Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: Evidence for novel Aβ species

Proteomics

Volumn 7, Issue 20, 2007, Pages 3815-3820

  Maler, Juan Manuel ^a   Klafki, Hans Wolfgang ^a   Paul, Sabine ^a   Spitzer, Philipp ^a   Groemer, Teja Wolfgang ^b   Henkel, Andreas Wolfram ^a   Esselmann, Hermann ^a   Lewczuk, Piotr ^a   Kornhuber, Johannes ^a   Wiltfang, Jens ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

A peptides; Alzheimer's disease; Beta amyloid; Biomarker; Plasma

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; BIOLOGICAL MARKER; UREA;

ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TWO DIMENSIONAL ELECTROPHORESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MIDDLE AGED; PEPTIDE FRAGMENTS; UREA;

EID: 35648929821     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200700311     Document Type: Article

References (18)

1. Andreasen, N., Sjogren, M., Blennow, K., CSF markers for Alzheimer's disease: Total tau, phospho-tau and Abeta42. World J. Biol. Psychiatry 2003, 4, 147-155.
2. Ida, N., Hartmann, T., Pantel, J., Schroder, J. et al., Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J. Biol. Chem. 1996, 271, 22908-22914.
3. Lewczuk, P., Esselmann, H., Bibl, M., Paul, S. et al., Electrophoretic separation of amyloid beta peptides in plasma. Electrophoresis 2004, 25, 3336-3343.
4. Fukumoto, H., Tennis, M., Locascio, J. J., Hyman, B. T. et al., Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch. Neurol. 2003, 60, 958-964.
5. Varesio, E., Rudaz, S., Krause, K. H., Veuthey, J. L., Nanoscale liquid chromatography and capillary electrophoresis coupled to electrospray mass spectrometry for the detection of amyloid-beta peptide related to Alzheimer's disease. J. Chromatogr. A 2002, 974, 135-142.
6. Du, C., Ramaley, C., McLean, H., Leonard, S. C. et al. High-performance liquid chromatography coupled with tandem mass spectrometry for the detection of amyloid Beta peptide related with Alzheimer's disease. J. Biomol. Tech. 2005, 16, 356-363.
7. Vanderstichele, H., Van, K. E., Hesse, C., Davidsson, P. et al., Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma. Amyloid 2000, 7, 245-258.
8. Sergeant, N., Bombois, S., Ghestem, A., Drobecq, H. et al., Truncated beta-amyloid peptide species in preclinical Alzheimer's disease as new targets for the vaccination approach. J. Neurochem. 2003, 85, 1581-1591.
9. Wiltfang, J., Esselmann, H., Bibl, M., Smirnov, A. et al., Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation. J. Neurochem. 2002, 81, 481-496.
10. Klafki, H. W., Wiltfang, J., Staufenbiel, M., Electrophoretic separation of betaA4 peptides (1-40) and (1-42). Anal. Biochem. 1996, 237, 24-29.
11. Wiltfang, J., Esselmann, H., Cupers, P., Neumann, M. et al., Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. J. Biol. Chem. 2001, 276, 42645-42657.
12. Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G. et al., Longer forms of amyloid beta protein: Implications for the mechanism of intramembrane cleavage by gamma-secretase. J. Neurosci. 2005, 25, 436-445.
13. Mehta, P. D., Pirttila, T., Mehta, S. P., Sersen, E. A. et al., Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch. Neurol. 2000, 57, 100-105.
14. Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S. et al., Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease. Neurology 2006, 66, 1506-1510.
15. Dyrks, T., Dyrks, E., Masters, C. L., Beyreuther, K., Amyloidogenicity of rodent and human beta A4 sequences. FEBS Lett. 1993, 324, 231-236.
16. Saido, T. C., Yamao-Harigaya, W., Iwatsubo, T., Kawashima, S., Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neurosci. Lett. 1996, 215, 173-176.
17. Atwood, C. S., Martins, R. N., Smith, M. A., Perry, G., Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides 2002, 23, 1343-1350.
18. Li, Q. X., Fuller, S. J., Beyreuther, K., Masters, C. L., The amyloid precursor protein of Alzheimer disease in human brain and blood. J. Leukoc. Biol. 1999, 66, 567-574.