Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages

Annals of the Rheumatic Diseases

Volumn 60, Issue SUPPL. 3, 2001, Pages

  Jones, B W ^a   Heldwein, K A ^a   Means, T K ^a   Saukkonen, J J ^a   Fenton, M J ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOARABINOMANNAN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEMBRANE LIPID; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; INFLAMMATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, PROTOZOAN; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; HUMANS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE; PROTOZOAN PROTEINS; RANTES; RECEPTORS, CELL SURFACE; SOYBEAN PROTEINS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034780463     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. A family of human receptors structurally related to Drosophila Toll
2. The biology of Toll-like receptors
3. Toll receptors in innate immunity
4. CD 14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
5. Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4
6. Mouse Toll-like receptor 4/MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
7. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
8. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
9. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
10. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
11. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
12. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
13. Different Toll-like receptor agonists induce distinct macrophage responses
14. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
15. Signaling by TLR2 versus TLR4 agonists results in differential gene expression in murine macrophages
16. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the tlr4 gene
17. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
18. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
19. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
20. Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
21. A Toll-like receptor recognizes bacterial DNA
22. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
23. Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis
24. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
25. 15N]nitrate in biological fluids
26. Unresponsiveness of MyD88-deficient mice to endotoxin
27. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TPAF) 6
28. Induction of direct antimicrobial activity through mammalian Toll-like receptors
29. Alveolar macrophages from C3H/HeJ mice show sensitivity to endotoxin
30. Activation of TNF-α transcription utilizes distinct MAP kinase pathways in different macrophage populations
31. Requirement for STAT1 in LPS-induced gene expression in macrophages
32. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-β
33. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages
34. Toll-like receptor 2-mediated NF-κB activation requires a Rac 1-dependent pathway
35. Human Toll-like receptors mediate cellular activation by M. tuberculosis
36. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids