Identification of an imino group indispensable for cleavage by a small ribozyme

Journal of the American Chemical Society

Volumn 131, Issue 17, 2009, Pages 6093-6095

  Spitale, Robert C ^b   Volpini, Rosaria ^c   Heller, Moriah G ^a   Krucinska, Jolanta ^a   Cristalli, Gloria ^c   Wedekind, Joseph E ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CHEMICAL ACTIVITIES; HAIRPIN RIBOZYME; IMINO GROUPS; MISFOLDING; NON-CODING RNA (NCRNA); PHOSPHODIESTER BONDS; RIBOZYMES; SITE-SPECIFIC; STRUCTURE-FUNCTION RELATIONSHIP; TRANSITION-STATE;

ATOMS; CHEMICAL BONDS; CHEMICAL MODIFICATION; FUNCTIONAL GROUPS; NUCLEIC ACIDS; RNA;

CRYSTAL ATOMIC STRUCTURE;

ADENOSINE DERIVATIVE; IMINO ACID; N1 DEAZAADENOSINE; RIBOZYME; UNCLASSIFIED DRUG; UNTRANSLATED RNA; HAIRPIN RIBOZYME; IMINE;

ARTICLE; ATOM; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; PHASE TRANSITION; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM;

CATALYTIC DOMAIN; IMINES; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949179163     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900450h     Document Type: Article

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