메뉴 건너뛰기




Volumn 17, Issue 2, 2011, Pages 213-221

Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data

Author keywords

General acid base catalysis; Nucleobase; RNA catalysis

Indexed keywords

ADENINE; GUANINE; HAIRPIN RIBOZYME; HELIX LOOP HELIX PROTEIN; IMIDAZOLE; PHOSPHATE; RIBOZYME; UNCLASSIFIED DRUG; VS RIBOZYME;

EID: 78751487465     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2473711     Document Type: Review
Times cited : (57)

References (63)
  • 1
    • 0029011972 scopus 로고
    • A secondary-structure model for the self-cleaving region of Neurospora VS RNA
    • Beattie TL, Olive JE, Collins RA. 1995. A secondary-structure model for the self-cleaving region of Neurospora VS RNA. Proc Natl Acad Sci 92: 4686-4690.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 4686-4690
    • Beattie, T.L.1    Olive, J.E.2    Collins, R.A.3
  • 2
    • 0037418547 scopus 로고    scopus 로고
    • Mechanistic considerations for general acid-base catalysis by RNA: Revisiting the mechanism of the hairpin ribozyme
    • Bevilacqua PC. 2003. Mechanistic considerations for general acid-base catalysis by RNA: Revisiting the mechanism of the hairpin ribozyme. Biochemistry 42: 2259-2265.
    • (2003) Biochemistry , vol.42 , pp. 2259-2265
    • Bevilacqua, P.C.1
  • 3
    • 77955258795 scopus 로고    scopus 로고
    • A 1.9 Å crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage
    • Chen JH, Yajima R, Chadalavada DM, Chase E, Bevilacqua PC, Golden BL. 2010. A 1.9 Å crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage. Biochemistry 49: 6508-6518.
    • (2010) Biochemistry , vol.49 , pp. 6508-6518
    • Chen, J.H.1    Yajima, R.2    Chadalavada, D.M.3    Chase, E.4    Bevilacqua, P.C.5    Golden, B.L.6
  • 4
    • 33846279049 scopus 로고    scopus 로고
    • Structural investigation of the GlmS ribozyme bound to its catalytic cofactor
    • Cochrane JC, Lipchock SV, Strobel SA. 2007. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor. Chem Biol 14: 97-105.
    • (2007) Chem Biol , vol.14 , pp. 97-105
    • Cochrane, J.C.1    Lipchock, S.V.2    Strobel, S.A.3
  • 5
    • 65249184394 scopus 로고    scopus 로고
    • Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme
    • Cochrane JC, Lipchock SV, Smith KD, Strobel SA. 2009. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme. Biochemistry 48: 3239-3246.
    • (2009) Biochemistry , vol.48 , pp. 3239-3246
    • Cochrane, J.C.1    Lipchock, S.V.2    Smith, K.D.3    Strobel, S.A.4
  • 6
    • 24644454458 scopus 로고    scopus 로고
    • General acid catalysis by the hepatitis delta virus ribozyme
    • Das SR, Piccirilli JA. 2005. General acid catalysis by the hepatitis delta virus ribozyme. Nat Chem Biol 1: 45-52.
    • (2005) Nat Chem Biol , vol.1 , pp. 45-52
    • Das, S.R.1    Piccirilli, J.A.2
  • 7
    • 0032497521 scopus 로고    scopus 로고
    • Crystal structure of a hepatitis delta virus ribozyme
    • DOI 10.1038/26912
    • Ferré-D'Amaré AR, Zhou K, Doudna JA. 1998. Crystal structure of a hepatitis delta virus ribozyme. Nature 395: 567-574. (Pubitemid 28475703)
    • (1998) Nature , vol.395 , Issue.6702 , pp. 567-574
    • Ferre-D'Amare, A.R.1    Zhou, K.2    Doudna, J.A.3
  • 8
    • 0028903816 scopus 로고
    • Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA
    • Grasby JA, Mersmann K, Singh M, Gait MJ. 1995. Purine functional groups in essential residues of the hairpin ribozyme required for catalytic cleavage of RNA. Biochemistry 34: 4068-4076.
    • (1995) Biochemistry , vol.34 , pp. 4068-4076
    • Grasby, J.A.1    Mersmann, K.2    Singh, M.3    Gait, M.J.4
  • 9
    • 0037243910 scopus 로고    scopus 로고
    • Crystallization and X-ray diffraction analysis of an all-RNA U39C mutant of the minimal hairpin ribozyme
    • Grum-Tokars V, Milovanovic M, Wedekind JE. 2003. Crystallization and X-ray diffraction analysis of an all-RNA U39C mutant of the minimal hairpin ribozyme. Acta Crystallogr D Biol Crystallogr 59: 142-145.
    • (2003) Acta Crystallogr D Biol Crystallogr , vol.59 , pp. 142-145
    • Grum-Tokars, V.1    Milovanovic, M.2    Wedekind, J.E.3
  • 11
    • 0024340908 scopus 로고
    • RNA Catalytic properties of the minimum (-)sTRSV sequence
    • DOI 10.1021/bi00438a002
    • Hampel A, Tritz R. 1989. RNA catalytic properties of the minimum (-)sTRSV sequence. Biochemistry 28: 4929-4933. (Pubitemid 19162737)
    • (1989) Biochemistry , vol.28 , Issue.12 , pp. 4929-4933
    • Hampel, A.1    Tritz, R.2
  • 12
    • 19644391548 scopus 로고    scopus 로고
    • Model for general acid-base catalysis by the hammerhead ribozyme: PH-activity relationships of G8 and G12 variants at the putative active site
    • DOI 10.1021/bi047941z
    • Han J, Burke JM. 2005. Model for general acid-base catalysis by the hammerhead ribozyme: pH-activity relationships of G8 and G12 variants at the putative active site. Biochemistry 44: 7864-7870. (Pubitemid 40740769)
    • (2005) Biochemistry , vol.44 , Issue.21 , pp. 7864-7870
    • Han, J.1    Burke, J.M.2
  • 13
    • 0037009368 scopus 로고    scopus 로고
    • 4-Thio-U cross-linking identifies the active site of the VS ribozyme
    • DOI 10.1093/emboj/cdf462
    • Hiley SL, Sood VD, Fan J, Collins RA. 2002. 4-thio-U cross-linking identifies the active site of the VS ribozyme. EMBO J 21: 4691-4698. (Pubitemid 34984356)
    • (2002) EMBO Journal , vol.21 , Issue.17 , pp. 4691-4698
    • Hiley, S.L.1    Sood, V.D.2    Fan, J.3    Collins, R.A.4
  • 14
    • 0037446518 scopus 로고    scopus 로고
    • Ionization of a critical adenosine residue in the Neurospora Varkud Satellite ribozyme active site
    • Jones FD, Strobel SA. 2003. Ionization of a critical adenosine residue in the Neurospora Varkud Satellite ribozyme active site. Biochemistry 42: 4265-4276.
    • (2003) Biochemistry , vol.42 , pp. 4265-4276
    • Jones, F.D.1    Strobel, S.A.2
  • 15
    • 0035945247 scopus 로고    scopus 로고
    • An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5′- and 3′-termini
    • Jones FD, Ryder SP, Strobel SA. 2001. An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5′- and 3′-termini. Nucleic Acids Res 29: 5115-5120.
    • (2001) Nucleic Acids Res , vol.29 , pp. 5115-5120
    • Jones, F.D.1    Ryder, S.P.2    Strobel, S.A.3
  • 16
    • 2442641641 scopus 로고    scopus 로고
    • A conformational switch controls hepatitis delta virus ribozyme catalysis
    • DOI 10.1038/nature02522
    • Ke A, Zhou K, Ding F, Cate JH, Doudna JA. 2004. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature 429: 201-205. (Pubitemid 38656198)
    • (2004) Nature , vol.429 , Issue.6988 , pp. 201-205
    • Ke, A.1    Zhou, K.2    Ding, F.3    Cate, J.H.D.4    Doudna, J.A.5
  • 17
    • 0043009734 scopus 로고    scopus 로고
    • Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
    • Khvorova A, Lescoute A, Westhof E, Jayasena SD. 2003. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity. Nat Struct Biol 10: 1-5.
    • (2003) Nat Struct Biol , vol.10 , pp. 1-5
    • Khvorova, A.1    Lescoute, A.2    Westhof, E.3    Jayasena, S.D.4
  • 18
    • 33748325570 scopus 로고    scopus 로고
    • Structural basis of glmS ribozyme activation by glucosamine-6-phosphate
    • Klein DJ, Ferré-D'Amaré AR. 2006. Structural basis of glmS ribozyme activation by glucosamine-6-phosphate. Science 313: 1752-1756.
    • (2006) Science , vol.313 , pp. 1752-1756
    • Klein, D.J.1    Ferré-D'Amaré, A.R.2
  • 19
    • 36849061230 scopus 로고    scopus 로고
    • Essential role of an active-site guanine in glmS ribozyme catalysis
    • Klein DJ, Been MD, Ferré-D'Amaré AR. 2007. Essential role of an active-site guanine in glmS ribozyme catalysis. J Am Chem Soc 129: 14858-14859.
    • (2007) J Am Chem Soc , vol.129 , pp. 14858-14859
    • Klein, D.J.1    Been, M.D.2    Ferré-D'Amaré, A.R.3
  • 20
    • 2942577491 scopus 로고    scopus 로고
    • Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue
    • Kuzmin YI, Da Costa CP, Fedor MJ. 2004. Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue. J Mol Biol 340: 233-251.
    • (2004) J Mol Biol , vol.340 , pp. 233-251
    • Kuzmin, Y.I.1    Da Costa, C.P.2    Fedor, M.J.3
  • 21
    • 20344405966 scopus 로고    scopus 로고
    • Role of an active site adenine in hairpin ribozyme catalysis
    • Kuzmin YI, Da Costa CP, Cottrell JW, Fedor MJ. 2005. Role of an active site adenine in hairpin ribozyme catalysis. J Mol Biol 349: 989-1010.
    • (2005) J Mol Biol , vol.349 , pp. 989-1010
    • Kuzmin, Y.I.1    Da Costa, C.P.2    Cottrell, J.W.3    Fedor, M.J.4
  • 22
    • 0035869008 scopus 로고    scopus 로고
    • Structure, folding and activity of the VS ribozyme: Importance of the 2-3-6 helical junction
    • Lafontaine DA, Norman DG, Lilley DMJ. 2001a. Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction. EMBO J 20: 1415-1424.
    • (2001) EMBO J , vol.20 , pp. 1415-1424
    • Lafontaine, D.A.1    Norman, D.G.2    Lilley, D.M.J.3
  • 23
    • 0035965132 scopus 로고    scopus 로고
    • The A730 loop is an important component of the active site of the VS ribozyme
    • Lafontaine DA, Wilson TJ, Norman DG, Lilley DMJ. 2001b. The A730 loop is an important component of the active site of the VS ribozyme. J Mol Biol 312: 663-674.
