Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain

Journal of Immunology

Volumn 185, Issue 12, 2010, Pages 7562-7572

  Medina, Edward A ^a,b   Morris, Ian R ^a   Berton, Michael T ^a  

^a Department of Microbiology and Immunology ^*  (Australia)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INTERLEUKIN 6; LIVE VACCINE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; FRANCISELLA TULARENSIS; HOST RESISTANCE; IMMUNOBLOTTING; IMMUNOREGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANDROSTADIENES; ANIMALS; BACTERIAL VACCINES; BONE MARROW CELLS; CHROMONES; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME INHIBITORS; FRANCISELLA TULARENSIS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; MYELOID DIFFERENTIATION FACTOR 88; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TULAREMIA; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, ATTENUATED;

EID: 78650642949     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903790     Document Type: Article

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