메뉴 건너뛰기




Volumn 112, Issue 4, 2004, Pages 607-619

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

Author keywords

Cancer; Mammary gland; Oncogene; Stat5; Transgenic mice

Indexed keywords

BETA LACTOGLOBULIN; CYCLIN D1; ESTROGEN RECEPTOR ALPHA; INITIATION FACTOR 4E; STAT5 PROTEIN;

EID: 7044272580     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20484     Document Type: Article
Times cited : (75)

References (54)
  • 1
    • 0032617467 scopus 로고    scopus 로고
    • The comparative pathology of human and mouse mammary glands
    • Cardiff RD, Wellings SR. The comparative pathology of human and mouse mammary glands. J Mamm Gland Biol Neoplasia 1999;4:105-22.
    • (1999) J Mamm Gland Biol Neoplasia , vol.4 , pp. 105-122
    • Cardiff, R.D.1    Wellings, S.R.2
  • 2
    • 0242667837 scopus 로고    scopus 로고
    • Stem cells and breast cancer: A field in transit
    • Smalley M, Ashworth A. Stem cells and breast cancer: a field in transit. Nat Rev Cancer 2003;3:832-44.
    • (2003) Nat Rev Cancer , vol.3 , pp. 832-844
    • Smalley, M.1    Ashworth, A.2
  • 3
    • 0021931794 scopus 로고
    • Risk factors for breast cancer in women with proliferative breast disease
    • Dupont WD, Page DL. Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 1985;312:146-51.
    • (1985) N Engl J Med , vol.312 , pp. 146-151
    • Dupont, W.D.1    Page, D.L.2
  • 4
    • 0029910401 scopus 로고    scopus 로고
    • Recent advances in breast cancer biology
    • Blackwood MA, Weber BL. Recent advances in breast cancer biology. Curr Opin Oncol 1996;8:449-54.
    • (1996) Curr Opin Oncol , vol.8 , pp. 449-454
    • Blackwood, M.A.1    Weber, B.L.2
  • 6
    • 0034658690 scopus 로고    scopus 로고
    • Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
    • Levy DE, Gilliland DG. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 2000;19:2505-10.
    • (2000) Oncogene , vol.19 , pp. 2505-2510
    • Levy, D.E.1    Gilliland, D.G.2
  • 10
    • 0345700700 scopus 로고    scopus 로고
    • Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis
    • Iavnilovitch E, Groner B, Barash I. Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis. Mol Cancer Res 2002;1:32-47.
    • (2002) Mol Cancer Res , vol.1 , pp. 32-47
    • Iavnilovitch, E.1    Groner, B.2    Barash, I.3
  • 11
    • 0028923658 scopus 로고
    • Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
    • Watson CJ, Miller WR. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer 1995;71:840-4.
    • (1995) Br J Cancer , vol.71 , pp. 840-844
    • Watson, C.J.1    Miller, W.R.2
  • 12
    • 0031025240 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells
    • Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res 1997;57:978-87.
    • (1997) Cancer Res , vol.57 , pp. 978-987
    • Sartor, C.I.1    Dziubinski, M.L.2    Yu, C.L.3    Jove, R.4    Ethier, S.P.5
  • 17
    • 0032713453 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis
    • Humphreys RC, Hennighausen L. Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis. Cell Growth Differ 1999;10:685-94.
    • (1999) Cell Growth Differ , vol.10 , pp. 685-694
    • Humphreys, R.C.1    Hennighausen, L.2
  • 18
    • 0025817299 scopus 로고
    • Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor
    • Schmitt-Ney M, Doppler W, Ball RK, Groner B. Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol Cell Biol 1991;11:3745-55.
    • (1991) Mol Cell Biol , vol.11 , pp. 3745-3755
    • Schmitt-Ney, M.1    Doppler, W.2    Ball, R.K.3    Groner, B.4
  • 20
    • 0028173290 scopus 로고
    • Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element
    • Burdon TG, Maitland KA, Clark AJ, Wallace R, Watson CJ. Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element. Mol Endocrinol 1994;8:1528-36.
    • (1994) Mol Endocrinol , vol.8 , pp. 1528-1536
    • Burdon, T.G.1    Maitland, K.A.2    Clark, A.J.3    Wallace, R.4    Watson, C.J.5
  • 21
    • 0029115640 scopus 로고
    • Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
    • Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 1995;92:8831-5.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8831-8835
    • Liu, X.1    Robinson, G.W.2    Gouilleux, F.3    Groner, B.4    Hennighausen, L.5
  • 23
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002;8:945-54.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 24
    • 0037142617 scopus 로고    scopus 로고
    • Loss of Stat5a delays mammary cancer progression in a mouse model
    • Ren S, Cai HR, Li M, Furth PA. Loss of Stat5a delays mammary cancer progression in a mouse model. Oncogene 2002;21:4335-9.
    • (2002) Oncogene , vol.21 , pp. 4335-4339
    • Ren, S.1    Cai, H.R.2    Li, M.3    Furth, P.A.4
  • 25
    • 0027993605 scopus 로고
    • Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
    • Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 1994;13:4361-9.
    • (1994) EMBO J , vol.13 , pp. 4361-4369
    • Gouilleux, F.1    Wakao, H.2    Mundt, M.3    Groner, B.4
  • 27
    • 0021153316 scopus 로고
    • Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro
    • Danielson KG, Oborn CJ, Durban EM, Butel JS, Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci USA 1984;81:3756-60.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3756-3760
