Res
    • Pollock, C.B.1    Rodriguez, O.2    Martin, P.L.3    Albanese, C.4    Li, X.5
  • 32
    • 0035956850 scopus 로고    scopus 로고
    • Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells
    • Park BH, Vogelstein B, Kinzler KW (2001) Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci U S A 98: 2598-2603.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2598-2603
    • Park, B.H.1    Vogelstein, B.2    Kinzler, K.W.3
  • 33
    • 0037039374 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
    • Barak Y, Liao D, He W, Ong ES, Nelson MC, et al. (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 99: 303-308.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 303-308
    • Barak, Y.1    Liao, D.2    He, W.3    Ong, E.S.4    Nelson, M.C.5
  • 34
    • 2442708845 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis
    • Harman FS, Nicol CJ, Marin HE, Ward JM, Gonzalez FJ, et al. (2004) Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat Med 10: 481-483.
    • (2004) Nat Med , vol.10 , pp. 481-483
    • Harman, F.S.1    Nicol, C.J.2    Marin, H.E.3    Ward, J.M.4    Gonzalez, F.J.5
  • 36
    • 0036771764 scopus 로고    scopus 로고
    • Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway
    • Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B (2002) Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 10: 721-733.
    • (2002) Mol Cell , vol.10 , pp. 721-733
    • Di-Poi, N.1    Tan, N.S.2    Michalik, L.3    Wahli, W.4    Desvergne, B.5
  • 37
    • 61549114992 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha
    • Han S, Ritzenthaler JD, Sun X, Zheng Y, Roman J (2009) Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. Am J Respir Cell Mol Biol 40: 325-331.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 325-331
    • Han, S.1    Ritzenthaler, J.D.2    Sun, X.3    Zheng, Y.4    Roman, J.5
  • 38
    • 34047243022 scopus 로고    scopus 로고
    • Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    • Wang D, Wang H, Guo Y, Ning W, Katkuri S, et al. (2006) Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 103: 19069-19074.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19069-19074
    • Wang, D.1    Wang, H.2    Guo, Y.3    Ning, W.4    Katkuri, S.5
  • 39
    • 58349086542 scopus 로고    scopus 로고
    • Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptordependent tumor specification
    • Yin Y, Yuan H, Zeng X, Kopelovich L, Glazer RI (2009) Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptordependent tumor specification. Cancer Res 69: 687-694.
    • (2009) Cancer Res , vol.69 , pp. 687-694
    • Yin, Y.1    Yuan, H.2    Zeng, X.3    Kopelovich, L.4    Glazer, R.I.5
  • 40
    • 24044433540 scopus 로고    scopus 로고
    • Characterization of medroxyprogesterone and DMBA-induced multilineage mammary tumors by gene expression profiling
    • Yin Y, Bai R, Russell RG, Beildeck ME, Xie Z, et al. (2005) Characterization of medroxyprogesterone and DMBA-induced multilineage mammary tumors by gene expression profiling. Mol Carcinog 44: 42-50.
    • (2005) Mol Carcinog , vol.44 , pp. 42-50
    • Yin, Y.1    Bai, R.2    Russell, R.G.3    Beildeck, M.E.4    Xie, Z.5
  • 41
    • 0034696279 scopus 로고    scopus 로고
    • The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting
    • Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, et al. (2000) The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 19: 968-988.
    • (2000) Oncogene , vol.19 , pp. 968-988
    • Cardiff, R.D.1    Anver, M.R.2    Gusterson, B.A.3    Hennighausen, L.4    Jensen, R.A.5
  • 42
    • 38849104440 scopus 로고    scopus 로고
    • UPLCESI-TOFMS-based metabolomics and gene expression dynamics inspector selforganizing metabolomic maps as tools for understanding the cellular response to ionizing radiation
    • Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, et al. (2008) UPLCESI-TOFMS-based metabolomics and gene expression dynamics inspector selforganizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 80: 665-674.
    • (2008) Anal Chem , vol.80 , pp. 665-674
    • Patterson, A.D.1    Li, H.2    Eichler, G.S.3    Krausz, K.W.4    Weinstein, J.N.5
  • 43
    • 0037096904 scopus 로고    scopus 로고
    • Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Ca
    • Zeng X, Xu H, Park B-K, Glazer RI (2002) Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Ca. Cancer Res 62: 3538-3543.
    • (2002) Cancer Res , vol.62 , pp. 3538-3543
    • Zeng, X.1    Xu, H.2    Park, B.-K.3    Glazer, R.I.4
  • 44
    • 0034176579 scopus 로고    scopus 로고
    • The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    • Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, et al. (2000) The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol 10: 439-448.
    • (2000) Curr Biol , vol.10 , pp. 439-448
    • Williams, M.R.1    Arthur, J.S.2    Balendran, A.3    van der, K.J.4    Poli, V.5
  • 45
    • 7944226627 scopus 로고    scopus 로고
    • Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
    • Altenberg B, Greulich KO (2004) Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 84: 1014-1020.
