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Volumn 6, Issue 1, 2011, Pages 71-84

Role of the growth hormone-IGF-1 axis in cancer

Author keywords

autocrine GH; breast cancer; colon cancer; epidemiology; GH receptor; growth hormone; insulin like growth factor 1; nuclear GH receptor; prolactin; prostate cancer; signal transducer and activator of transcription 5

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH HORMONE; JANUS KINASE; PEGVISOMANT; PROLACTIN RECEPTOR; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 78650532040     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/eem.10.73     Document Type: Review
Times cited : (75)

References (147)
  • 1
    • 0025278021 scopus 로고
    • Regulation by GH of insulin-like growth factor-I mRNA expression in rat epiphyseal growth plate as studied with in situ hybridization
    • Nilsson A, Carlsson B, Isgaard J, Isaksson OG, Rymo L. Regulation by GH of insulin-like growth factor-I mRNA expression in rat epiphyseal growth plate as studied with in situ hybridization. J. Endocrinol. 125(1), 67-74 (1990).
    • (1990) J. Endocrinol. , vol.125 , Issue.1 , pp. 67-74
    • Nilsson, A.1    Carlsson, B.2    Isgaard, J.3    Isaksson, O.G.4    Rymo, L.5
  • 2
    • 0033594893 scopus 로고    scopus 로고
    • Normal growth and development in the absence of hepatic insulin-like growth factor I
    • USA
    • Yakar S, Liu JL, Stannard B et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl Acad. Sci. USA 96(13), 7324-7329 (1999).
    • (1999) Proc. Natl Acad. Sci. , vol.96 , Issue.13 , pp. 7324-7329
    • Yakar, S.1    Liu, J.L.2    Stannard, B.3
  • 4
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr. Rev. 28(1), 20-47 (2007).
    • (2007) Endocr. Rev. , vol.28 , Issue.1 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 5
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0029835895 scopus 로고    scopus 로고
    • Genetic and environmental components of interindividual variation in circulating levels of IGF-I IGF-II IGFBP-1 and IGFBP-3
    • Harrela M, Koistinen H, Kaprio J et al. Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. J. Clin. Invest. 98(11), 2612-2615 (1996).
    • (1996) J. Clin. Invest. , vol.98 , Issue.11 , pp. 2612-2615
    • Harrela, M.1    Koistinen, H.2    Kaprio, J.3
  • 7
    • 0033897155 scopus 로고    scopus 로고
    • The question of a link between insulin-like growth factor physiology and neoplasia
    • Pollak M. The question of a link between insulin-like growth factor physiology and neoplasia. Growth Horm. IGF Res. 10(Suppl. B), S21-S24 (2000).
    • (2000) Growth Horm. IGF Res. , vol.10 , Issue.SUPPL. B
    • Pollak, M.1
  • 9
    • 0030656447 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
    • Yamauchi T, Ueki K, Tobe K et al. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature 390(6655), 91-96 (1997).
    • (1997) Nature , vol.390 , Issue.6655 , pp. 91-96
    • Yamauchi, T.1    Ueki, K.2    Tobe, K.3
  • 10
    • 40249094410 scopus 로고    scopus 로고
    • Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling
    • Frank SJ. Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling. J. Mammary Gland Biol. Neoplasia. 13(1), 119-129 (2008).
    • (2008) J. Mammary Gland Biol. Neoplasia. , vol.13 , Issue.1 , pp. 119-129
    • Frank, S.J.1
  • 13
    • 78049317978 scopus 로고    scopus 로고
    • Serum and intratumoural GH and IGF-I concentrations: Prognostic factors in the outcome of canine mammary cancer
    • Queiroga FL, Perez-Alenza D, Silvan G, Pena L, Lopes CS, Illera JC. Serum and intratumoural GH and IGF-I concentrations: Prognostic factors in the outcome of canine mammary cancer. Res. Vet. Sci. 89(3), 396-403 (2010).
    • (2010) Res. Vet. Sci. , vol.89 , Issue.3 , pp. 396-403
    • Queiroga, F.L.1    Perez-Alenza, D.2    Silvan, G.3    Pena, L.4    Lopes, C.S.5    Illera, J.C.6
  • 14
    • 34547103977 scopus 로고    scopus 로고
    • Co-twin control and cohort analyses of body mass index and height in relation to breast prostate ovarian corpus uteri colon and rectal cancer among swedish and finnish twins
    • Lundqvist E, Kaprio J, Verkasalo PK et al. Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins. Int. J. Cancer 121(4), 810-818 (2007).
    • (2007) Int. J. Cancer , vol.121 , Issue.4 , pp. 810-818
    • Lundqvist, E.1    Kaprio, J.2    Verkasalo, P.K.3
  • 15
    • 77953536809 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 IGF1 IGF binding protein 3 IGFBP3 and breast cancer risk: Pooled individual data analysis of 17 prospective studies
    • Key TJ, Appleby PN, Reeves GK, Roddam AW. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol. 11(6), 530-542 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.6 , pp. 530-542
    • Key, T.J.1    Appleby, P.N.2    Reeves, G.K.3    Roddam, A.W.4
  • 16
    • 0027454914 scopus 로고
    • Plasma insulin-like growth factor-1 IGF-1 concentrations in human breast cancer
    • Peyrat JP, Bonneterre J, Hecquet B et al. Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer. Eur. J. Cancer 29A(4), 492-497 (1993).
    • (1993) Eur. J. Cancer , vol.1-29 A , Issue.4 , pp. 492-497
    • Peyrat, J.P.1    Bonneterre, J.2    Hecquet, B.3
  • 17
    • 0034967344 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: New insights into their synergistic effects
    • Dupont J, Le Roith D. Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects. Mol. Pathol. 54(3), 149-154 (2001).
    • (2001) Mol. Pathol. , vol.54 , Issue.3 , pp. 149-154
    • Dupont, J.1    Le Roith, D.2
  • 18
    • 0034660884 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density
    • Byrne C, Colditz GA, Willett WC, Speizer FE, Pollak M, Hankinson SE. Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density. Cancer Res. 60(14), 3744-3748 (2000). (Pubitemid 32204562)
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3744-3748
    • Byrne, C.1    Colditz, G.A.2    Willet, W.C.3    Speizer, F.E.4    Pollak, M.5    Hankinson, S.E.6
  • 19
    • 57149143868 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
    • Kleinberg DL, Wood TL, Furth PA, Lee AV. Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr. Rev. 30(1), 51-74 (2009).
    • (2009) Endocr. Rev. , vol.30 , Issue.1 , pp. 51-74
    • Kleinberg, D.L.1    Wood, T.L.2    Furth, P.A.3    Lee, A.V.4
  • 20
    • 33744785962 scopus 로고    scopus 로고
    • Variants in the GH-IGF axis confer susceptibility to lung cancer
    • Rudd MF, Webb EL, Matakidou A et al. Variants in the GH-IGF axis confer susceptibility to lung cancer. Genome Res. 16(6), 693-701 (2006).
    • (2006) Genome Res. , vol.16 , Issue.6 , pp. 693-701
    • Rudd, M.F.1    Webb, E.L.2    Matakidou, A.3
  • 22
    • 77953151341 scopus 로고    scopus 로고
    • Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade
    • Menashe I, Maeder D, Garcia-Closas M et al. Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade. Cancer Res. 70(11), 4453-4459 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.11 , pp. 4453-4459
    • Menashe, I.1    Maeder, D.2    Garcia-Closas, M.3
  • 23
    • 26444620298 scopus 로고    scopus 로고
    • Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I insulin-like growth factor binding protein-3 and breast cancer risk: Results from the European prospective investigation into cancer and nutrition study
    • Canzian F, McKay JD, Cleveland RJ et al. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. Cancer Epidemiol. Biomarkers Prev. 14(10), 2316-2325 (2005).
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , Issue.10 , pp. 2316-2325
    • Canzian, F.1    McKay, J.D.2    Cleveland, R.J.3
  • 24
    • 42149084438 scopus 로고    scopus 로고
    • Genetic polymorphisms involved in insulin-like growth factor IGF pathway in relation to mammographic breast density and IGF levels
    • Diorio C, Brisson J, Berube S, Pollak M. Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels. Cancer Epidemiol. Biomarkers Prev. 17(4), 880-888 (2008).
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , Issue.4 , pp. 880-888
    • Diorio, C.1    Brisson, J.2    Berube, S.3    Pollak, M.4
  • 25
  • 26
    • 77955481933 scopus 로고    scopus 로고
    • IGF1 IGFBP1 and IGFBP3 genes and mammographic density: The Multiethnic Cohort
    • Verheus M, Maskarinec G, Woolcott CG et al. IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort. Int. J. Cancer 127(5), 1115-1123 (2010).
    • (2010) Int. J. Cancer , vol.127 , Issue.5 , pp. 1115-1123
    • Verheus, M.1    Maskarinec, G.2    Woolcott, C.G.3
  • 28
    • 24944531217 scopus 로고    scopus 로고
    • IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer
    • Friedrichsen DM, Hawley S, Shu J et al. IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer. Prostate 65(1), 44-51 (2005).
    • (2005) Prostate , vol.65 , Issue.1 , pp. 44-51
    • Friedrichsen, D.M.1    Hawley, S.2    Shu, J.3
  • 29
    • 77952744178 scopus 로고    scopus 로고
    • Influence of IGFBP3 gene polymorphisms on IGFBP3 serum levels and the risk of prostate cancer in low-risk Korean men
    • 1516
    • Park K, Kim JH, Jeon HG, Byun SS, Lee E. Influence of IGFBP3 gene polymorphisms on IGFBP3 serum levels and the risk of prostate cancer in low-risk Korean men. Urology 75(6), 1516, e1-e7 (2010).
    • (2010) Urology , vol.75 , Issue.6
    • Park, K.1    Kim, J.H.2    Jeon, H.G.3    Byun, S.S.4    Lee, E.5
  • 30
    • 64249111139 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor peptides and prostate cancer risk: A systematic review and meta-analysis
    • Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM. Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis. Int. J. Cancer 124(10), 2416-2429 (2009).
    • (2009) Int. J. Cancer , vol.124 , Issue.10 , pp. 2416-2429
    • Rowlands, M.A.1    Gunnell, D.2    Harris, R.3    Vatten, L.J.4    Holly, J.M.5    Martin, R.M.6
  • 31
    • 77449111832 scopus 로고    scopus 로고
    • Serum levels of IGF-I IGFBP-3 and colorectal cancer risk: Results from the EPIC cohort plus a meta-analysis of prospective studies
    • Rinaldi S, Cleveland R, Norat T et al. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. Int. J. Cancer 126(7), 1702-1715 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.7 , pp. 1702-1715
    • Rinaldi, S.1    Cleveland, R.2    Norat, T.3
  • 32
    • 58249092146 scopus 로고    scopus 로고
    • Insulin the insulin-like growth factor axis and mortality in patients with nonmetastatic colorectal cancer
    • Wolpin BM, Meyerhardt JA, Chan AT et al. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J. Clin. Oncol. 27(2), 176-185 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.2 , pp. 176-185
    • Wolpin, B.M.1    Meyerhardt, J.A.2    Chan, A.T.3
  • 33
    • 0034614104 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I insulin-like growth factor-binding proteins and prostate cancer risk: A prospective study
    • Stattin P, Bylund A, Rinaldi S et al. Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study. J. Natl Cancer Inst. 92(23), 1910-1917 (2000).
    • (2000) J. Natl Cancer Inst. , vol.92 , Issue.23 , pp. 1910-1917
    • Stattin, P.1    Bylund, A.2    Rinaldi, S.3
  • 35
    • 39149139330 scopus 로고    scopus 로고
    • Acromegaly: Re-thinking the cancer risk
    • Loeper S, Ezzat S. Acromegaly: re-thinking the cancer risk. Rev. Endocr. Metab. Disord. 9(1), 41-58 (2008).
    • (2008) Rev. Endocr. Metab. Disord. , vol.9 , Issue.1 , pp. 41-58
    • Loeper, S.1    Ezzat, S.2
  • 36
    • 35348992128 scopus 로고    scopus 로고
    • The association of fasting insulin concentrations and colonic neoplasms in acromegaly: A colonoscopy-based study in 210 patients
    • Colao A, Pivonello R, Auriemma RS et al. The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. J. Clin. Endocrinol. Metab. 92(10), 3854-3860 (2007).
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , Issue.10 , pp. 3854-3860
    • Colao, A.1    Pivonello, R.2    Auriemma, R.S.3
  • 37
    • 33847198926 scopus 로고    scopus 로고
    • Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report
    • Shevah O, Laron Z. Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. Growth Horm. IGF Res. 17(1), 54-57 (2007).
    • (2007) Growth Horm. IGF Res , vol.17 , Issue.1 , pp. 54-57
    • Shevah, O.1    Laron, Z.2
  • 38
    • 77951698107 scopus 로고    scopus 로고
    • Growth and development: How safe is growth hormone therapy for children
    • Chernausek SD. Growth and development: how safe is growth hormone therapy for children? Nat. Rev. Endocrinol. 6(5), 251-253 (2010).
    • (2010) Nat. Rev. Endocrinol. , vol.6 , Issue.5 , pp. 251-253
    • Chernausek, S.D.1
  • 40
    • 33748756346 scopus 로고    scopus 로고
    • Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor
    • Ergun-Longmire B, Mertens AC, Mitby P et al. Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor. J. Clin. Endocrinol. Metab. 91(9), 3494-3498 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , Issue.9 , pp. 3494-3498
    • Ergun-Longmire, B.1    Mertens, A.C.2    Mitby, P.3
  • 41
    • 0038074997 scopus 로고
    • Hypophysectomy in the treatment of malignant tumors
    • Luft R, Olivecrona H. Hypophysectomy in the treatment of malignant tumors. Cancer 10(4), 789-794 (1957).
    • (1957) Cancer , vol.10 , Issue.4 , pp. 789-794
    • Luft, R.1    Olivecrona, H.2
  • 42
    • 0000288871 scopus 로고
    • Neoplasms in rats treated with pituitary growth hormone; Pulmonary and lymphatic tissues
    • Moon HD, Simpson ME, Li CH, Evans HM. Neoplasms in rats treated with pituitary growth hormone; pulmonary and lymphatic tissues. Cancer Res. 10(5), 297-308 (1950).
    • (1950) Cancer Res. , vol.10 , Issue.5 , pp. 297-308
    • Moon, H.D.1    Simpson, M.E.2    Li, C.H.3    Evans, H.M.4
  • 43
    • 0026767794 scopus 로고
    • High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice
    • Tornell J, Carlsson B, Pohjanen P, Wennbo H, Rymo L, Isaksson O. High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice. J. Steroid Biochem. Mol. Biol. 43(1-3), 237-242 (1992).
    • (1992) J. Steroid Biochem. Mol. Biol. , vol.43 , Issue.1-3 , pp. 237-242
    • Tornell, J.1    Carlsson, B.2    Pohjanen, P.3    Wennbo, H.4    Rymo, L.5    Isaksson, O.6
  • 44
    • 0028880017 scopus 로고
    • Mammary cancer in transgenic mice expressing insulin-like growth factor II IGF-II
    • Bates P, Fisher R, Ward A, Richardson L, Hill DJ, Graham CF. Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). Br. J. Cancer 72(5), 1189-1193 (1995).
    • (1995) Br. J. Cancer , vol.72 , Issue.5 , pp. 1189-1193
    • Bates, P.1    Fisher, R.2    Ward, A.3    Richardson, L.4    Hill, D.J.5    Graham, C.F.6
  • 45
    • 0035030274 scopus 로고    scopus 로고
    • Overexpressed growth hormone GH synergistically promotes carcinogeninitiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice
    • Snibson KJ, Bhathal PS, Adams TE. Overexpressed growth hormone (GH) synergistically promotes carcinogeninitiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice. Liver 21(2), 149-158 (2001).
    • (2001) Liver , vol.21 , Issue.2 , pp. 149-158
    • Snibson, K.J.1    Bhathal, P.S.2    Adams, T.E.3
  • 46
    • 51349161232 scopus 로고    scopus 로고
    • Transgenic mice overexpressing GH exhibit hepatic upregulation of GHsignaling mediators involved in cell proliferation
    • Miquet JG, Gonzalez L, Matos MN et al. Transgenic mice overexpressing GH exhibit hepatic upregulation of GHsignaling mediators involved in cell proliferation. J. Endocrinol. 198(2), 317-330 (2008).
    • (2008) J. Endocrinol. , vol.198 , Issue.2 , pp. 317-330
    • Miquet, J.G.1    Gonzalez, L.2    Matos, M.N.3
  • 47
    • 0034677588 scopus 로고    scopus 로고
    • Cooperative interaction between mutant p53 and des1-3 IGF-I accelerates mammary tumorigenesis
    • Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM. Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis. Oncogene 19(7), 889-898 (2000).
    • (2000) Oncogene , vol.19 , Issue.7 , pp. 889-898
    • Hadsell, D.L.1    Murphy, K.L.2    Bonnette, S.G.3    Reece, N.4    Laucirica, R.5    Rosen, J.M.6
  • 48
    • 20944440088 scopus 로고    scopus 로고
    • Tumor development by transgenic expression of a constitutively active insulinlike growth factor I receptor
    • Carboni JM, Lee AV, Hadsell DL et al. Tumor development by transgenic expression of a constitutively active insulinlike growth factor I receptor. Cancer Res. 65(9), 3781-3787 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.9 , pp. 3781-3787
    • Carboni, J.M.1    Lee, A.V.2    Hadsell, D.L.3
  • 49
    • 33748320920 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo
    • Michaylira CZ, Simmons JG, Ramocki NM et al. Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo. Am. J. Physiol. Gastrointest. Liver Physiol. 291(3), G472-G481 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.291 , Issue.3
    • Michaylira, C.Z.1    Simmons, J.G.2    Ramocki, N.M.3
  • 50
    • 65549149453 scopus 로고    scopus 로고
    • Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor binding protein knockout mice
    • Ikeno Y, Hubbard GB, Lee S et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J. Gerontol. A Biol. Sci. Med. Sci. 64(5), 522-529 (2009).
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , Issue.5 , pp. 522-529
    • Ikeno, Y.1    Hubbard, G.B.2    Lee, S.3
  • 51
    • 33845609734 scopus 로고    scopus 로고
    • Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling
    • Zhang X, Mehta RG, Lantvit DD et al. Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis 28(1), 143-150 (2007).
    • (2007) Carcinogenesis , vol.28 , Issue.1 , pp. 143-150
    • Zhang, X.1    Mehta, R.G.2    Lantvit, D.D.3
  • 52
    • 0029976435 scopus 로고    scopus 로고
    • Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation
    • Yang XF, Beamer WG, Huynh H, Pollak M. Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation. Cancer Res. 56(7), 1509-1511 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.7 , pp. 1509-1511
    • Yang, X.F.1    Beamer, W.G.2    Huynh, H.3    Pollak, M.4
  • 53
    • 8644285461 scopus 로고    scopus 로고
    • Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments
    • Thordarson G, Semaan S, Low C et al. Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments. Breast Cancer Res. Treat. 87(3), 277-290 (2004).
    • (2004) Breast Cancer Res. Treat. , vol.87 , Issue.3 , pp. 277-290
    • Thordarson, G.1    Semaan, S.2    Low, C.3
  • 54
    • 34748861427 scopus 로고    scopus 로고
    • Advanced rat mammary cancers are growth hormone dependent
    • Shen Q, Lantvit DD, Lin Q et al. Advanced rat mammary cancers are growth hormone dependent. Endocrinology 148(10), 4536-4544 (2007).
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4536-4544
    • Shen, Q.1    Lantvit, D.D.2    Lin, Q.3
  • 55
    • 27844525887 scopus 로고    scopus 로고
    • Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C31 T antigen mouse
    • Wang Z, Prins GS, Coschigano KT et al. Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. Endocrinology 146(12), 5188-5196 (2005).
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5188-5196
    • Wang, Z.1    Prins, G.S.2    Coschigano, K.T.3
  • 56
    • 0035800512 scopus 로고    scopus 로고
    • Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist
    • Pollak M, Blouin MJ, Zhang JC, Kopchick JJ. Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist. Br. J. Cancer 85(3), 428-430 (2001).
