Intraprotein radical transfer during photoactivation of DNA photolyase

Nature

Volumn 405, Issue 6786, 2000, Pages 586-570

  Aubert, Corinne ^a   Vos, Marten H ^b   Mathis, Paul ^a   Eker, André P M ^c   Brettel, Klaus ^a  

^a CEA SACLAY   (France)

^b LABORATOIRE D OPTIQUE APPLIQUÉE   (France)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBODIPYRIMIDINE PHOTOLYASE;

ARTICLE; CATALYSIS; DISSOCIATION; ELECTRON TRANSPORT; ENZYME ACTIVATION; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; PROTON TRANSPORT; REGULATORY MECHANISM;

DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; DNA REPAIR; ELECTRON TRANSPORT; ENZYME ACTIVATION; ESCHERICHIA COLI; FLAVIN-ADENINE DINUCLEOTIDE; KINETICS; PHOTOCHEMISTRY; PROTONS; RECOMBINANT PROTEINS; TRYPTOPHAN; ULTRAVIOLET RAYS;

EID: 0034214080     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35014644     Document Type: Article

References (28)

1. Stubbe, J. & van der Donk, W. A. Protein radicals in enzyme catalysis. Chem. Rev. 98, 705-762 (1998).
2. Uhlin, U. & Eklund, H. Structure of ribonucleotide reductase protein R1. Nature 370, 533-539 (1994).
3. Sjöberg, B.-M. The ribonucleotide reductase jigsaw puzzle: a large piece falls into place. Structure 2, 793-796 (1994).
4. Siegbahn, P. E. M., Blomberg, M. R. A. & Crabtree, R. H. Hydrogen transfer in the presence of amino acid radicals. Theor. Chem. Acc. 97, 289-300 (1997).
5. Siegbahn, P. E. M., Eriksson, L., Himo, F. & Pavlov, M. Hydrogen atom transfer in ribonucleotide reductase (RNR). J. Phys. Chem. 102, 10622-30629 (1998).
6. Cukier, R. I. & Nocera, D. G. Proton coupled electron transfer. Annu. Rev. Phys. Chem. 49, 337-369 (1998).
7. Page, C. C., Moser, C. C., Chen, X. & Dutton, P. L. Natural engineering principles of electron tunnelling in biological oxidation-reduction. Nature 402, 47-52 (1999).
8. Sancar, A. No "end of history" for photolyases. Science 272, 48-49 (1996).
9. Kim, S. -T., Heelis, P. F. & Sancar, A. Role of tryptophans in substrate binding and catalysis by DNA photolyase. Methods Enzymol. 258, 319-343 (1995).
10. Yasui, A. & Eker, A. P. M. in DNA Damage and Repair. Vol 2. DNA Repair in Higher Eukaryotes (eds Nickoloff, J. A. & Hoekstra, M., F.) 9-32 (Humana, Totowa, 1998).
11. Heelis, P. F., Okamura, T. & Sancar, A. Excited-state properties of Escherichia coli DNA phntolyase in the picosecond to millisecond time scale. Biochemistry 29, 5694-5698 (1990).
12. Li, Y. F., Heelis, P. F. & Sancar, A. Active site of DNA photolyase: tryptophan-306 is the intrinsic hydrogen atom donor essential for flavin radical photoreduction and DNA repair in vitro. Biochemistry 30, 6322-6329 (1991).
13. Eker, A. P. M., Yajima, H. & Yasui, A. DNA photolyase from the fungus Neurospora crassa. Purification, characterization and comparison with other photolyases. Photochem. Photobiol. 60, 125-133 (1994).
14. Tommos, C., Skalicky, J. J., Pilloud, D. L., Wand, A. J. & Dutton, P. L. De novo proteins as models of radical enzymes. Biochemistry 38, 9495-9507 (1999).
15. 2 radicals in light-and heavy-water solutions: A pulse radiolysis study. J. Phys. Chem. 95, 3636-3643 (1991).
16. Aubert, C., Mathis, P., Eker, A. P. M. & Brettel, K. Intraprotein electron transfer between tyrosine and tryptophan in DNA photolyase from Anacystis nidulans. Proc. Natl Acad. Sci. USA 96, 5423-5427 (1999).
17. Aubert, C., Brettel, K., Mathis, P., Eker, A. P. M. & Boussac, A. EPR detection of the transient tyrosyl radical in DNA photolyase from Anacystis nidulans. J. Am. Chem. Soc. 121, 8659-8660 (1999).
18. Cleland, W. W., O'Leary, M. H. & Northrop, D. B. Isotope Effects on Enzyme-Catalyzed Reactions (Univ. Park Press, Baltimore, London, Tokyo, 1977).
19. Eigen, M. Proton transfer, acid-base catalysis, and enzymatic hydrolysis Part I: elementary processes. Angew. Chem. Internal. Edn. 3, 1-19 (1964).
20. Okamura, T., Sancar, A., Heelis, P. F., Hirata, Y. & Mataga, N. Doublet-quartet intersystem crossing of flavin radical in DNA photolyase. J. Am. Chem. Soc. 111, 5967-5969 (1989).
21. Park, H. W., Kim, S. T., Sancar, A. & Deisenhofer, J. Crystal structure of DNA photolyase from Escherichia coli. Science 268, 1866-1872 (1995).
22. 306 to FADH. Biophys J. 76, 1241-1249 (1999).
23. -, the catalytically active form of the cofactor, Proc. Natl Acad. Sci. USA 90, 8023-8027 (1993).
24. Gindt, Y. M. et al. Origin of the transient electron paramagnetic resonance signals in DNA photolyase, Biochemistry 38, 3857-3866 (1999).
25. Cashmore, A. R., Jarillo, J. A., Xu, Y. -J. & Liu, D. Cryptochromes: blue light receptors for plants and animals. Science 284, 760-765 (1999).
26. Martin, J.-L. & Vos, M. H. Femtosecond measurements of geminate recombination in heme proteins. Methods Enzymol 232, 416-430 (1994).
27. Heelis, P. F., Deeble, D. J., Kim, S. T. & Sancar, A. Splitting of cys-syn cyclobutane thymine-thymine dimers by radiolysis and its relevance to enzymatic photoreactivation. Int. J. Radiat. Biol. 62, 137-143 (1992).
28. Guex, N. & Peitsch, M. N. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling. Electrophoresis 18, 2714-2723 (1997).