Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: New insights into their synergistic effects

Journal of Clinical Pathology - Molecular Pathology

Volumn 54, Issue 3, 2001, Pages 149-154

  Dupont, J ^a   Le Roith, D ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Breast cancer; Cell cycle; Insulin like growth factor 1 receptor; Oestrogen receptor

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; ESTRADIOL RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

BREAST CANCER; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL DIVISION; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ESTRADIOL; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE PROTEINS; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0034967344     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.54.3.149     Document Type: Review

References (43)

1. The insulin-like growth factor system as a target in breast cancer
2. Insulin-like growth factors and prostate cancer
3. IGF-I and IGF-II in relation to colorectal cancer
4. Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers
5. Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients
6. Insulin-like growth factor 1 (IGF- 1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
7. Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor
8. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice
9. Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell - Cell adhesion in human breast cancer cells
10. The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
11. The PI3K-PDK1 connection: More than just a road to PKB
12. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
13. Animal cell cycles and their control
14. CDK inhibitors: Positive and negative regulators of GI-phase progression
15. The INK4 family of cell cycle inhibitors in cancer
16. G1 phase progression: Cycling on cue
17. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint
18. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
19. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
20. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
21. Role of the INK4a locus in tumor suppression and cell mortality
22. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27 (Kip1)-deficient mice
23. Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle regulatory retinoblastoma protein in skeletal myoblasts
24. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
25. E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I
26. Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: A potential regulatory role of IGF- 1 pathway in distribution of p27Kip1 between different cyclins
27. The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components
28. p21-containing cyclin kinases exist in both active and inactive states
29. Cloning of the human estrogen receptor cDNA
30. Cloning of a novel receptor expressed in rat prostate and ovary
31. Estrogen receptors and cell proliferation in breast cancer
32. Nongenomic actions of steroid hormones in reproductive tissues
33. Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling
34. Estrogen induces the Akt-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells
35. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
36. A novel, nongenomic action of estrogen on the cardiovascular system
37. Calcium antagonistic effect of natural and synthetic estrogens - Investigations on a nongenomic mechanism of direct vascular action
38. Estradiol modulates breast cancer cell apoptosis: A novel nongenomic steroid action relevant to carcinogenesis
39. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid
40. Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
41. Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells
42. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
43. New functional activities for the p21 family of CDK inhibitors