    • (2001) Br. J. Cancer , vol.85 , Issue.3 , pp. 428-430
    • Pollak, M.1    Blouin, M.J.2    Zhang, J.C.3    Kopchick, J.J.4
  • 57
    • 33746906218 scopus 로고    scopus 로고
    • The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth
    • Divisova J, Kuiatse I, Lazard Z et al. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res. Treat. 98(3), 315-327 (2006).
    • (2006) Breast Cancer Res. Treat. , vol.98 , Issue.3 , pp. 315-327
    • Divisova, J.1    Kuiatse, I.2    Lazard, Z.3
  • 58
    • 0034866455 scopus 로고    scopus 로고
    • Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice
    • McCutcheon IE, Flyvbjerg A, Hill H et al. Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. J. Neurosurg. 94(3), 487-492 (2001).
    • (2001) J. Neurosurg. , vol.94 , Issue.3 , pp. 487-492
    • McCutcheon, I.E.1    Flyvbjerg, A.2    Hill, H.3
  • 59
    • 14944365026 scopus 로고    scopus 로고
    • Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice
    • Dagnaes-Hansen F, Duan H, Rasmussen LM, Friend KE, Flyvbjerg A. Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. Anticancer Res. 24(6), 3735-3742 (2004).
    • (2004) Anticancer Res. , vol.24 , Issue.6 , pp. 3735-3742
    • Dagnaes-Hansen, F.1    Duan, H.2    Rasmussen, L.M.3    Friend, K.E.4    Flyvbjerg, A.5
  • 60
    • 51349155158 scopus 로고    scopus 로고
    • Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo
    • de Ostrovich KK, Lambertz I, Colby JK et al. Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo. Am. J. Pathol. 173(3), 824-834 (2008).
    • (2008) Am. J. Pathol. , vol.173 , Issue.3 , pp. 824-834
    • De Ostrovich, K.K.1    Lambertz, I.2    Colby, J.K.3
  • 61
    • 73349105273 scopus 로고    scopus 로고
    • Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice
    • Olivo-Marston SE, Hursting SD, Lavigne J et al. Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice. Mol. Carcinog. 48(12), 1071-1076 (2009).
    • (2009) Mol. Carcinog. , vol.48 , Issue.12 , pp. 1071-1076
    • Olivo-Marston, S.E.1    Hursting, S.D.2    Lavigne, J.3
  • 62
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res. 62(4), 1030-1035 (2002).
    • (2002) Cancer Res. , vol.62 , Issue.4 , pp. 1030-1035
    • Wu, Y.1    Yakar, S.2    Zhao, L.3    Hennighausen, L.4    LeRoith, D.5
  • 63
    • 0042090507 scopus 로고    scopus 로고
    • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
    • Wu Y, Cui K, Miyoshi K et al. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res. 63(15), 4384-4388 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.15 , pp. 4384-4388
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3
  • 64
    • 0001197164 scopus 로고    scopus 로고
    • The growth hormone receptor
    • Kostyo JL, Goodman HM (Eds) Oxford University Press, NY, USA
    • Waters MJ. The growth hormone receptor. In: The Handbook of Physiology. Kostyo JL, Goodman HM (Eds). Oxford University Press, NY, USA, 397-444 (1999).
    • (1999) The Handbook of Physiology , pp. 397-444
    • Waters, M.J.1
  • 66
    • 8544277301 scopus 로고    scopus 로고
    • Growth hormone receptor messenger ribonucleic acid in normal and pathologic human adrenocortical tissues - an analysis by quantitative polymerase chain reaction technique
    • Lin CJ, Mendonca BB, Lucon AM, Guazzelli IC, Nicolau W, Villares SM. Growth hormone receptor messenger ribonucleic acid in normal and pathologic human adrenocortical tissues - an analysis by quantitative polymerase chain reaction technique. J. Clin. Endocrinol. Metab. 82(8), 2671-2676 (1997).
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , Issue.8 , pp. 2671-2676
    • Lin, C.J.1    Mendonca, B.B.2    Lucon, A.M.3    Guazzelli, I.C.4    Nicolau, W.5    Villares, S.M.6
  • 67
    • 36048979340 scopus 로고    scopus 로고
    • Growth hormone receptor expression is up-regulated during tumorigenesis of human colorectal cancer
    • Wu X, Liu F, Yao X, Li W, Chen C. Growth hormone receptor expression is up-regulated during tumorigenesis of human colorectal cancer. J. Surg. Res. 143(2), 294-299 (2007).
    • (2007) J. Surg. Res. , vol.143 , Issue.2 , pp. 294-299
    • Wu, X.1    Liu, F.2    Yao, X.3    Li, W.4    Chen, C.5
  • 68
    • 0028966148 scopus 로고
    • Control of growth hormone GH binding protein release from human hepatoma cells expressing full-length GH receptor
    • Harrison SM, Barnard R, Ho KY, Rajkovic I, Waters MJ. Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor. Endocrinology 136(2), 651-659 (1995).
    • (1995) Endocrinology , vol.136 , Issue.2 , pp. 651-659
    • Harrison, S.M.1    Barnard, R.2    Ho, K.Y.3    Rajkovic, I.4    Waters, M.J.5
  • 69
    • 33947722604 scopus 로고    scopus 로고
    • Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer
    • Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I et al. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Eur. J. Endocrinol. 156(2), 187-194 (2007).
    • (2007) Eur. J. Endocrinol. , vol.156 , Issue.2 , pp. 187-194
    • Pazaitou-Panayiotou, K.1    Kelesidis, T.2    Kelesidis, I.3
  • 71
    • 2942596479 scopus 로고    scopus 로고
    • Growth hormone GH receptors in prostate cancer: Gene expression in human tissues and cell lines and characterization GH signaling and androgen receptor regulation in LNCaP cells
    • Weiss-Messer E, Merom O, Adi A et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells. Mol. Cell Endocrinol. 220(1-2), 109-123 (2004).
    • (2004) Mol. Cell Endocrinol. , vol.220 , Issue.1-2 , pp. 109-123
    • Weiss-Messer, E.1    Merom, O.2    Adi, A.3
  • 75
    • 18744404217 scopus 로고    scopus 로고
    • High stromal and epithelial human GH gene expression is associated with proliferative disorders of the mammary gland
    • Raccurt M, Lobie PE, Moudilou E et al. High stromal and epithelial human GH gene expression is associated with proliferative disorders of the mammary gland. J. Endocrinol. 175(2), 307-318 (2002).
    • (2002) J. Endocrinol. , vol.175 , Issue.2 , pp. 307-318
    • Raccurt, M.1    Lobie, P.E.2    Moudilou, E.3
  • 76
    • 77949425111 scopus 로고    scopus 로고
    • Integrated gene networks in breast cancer development
    • Ratkaj I, Stajduhar E, Vucinic S et al. Integrated gene networks in breast cancer development. Funct. Integr. Genomics 10(1), 11-19 (2010).