    • (2001) J Mol Biol , vol.312 , pp. 663-674
    • Lafontaine, D.A.1    Wilson, T.J.2    Norman, D.G.3    Lilley, D.M.J.4
  • 24
  • 25
    • 0036396544 scopus 로고    scopus 로고
    • Functional group requirements in the probable active site of the VS ribozyme
    • DOI 10.1016/S0022-2836(02)00910-5
    • Lafontaine DA, Wilson TJ, Zhao Z-Y, Lilley DMJ. 2002b. Functional group requirements in the probable active site of the VS ribozyme. J Mol Biol 323: 23-34. (Pubitemid 35168478)
    • (2002) Journal of Molecular Biology , vol.323 , Issue.1 , pp. 23-34
    • Lafontaine, D.A.1    Wilson, T.J.2    Zhao, Z.-Y.3    Lilley, D.M.J.4
  • 26
    • 0036237379 scopus 로고    scopus 로고
    • Rescue of an abasic hairpin ribozyme by cationic nucleobases. Evidence for a novel mechanism of RNA catalysis
    • Lebruska LL, Kuzmine I, Fedor MJ. 2002. Rescue of an abasic hairpin ribozyme by cationic nucleobases. Evidence for a novel mechanism of RNA catalysis. Chem Biol 9: 465-473.
    • (2002) Chem Biol , vol.9 , pp. 465-473
    • Lebruska, L.L.1    Kuzmine, I.2    Fedor, M.J.3
  • 28
    • 50649108803 scopus 로고    scopus 로고
    • The complete VS ribozyme in solution studied by small-angle X-ray scattering
    • Lipfert J, Ouellet J, Norman DG, Doniach S, Lilley DMJ. 2008. The complete VS ribozyme in solution studied by small-angle X-ray scattering. Structure 16: 1357-1367.
    • (2008) Structure , vol.16 , pp. 1357-1367
    • Lipfert, J.1    Ouellet, J.2    Norman, D.G.3    Doniach, S.4    Lilley, D.M.J.5
  • 29
    • 67349198163 scopus 로고    scopus 로고
    • Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme
    • Liu L, Cottrell JW, Scott LG, Fedor MJ. 2009. Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme. Nat Chem Biol 5: 351-357.
    • (2009) Nat Chem Biol , vol.5 , pp. 351-357
    • Liu, L.1    Cottrell, J.W.2    Scott, L.G.3    Fedor, M.J.4
  • 30
    • 47949090344 scopus 로고    scopus 로고
    • Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme
    • MacElrevey C, Salter JD, Krucinska J, Wedekind JE. 2008. Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme. RNA 14: 1600-1616.
    • (2008) RNA , vol.14 , pp. 1600-1616
    • MacElrevey, C.1    Salter, J.D.2    Krucinska, J.3    Wedekind, J.E.4
  • 31
    • 33746228126 scopus 로고    scopus 로고
    • Tertiary Contacts Distant from the Active Site Prime a Ribozyme for Catalysis
    • DOI 10.1016/j.cell.2006.06.036, PII S0092867406008567
    • Martick M, Scott WG. 2006. Tertiary contacts distant from the active site prime a ribozyme for catalysis. Cell 126: 309-320. (Pubitemid 44092962)
    • (2006) Cell , vol.126 , Issue.2 , pp. 309-320
    • Martick, M.1    Scott, W.G.2
  • 32
    • 49649109010 scopus 로고    scopus 로고
    • A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA
    • Martick M, Horan LH, Noller HF, Scott WG. 2008. A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA. Nature 454: 899-902.
    • (2008) Nature , vol.454 , pp. 899-902
    • Martick, M.1    Horan, L.H.2    Noller, H.F.3    Scott, W.G.4
  • 33
    • 0942279692 scopus 로고    scopus 로고
    • Efficient, pH-dependent RNA ligation by the VS ribozyme in trans
    • McLeod AC, Lilley DMJ. 2004. Efficient, pH-dependent RNA ligation by the VS ribozyme in trans. Biochemistry 43: 1118-1125.
