Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 14, 2007, Pages 5818-5823

  Smith, M Duane ^a   Collins, Richard A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Medical Sciences Building ^*  (Canada)

Author keywords

Kinetic solvent isotope effect; Kinetics; Neurospora; pH vs. rate

Indexed keywords

ADENOSINE; CYTOSINE; DEUTERIUM OXIDE; ISOTOPE; NUCLEOTIDE DERIVATIVE; RIBOZYME; RNA; SOLVENT; WATER; BUFFER; FUNGAL RNA; PROTON; RIBONUCLEASE; UNCLASSIFIED DRUG; VARKUD SATELLITE RIBOZYME;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME MECHANISM; MOLECULAR INTERACTION; MUTANT; MUTATION; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; WILD TYPE; BIOLOGICAL MODEL; CHEMISTRY; CONFORMATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; NEUROSPORA; NUCLEOTIDE SEQUENCE; TEMPERATURE;

NEUROSPORA;

BASE SEQUENCE; BUFFERS; DEUTERIUM OXIDE; ENDORIBONUCLEASES; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, BIOLOGICAL; MUTATION; NEUROSPORA; NUCLEIC ACID CONFORMATION; PROTONS; RNA, CATALYTIC; RNA, FUNGAL; SOLVENTS; TEMPERATURE;

EID: 34347246717     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608864104     Document Type: Article

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