메뉴 건너뛰기




Volumn 151, Issue 9, 2010, Pages 4133-4145

STAT3α is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HUMAN GROWTH HORMONE; JANUS KINASE 2; JSI 124; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT3ALPHA PROTEIN; UNCLASSIFIED DRUG; CUCURBITACIN I; DELTA HGHR; DELTA-HGHR; MEMBRANE PROTEIN; TRITERPENE;

EID: 77956020768     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0273     Document Type: Article
Times cited : (38)

References (76)
  • 2
    • 61449307070 scopus 로고    scopus 로고
    • Current treatment of metastatic endometrial cancer
    • Temkin SM, Fleming G 2009 Current treatment of metastatic endometrial cancer. Cancer Control 16:38-45
    • (2009) Cancer Control , vol.16 , pp. 38-45
    • Temkin, S.M.1    Fleming, G.2
  • 3
    • 62949201676 scopus 로고    scopus 로고
    • Management of advanced-stage and recurrent endometrial cancer
    • Ray M, Fleming G 2009 Management of advanced-stage and recurrent endometrial cancer. Semin Oncol 36:145-154
    • (2009) Semin Oncol , vol.36 , pp. 145-154
    • Ray, M.1    Fleming, G.2
  • 4
    • 0034907888 scopus 로고    scopus 로고
    • Signal transduction via the growth hormone receptor
    • DOI 10.1016/S0898-6568(01)00186-3, PII S0898656801001863
    • Zhu T, Goh EL, Graichen R, Ling L, Lobie PE 2001 Signal transduction via the growth hormone receptor. Cell Signal 13:599-616 (Pubitemid 32734097)
    • (2001) Cellular Signalling , vol.13 , Issue.9 , pp. 599-616
    • Zhu, T.1    Goh, E.L.K.2    Graichen, R.3    Ling, L.4    Lobie, P.E.5
  • 7
    • 33646017701 scopus 로고    scopus 로고
    • Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma
    • Slater M, Cooper M, Murphy CR 2006 Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma. Acta Histochem 108:13-18
    • (2006) Acta Histochem , vol.108 , pp. 13-18
    • Slater, M.1    Cooper, M.2    Murphy, C.R.3
  • 11
    • 33645851038 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone in oncology
    • Schally AV, Varga JL 2006 Antagonists of growth hormone-releasing hormone in oncology. Comb Chem High Throughput Screen 9:163-170
    • (2006) Comb Chem High Throughput Screen , vol.9 , pp. 163-170
    • Schally, A.V.1    Varga, J.L.2
  • 12
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • Al Zaid Siddiquee K, Turkson J 2008 STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res 18:254-267
    • (2008) Cell Res , vol.18 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 13
    • 34547897027 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis
    • Kim DJ, Chan KS, Sano S, Digiovanni J 2007 Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol Carcinog 46:725-731
    • (2007) Mol Carcinog , vol.46 , pp. 725-731
    • Kim, D.J.1    Chan, K.S.2    Sano, S.3    Digiovanni, J.4
  • 14
    • 0029113153 scopus 로고
    • Receptors for interleukin-3 (IL-3) and growth hormone mediate an IL-6-type transcriptional induction in the presence of JAK2 or STAT3
    • Wang Y, Morella KK, Ripperger J, Lai CF, Gearing DP, Fey GH, Campos SP, Baumann H 1995 Receptors for interleukin-3 (IL-3) and growth hormone mediate an IL-6-type transcriptional induction in the presence of JAK2 or STAT3. Blood 86:1671-1679
    • (1995) Blood , vol.86 , pp. 1671-1679
    • Wang, Y.1    Morella, K.K.2    Ripperger, J.3    Lai, C.F.4    Gearing, D.P.5    Fey, G.H.6    Campos, S.P.7    Baumann, H.8
  • 16
    • 0028952414 scopus 로고
    • Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone
    • Campbell GS, Meyer DJ, Raz R, Levy DE, Schwartz J, Carter-Su C 1995 Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone. J Biol Chem 270:3974-3979
    • (1995) J Biol Chem , vol.270 , pp. 3974-3979
    • Campbell, G.S.1    Meyer, D.J.2    Raz, R.3    Levy, D.E.4    Schwartz, J.5    Carter-Su, C.6
  • 17
    • 48249130514 scopus 로고    scopus 로고
    • JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma Cells