    • Danielson, K.G.1    Oborn, C.J.2    Durban, E.M.3    Butel, J.S.4    Medina, D.5
  • 28
    • 0036588318 scopus 로고    scopus 로고
    • Characterization of an epithelial cell line from bovine mammary gland
    • German T, Barash I. Characterization of an epithelial cell line from bovine mammary gland. In Vitro Cell Dev Biol Anim 2002;38:282-92.
    • (2002) In Vitro Cell Dev Biol Anim , vol.38 , pp. 282-292
    • German, T.1    Barash, I.2
  • 29
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000;19:2468-73.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 30
    • 0034773690 scopus 로고    scopus 로고
    • A new beta-lactoglobulin-based vector targets luciferase cDNA expression to the mammary gland of transgenic mice
    • Reichenstein M, Gottlieb H, Damari GM, Iavnilovitch E, Barash I. A new beta-lactoglobulin-based vector targets luciferase cDNA expression to the mammary gland of transgenic mice. Transgenic Res 2001;10:445-56.
    • (2001) Transgenic Res , vol.10 , pp. 445-456
    • Reichenstein, M.1    Gottlieb, H.2    Damari, G.M.3    Iavnilovitch, E.4    Barash, I.5
  • 36
    • 0029847574 scopus 로고    scopus 로고
    • Expression of cytokeratin messenger RNA versus protein in the normal mammary gland and in breast cancer
    • Su L, Morgan PR, Lane EB. Expression of cytokeratin messenger RNA versus protein in the normal mammary gland and in breast cancer. Hum Pathol 1996;27:800-6.
    • (1996) Hum Pathol , vol.27 , pp. 800-806
    • Su, L.1    Morgan, P.R.2    Lane, E.B.3
  • 42
    • 0035057846 scopus 로고    scopus 로고
    • The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
    • Chiarle R, Pagano M, Inghirami G. The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer. Breast Cancer Res 2001;3:91-4.
    • (2001) Breast Cancer Res , vol.3 , pp. 91-94
    • Chiarle, R.1    Pagano, M.2    Inghirami, G.3
  • 43
    • 0037443835 scopus 로고    scopus 로고
    • Molecular assay to generate expression profile of eight estrogen receptor alpha isoform mRNA copy numbers in picogram amounts of total RNA from breast cancer tissues
    • Poola I. Molecular assay to generate expression profile of eight estrogen receptor alpha isoform mRNA copy numbers in picogram amounts of total RNA from breast cancer tissues. Anal Biochem 2003;314:217-26.
    • (2003) Anal Biochem , vol.314 , pp. 217-226
    • Poola, I.1
  • 45
    • 0037088997 scopus 로고    scopus 로고
    • The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex
    • Maurer AB, Wichmann C, Gross A, Kunkel H, Heinzel T, Ruthardt M, Groner B, Grez M. The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex. Blood 2002;99:2647-52.
    • (2002) Blood , vol.99 , pp. 2647-2652
    • Maurer, A.B.1    Wichmann, C.2    Gross, A.3    Kunkel, H.4    Heinzel, T.5    Ruthardt, M.6    Groner, B.7    Grez, M.8
  • 46
    • 0035803483 scopus 로고    scopus 로고
    • Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: Implications in negative regulation of STAT5-dependent transcription
    • Nakajima H, Brindle PK, Handa M, Ihle JN. Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. EMBO J 2001;20:6836-44.
    • (2001) EMBO J , vol.20 , pp. 6836-6844
    • Nakajima, H.1    Brindle, P.K.2    Handa, M.3    Ihle, J.N.4
  • 47
    • 0029892570 scopus 로고    scopus 로고
    • Isolation and characterization of Nmi, a novel partner of Myc proteins
    • Bao J, Zervos AS. Isolation and characterization of Nmi, a novel partner of Myc proteins. Oncogene 1996;12:2171-6.
    • (1996) Oncogene , vol.12 , pp. 2171-2176
    • Bao, J.1    Zervos, A.S.2
  • 48
    • 0033534562 scopus 로고    scopus 로고
    • Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling
    • Zhu M, John S, Berg M, Leonard WJ. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell 1999;96:121-30.
    • (1999) Cell , vol.96 , pp. 121-130
    • Zhu, M.1    John, S.2    Berg, M.3    Leonard, W.J.4
  • 49
    • 0033044355 scopus 로고    scopus 로고
    • eIF4E expression in tumors: Its possible role in progression of malignancies
    • De Benedetti A, Harris AL. eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol 1999;31:59-72.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 59-72
    • De Benedetti, A.1    Harris, A.L.2
  • 50
  • 52
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer: New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer: new molecular targets come of age. Nat Rev Cancer 2004;4:97-105.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 53
    • 0038387495 scopus 로고    scopus 로고
    • Cancer revoked: Oncogenes as therapeutic targets
    • Felsher DW. Cancer revoked: oncogenes as therapeutic targets. Nat Rev Cancer 2003;3:375-80.
    • (2003) Nat Rev Cancer , vol.3 , pp. 375-380
    • Felsher, D.W.1
  • 54
    • 0028916539 scopus 로고
    • Synthesis and secretion of caseins by the mouse mammary gland: Production and characterization of new polyclonal antibodies
    • Barash I, Faerman A, Puzis R, Peterson D, Shani M. Synthesis and secretion of caseins by the mouse mammary gland: production and characterization of new polyclonal antibodies. Mol Cell Biochem 1995;144:175-80.
    • (1995) Mol Cell Biochem , vol.144 , pp. 175-180
    • Barash, I.1    Faerman, A.2    Puzis, R.3    Peterson, D.4    Shani, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.