Cardioprotection with palm oil tocotrienols: Comparision of different isomers

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 2, 2008, Pages

  Das, Samarjit ^a,b   Lekli, Istvan ^b   Das, Manika ^a   Szabo, Gergo ^b   Varadi, Judit ^b   Juhasz, Bela ^b   Bak, Istvan ^b   Nesaretam, Kalanithi ^c   Tosaki, Arpad ^b   Powell, Saul R ^d   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c MALAYSIAN PALM OIL BOARD   (Malaysia)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

tocotrienol; tocotrienol; tocotrienol; Akt; c Src; Tocotrienol rich fraction

Indexed keywords

ALPHA TOCOTRIENOL; DELTA TOCOTRIENOL; GAMMA TOCOTRIENOL; PALM OIL; PROTEASOME; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG MECHANISM; DRUG POTENCY; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE FUNCTION; ISOMER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STROKE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, SRC; HEART; HEART FUNCTION TESTS; ISOMERISM; MALE; MALONDIALDEHYDE; MYOCARDIAL INFARCTION; MYOCARDIUM; ONCOGENE PROTEIN V-AKT; PLANT OILS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; TOCOTRIENOLS;

EID: 39149121499     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01200.2007     Document Type: Article

References (31)

1. Burton GW, Ingold KU. Vitamin E as an in vitro and in vivo antioxidant. Ann NY Acad Sci 570: 7-22, 1989.
2. Cordis GA, Maulik G, Bagchi D, Riedel W, Das DK. Detection of oxidative DNA damage to ischemic reperfused rat hearts by 8- hydroxydeoxyguanosine formation. J Mol Cell Cardiol 30: 1939-1944, 1998.
3. Das S, Alagappan VK, Bagchi D, Sharma HS, Maulik N, Das DK. Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart. Vascul Pharmacol 42: 281-289, 2005.
4. Das S, Nesaretnam K, Das DK. Tocotrienols in cardioprotection. Vitam Horm 76: 419-433, 2007.
5. Das S, Otani H, Maulik N, Das DK. Lycopene, tomatoes, and coronary heart disease. Free Radic Res 39: 449-455, 2005.
6. Das S, Otani H, Maulik N, Das DK. Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling. J Mol Cell Cardiol 41: 248-255, 2006.
7. Das S, Powell SR, Wang P, Divald A, Nesaretnam K, Tosaki A, Cordis GA, Maulik N, Das DK. Cardioprotection with palm tocotrienol: antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes. Am J Physiol Heart Circ Physiol 289: H361-H367, 2005.
8. Das S, Tosaki A, Bagchi D, Maulik N, Das DK. Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling. J Pharmacol Exp Ther 317: 980-988, 2006.
9. Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner SF, Madura K. Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 114: 1821-1828, 2006.
10. Devaraj S, Jialal I. Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radic Biol Med 38: 1212-1220, 2005.
11. Grune T, Reinheckel T, Davies KJA. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem 271: 15504-15509, 1996.
12. Guthrie N, Gapor A, Chambers AF, Carroll KK. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxife, alone and in comnbination. J Nutr 127: 544S-548S, 1997.
13. Hakak Y, Martin GS. Ubiquitin-dependent degradation of active Src. Curr Biol 9: 1039-1042, 1999.
14. Harris KF, Shoji I, Cooper EM, Kumar S, Oda H, Howley PM. Ubiquitin-mediated degradation of active Src tyrosine kinase. Proc Natl Acad Sci USA 96: 13738-13743, 1999.
15. He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 127: 668-674, 1997.
16. LuD, Maulik N, Moraru II, Kreutzer DL, Das DK. Molecular adaptation of vascular endothelial cells to oxidative stress. Am J Physiol Cell Physiol 264: C715-C722, 1993.
17. Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Reimann K, Razak G, Virgili F. Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39: 459-467, 2004.
18. Nesaretnam K, Guthrie N, Chambers AF, Carroll KK. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30: 1139-1143, 1995.
19. Palozza P, Verdecchia S, Avanzi L, Vertuani S, Serini S, Iannone A, Manfredini S. Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells. Mol Cell Biochem 287: 21-32, 2006.
20. Powell SR, Davies KJA, Divald A. Optimal determination of heart tissue 26S Proteasome activity requires maximal stimulating concentrations of ATP. J Mol Cell Cardiol 42: 265-269, 2007.
21. Powell SR, Wang P, Katzeff HL, Shringarpure R, Teoh C, Khaliulin I, Das DK, Schwalb H. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function. Essential role of the proteasome. Antioxid Redox Signal 7: 538-535, 2005.
22. Qureshi AA, Bradlow BA, Brace L, Manganello L, Peterson DM, Pearce BC, Wright JJ, Gapor A, Elson CE. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30: 1161-1177, 1995.
23. Qureshi AA, Qureshi N, Hasler-Rapacz JO, Weber FE, Chaudhary V, Crenshaww TD, Gapor A, Ong AS, Chong YH, Peterson D, Rapacz J. Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. Am J Clin Nutr 53, Suppl 4: 1042S-1046S, 1991.
24. Qureshi AA, Qureshi N, Wright JJ, Shen Z, Kramer G, Gapor A, Chong YH, DeWitt G, Ong A, Peterson DM. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am J Clin Nutr 53: 1021S-1026S, 1991.
25. Qureshi AA, Sami SA, Salser WA, Khan FA. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 161: 199-207, 2002.
26. Riesterer O, Zingg D, Hummerjohann J, Bodis S, Pruschy M. Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene 23: 4624-4635, 2004.
27. c-src kinase activation and death of HT4 neuronal cells. J Biol Chem 275: 13049-13055, 2000.
28. Srivastava JK, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun 346: 447-453, 2006.
29. Yan D, Guo L, Wang Y. Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. J Cell Biol 174: 415-424, 2006.
30. Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids 123: 63-75, 2003.
31. Yu W, Simmons-Menchaca M, Gapor A, Sanders BG, Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33: 26-32, 1999.