    • Jin H, Lanning NJ, Carter-Su C 2008 JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma Cells. Mol Endocrinol 22:1825-1841
    • (2008) Mol Endocrinol , vol.22 , pp. 1825-1841
    • Jin, H.1    Lanning, N.J.2    Carter-Su, C.3
  • 18
    • 65549094595 scopus 로고    scopus 로고
    • Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation
    • Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L 2009 Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation. J Exp Med 206:819-831
    • (2009) J Exp Med , vol.206 , pp. 819-831
    • Hosui, A.1    Kimura, A.2    Yamaji, D.3    Zhu, B.M.4    Na, R.5    Hennighausen, L.6
  • 19
    • 0029796380 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells
    • Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ 1996 Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood 88:2442-2449 (Pubitemid 26327492)
    • (1996) Blood , vol.88 , Issue.7 , pp. 2442-2449
    • Chakraborty, A.1    White, S.M.2    Schaefer, T.S.3    Ball, E.D.4    Dyer, K.F.5    Tweardy, D.J.6
  • 21
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell Jr JE 1995 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241-250
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 22
    • 14644415484 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas
    • DOI 10.1111/j.1365-2567.2005.02091.x
    • Mitchell TJ, John S 2005 Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas. Immunology 114:301-312 (Pubitemid 40314803)
    • (2005) Immunology , vol.114 , Issue.3 , pp. 301-312
    • Mitchell, T.J.1    John, S.2
  • 25
    • 34250217027 scopus 로고    scopus 로고
    • Constitutively activated stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin B6
    • Azare J, Leslie K, Al-Ahmadie H, Gerald W, Weinreb PH, Violette SM, Bromberg J 2007 Constitutively activated stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin B6. Mol Cell Biol 27:4444-4453
    • (2007) Mol Cell Biol , vol.27 , pp. 4444-4453
    • Azare, J.1    Leslie, K.2    Al-Ahmadie, H.3    Gerald, W.4    Weinreb, P.H.5    Violette, S.M.6    Bromberg, J.7
  • 26
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via PP-regulation of TWIST gene expression
    • Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC 2007 Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via PP-regulation of TWIST gene expression. Cancer Res 67:9066-9076
    • (2007) Cancer Res , vol.67 , pp. 9066-9076
    • Lo, H.W.1    Hsu, S.C.2    Xia, W.3    Cao, X.4    Shih, J.Y.5    Wei, Y.6    Abbruzzese, J.L.7    Hortobagyi, G.N.8    Hung, M.C.9
  • 27
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K 2003 Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22:319-329
    • (2003) Oncogene , vol.22 , pp. 319-329
    • Wei, D.1    Le, X.2    Zheng, L.3    Wang, L.4    Frey, J.A.5    Gao, A.C.6    Peng, Z.7    Huang, S.8    Xiong, H.Q.9    Abbruzzese, J.L.10    Xie, K.11
  • 28
    • 67349141286 scopus 로고    scopus 로고
    • Endometrial cancer and obesity: Epidemiology, biomarkers, prevention and survivorship
    • Fader AN, Arriba LN, Frasure HE, von Gruenigen VE 2009 Endometrial cancer and obesity: epidemiology, biomarkers, prevention and survivorship. Gynecol Oncol 114:121-127
    • (2009) Gynecol Oncol , vol.114 , pp. 121-127
    • Fader, A.N.1    Arriba, L.N.2    Frasure, H.E.3    Von Gruenigen, V.E.4
  • 29
    • 37548999022 scopus 로고    scopus 로고
    • Leptin levels in serum depending on body mass index in patients with endometrial hyperplasia and cancer
    • Cymbaluk A, Chudecka-Glaz A, Rzepka-Górska I 2008 Leptin levels in serum depending on body mass index in patients with endometrial hyperplasia and cancer. Eur J Obstet Gynecol Reprod Biol 136:74-77
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.136 , pp. 74-77
    • Cymbaluk, A.1    Chudecka-Glaz, A.2    Rzepka-Górska, I.3
  • 30
    • 33745108419 scopus 로고    scopus 로고
    • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
    • DOI 10.1677/erc.1.01169
