IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

Molecular and Cellular Biochemistry

Volumn 324, Issue 1-2, 2009, Pages 183-190

  Wang, Q ^a   Zhang, H ^a   Zhao, B ^a   Fei, H ^a  

^a Shanghai Jiao Tong University   (China)

Author keywords

cellapoptosis; c Jun N terminal Kinase (JNK); Calcium; Diabetes; Endoplasmic reticulum (ER) stress; Interleukin(IL)

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM ION; CYCLOPIAZONIC ACID; INTERLEUKIN 1BETA; PROTEIN KINASE R; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; CALCIUM; PERK KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CELL FUNCTION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HOMEOSTASIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; PATHOLOGY;

RATTUS;

ANIMALS; APOPTOSIS; CALCIUM; CELLS, CULTURED; EIF-2 KINASE; ENDOPLASMIC RETICULUM; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; RATS;

EID: 61549086548     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9997-9     Document Type: Article

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