Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation

Journal of the American Chemical Society

Volumn 131, Issue 36, 2009, Pages 12908-12909

  Guo, Man ^c   Spitale, Robert C ^a   Volpini, Rosaria ^b   Krucinska, Jolanta ^a   Cristalli, Gloria ^b   Carey, Paul R ^c   Wedekind, Joseph E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF CAMERINO   (Italy)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID CATALYST; ACTIVE SITE; BIOLOGICAL REACTION; BOND SCISSIONS; CATALYTIC RNA; HAIRPIN RIBOZYME; NUCLEOBASES; PHOSPHORANES; PHOSPHORYL TRANSFER; PROTONATED; RAMAN MEASUREMENTS; RATE ACCELERATION; RATE PROFILES; REFERENCE SOLUTION; RIBOZYMES; RNA STRUCTURES; TRANSITION STATE; WATER MOLECULE;

ACIDS; CONFORMATIONS; MOLECULES; NUCLEIC ACIDS; RAMAN SPECTROSCOPY; RNA;

PROTON TRANSFER;

HAIRPIN RIBOZYME; IMINE; RIBOZYME; RNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; PH; RAMAN SPECTROMETRY; TITRIMETRY;

CATALYTIC DOMAIN; CRYSTALLIZATION; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; SPECTRUM ANALYSIS, RAMAN;

EID: 70349095576     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9060883     Document Type: Article

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