Both Erk and p38 kinases are necessary for cytokine gene transcription

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 4, 1999, Pages 751-758

  Carter, Aaron Brent ^a,b   Monick, Martha M ^a   Hunninghake, Gary W ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYTOKINE; ENZYME INHIBITOR; FLAVONOID; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE (CALCIUM,CALMODULIN); TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; METABOLISM; PHYSIOLOGY; REFERENCE VALUE;

ADULT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CYTOKINES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REFERENCE VALUES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033111732     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.4.3420     Document Type: Article

References (48)

1. Hudson, L. D., J. A. Milberg, D. Anardi, and R. J. Maunder. 1995. Clinical risks for the development of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 151:293-301.
2. Pittet, J. F., R. C. Mackersie, T. R. Martin, and M. A. Matthay. 1997. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am. J. Respir. Crit. Care Med. 155:1187-1205.
3. Meduri, G. U., S. Healey, G. Kohler, F. Stentz, E. Tollet, R. Umberger, and K. Leeper. 1995. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS: plasma IL-1β and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107:1062-1173.
4. Meduri, G. U., G. Kohler, S. Healey, E. Tolley, F. Stentz, and A. Postlethwaite. 1995. Inflammatory cytokines in the BAL of patients with ARDS: persistent elevation over time predicts poor outcome. Chest 108:1303-1314.
5. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, J. E. Strickler, M. M. McLaughlin, I. R. Siemens, S. M. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
6. Lee, J. C., and P. R. Young. 1996. Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J. Leukoc. Biol. 59:152-157.
7. Liu, M. K., P. Herrera-Velit, R. W. Brownsey, and N. E. Reiner. 1994. CD 14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153:2642-2652.
8. Nick, J. A., N. J. Avdi, P. Gerwins, G. L. Johnson, and G. S. Worthen. 1996. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156:4867-4875.
9. Sanghera, J. S., S. L. Weinstein, M. Aluwalia, J. Girn, and S. L. Pelech. 1996. Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages. J. Immunol. 156:4457-4465.
10. Han, J., J.-D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811.
11. Hambleton, J., S. L. Weinstein, L. Lern, and A. L. DeFranco. 1996. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 93:2774-2778.
12. Guthridge, C. J., D. Eidlen, W. P. Arend, A. Gutierrez-Hartmann, and M. F. J. Smith. 1997. Lipopolysaccharide and Raf-I kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms. Mol. Cell. Biol. 17:1118-1128.
13. Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. DeFranco, and S. L. Pelech. 1992. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267:14955-14962.
14. Joto, N., T. Akimoto, K. Someya, and A. Tohgo. 1995. Production of tumor necrosis factor induced by synthetic low-toxicity lipid A analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase-MAP kinase signaling pathway in murine macrophages. Cell Immunol. 160:1-7.
15. Reimann, T., D. Buscher, R. A. Hipskind, S. Krautwald, M.-L. Lohmann-Matthes, and M. Baccarini. 1994. Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway: a putative role for Raf-1 in the induction of IL-1β and the TNF-α genes. J. Immunol. 153:5740-5749.
16. Trotta, R., P. Kanakaraj, and B. Perussia. 1996. FcγR-dependent mitogen-activated protein kinase activation in leukocytes: a common signal transduction event necessary for expression of TNF-α and early activation genes. J. Exp. Med. 184:1027-1035.
17. MAPK in Fcγ receptor-stimulated TNF-α synthesis. J. Immunol. 158:3433-3438.
18. Zhang, C., R. A. Baumgartner, K. Yamada, and M. A. Beaven. 1997. Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-α and release of arachidonic acid in mast cells: indications of communication between p38 and p42 MAP kinases. J. Biol. Chem. 272: 13397-13402.
19. Dudley, D. T., L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92:7686-7689.
20. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489-27494.
21. Shapiro, L., and C. A. Dinarello. 1995. Osmotic regulation of cytokine synthesis in vitro. Proc. Natl. Acad. Sci. USA 92:12230-12234.
22. Saklatvala, J., L. Rawlinson, R. J. Waller, S. Sarsfield, J. C. Lee, L. F. Morton, M. J. Barnes, and R. W. Farndale. 1996. Role of p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J. Biol. Chem. 271:6586-6589.
23. Kumar, S., M. J. Orsini, J. C. Lee, P. C. McDonnell, C. Debouck, and P. R. Young. 1996. Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase. J. Biol. Chem. 271:30864-30869.
24. Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Yound, and J. C. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:229-233.
25. Pang, L., T. Sawanda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270:13585-13588.
26. Cuenda, A., P. Cohen, V. Buee-Scherrer, and M. Goedert. 1997. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6): comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J. 16:295-305.
27. Derijard, B., J. Raingeaud, T. Barrett, I. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
28. Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420-7426.
29. Stein, B., A. S. Baldwin, Jr., D. W. Ballard, W. C. Greene, P. Angel, and P. Herrlich. 1993. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 12: 3879-3891.
30. Wang, X., and D. Ron. 1996. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272:1347-1349.
31. Meyer, C. F., X. Wang, C. Chang, D. Templeton, and T.-H. Tan. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating κB enhancer activation. J. Biol. Chem. 271:8971-8976.
32. Minden, A., A. Lin, T. Smeal, D. Derijard, M. Cobb, R. Davis, and M. Karin. 1994. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14:6683-6688.
33. Frost, J. A., T. D. Geppert, M. H. Cobb, and J. R. Feramisco. 1994. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc. Natl. Acad Sci. USA 91:3844-3848.
34. Frost, J. A., A. S. Alberts, E. Sontag, K. Guan, M. C. Mumbay, and J. R. Feramisco. 1994. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol. Cell. Biol. 14:6244-6252.
35. 2-terminal kinase and mitogen-activated protein kinase signaling pathways. J. Exp. Med. 183:2017-2023.
36. Akira, S., and T. Kishimoto. 1992. IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol. Rev. 127:25-50.
37. Huang, J. H., and W. S. L. Liao. 1994. Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor. Mol. Cell. Biol. 14:4475-4484.
38. Ray, A., and R. B. Ray. 1994. Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBPβ and C/EBPδ and their activation by phosphorylation. Mol. Cell. Biol. 14:4324-4332.
39. Alam, T., R. An, and J. Papaconstantinou. 1992. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J. Biol. Chem. 267:5021-5024.
40. Pope, R. M., A. Leutz, and S. A. Ness. 1994. C/EBP beta regulation of the tumor necrosis factor alpha gene. J. Clin. Invest. 94:1449-1455.
41. Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira. 1993, Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207-2211.
42. Alvarez, E., I. C. Northwood, F. A. Bonsalez, D. A. Latour, A. Seth, C. Abate, T. Curran, and R. J. Davis. 1991. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation: characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266: 15277-15285.
43. Gupta, S., A. Seth, and R. J. Davis. 1993. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc. Natl. Acad Sci. USA 90:3216-3220.
44. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414-417.
45. Abdel-Hafiz, H. A., L. E. Heasley, J. M. Kyriakis, J. Avruch, D. J. Kroll, G. L. Johnson, and J. P. Hoeffler. 1992. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol. Endocrinol. 6:2079-2089.
46. Deng, T., and M. Karin. 1994. C-fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature 371: 171-175.
47. Minden, A., A. Lin, F. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc-42Hs. Cell 81:1147-1157.
48. Derijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037.