UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 1, 2011, Pages

  Bromati, Carla R ^a   Lellis Santos, Camilo ^a   Yamanaka, Tatiana S ^a   Nogueira, Tatiane C A ^a   Leonelli, Mauro ^a   Caperuto, Luciana C ^b   Gorjão, Renata ^c   Leite, Adriana R ^a   Anhê, Gabriel F ^d   Bordin, Silvana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDADE CRUZEIRO DO SUL   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

cell apoptosis; Endocrine pancreas; Lactation; Pregnancy; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; CELL CYCLE PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PHOSPHOTRANSFERASE; PROLACTIN; PROTEIN KINASE B; TRIBBLE 3; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LACTATION; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT; UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CELLS, CULTURED; FEMALE; INSULIN; ISLETS OF LANGERHANS; LACTATION; MODELS, ANIMAL; PHOSPHORYLATION; PROLACTIN; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 78650653277     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00169.2010     Document Type: Article

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