    • (2010) Funct. Integr. Genomics , vol.10 , Issue.1 , pp. 11-19
    • Ratkaj, I.1    Stajduhar, E.2    Vucinic, S.3
  • 77
    • 0037195533 scopus 로고    scopus 로고
    • Morphogenic and tumorigenic potentials of the mammary growth hormone growth hormone receptor system
    • van Garderen E, Schalken JA. Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system. Mol. Cell Endocrinol. 197(1-2), 153-165 (2002).
    • (2002) Mol. Cell Endocrinol. , vol.197 , Issue.1-2 , pp. 153-165
    • Van Garderen, E.1    Schalken, J.A.2
  • 80
    • 0033763467 scopus 로고    scopus 로고
    • Effect of two years of growth hormone and insulinlike growth factor-I suppression on prostate diseases in acromegalic patients
    • Colao A, Marzullo P, Spiezia S et al. Effect of two years of growth hormone and insulinlike growth factor-I suppression on prostate diseases in acromegalic patients. J. Clin. Endocrinol. Metab. 85(10), 3754-3761 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , Issue.10 , pp. 3754-3761
    • Colao, A.1    Marzullo, P.2    Spiezia, S.3
  • 81
  • 82
    • 58149332682 scopus 로고    scopus 로고
    • Effects of high-dose IFNa2b on regional lymph node metastases of human melanoma: Modulation of STAT5 FOXP3 and IL-17
    • Wang W, Edington HD, Rao UN et al. Effects of high-dose IFNa2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clin. Cancer Res. 14(24), 8314-8320 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8314-8320
    • Wang, W.1    Edington, H.D.2    Rao, U.N.3
  • 83
    • 0033306843 scopus 로고    scopus 로고
    • Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development
    • Ruan W, Powell-Braxton L, Kopchick JJ, Kleinberg DL. Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 140(5), 1984-1989 (1999).
    • (1999) Endocrinology , vol.140 , Issue.5 , pp. 1984-1989
    • Ruan, W.1    Powell-Braxton, L.2    Kopchick, J.J.3    Kleinberg, D.L.4
  • 84
    • 0025615418 scopus 로고
    • Zinc mediation of the binding of human growth hormone to the human prolactin receptor
    • Cunningham BC, Bass S, Fuh G, Wells JA. Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science 250(4988), 1709-1712 (1990).
    • (1990) Science , vol.250 , Issue.4988 , pp. 1709-1712
    • Cunningham, B.C.1    Bass, S.2    Fuh, G.3    Wells, J.A.4
  • 85
    • 11244313444 scopus 로고    scopus 로고
    • Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone
    • Zhu T, Starling-Emerald B, Zhang X et al. Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res. 65(1), 317-324 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.1 , pp. 317-324
    • Zhu, T.1    Starling-Emerald, B.2    Zhang, X.3
  • 86
    • 21244457302 scopus 로고    scopus 로고
    • Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma
    • Xu XQ, Emerald BS, Goh EL et al. Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J. Biol. Chem. 280(25), 23987-24003 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.25 , pp. 23987-24003
    • Xu, X.Q.1    Emerald, B.S.2    Goh, E.L.3
  • 88
    • 62749110757 scopus 로고    scopus 로고
    • Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma
    • Brunet-Dunand SE, Vouyovitch C, Araneda S et al. Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. Endocrinology 150(3), 1341-1352 (2009).
    • (2009) Endocrinology , vol.150 , Issue.3 , pp. 1341-1352
    • Brunet-Dunand, S.E.1    Vouyovitch, C.2    Araneda, S.3
  • 89
    • 0035108846 scopus 로고    scopus 로고
    • The effects of autocrine human growth hormone hGH on human mammary carcinoma cell behavior are mediated via the hGH receptor
    • Kaulsay KK, Zhu T, Bennett W, Lee KO, Lobie PE. The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor. Endocrinology 142(2), 767-777 (2001).
    • (2001) Endocrinology , vol.142 , Issue.2 , pp. 767-777
    • Kaulsay, K.K.1    Zhu, T.2    Bennett, W.3    Lee, K.O.4    Lobie, P.E.5
  • 90
    • 35648942709 scopus 로고    scopus 로고
    • Autocrine growth hormone: Effects on growth hormone receptor trafficking and signaling
    • van den Eijnden MJ, Strous GJ. Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling. Mol. Endocrinol. 21(11), 2832-2846 (2007).
    • (2007) Mol. Endocrinol. , vol.21 , Issue.11 , pp. 2832-2846
    • Van Den Eijnden, M.J.1    Strous, G.J.2
  • 91
    • 34548087567 scopus 로고    scopus 로고
    • Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis
    • USA
    • Conway-Campbell BL, Wooh JW, Brooks AJ et al. Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proc. Natl Acad. Sci. USA 104(33), 13331-13336 (2007).
    • (2007) Proc. Natl Acad. Sci. , vol.104 , Issue.33 , pp. 13331-13336
    • Conway-Campbell, B.L.1    Wooh, J.W.2    Brooks, A.J.3
  • 92
    • 18344401383 scopus 로고    scopus 로고
    • Cellular expression of growth hormone and prolactin receptors in human breast disorders
    • Mertani HC, Garcia-Caballero T, Lambert A et al. Cellular expression of growth hormone and prolactin receptors in human breast disorders. Int. J. Cancer 79(2), 202-211 (1998).
    • (1998) Int. J. Cancer , vol.79 , Issue.2 , pp. 202-211
    • Mertani, H.C.1    Garcia-Caballero, T.2    Lambert, A.3
  • 93
    • 0034025706 scopus 로고    scopus 로고
    • Growth hormone and colorectal carcinoma: Localization of receptors
    • Lincoln DT, Kaiser HE, Raju GP, Waters MJ. Growth hormone and colorectal carcinoma: localization of receptors. In Vivo 14(1), 41-49 (2000).
    • (2000) Vivo , vol.14 , Issue.1 , pp. 41-49
    • Lincoln, D.T.1    Kaiser, H.E.2    Raju, G.P.3    Waters, M.J.4
  • 94
    • 0033948174 scopus 로고    scopus 로고
    • Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas
    • Garcia-Caballero T, Mertani HM, Lambert A et al. Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas. Endocrine 12(3), 265-271 (2000).
    • (2000) Endocrine , vol.12 , Issue.3 , pp. 265-271
    • Garcia-Caballero, T.1    Mertani, H.M.2    Lambert, A.3
  • 95
    • 54149085728 scopus 로고    scopus 로고
    • Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old
    • Dehari R, Nakamura Y, Okamoto N, Nakayama H. Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old. Tohoku J. Exp. Med. 216(2), 165-172 (2008).
    • (2008) Tohoku J. Exp. Med. , vol.216 , Issue.2 , pp. 165-172
    • Dehari, R.1    Nakamura, Y.2    Okamoto, N.3    Nakayama, H.4
  • 96
    • 31444440292 scopus 로고    scopus 로고
    • Nuclear EGFR signalling network in cancers: Linking EGFR pathway to cell cycle progression nitric oxide pathway and patient survival
    • Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br. J. Cancer 94(2), 184-188 (2006).