    • (2004) Biochemistry , vol.43 , pp. 1118-1125
    • McLeod, A.C.1    Lilley, D.M.J.2
  • 34
    • 0032061318 scopus 로고    scopus 로고
    • Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops
    • Murchie AIH, Thomson JB, Walter F, Lilley DMJ. 1998. Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops. Mol Cell 1: 873-881. (Pubitemid 128379071)
    • (1998) Molecular Cell , vol.1 , Issue.6 , pp. 873-881
    • Murchie, A.I.H.1    Thomson, J.B.2    Walter, F.3    Lilley, D.M.J.4
  • 35
    • 0032192761 scopus 로고    scopus 로고
    • The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
    • Murray JB, Seyhan AA, Walter NG, Burke JM, Scott WG. 1998. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone. Chem Biol 5: 587-595.
    • (1998) Chem Biol , vol.5 , pp. 587-595
    • Murray, J.B.1    Seyhan, A.A.2    Walter, N.G.3    Burke, J.M.4    Scott, W.G.5
  • 37
    • 0034712097 scopus 로고    scopus 로고
    • General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
    • DOI 10.1126/science.287.5457.1493
    • Nakano S, Chadalavada DM, Bevilacqua PC. 2000. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme. Science 287: 1493-1497. (Pubitemid 30127144)
    • (2000) Science , vol.287 , Issue.5457 , pp. 1493-1497
    • Nakano, S.-I.1    Chadalavada, D.M.2    Bevilacqua, P.C.3
  • 38
    • 47949085748 scopus 로고    scopus 로고
    • Electrostatic interactions in the hairpin ribozyme account for the majority of the rate acceleration without chemical participation by nucleobases
    • Nam K, Gao J, York DM. 2008. Electrostatic interactions in the hairpin ribozyme account for the majority of the rate acceleration without chemical participation by nucleobases. RNA 14: 1501-1507.
    • (2008) RNA , vol.14 , pp. 1501-1507
    • Nam, K.1    Gao, J.2    York, D.M.3
  • 39
    • 70349087808 scopus 로고    scopus 로고
    • Formation of an active site in trans by interaction of two complete Varkud Satellite ribozymes
    • Ouellet J, Byrne M, Lilley DMJ. 2009. Formation of an active site in trans by interaction of two complete Varkud Satellite ribozymes. RNA 15: 1822-1826.
    • (2009) RNA , vol.15 , pp. 1822-1826
    • Ouellet, J.1    Byrne, M.2    Lilley, D.M.J.3
  • 40
    • 1942533453 scopus 로고    scopus 로고
    • Folding of the natural hammerhead ribozyme is enhanced by interaction of auxiliary elements
    • DOI 10.1261/rna.5268404
    • Penedo JC, Wilson TJ, Jayasena SD, Khvorova A, Lilley DMJ. 2004. Folding of the natural hammerhead ribozyme is enhanced by interaction of auxiliary elements. RNA 10: 880-888. (Pubitemid 38529750)
    • (2004) RNA , vol.10 , Issue.5 , pp. 880-888
    • Penedo, J.C.1    Wilson, T.J.2    Jayasena, S.D.3    Khvorova, A.4    Lilley, D.M.J.5
  • 42
    • 0029948820 scopus 로고    scopus 로고
    • A long-range pseudoknot is required for activity of the Neurospora VS ribozyme
    • Rastogi T, Beattie TL, Olive JE, Collins RA. 1996. A long-range pseudoknot is required for activity of the Neurospora VS ribozyme. EMBO J 15: 2820-2825.
    • (1996) EMBO J , vol.15 , pp. 2820-2825
    • Rastogi, T.1    Beattie, T.L.2    Olive, J.E.3    Collins, R.A.4
  • 43
    • 0035848837 scopus 로고    scopus 로고
    • Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis
    • DOI 10.1038/35071009
    • Rupert PB, Ferré-D'Amaré AR. 2001. Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis. Nature 410: 780-786. (Pubitemid 32303769)
    • (2001) Nature , vol.410 , Issue.6830 , pp. 780-786
    • Rupert, P.B.1    Ferre-D'Amare, A.R.2
  • 45
    • 0034757632 scopus 로고    scopus 로고
    • Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping
    • Ryder SP, Oyelere AK, Padilla JL, Klostermeier D, Millar DP, Strobel SA. 2001. Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping. RNA 7: 1454-1463. (Pubitemid 32973231)
    • (2001) RNA , vol.7 , Issue.10 , pp. 1454-1463
    • Ryder, S.P.1    Oyelere, A.K.2    Padilla, J.L.3    Klostermeier, D.4    Millar, D.P.5    Strobel, S.A.6
  • 46
    • 31044455894 scopus 로고    scopus 로고
    • Water in the active site of an All-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer
    • DOI 10.1021/bi051887k
    • Salter J, Krucinska J, Alam S, Grum-Tokars V, Wedekind JE. 2006. Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer. Biochemistry 45: 686-700. (Pubitemid 43122234)
    • (2006) Biochemistry , vol.45 , Issue.3 , pp. 686-700
    • Salter, J.1    Krucinska, J.2    Alam, S.3    Grum-Tokars, V.4    Wedekind, J.E.5
  • 47
    • 0032512431 scopus 로고    scopus 로고
    • Mutational analysis of loops 1 and 5 of the hairpin ribozyme
    • DOI 10.1021/bi9721288
    • Shippy R, Siwkowski A, Hampel A. 1998. Mutational analysis of loops 1 and 5 of the hairpin ribozyme. Biochemistry 37: 564-570. (Pubitemid 28123789)
    • (1998) Biochemistry , vol.37 , Issue.2 , pp. 564-570
    • Shippy, R.1    Siwkowski, A.2    Hampel, A.3
  • 48
    • 34347246717 scopus 로고    scopus 로고
    • Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme
    • Smith MD, Collins RA. 2007. Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme. Proc Natl Acad Sci 104: 5818-5823.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 5818-5823
    • Smith, M.D.1    Collins, R.A.2
  • 49
    • 0032475835 scopus 로고    scopus 로고
    • Identification of phosphate groups involved in metal binding and tertiary interactions in the core of the Neurospora VS ribozyme
    • Sood VD, Beattie TL, Collins RA. 1998. Identification of phosphate groups involved in metal binding and tertiary interactions in the core of the Neurospora VS ribozyme. J Mol Biol 282: 741-750.
    • (1998) J Mol Biol , vol.282 , pp. 741-750
    • Sood, V.D.1    Beattie, T.L.2    Collins, R.A.3
  • 51
    • 77951674713 scopus 로고    scopus 로고
    • Catalytic importance of a protonated adenosine in the hairpin ribozyme active site
    • Suydam IT, Levandoski SD, Strobel SA. 2010. Catalytic importance of a protonated adenosine in the hairpin ribozyme active site. Biochemistry 49: 3723-3732.
    • (2010) Biochemistry , vol.49 , pp. 3723-3732
    • Suydam, I.T.1    Levandoski, S.D.2    Strobel, S.A.3
  • 52
    • 0043009768 scopus 로고    scopus 로고
    • A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate
    • Tan E, Wilson TJ, Nahas MK, Clegg RM, Lilley DMJ, Ha T. 2003. A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate. Proc Natl Acad Sci 100: 9308-9313.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 9308-9313
    • Tan, E.1    Wilson, T.J.2    Nahas, M.K.3    Clegg, R.M.4    Lilley, D.M.J.5    Ha, T.6
  • 53
    • 33846804221 scopus 로고    scopus 로고
    • as in RNA: On the structural origins and functional roles of protonated nucleotides
    • as in RNA: On the structural origins and functional roles of protonated nucleotides. J Mol Biol 366: 1475-1496.
