Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate

Biochemistry

Volumn 48, Issue 5, 2009, Pages 917-928

  Yeh, Hui Chun ^a   Gerfen, Gary J ^b   Wang, Jinn Shyan ^a,c   Tsai, Ah Lim ^a   Wang, Lee Ho ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RADICALS; CYTOCHROME P-450; CYTOCHROMES P450; ELECTRON MIGRATIONS; ENDOPEROXIDE; EPR SIGNALS; FERRIC SPECIES; HIGH FIELDS; HYDROGEN BONDINGS; IODOSYLBENZENE; LINE WIDTHS; MECHANISTIC MODELS; MEMBRANE BOUNDS; PERACETIC ACIDS; REACTION CATALYZED; REDUCTANT; SATURATION POWER; STOPPED-FLOW EXPERIMENTS; SYNTHASE; TENSOR COMPONENTS; TYROSYL RADICALS; UNPAIRED ELECTRONS;

AMINES; AMINO ACIDS; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYMES; HYDROGEN; HYDROGEN BONDS; ORGANIC ACIDS; PARAMAGNETIC RESONANCE; PORPHYRINS; QUANTUM THEORY;

ABSORPTION SPECTROSCOPY;

CYTOCHROME P450; FERRIC ION; HEME; IODOSOBENZENE; PERACETIC ACID; PEROXIDASE; PEROXIDE; PROSTACYCLIN SYNTHASE; TYROSINE; DRUG DERIVATIVE; FREE RADICAL; IODOBENZENE; ISOMERASE; RECOMBINANT PROTEIN; TYROSYL RADICAL Y(D);

ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ANALYSIS; ENZYME INACTIVATION; HYDROGEN BOND; PRIORITY JOURNAL; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; HUMAN; METABOLISM; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; FREE RADICALS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; IODOBENZENES; MODELS, CHEMICAL; PERACETIC ACID; PEROXIDASES; PEROXIDES; RECOMBINANT PROTEINS; TYROSINE;

EID: 61449159908     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801382v     Document Type: Article

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