    • (2006) Br. J. Cancer , vol.94 , Issue.2 , pp. 184-188
    • Lo, H.W.1    Hung, M.C.2
  • 97
    • 50649086109 scopus 로고    scopus 로고
    • The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation
    • Conway-Campbell BL, Brooks AJ, Robinson PJ, Perani M, Waters MJ. The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation. Mol. Endocrinol. 22(9), 2190-2202 (2008).
    • (2008) Mol. Endocrinol. , vol.22 , Issue.9 , pp. 2190-2202
    • Conway-Campbell, B.L.1    Brooks, A.J.2    Robinson, P.J.3    Perani, M.4    Waters, M.J.5
  • 98
    • 33846946819 scopus 로고    scopus 로고
    • Gene amplification and associated loss of 5r̀egulatory sequences of CoAA in human cancers
    • Sui Y, Yang Z, Xiong S et al. Gene amplification and associated loss of 5r̀egulatory sequences of CoAA in human cancers. Oncogene 26(6), 822-835 (2007).
    • (2007) Oncogene , vol.26 , Issue.6 , pp. 822-835
    • Sui, Y.1    Yang, Z.2    Xiong, S.3
  • 99
    • 70349229261 scopus 로고    scopus 로고
    • Co-activator activator CoAA prevents the transcriptional activity of Runt domain transcription factors
    • Li X, Hoeppner LH, Jensen ED, Gopalakrishnan R, Westendorf JJ. Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors. J. Cell. Biochem. 108(2), 378-387 (2009).
    • (2009) J. Cell. Biochem. , vol.108 , Issue.2 , pp. 378-387
    • Li, X.1    Hoeppner, L.H.2    Jensen, E.D.3    Gopalakrishnan, R.4    Westendorf, J.J.5
  • 100
    • 0347624592 scopus 로고    scopus 로고
    • CoAA a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing
    • Auboeuf D, Dowhan DH, Li X et al. CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing. Mol. Cell Biol. 24(1), 442-453 (2004).
    • (2004) Mol. Cell Biol. , vol.24 , Issue.1 , pp. 442-453
    • Auboeuf, D.1    Dowhan, D.H.2    Li, X.3
  • 101
    • 42049116315 scopus 로고    scopus 로고
    • Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells
    • Carver KC, Schuler LA. Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells. Mol. Cancer Res. 6(4), 634-643 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , Issue.4 , pp. 634-643
    • Carver, K.C.1    Schuler, L.A.2
  • 102
    • 67349104572 scopus 로고    scopus 로고
    • Complex prolactin crosstalk in breast cancer: New therapeutic implications
    • Carver KC, Arendt LM, Schuler LA. Complex prolactin crosstalk in breast cancer: new therapeutic implications. Mol. Cell Endocrinol. 307(1-2), 1-7 (2009).
    • (2009) Mol. Cell Endocrinol. , vol.307 , Issue.1-2 , pp. 1-7
    • Carver, K.C.1    Arendt, L.M.2    Schuler, L.A.3
  • 103
    • 0025836230 scopus 로고
    • Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice
    • Tornell J, Rymo L, Isaksson OG. Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice. Int. J. Cancer 49(1), 114-117 (1991).
    • (1991) Int. J. Cancer , vol.49 , Issue.1 , pp. 114-117
    • Tornell, J.1    Rymo, L.2    Isaksson, O.G.3
  • 104
    • 0031454715 scopus 로고    scopus 로고
    • Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice
    • Wennbo H, Gebre-Medhin M, Gritli-Linde A, Ohlsson C, Isaksson OG, Tornell J. Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice. J. Clin. Invest. 100(11), 2744-2751 (1997).
    • (1997) J. Clin. Invest. , vol.100 , Issue.11 , pp. 2744-2751
    • Wennbo, H.1    Gebre-Medhin, M.2    Gritli-Linde, A.3    Ohlsson, C.4    Isaksson, O.G.5    Tornell, J.6
  • 105
    • 4444255613 scopus 로고    scopus 로고
    • Role of prolactin/prolactin receptor signaling in human breast cancer
    • Clevenger CV. Role of prolactin/prolactin receptor signaling in human breast cancer. Breast Dis. 18, 75-86 (2003).
    • (2003) Breast Dis. , vol.18 , pp. 75-86
    • Clevenger, C.V.1
  • 106
    • 34347271908 scopus 로고    scopus 로고
    • Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription- 5a/b signaling pathway
    • Dagvadorj A, Collins S, Jomain JB et al. Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription- 5a/b signaling pathway. Endocrinology 148(7), 3089-3101 (2007).
    • (2007) Endocrinology , vol.148 , Issue.7 , pp. 3089-3101
    • Dagvadorj, A.1    Collins, S.2    Jomain, J.B.3
  • 107
    • 77957003255 scopus 로고    scopus 로고
    • Local prolactin is a target to prevent expansion of basal stem cells in prostate tumors
    • USA
    • Rouet V, Bogorad RL, Kayser C et al. Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc. Natl Acad. Sci. USA 107(34), 15199-15204 (2010).
    • (2010) Proc. Natl Acad. Sci. , vol.107 , Issue.34 , pp. 15199-15204
    • Rouet, V.1    Bogorad, R.L.2    Kayser, C.3
  • 108
    • 77954244966 scopus 로고    scopus 로고
    • Clinicopathological significance of prolactin receptor expression in colorectal carcinoma and corresponding metastases
    • Harbaum L, Pollheimer MJ, Bauernhofer T et al. Clinicopathological significance of prolactin receptor expression in colorectal carcinoma and corresponding metastases. Mod. Pathol. 23(7), 961-971 (2010).
    • (2010) Mod. Pathol. , vol.23 , Issue.7 , pp. 961-971
    • Harbaum, L.1    Pollheimer, M.J.2    Bauernhofer, T.3
  • 109
    • 42449141532 scopus 로고    scopus 로고
    • Transcriptional activation of signal transducer and activator of transcription STAT 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell
    • Mohankumar KM, Perry JK, Kannan N et al. Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology 149(5), 2219-2229 (2008).
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2219-2229
    • Mohankumar, K.M.1    Perry, J.K.2    Kannan, N.3
  • 110
    • 73649093445 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription STAT-5A and STAT5B differentially regulate human mammary carcinoma cell behavior
    • Tang JZ, Zuo ZH, Kong XJ et al. Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior. Endocrinology 151(1), 43-55 (2010).
    • (2010) Endocrinology , vol.151 , Issue.1 , pp. 43-55
    • Tang, J.Z.1    Zuo, Z.H.2    Kong, X.J.3
  • 111
    • 77956020768 scopus 로고    scopus 로고
    • STAT3a is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone
    • Tang JZ, Kong XJ, Banerjee A et al. STAT3a is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone. Endocrinology 151(9), 4133-4145 (2010).