    • Sharma D, Saxena NK, Vertino PM, Anania FA 2006 Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer 13:629-640 (Pubitemid 43886682)
    • (2006) Endocrine-Related Cancer , vol.13 , Issue.2 , pp. 629-640
    • Sharma, D.1    Saxena, N.K.2    Vertino, P.M.3    Anania, F.A.4
  • 32
    • 70349339632 scopus 로고    scopus 로고
    • Biologic markers in endometrial cancer treatment
    • Engelsen IB, Akslen LA, Salvesen HB 2009 Biologic markers in endometrial cancer treatment. APMIS 117:693-707
    • (2009) APMIS , vol.117 , pp. 693-707
    • Engelsen, I.B.1    Akslen, L.A.2    Salvesen, H.B.3
  • 34
    • 61449282506 scopus 로고    scopus 로고
    • The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
    • Bansal N, Yendluri V, Wenham RM 2009 The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control 16:8-13
    • (2009) Cancer Control , vol.16 , pp. 8-13
    • Bansal, N.1    Yendluri, V.2    Wenham, R.M.3
  • 35
    • 85047699773 scopus 로고    scopus 로고
    • p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3
    • Lin J, Tang H, Jin X, Jia G, Hsieh JT 2002 p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3. Oncogene 21:3082-3088
    • (2002) Oncogene , vol.21 , pp. 3082-3088
    • Lin, J.1    Tang, H.2    Jin, X.3    Jia, G.4    Hsieh, J.T.5
  • 38
    • 42449141532 scopus 로고    scopus 로고
    • Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell
    • Mohankumar KM, Perry JK, Kannan N, Kohno K, Gluckman PD, Emerald BS, Lobie PE 2008 Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology 149:2219-2229
    • (2008) Endocrinology , vol.149 , pp. 2219-2229
    • Mohankumar, K.M.1    Perry, J.K.2    Kannan, N.3    Kohno, K.4    Gluckman, P.D.5    Emerald, B.S.6    Lobie, P.E.7
  • 40
    • 73649093445 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior
    • Tang JZ, Zuo ZH, Kong XJ, Steiner M, Yin Z, Perry JK, Zhu T, Liu DX, Lobie PE 2010 Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior. Endocrinology 151:43-55
    • (2010) Endocrinology , vol.151 , pp. 43-55
    • Tang, J.Z.1    Zuo, Z.H.2    Kong, X.J.3    Steiner, M.4    Yin, Z.5    Perry, J.K.6    Zhu, T.7    Liu, D.X.8    Lobie, P.E.9
  • 41
    • 0035223162 scopus 로고    scopus 로고
    • In vitro assays to study epithelial cell growth
    • Dawson CW, Young LS 2001 In vitro assays to study epithelial cell growth. Methods Mol Biol 174:165-172
    • (2001) Methods Mol Biol , vol.174 , pp. 165-172
    • Dawson, C.W.1    Young, L.S.2
  • 42
    • 0035167659 scopus 로고    scopus 로고
    • Molecular cloning of a functional promoter of the human plakoglobin gene
    • Pötter E, Braun S, Lehmann U, Brabant G 2001 Molecular cloning of a functional promoter of the human plakoglobin gene. Eur J Endocrinol 145:625-633 (Pubitemid 33061909)
    • (2001) European Journal of Endocrinology , vol.145 , Issue.5 , pp. 625-633
    • Potter, E.1    Braun, S.2    Lehmann, U.3    Brabant, G.4
  • 44
    • 0028211553 scopus 로고
    • The signalling pathways of interleukin-6 and γ interferon converge by the activation of different transcription factors which bind to common responsive DNA elements
    • Yuan J, Wegenka UM, Lütticken C, Buschmann J, Decker T, Schindler C, Heinrich PC, Horn F 1994 The signalling pathways of interleukin-6 and γ interferon converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol Cell Biol 14:1657-1668
    • (1994) Mol Cell Biol , vol.14 , pp. 1657-1668
    • Yuan, J.1    Wegenka, U.M.2    Lütticken, C.3    Buschmann, J.4    Decker, T.5    Schindler, C.6    Heinrich, P.C.7    Horn, F.8
  • 45
    • 0036800303 scopus 로고    scopus 로고
    • Growth hormone receptor antagonists: Discovery, development, and use in patients with acromegaly
    • Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ 2002 Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr Rev 23:623-646
    • (2002) Endocr Rev , vol.23 , pp. 623-646
    • Kopchick, J.J.1    Parkinson, C.2    Stevens, E.C.3    Trainer, P.J.4
  • 47
