Role of prolactin/prolactin receptor signaling in human breast cancer

Breast Disease

Volumn 18, Issue , 2003, Pages 75-86

  Clevenger, Charles V ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; ISOMERASE; JANUS KINASE 2; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; REPRESSOR PROTEIN; SERINE; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TYROSINE;

BREAST CANCER; CANCER GROWTH; CELL NUCLEUS; DNA BINDING; ENZYME ACTIVATION; GENE EXPRESSION; GENOME ANALYSIS; HUMAN; LIGAND BINDING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 4444255613     PISSN: 08886008     EISSN: None     Source Type: Journal    
DOI: 10.3233/BD-2003-18108     Document Type: Review

References (118)

1. J.F. Bazan, Structural design and molecular evolution of a cytokine receptor superfamily, Proc Natl Acad Sci USA 87 (1990), 6934-6938.
2. J. Russo and I.H. Russo, Development of the human mammary gland, in: The mammary gland, M.C. Neville and C.W. Daniels, New York, Plenum Press, 1987, pp. 67-93.
3. M.C. Neville, T.B. McFadden and I. Forsyth, Hormonal regulation of mammary differentiation and milk secretion, J Mammary Gland Biol Neoplasia 7 (2002), 49-66.
4. C.W. Welsch and H. Nagasawa, Prolactin and Murine Mammary Tumorigenesis, A Review, Cancer Res 37 (1977), 951-963.
5. C.W. Welsch, Host factors affecting the growth of carcinogen-induced rat mammary carcinomas, A review and tribute to Charles Brenton Huggins, Cancer Res 45 (1985), 3415-3443.
6. A. Manni, C. Wright, G. Davis, J. Glenn, R. Joehl and P. Feil, Promotion by prolactin of the growth of human breast neoplasms cultured in vitro in the soft agar clonogenic assay, Cancer Res 46 (1986), 1669-1672.
7. W.B. Malarkey, M. Kennedy, L.E. Allred and G. Milo, Physiological concentrations of prolactin can promote the growth of human breast tumor cells in culture, J Clin Endocrinol Metab 56 (1983), 673-677.
8. F.E. Chang, S.R. Richards, M.H. Kim and W.B. Malarkey, Twenty-four hour prolactin profiles and prolactin response to dopamine in long distance running women, J Clin Endocrinol Metab 59 (1984), 631-635.
9. J.P. Peyrat, P.H. Venin, J. Bonneterre, B. Hecquet, B. Vandewalle, P.A. Kelly and J. Dijane, Effect of Bromocriptin treatment on prolactin and steroid receptor levels in human breast cancer, Eur J Cancer Clin Oncol 20 (1984), 1363-1367.
10. J.C. Heuson, A. Coune and M. Staquet, Clinical trial of 2-Br-a-ergocryptine (CB154) in advanced breast cancer, Eur J Cancer 8 (1972), 155-156.
11. J. Bonneterre, L. Mauriac, B. Weber, H. Roche, P. Fargeot, M. Tubiana-Hulin, M. Sevin, P. Chollet and P. Cappelaere, Tamoxifen plus bromocriptine versus tamoxifen plus placebo in advanced breast cancer, Results of a double blind multicenter clinical trial, Eur J Cancer 24 (1988), 1851-1853.
12. C.V. Clevenger, W.-P. Chang, W. Ngo, T.L.M. Pasha, K.T. Montone and J.E. Tomaszewski, Expression of prolactin and prolactin receptor in human breast carcinoma, Evidence for an autocrine/paracrine loop, Am J Pathol 146 (1995), 695-705.
13. C. Reynolds, K.T. Montone, C.M. Powell, J.E. Tomaszewski and C.V. Clevenger, Distribution of prolactin and its receptor in human breast carcinoma, Endocrinology 138 (1997), 5555-5560.
14. C.V. Clevenger and T.L. Plank, Prolactin as an autocrine/ paracrine growth factor in breast tissue, J Mammary Gland Biol Neoplasia 2 (1997), 59-68.
15. C.V. Clevenger, P.A. Furth, S.E. Hankinson and L.A. Schuler, The role of prolactin in mammary carcinoma, Endocrine Rev 24 (2003), 1-27.