    • (2010) Endocrinology , vol.151 , Issue.9 , pp. 4133-4145
    • Tang, J.Z.1    Kong, X.J.2    Banerjee, A.3
  • 112
    • 33845355846 scopus 로고    scopus 로고
    • JAK-2 mutations and their relevance to myeloproliferative disease
    • Levine RL, Gilliland DG. JAK-2 mutations and their relevance to myeloproliferative disease. Curr. Opin Hematol. 14(1), 43-47 (2007).
    • (2007) Curr. Opin Hematol. , vol.14 , Issue.1 , pp. 43-47
    • Levine, R.L.1    Gilliland, D.G.2
  • 113
    • 39649099388 scopus 로고    scopus 로고
    • A role for JAK2 mutations in myeloproliferative diseases
    • Morgan KJ, Gilliland DG. A role for JAK2 mutations in myeloproliferative diseases. Annu. Rev. Med. 59, 213-222 (2008).
    • (2008) Annu. Rev. Med. , vol.59 , pp. 213-222
    • Morgan, K.J.1    Gilliland, D.G.2
  • 114
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278(5341), 1309-1312 (1997).
    • (1997) Science , vol.278 , Issue.5341 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3
  • 115
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription STAT proteins in hematopoietic cell lines transformed by Bcr Abl
    • Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 183(3), 811-820 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.3 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 116
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 3(7), e270 (2006).
    • (2006) PLoS Med. , vol.3 , Issue.7
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 117
    • 77949331464 scopus 로고    scopus 로고
    • STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant
    • Funakoshi-Tago M, Tago K, Abe M, Sonoda Y, Kasahara T. STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant. J. Biol. Chem. 285(8), 5296-5307 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.8 , pp. 5296-5307
    • Funakoshi-Tago, M.1    Tago, K.2    Abe, M.3    Sonoda, Y.4    Kasahara, T.5
  • 118
    • 77953667590 scopus 로고    scopus 로고
    • STAT5 is indispensable for the maintenance of Bcr/Abl-positive leukaemia
    • Hoelbl A, Schuster C, Kovacic B et al. STAT5 is indispensable for the maintenance of Bcr/Abl-positive leukaemia. EMBO Mol. Med. 2(3), 98-110 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , Issue.3 , pp. 98-110
    • Hoelbl, A.1    Schuster, C.2    Kovacic, B.3
  • 119
    • 0033639119 scopus 로고    scopus 로고
    • STAT5 is essential for the myelo- and lymphoproliferative disease induced by TEL JAK2
    • Schwaller J, Parganas E, Wang D et al. STAT5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol. Cell 6(3), 693-704 (2000).
    • (2000) Mol. Cell. , vol.6 , Issue.3 , pp. 693-704
    • Schwaller, J.1    Parganas, E.2    Wang, D.3
  • 120
    • 77953578552 scopus 로고    scopus 로고
    • STAT5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo
    • Gu L, Vogiatzi P, Puhr M et al. STAT5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. Endocr. Relat. Cancer 17(2), 481-493 (2010).
    • (2010) Endocr. Relat. Cancer , vol.17 , Issue.2 , pp. 481-493
    • Gu, L.1    Vogiatzi, P.2    Puhr, M.3
  • 121
    • 33748802513 scopus 로고    scopus 로고
    • STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through Srs and Jak1 kinases
    • Mirmohammadsadegh A, Hassan M, Bardenheuer W et al. STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through Srs and Jak1 kinases. J. Invest. Dermatol. 126(10), 2272-2280 (2006).
    • (2006) J. Invest. Dermatol. , vol.126 , Issue.10 , pp. 2272-2280
    • Mirmohammadsadegh, A.1    Hassan, M.2    Bardenheuer, W.3
  • 123
    • 33750559636 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition
    • Lee TK, Man K, Poon RT et al. Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. Cancer Res. 66(20), 9948-9956 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.20 , pp. 9948-9956
    • Lee, T.K.1    Man, K.2    Poon, R.T.3
  • 124
    • 40449135440 scopus 로고    scopus 로고
    • Jak2 STAT5 signaling in mammogenesis breast cancer initiation and progression
    • Wagner KU, Rui H. Jak2/STAT5 signaling in mammogenesis, breast cancer initiation and progression. J. Mammary Gland Biol. Neoplasia. 13(1), 93-103 (2008).
    • (2008) J. Mammary Gland Biol. Neoplasia. , vol.13 , Issue.1 , pp. 93-103
    • Wagner, K.U.1    Rui, H.2
  • 125
    • 59449109107 scopus 로고    scopus 로고
    • Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth epithelial-mesenchymal transition and resistance to epidermal growth factor receptor targeting
    • Koppikar P, Lui VW, Man D et al. Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting. Clin. Cancer Res. 14(23), 7682-7690 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.23 , pp. 7682-7690
    • Koppikar, P.1    Lui, V.W.2    Man, D.3
  • 126
    • 41549149451 scopus 로고    scopus 로고
    • Cellular senescence in vivo: A barrier to tumorigenesis
    • Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr. Opin Cell Biol. 20(2), 150-155 (2008).
    • (2008) Curr. Opin Cell Biol. , vol.20 , Issue.2 , pp. 150-155
    • Prieur, A.1    Peeper, D.S.2
  • 127
    • 36849015753 scopus 로고    scopus 로고
    • Myc down-regulation as a mechanism to activate the Rb pathway in STAT5a-induced senescence
    • Mallette FA, Gaumont-Leclerc MF, Huot G, Ferbeyre G. Myc down-regulation as a mechanism to activate the Rb pathway in STAT5a-induced senescence. J. Biol. Chem. 282(48), 34938-34944 (2007).
    • (2007) J. Biol. Chem. , vol.282 , Issue.48 , pp. 34938-34944
    • Mallette, F.A.1    Gaumont-Leclerc, M.F.2    Huot, G.3    Ferbeyre, G.4
  • 129
    • 72049113079 scopus 로고    scopus 로고
    • A mutated EGFR is sufficient to induce malignant melanoma with genetic backgrounddependent histopathologies
    • Schartl M, Wilde B, Laisney JA, Taniguchi Y, Takeda S, Meierjohann S. A mutated EGFR is sufficient to induce malignant melanoma with genetic backgrounddependent histopathologies. J. Invest. Dermatol. 130(1), 249-258 (2010).
    • (2010) J. Invest. Dermatol. , vol.130 , Issue.1 , pp. 249-258
    • Schartl, M.1    Wilde, B.2    Laisney, J.A.3    Taniguchi, Y.4    Takeda, S.5    Meierjohann, S.6
  • 130
    • 33947249150 scopus 로고    scopus 로고
    • Roscovitine inhibits differentiation and invasion in a threedimensional skin reconstruction model of metastatic melanoma
    • Mohapatra S, Coppola D, Riker AI, Pledger WJ. Roscovitine inhibits differentiation and invasion in a threedimensional skin reconstruction model of metastatic melanoma. Mol. Cancer Res. 5(2), 145-151 (2007).