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (Cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM 2003 Discovery of JSI-124 (Cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 63:1270-1279
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 48
    • 49749129612 scopus 로고    scopus 로고
    • JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
    • Su Y, Li G, Zhang X, Gu J, Zhang C, Tian Z, Zhang J 2008 JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment. Cancer Biol Ther 7:1243-1249
    • (2008) Cancer Biol Ther , vol.7 , pp. 1243-1249
    • Su, Y.1    Li, G.2    Zhang, X.3    Gu, J.4    Zhang, C.5    Tian, Z.6    Zhang, J.7
  • 49
    • 0037160137 scopus 로고    scopus 로고
    • Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity: GH activation of Ral and phospholipase D is Src-dependent
    • DOI 10.1074/jbc.M201385200
    • Zhu T, Ling L, Lobie PE 2002 Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent. J Biol Chem 277:45592-45603 (Pubitemid 36159170)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 45592-45603
    • Zhu, T.1    Ling, L.2    Lobie, P.E.3
  • 51
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA 2000 The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 52
    • 33646386142 scopus 로고    scopus 로고
    • Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
    • Hotulainen P, Lappalainen P 2006 Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol 173:383-394
    • (2006) J Cell Biol , vol.173 , pp. 383-394
    • Hotulainen, P.1    Lappalainen, P.2
  • 53
    • 42249115503 scopus 로고    scopus 로고
    • DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells
    • Shafiei F, Rahnama F, Pawella L, Mitchell MD, Gluckman PD, Lobie PE 2008 DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells. Oncogene 27:2602-2612
    • (2008) Oncogene , vol.27 , pp. 2602-2612
    • Shafiei, F.1    Rahnama, F.2    Pawella, L.3    Mitchell, M.D.4    Gluckman, P.D.5    Lobie, P.E.6
  • 54
    • 3042811414 scopus 로고    scopus 로고
    • Prognostic parameters of endometrial carcinoma
    • Prat J 2004 Prognostic parameters of endometrial carcinoma. Hum Pathol 35:649-662
    • (2004) Hum Pathol , vol.35 , pp. 649-662
    • Prat, J.1
  • 55
    • 0037081296 scopus 로고    scopus 로고
    • Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells
    • Lin J, Jin X, Rothman K, Lin HJ, Tang H, Burke W 2002 Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells. Cancer Res 62:376-380
    • (2002) Cancer Res , vol.62 , pp. 376-380
    • Lin, J.1    Jin, X.2    Rothman, K.3    Lin, H.J.4    Tang, H.5    Burke, W.6
  • 56
    • 40749103000 scopus 로고    scopus 로고
    • A signal network involving coactivated NF-κB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
    • Lee TL, Yeh J, Friedman J, Yan B, Yang X, Yeh NT, Van Waes C, Chen Z 2008 A signal network involving coactivated NF-κB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer 122:1987-1998
    • (2008) Int J Cancer , vol.122 , pp. 1987-1998
    • Lee, T.L.1    Yeh, J.2    Friedman, J.3    Yan, B.4    Yang, X.5    Yeh, N.T.6    Van Waes, C.7    Chen, Z.8
  • 57
    • 0026344260 scopus 로고
    • Analysis of the p53 gene in human uterine carcinoma cell lines
    • Yaginuma Y, Westphal H 1991 Analysis of the p53 gene in human uterine carcinoma cell lines. Cancer Res 51:6506-6509
    • (1991) Cancer Res , vol.51 , pp. 6506-6509
    • Yaginuma, Y.1    Westphal, H.2
  • 58
    • 30344450822 scopus 로고    scopus 로고
    • Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors
    • DOI 10.1158/1535-7163.MCT-05-0274
    • Albitar L, Laidler LL, Abdallah R, Leslie KK 2005 Regulation of signaling phosphoproteins by epidermal growth factor and Iressa (ZD1839) in human endometrial cancer cells that model type I and II tumors. Mol Cancer Ther 4:1891-1899 (Pubitemid 43056972)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.12 , pp. 1891-1899
    • Albitar, L.1    Laidler, L.L.2    Abdallah, R.3    Leslie, K.K.4
