Catalytic mechanism of a heme and tyrosyl radical-containing fatty acid α-(di)oxygenase

Journal of the American Chemical Society

Volumn 133, Issue 2, 2011, Pages 227-238

  Mukherjee, Arnab ^a   Angeles Boza, Alfredo M ^a   Huff, Gregory S ^a   Roth, Justine P ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RADICALS; ACTIVATION BARRIERS; APPARENT RATE CONSTANT; CARBON RADICALS; CATALYTIC MECHANISMS; DEUTERIUM KINETIC ISOTOPE EFFECT; FATTY ACID BINDING; FATTY ACID CHAINS; H-BONDS; HOMOLYSIS; HYDROPEROXIDES; ISOTOPE EXCHANGE; OXYGENASES; PEROXYL RADICAL; TYROSYL RADICALS;

AMINO ACIDS; BINDING ENERGY; DEUTERIUM; PORPHYRINS; QUANTUM CHEMISTRY; RATE CONSTANTS;

FATTY ACIDS;

CARBON; DECANOIC ACID; DEUTERIUM; DIOXYGENASE; FATTY ACID ALPHA (DI)OXYGENASEA; HEME; HYDROGEN; HYDROPEROXIDE DERIVATIVE; LAURIC ACID; OXYGEN; PALMITIC ACID; PEROXY RADICAL; RADICAL; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; KINETICS; RICE; STEADY STATE;

BIOCATALYSIS; DIOXYGENASES; ENZYME ACTIVATION; FATTY ACIDS; FREE RADICALS; HEME; KINETICS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXYGEN; TYROSINE;

EID: 78651393044     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja104180v     Document Type: Article

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