    • (2007) J Mol Biol , vol.366 , pp. 1475-1496
    • Tang, C.L.1    Alexov, E.2    Pyle, A.M.3    Honig, B.4
  • 54
    • 33845932882 scopus 로고    scopus 로고
    • Active site labeling of G8 in the hairpin ribozyme: Implications for structure and mechanism
    • Thomas JM, Perrin DM. 2006. Active site labeling of G8 in the hairpin ribozyme: Implications for structure and mechanism. J Am Chem Soc 128: 16540-16545.
    • (2006) J Am Chem Soc , vol.128 , pp. 16540-16545
    • Thomas, J.M.1    Perrin, D.M.2
  • 55
    • 0032535607 scopus 로고    scopus 로고
    • The folding of the fourway RNA junction of the hairpin ribozyme
    • Walter F, Murchie AIH, Lilley DMJ. 1998a. The folding of the fourway RNA junction of the hairpin ribozyme. Biochemistry 37: 17629-17636.
    • (1998) Biochemistry , vol.37 , pp. 17629-17636
    • Walter, F.1    Murchie, A.I.H.2    Lilley, D.M.J.3
  • 56
    • 0032491204 scopus 로고    scopus 로고
    • Structure and activity of the hairpin ribozyme in its natural junction conformation: Effect of metal ions
    • DOI 10.1021/bi981513+
    • Walter F, Murchie AIH, Thomson JB, Lilley DMJ. 1998b. Structure and activity of the hairpin ribozyme in its natural junction conformation; effect of metal ions. Biochemistry 37: 14195-14203. (Pubitemid 28471255)
    • (1998) Biochemistry , vol.37 , Issue.40 , pp. 14195-14203
    • Walter, F.1    Murchie, A.I.H.2    Thomson, J.B.3    Lilley, D.M.J.4
  • 57
    • 0032979707 scopus 로고    scopus 로고
    • Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction
    • DOI 10.1038/9316
    • Walter NG, Burke JM, Millar DP. 1999. Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction. Nat Struct Biol 6: 544-549. (Pubitemid 29252833)
    • (1999) Nature Structural Biology , vol.6 , Issue.6 , pp. 544-549
    • Walter, N.G.1    Burke, J.M.2    Millar, D.P.3
  • 58
    • 0036249718 scopus 로고    scopus 로고
    • Metal ion binding and the folding of the hairpin ribozyme
    • DOI 10.1017/S1355838202020514
    • Wilson TJ, Lilley DMJ. 2002. Metal ion binding and the folding of the hairpin ribozyme. RNA 8: 587-600. (Pubitemid 34506231)
    • (2002) RNA , vol.8 , Issue.5 , pp. 587-600
    • Wilson, T.J.1    Lilley, D.M.J.2
  • 59
    • 0035916297 scopus 로고    scopus 로고
    • Importance of specific nucleotides in the folding of the natural form of the hairpin ribozyme
    • DOI 10.1021/bi002644p
    • Wilson TJ, Zhao Z-Y, Maxwell K, Kontogiannis L, Lilley DMJ. 2001. Importance of specific nucleotides in the folding of the natural form of the hairpin ribozyme. Biochemistry 40: 2291-2302. (Pubitemid 32165701)
    • (2001) Biochemistry , vol.40 , Issue.7 , pp. 2291-2302
    • Wilson, T.J.1    Zhao, Z.-Y.2    Maxwell, K.3    Kontogiannis, L.4    Lilley, D.M.J.5
  • 61
    • 34249098371 scopus 로고    scopus 로고
    • A guanine nucleobase important for catalysis by the VS ribozyme
    • DOI 10.1038/sj.emboj.7601698, PII 7601698
    • Wilson TJ, McLeod AC, Lilley DMJ. 2007. A guanine nucleobase important for catalysis by the VS ribozyme. EMBO J 26: 2489-2500. (Pubitemid 46788324)
    • (2007) EMBO Journal , vol.26 , Issue.10 , pp. 2489-2500
    • Wilson, T.J.1    McLeod, A.C.2    Lilley, D.M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.