    • (2004) Genomics , vol.84 , pp. 1014-1020
    • Altenberg, B.1    Greulich, K.O.2
  • 46
    • 57449087215 scopus 로고    scopus 로고
    • Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
    • DeBerardinis RJ (2008) Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med 10: 767-777.
    • (2008) Genet Med , vol.10 , pp. 767-777
    • Deberardinis, R.J.1
  • 47
    • 34547112065 scopus 로고    scopus 로고
    • Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle
    • Kramer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, et al. (2007) Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle. J Biol Chem 282: 19313-19320.
    • (2007) J Biol Chem , vol.282 , pp. 19313-19320
    • Kramer, D.K.1    Al-Khalili, L.2    Guigas, B.3    Leng, Y.4    Garcia-Roves, P.M.5
  • 49
    • 74049132806 scopus 로고    scopus 로고
    • Glycolytic phenotype in breast cancer: Activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK
    • Schmidt M, Voelker HU, Kapp M, Krockenberger M, Dietl J, et al. (2009) Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. J Cancer Res Clin Oncol.
    • (2009) J Cancer Res Clin Oncol
    • Schmidt, M.1    Voelker, H.U.2    Kapp, M.3    Krockenberger, M.4    Dietl, J.5
  • 50
    • 54249161009 scopus 로고    scopus 로고
    • ATP citrate lyase: Activation and therapeutic implications in non-small cell lung cancer
    • Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, et al. (2008) ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res 68: 8547-8554.
    • (2008) Cancer Res , vol.68 , pp. 8547-8554
    • Migita, T.1    Narita, T.2    Nomura, K.3    Miyagi, E.4    Inazuka, F.5
  • 51
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB (2005) ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24: 6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 52
    • 21344434775 scopus 로고    scopus 로고
    • Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells
    • Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, et al. (2005) Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. Febs J 272: 3004-3014.
    • (2005) Febs J , vol.272 , pp. 3004-3014
    • Abbot, E.L.1    McCormack, J.G.2    Reynet, C.3    Hassall, D.G.4    Buchan, K.W.5
  • 54
    • 27144480288 scopus 로고    scopus 로고
    • Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/2) mice
    • Bayascas JR, Leslie NR, Parsons R, Fleming S, Alessi DR (2005) Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/2) mice. Curr Biol 15: 1839-1846.
    • (2005) Curr Biol , vol.15 , pp. 1839-1846
    • Bayascas, J.R.1    Leslie, N.R.2    Parsons, R.3    Fleming, S.4    Alessi, D.R.5
  • 55
    • 0036606010 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
    • Shao J, Sheng H, DuBois RN (2002) Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res 62: 3282-3288.
    • (2002) Cancer Res , vol.62 , pp. 3282-3288
    • Shao, J.1    Sheng, H.2    Dubois, R.N.3
  • 56
    • 4043102610 scopus 로고    scopus 로고
    • Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway
    • Sato S, Fujita N, Tsuruo T (2004) Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J Biol Chem 279: 33759-33767.
    • (2004) J Biol Chem , vol.279 , pp. 33759-33767
    • Sato, S.1    Fujita, N.2    Tsuruo, T.3
  • 57
    • 0033615352 scopus 로고    scopus 로고
    • PPARdelta is an APCregulated target of nonsteroidal anti-inflammatory drugs
    • He TC, Chan TA, Vogelstein B, Kinzler KW (1999) PPARdelta is an APCregulated target of nonsteroidal anti-inflammatory drugs. Cell 99: 335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 58
    • 34249696521 scopus 로고    scopus 로고
    • Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity
    • Genini D, Catapano CV (2007) Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity. J Biol Chem 282: 11776-11785.
    • (2007) J Biol Chem , vol.282 , pp. 11776-11785
    • Genini, D.1    Catapano, C.V.2
  • 59
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A 94: 4312-4317.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 60
    • 33745488426 scopus 로고    scopus 로고
    • Transcriptional profiling of mammary gland side population cells
    • Behbod F, Xian W, Shaw CA, Hilsenbeck SG, Tsimelzon A, et al. (2006) Transcriptional profiling of mammary gland side population cells. Stem Cells 24: 1065-1074.
    • (2006) Stem Cells , vol.24 , pp. 1065-1074
    • Behbod, F.1    Xian, W.2    Shaw, C.A.3    Hilsenbeck, S.G.4    Tsimelzon, A.5
  • 61
    • 41149160634 scopus 로고    scopus 로고
    • Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha
    • Li Y, Chen B, Chen J, Lou G, Chen S, et al. (2008) Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha. Biochem Biophys Res Commun 369: 1034-1040.
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 1034-1040
    • Li, Y.1    Chen, B.2    Chen, J.3    Lou, G.4    Chen, S.5
  • 62
    • 53849088227 scopus 로고    scopus 로고
    • Transcriptional control of energy homeostasis by the estrogenrelated receptors
    • Giguere V (2008) Transcriptional control of energy homeostasis by the estrogenrelated receptors. Endocr Rev 29: 677-696.
    • (2008) Endocr Rev , vol.29 , pp. 677-696
    • Giguere, V.1


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