The association of fasting insulin concentrations and colonic neoplasms in acromegaly: A colonoscopy-based study in 210 patients

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 10, 2007, Pages 3854-3860

  Colao, Annamaria ^a   Pivonello, Rosario ^a   Auriemma, Renata S ^a   Galdiero, Mariano ^a   Ferone, Diego ^b   Minuto, Francesco ^a   Marzullo, Paolo ^c   Lombardi, Gaetano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ACROMEGALY; ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; COLON ADENOMA; COLON TUMOR; COLONOSCOPY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GROUPS BY AGE; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

EID: 35348992128     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2551     Document Type: Article

References (40)

1. Larsson SC, Orsini N, Wolk A 2005 Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 97:1679-1687
2. Schoen RE, Tangen CM, Kuller LH, Burke GL, Cushman M, Tracy RP, Dobs Savane PL 1999 Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst 91:1147-1154
3. Le Roith D, Parrizas M, Blakesley VA 1997 The insulin-like growth factor-I receptor and apoptosis. Implications for the aging progress. Endocrine 7:103-105
4. Tran TT, Medline A, Bruce WR 1996 Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomarkers Prev 5:1013-1015
5. Ewton DZ, Kansra S, Lim S, Friedman E 2002 Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. Int J Cancer 98:665-673
6. Giovannucci E 1995 Insulin and colon cancer. Cancer Causes Control 6:164-179
7. Colao A, Ferone D, Marzullo P, Lombardi G 2004 Systemic complications of acromegaly: epidemiology, pathogenesis and management. Endocr Rev 25:102-152
8. Renehan AG, Bhaskar P, Painter JE, O'Dwyer ST, Haboubi N, Varma J, Ball SG, Shalet SM 2000 The prevalence and characteristics of colorectal neoplasia in acromegaly. J Clin Endocrinol Metab 85: 3417-3424
9. Klein I, Parveen G, Gavaler JS, Vanthiel DH 1982 Colonic polyps in patients with acromegaly. Ann Intern Med 97:27-30
10. Ituarte EM, Petrini J, Hershaman JM 1984 Acromegaly and colon cancer. Ann Intern Med 101:627-628
11. Pines A, Rozen P, Ron E, Gilat T 1985 Gastrointestinal tumors in acromegalic patients. Am J Gastroenterol 80:266-269
12. Ezzat S, Strom C, Melmed S 1991 Colon polyps in acromegaly. Ann Intern Med 114:754-755
13. Vasen HF, van Erpecum KJ, Roelfsema F, Raue F, Koppeschaar H, Griffioen G, van Berge Henegouwen GP 1994 Increased prevalence of colonic adenomas in patients with acromegaly. Eur J Endocrinol 131:235-237
14. Ortego J, Vega B, Sampedro J, Escalada J, Boixeda D, Varela C 1994 Neoplastic colonic polyps in acromegaly. Horm Metab Res 26:609-661
15. Delhougne B, Deneux C, Abs R, Chanson P, Fierens H, Laurent-Puig P, Duysburgh I, Stevenaert A, Tabarin A, Delwaide J 1995 The prevalence of colonic polyps in acromegaly: a colonoscopic and pathological study in 103 patients. J Clin Endocrinol Metab 80:3223-3226
16. Colao A, Balzano A, Ferone D, Panza N, Grande G, Marzullo P, Bove A, Iodice G, Merola B, Lombardi G 1997 Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly. Clin Endocrinol (Oxf) 47:23-28
17. Jenkins PJ, Fairclough PD, Richards T, Lowe DG, Monson J, Grossman A, Wass JA, Besser M 1997 Acromegaly, colonic polyps and carcinoma. Clin Endocrinol (Oxf) 47:17-22
18. Baris D, Gridley G, Ron E, Weiderpass E, Mellemkjaer L, Ekbom A, Olsen JH, Baron JA, Fraumeni Jr JF 2002 Acromegaly and cancer risk: a cohort study in Sweden and Denmark. Cancer Causes Control 13:395-400
19. Terzolo M, Reimondo G, Gasperi M, Cozzi R, Pivonello R, Vitale G, Scillitani A, Attanasio R, Cecconi E, Daffara F, Gaia E, Martino E, Lombardi G, Angeli A, Colao A 2005 Colonoscopic screening and follow-up in patients with acromegaly: a multicenter study in Italy. J Clin Endocrinol Metab 90:84-90
20. Bogazzi F, Cosci C, Sardella C, Costa A, Manetti L, Gasperi M, Rossi G, Bartalena L, Martino E 2006 Identification of acromegalic patients at risk of developing colonic adenomas. J Clin Endocrinol Metab 91:1351-1356
21. Colao A, Lombardi G 1998 Growth hormone and prolactin excess. Lancet 352:1455-1461
22. American Diabetes Association 2006 Diagnosis and classification of diabetes mellitus. Diabetes Care 29(Suppl 1):S43-S48
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
24. Hamilton SR, Vogelstein B, Kudo S, Riboli E, Nakamura S, Hainaut P, Rubio CA, Sobin LH, Fogt F, Winawer SJ, Goldgar DE, Jass JR 2000 Tumours of the colon and rectum. In: Hamilton SR, Aaltonen LA, eds. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon, France: IARC Press; 103-143
25. Longacre TA, Fenoglio Preiser CM 1990 Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 14:524-537
26. Burt RW, Samowitz WS 1988 The adenomatous polyp and the hereditary polyposis syndromes. Gastroenterol Clin North Am 17:657-678
27. Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D 2002 Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62:1030-1035
28. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ 1999 Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 91:620-625
29. Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, Dechaud H, Rinaldi S, Zeleniuch-Jacquotte A, Shore RE, Riboli E 2000 Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst 92:1592-1600
30. Hoeflich A, Reisinger R2, Lahm H, Kiess W, Blum WF, Kolb HJ, Weber MM, Wolf E 2001 Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Cancer Res 61:8601-8610
31. Giovannucci E 2001 Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 131(Suppl 11):3109S-3120S
32. Moller DE, Flier JS 1991 Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med 325:938-948
33. Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K 1990 Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J 270:383-390
34. Sciacca L, Prisco M, Wu A, Belfiore A, Vigneri R, Baserga R 2003 Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1. Endocrinology. 144:2650-2658
35. Cohen P, Fielder PJ, Hasegawa Y, Frisch H, Giudice LC, Rosenfeld RG 1991 Clinical aspects of insulin-like growth factor binding proteins. Acta Endocrinol (Copenh) 124(Suppl 2):74-85
36. Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB 1997 Effect of obesity on total and free insulin-like growth factor (IGF)-I and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord 21:355-359
37. Renehan AG, Painter JE, O'Halloran D, Atkin WS, Potten CS, O'Dwyer ST, Shalet S 2000 Circulating insulin-like growth factor II and colon adenomas. J Clin Endocrinol Metab 85:3402-3408
38. Renehan AG, Jones J, Pottem CS, Shalet SM, O'Dwyer ST 2000 Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. Br J Cancer 83:1344-1350
39. Yoshida I, Suzuki A, Vallee M, Matano Y, Masunaga T, Zenda T, Shinozaki K, Okada T 2006 Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon. Clin Gastroenterol Hepatol [Erratum (2007) 5:137] 4:1225-1231
40. Jenkins PJ, Frajese V, Jones AM, Camacho-Hubner C, Lowe DG, Fairclough PD, Chew SL, Grossman AB, Monson JP, Besser GM 2000 Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly. J Clin Endocrinol Metab 85:3218-3221