Catalytic importance of a protonated adenosine in the hairpin ribozyme active site

Biochemistry

Volumn 49, Issue 17, 2010, Pages 3723-3732

  Suydam, Ian T ^a   Levandoski, Stephen D ^a   Strobel, Scott A ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BASE CATALYSIS; ACTIVE SITE; BIOCHEMICAL STUDIES; CATALYTIC ACTIVITY; HAIRPIN RIBOZYME; INTERFERENCE MAPPING; INTERFERENCE PATTERNS; NUCLEOTIDE ANALOGUES; ORDERS OF MAGNITUDE; PHOSPHATE LINKAGES; PHOSPHODIESTERS; PROTONATED; RATE ENHANCEMENT; STRONG INTERFERENCE; STRUCTURAL REARRANGEMENT; TRANSFER REACTION; TRANSITION STATE; X RAY CRYSTAL STRUCTURES;

CATALYSIS; FLUORINE; FUNCTIONAL GROUPS; IONIZATION; NUCLEOTIDES; PARTICLE DETECTORS; RNA; SUBSTRATES;

CRYSTAL STRUCTURE;

2 FLUOROADENOSINE; ADENOSINE; FLUORINE; HAIRPIN RIBOZYME; NUCLEOTIDE DERIVATIVE; PHOSPHATE; RIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA TEMPLATE; IONIZATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RNA INTERFERENCE; RNA TRANSCRIPTION; X RAY CRYSTALLOGRAPHY;

ADENOSINE; BASE PAIRING; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; FLUORINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC;

EID: 77951674713     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100234v     Document Type: Article

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