  • 59
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle TE, Frank DA 2002 The role of STATs in apoptosis. Curr Mol Med 2:381-392
    • (2002) Curr Mol Med , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 61
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R 2009 STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9:798-809
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 62
    • 77549088772 scopus 로고    scopus 로고
    • Pathways mediating VEGF-independent tumor angiogenesis
    • Ferrara N 2010 Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev 21:21-26
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 21-26
    • Ferrara, N.1
  • 64
    • 51649096739 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1α RNA expression in both tumor cells and tumor-associated myeloid cells
    • Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H 2008 Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1α RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res 6:1099-1105
    • (2008) Mol Cancer Res , vol.6 , pp. 1099-1105
    • Niu, G.1    Briggs, J.2    Deng, J.3    Ma, Y.4    Lee, H.5    Kortylewski, M.6    Kujawski, M.7    Kay, H.8    Cress, W.D.9    Jove, R.10    Yu, H.11
  • 65
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • DOI 10.1038/nri1995, PII NRI1995
    • Yu H, Kortylewski M, Pardoll D 2007 Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41-51 (Pubitemid 46020826)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.1 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 68
    • 33644518982 scopus 로고    scopus 로고
    • Fibronectin as target for tumor therapy
    • Kaspar M, Zardi L, Neri D 2006 Fibronectin as target for tumor therapy. Int J Cancer 118:1331-1339
    • (2006) Int J Cancer , vol.118 , pp. 1331-1339
    • Kaspar, M.1    Zardi, L.2    Neri, D.3
  • 69
    • 0037434666 scopus 로고    scopus 로고
    • Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells
    • Zhang F, Li C, Halfter H, Liu J 2003 Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22:894-905
    • (2003) Oncogene , vol.22 , pp. 894-905
    • Zhang, F.1    Li, C.2    Halfter, H.3    Liu, J.4
  • 71
    • 0036957026 scopus 로고    scopus 로고
    • Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma
    • Kim YT, Choi EK, Kim JW, Kim DK, Kim SH, Yang WI 2002 Expression of E-cadherin and α-, β-, γ-catenin proteins in endometrial carcinoma. Yonsei Med J 43:701-711
    • (2002) Yonsei Med J , vol.43 , pp. 701-711
    • Kim, Y.T.1    Choi, E.K.2    Kim, J.W.3    Kim, D.K.4    Kim, S.H.5    Yang, W.I.6
  • 73
    • 0030696926 scopus 로고    scopus 로고
    • Suppression of E-cadherin and α- And β-catenin mRNA expression in the metastatic lesions of gynecological cancers
    • Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T 1997 Suppression of E-cadherin and α- and β-catenin mRNA expression in the metastatic lesions of gynecological cancers. Eur J Gynaecol Oncol 18:484-487 (Pubitemid 27519415)
    • (1997) European Journal of Gynaecological Oncology , vol.18 , Issue.6 , pp. 484-487
    • Fujimoto, J.1    Ichigo, S.2    Hirose, R.3    Sakaguchi, H.4    Tamaya, T.5
  • 74
    • 33746651038 scopus 로고    scopus 로고
    • STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
    • Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik MA 2006 STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood 108:1058-1064
    • (2006) Blood , vol.108 , pp. 1058-1064
    • Zhang, Q.1    Wang, H.Y.2    Woetmann, A.3    Raghunath, P.N.4    Odum, N.5    Wasik, M.A.6
  • 75
    • 0141841787 scopus 로고    scopus 로고
    • Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer
    • Holland CM, Day K, Evans A, Smith SK 2003 Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer. Br J Cancer 89:891-898
    • (2003) Br J Cancer , vol.89 , pp. 891-898
    • Holland, C.M.1    Day, K.2    Evans, A.3    Smith, S.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.