The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds

Neuroscience

Volumn 142, Issue 4, 2006, Pages 991-997

  Lunardi, G ^a   Parodi, A ^a   Perasso, L ^a   Pohvozcheva, A V ^b   Scarrone, S ^c   Adriano, E ^a   Florio, T ^a   Gandolfo, C ^a   Cupello, A ^c   Burov, S V ^b   Balestrino, M ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b INSTITUTE OF MACROMOLECULAR COMPOUNDS   (Russian Federation)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CREATINE BENZYL ESTER; CREATINE PHOSPHATE; CREATINE TRANSPORTER; GUANIDINE DERIVATIVE; GUANIDINOPROPIONIC ACID; PHOSPHOCREATINE MAGNESIUM COMPLEX ACETATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DRUG POTENCY; FUNCTIONAL PROTEOMICS; GLIA CELL; HEREDITARY CREATINE TRANSPORTER DEFICIENCY; HIPPOCAMPUS; IN VITRO STUDY; INCUBATION TIME; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; TISSUE DISTRIBUTION;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; BRAIN DISEASES, METABOLIC; CELL MEMBRANE; CREATINE; ENZYME INHIBITORS; GUANIDINES; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED ICR; NEURONS; ORGAN CULTURE TECHNIQUES; PROPIONIC ACIDS;

EID: 33750297109     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.06.058     Document Type: Article

References (26)

1. Acosta M.L., Kalloniatis M., and Christie D.L. Creatine transporter localization in developing and adult retina: importance of creatine to retinal function. Am J Physiol Cell Physiol 289 (2005) C1015-C1023
2. Balestrino M., Burov S.V., Lensman M., Polenov S., and Yakutseni P.P. Complessi di fosfocreatina [Patent], Italian Patent Application TO2005A000847 of November 30 (2000)
3. Balestrino M., Rebaudo R., and Lunardi G. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship. Brain Res 816 (1999) 124-130
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
5. Braissant O., Henry H., Loup M., Eilers B., and Bachmann C. Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study. Mol Brain Res 86 1-2 (2001) 193-201
6. Dai W., Vinnakota S., Qian X., Kunze D.L., and Sarkar H.K. Molecular characterization of the human CRT-1 creatine transporter expressed in Xenopus oocytes. Arch Biochem Biophys 361 (1999) 75-84
7. Degrauw T.J., Cecil K.M., Byars A.W., Salomons G.S., Ball W.S., and Jakobs C. The clinical syndrome of creatine transporter deficiency. Mol Cell Biochem 244 (2003) 45-48
8. Happe H.K., and Murrin L.C. In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system. J Comp Neurol 351 (1995) 94-103
9. Item C.B., Stockler-Ipsiroglu S., Stromberger C., Muhl A., Alessandri M.G., Bianchi M.C., Tosetti M., Fornai F., and Cioni G. Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. Am J Hum Genet 69 5 (2001) 1127-1133
10. National Toxicology Program Technical Reports Series. NTP toxicology and carcinogenesis studies of benzyl alcohol (CAS No. 100-51-6) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 343 (1989) 1-158
11. Ohtsuki S., Tachikawa M., Takanaga T., Shimizu H., Watanabe T.M., Hosoya K., and Terasaki T. The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J Cereb Blood Flow Metab 22 (2002) 1327-1335
12. Perasso L., Cupello A., Lunardi G.L., Principato C., Gandolfo C., and Balestrino M. Kinetics of creatine in blood and brain after intraperitoneal injection in the rat. Brain Res 974 (2003) 37-42
13. Salomons G.S., Van Dooren S.J., Verhoeven N.M., Cecil K.M., Ball W.S., Degrauw T.J., and Jacobs C. X linked creatine-transporter gene (SLC6A8) defect a new creatine-deficiency syndrome. Am J Hum Genet 68 5 (2001) 1497-1500
14. Saltarelli M.D., Bauman A.L., Moore K.R., Bradley C.C., and Blakely R.D. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev Neurosci 18 (1996) 524-534
15. Shah V.P., Midha K.K., Dighe S., McGilveray I.J., Skelly J.P., Yacobi A., Layloff T., Viswanathan C.T., Cook C.E., and McDowall R.D. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report. Eur J Drug Metab Pharmacokinet 16 (1991) 249-255
16. Stockler S., and Hanefeld F. Creatine deficiency in the brain: a new, treatable inborn error of metabolism. Pediatr Res 36 3 (1994) 409-413
17. Stromberger C., Bodamer O.A., and Stockler I.S. Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism. J Inherit Metab Dis 26 (2003) 299-308
18. Tachikawa M., Fukaya M., Terasaki T., Ohtsuki S., and Watanabe M. Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis. Eur J Neurosci 20 (2004) 144-160
19. Tarnopolsky M.A., and Beal M.F. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol 49 (2001) 561-574
20. Vennerstrom J.L., and Miller D.W. Creatine ester pronutrient compounds and formulations (2002) [Patent]. Patent number WO0222135. USA.
21. Wheelwright D.C., and Ashmead S.D. Bioavailable chelates of creatine and essential metals (2000) [Patent]. Patent 6,114,379. USA.
22. Whittingham T.S., and Lipton P. Cerebral synaptic transmission during anoxia is protected by creatine. J Neurochem 37 (1981) 1618-1621
23. Wick M., Fujimori H., Michaelis T., and Frahm J. Brain water diffusion in normal and creatine-supplemented rats during transient global ischemia. Magn Reson Med 42 (1999) 798-802
24. Wyss M., and Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 80 (2000) 1107-1212
25. Yoneda K., and Okada Y. Effects of anoxia and recovery on the neurotransmission and level of high-energy phosphates in thin hippocampal slices from the guinea-pig. Neuroscience 28 (1989) 401-407
26. Zhu S., Li M., Figueroa B.E., Liu A., Stavrovskaya I.G., Pasinelli P., Beal M.F., Brown Jr. R.H., Kristal B.S., Ferrante R.J., and Friedlander R.M. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J Neurosci 24 (2004) 5909-5912