    • (2007) Mol. Cancer Res. , vol.5 , Issue.2 , pp. 145-151
    • Mohapatra, S.1    Coppola, D.2    Riker, A.I.3    Pledger, W.J.4
  • 131
    • 0242708738 scopus 로고    scopus 로고
    • Small-molecule cyclin-dependent kinase modulators
    • Senderowicz AM. Small-molecule cyclin-dependent kinase modulators. Oncogene 22(42), 6609-6620 (2003).
    • (2003) Oncogene , vol.22 , Issue.42 , pp. 6609-6620
    • Senderowicz, A.M.1
  • 132
    • 0347626096 scopus 로고    scopus 로고
    • Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2
    • Mohapatra S, Chu B, Wei S et al. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 63(23), 8523-8530 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.23 , pp. 8523-8530
    • Mohapatra, S.1    Chu, B.2    Wei, S.3
  • 133
    • 0038711502 scopus 로고    scopus 로고
    • Inhibition of transcription factor STAT5 induces cell death of human prostate cancer cells
    • Ahonen TJ, Xie J, LeBaron MJ et al. Inhibition of transcription factor STAT5 induces cell death of human prostate cancer cells. J. Biol. Chem. 278(29), 27287-27292 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.29 , pp. 27287-27292
    • Ahonen, T.J.1    Xie, J.2    LeBaron, M.J.3
  • 134
    • 40949103423 scopus 로고    scopus 로고
    • Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo
    • Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. Clin. Cancer Res. 14(5), 1317-1324 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.5 , pp. 1317-1324
    • Dagvadorj, A.1    Kirken, R.A.2    Leiby, B.3    Karras, J.4    Nevalainen, M.T.5
  • 135
    • 0347951248 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: Evidence from the transgenic adenocarcinoma of the mouse prostate system
    • Kazansky AV, Spencer DM, Greenberg NM. Activation of signal transducer and activator of transcription 5 is required for progression of autochthonous prostate cancer: evidence from the transgenic adenocarcinoma of the mouse prostate system. Cancer Res. 63(24), 8757-8762 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.24 , pp. 8757-8762
    • Kazansky, A.V.1    Spencer, D.M.2    Greenberg, N.M.3
  • 136
    • 36148966700 scopus 로고    scopus 로고
    • Mammary stem cell number as a determinate of breast cancer risk
    • Ginestier C, Wicha MS. Mammary stem cell number as a determinate of breast cancer risk. Breast Cancer Res. 9(4), 109 (2007).
    • (2007) Breast Cancer Res. , vol.9 , Issue.4 , pp. 109
    • Ginestier, C.1    Wicha, M.S.2
  • 137
    • 39149111601 scopus 로고    scopus 로고
    • Transcription factor STAT5 synergizes with androgen receptor in prostate cancer cells
    • Tan SH, Dagvadorj A, Shen F et al. Transcription factor STAT5 synergizes with androgen receptor in prostate cancer cells. Cancer Res. 68(1), 236-248 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.1 , pp. 236-248
    • Tan, S.H.1    Dagvadorj, A.2    Shen, F.3
  • 138
    • 0037457078 scopus 로고    scopus 로고
    • Naturally occurring dominant-negative STAT5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells
    • Yamashita H, Iwase H, Toyama T, Fujii Y. Naturally occurring dominant-negative STAT5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. Oncogene 22(11), 1638-1652 (2003).
    • (2003) Oncogene , vol.22 , Issue.11 , pp. 1638-1652
    • Yamashita, H.1    Iwase, H.2    Toyama, T.3    Fujii, Y.4
  • 139
    • 0345700700 scopus 로고    scopus 로고
    • Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation enhances differentiation and delays postlactational apoptosis
    • Iavnilovitch E, Groner B, Barash I. Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis. Mol. Cancer Res. 1(1), 32-47 (2002).
    • (2002) Mol. Cancer Res. , vol.1 , Issue.1 , pp. 32-47
    • Iavnilovitch, E.1    Groner, B.2    Barash, I.3
  • 140
    • 7044272580 scopus 로고    scopus 로고
    • Deregulation of STAT5 expression and activation causes mammary tumors in transgenic mice
    • Iavnilovitch E, Cardiff RD, Groner B, Barash I. Deregulation of STAT5 expression and activation causes mammary tumors in transgenic mice. Int. J. Cancer 112(4), 607-619 (2004).
    • (2004) Int. J. Cancer , vol.112 , Issue.4 , pp. 607-619
    • Iavnilovitch, E.1    Cardiff, R.D.2    Groner, B.3    Barash, I.4
  • 141
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108(10), 3472-3476 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3
  • 142
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene which encodes for the receptor for thrombopoietin
    • Ding J, Komatsu H, Wakita A et al. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 103(11), 4198-4200 (2004).
    • (2004) Blood , vol.103 , Issue.11 , pp. 4198-4200
    • Ding, J.1    Komatsu, H.2    Wakita, A.3
  • 144
    • 12444320971 scopus 로고    scopus 로고
    • Growth hormone protects human lymphocytes from irradiation-induced cell death
    • Lempereur L, Brambilla D, Scoto GM et al. Growth hormone protects human lymphocytes from irradiation-induced cell death. Br. J. Pharmacol. 138(8), 1411-1416 (2003).
    • (2003) Br. J. Pharmacol. , vol.138 , Issue.8 , pp. 1411-1416
    • Lempereur, L.1    Brambilla, D.2    Scoto, G.M.3
  • 145
    • 33745324588 scopus 로고    scopus 로고
    • Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy
    • Wu X, Wan M, Li G et al. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy. Eur. J. Cancer 42(7), 888-894 (2006).
    • (2006) Eur. J. Cancer , vol.42 , Issue.7 , pp. 888-894
    • Wu, X.1    Wan, M.2    Li, G.3
  • 146
    • 70349909883 scopus 로고    scopus 로고
    • Growth hormone excess promotes breast cancer chemoresistance
    • Zatelli MC, Minoia M, Mole D et al. Growth hormone excess promotes breast cancer chemoresistance. J. Clin. Endocrinol. Metab. 94(10), 3931-3938 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.10 , pp. 3931-3938
    • Zatelli, M.C.1    Minoia, M.2    Mole, D.3
  • 147
    • 69249122509 scopus 로고    scopus 로고
    • Exercise increases neural stem cell number in a growth hormone-dependent manner augmenting the regenerative response in aged mice
    • Blackmore DG, Golmohammadi MG, Large B, Waters MJ, Rietze RL. Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice. Stem Cells 27(8), 2044-2052 (2009).
    • (2009) Stem Cells , vol.27 , Issue.8 , pp. 2044-2052
    • Blackmore, D.G.1    Golmohammadi, M.G.2    Large, B.3    Waters, M.J.4    Rietze, R.L.5


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