16. R. Das and B.K. Vonderhaar, Prolactin as a mitogen in mammary cells, J Mammary Gland Biol Neoplasia 2 (1997), 29-39.
17. E. Ginsburg and B.K. Vonderhaar, Prolactin synthesis and secretion by human breast cancer cells, Cancer Res 55 (1995), 2591-2595.
18. B.K. Vonderhaar, Prolactin, The forgotten hormone of human breast cancer, Pharmacol Ther 79 (1998), 169-178.
19. M.J. Naylor, J.A. Lockefeer, N.D. Horseman and C.J. Ormandy, Prolactin regulates mammary epithelial cell proliferation via autocrine/paracrine mechanism, Endocrine 20 (2003), 111-114.
20. I. Pellegrini, J-J. Lebrun, S. Ali and P.A. Kelly, Expression of prolactin and its receptor in human lymphoid cells, Mol Endocrinol 6 (1992), 1023-1031.
21. B. Gellersen, G.E. DiMattia, H.G. Friesen and H.G. Bohnet, Regulation of prolactin secretion in the human B-lymphoblastoid cell line IM-9-P3 by dexamethasone but not other regulators of pituitary prolactin secretion, Endocrinology 125 (1989), 2853-2861.
22. G.C.L. Lachelin, S.S.C. Yen and J.F.N. Alksne, Hormonal changes following hypophysectomy in humans, Obstet Gynecol 50 (1977), 333-339.
23. S.E. Hankinson, W.C. Willett, D.S. Michaud, J.E. Manson, G.A.L.C. Colditz and B.S.F.E. Rosner, Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women, J Natl Cancer Inst 91 (1999), 629-634.
24. C. Brisken, A. Ayyannan, C. Nguyen, F. Reinhardt, T. Jan, S.K. Dey, G.P. Dotto and R.A. Weinberg, IGF-2 is a mediator of prolactin-induced morphogenesis in the breast, Developmental Cell 877 (2002), 887.
25. J.M. Boutin, M. Edery, M. Shirota, C. Jolicoeur, L. Lesueur, S. Ali, D. Gould, J. Djiane and P.A. Kelly, Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells, Mol Endocrinol 3 (1989), 1455-1461.
26. L. DaSilva, O.M.Z. Howard, H. Rui, R.A. Kirken and W.L. Farrar, Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors, J Biol Chem 269 (1994), 18267-18270.
27. J.B. Kline, H. Roehrs and C.V. Clevenger, Functional characterization of the intermediate isoform of the human prolactin receptor, J Biol Chem 274 (1999), 35461-35468.
28. J.B. Kline, M.A. Rycyzyn and C.V. Clevenger, Characterization of a novel and functional human prolactin receptor isoform (Δ SIPRCr) containing only one fibronectin-like domain, Mol Endocrinol 16 (2002), 2310-2322.
29. J.B. Kline and C.V. Clevenger, Identification and characterization of the prolactin-binding protein (PRLBP) in human serum and milk, J Biol Chem 276 (2001), 24760-24766.
30. J. Trott, R. Hovey, S. Koduri and B.K. Vonderhaar, Alternative splicing to exon 11 of human prolactin receptor results in multiple isoforms including a secreted prolactin-binding protein, J Mol Endocrinol 30 (2003), 31-47.
31. R.G. Clark, D.L. Mortensen, L.M.S. Carlson, S.A. Spencer, P. McKay, M. Mulkerrin, J. Moore and B.C. Cunningham, Recombinant human browth hormone (GH)-binding protein enhances the growth-promoting activity of human GH in the rat, Endocrinology 137 (1996), 4308-4315.
32. Z-Z. Hu, J. Meng and M.L. Dufau, Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11, J Biol Chem (2001), in press.
33. A. Gertler, J. Grosclaude, C.J. Strasburger, S. Nir and J. Djiane, Real-time measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model hormone-induced transient receptor dimerization, J Biol Chem 271 (1996), 24482-24491.
34. W. Somers, M. Ultsch, A.M. de Vos and A.A. Kossiakoff, The X-ray structure of a growth hormone-prolactin receptor complex, Nature 272 (1994), 478-481.
35. K.F. Kubatszky, W. Ruan, R. Gurezka, J. Cohen, R. Ketteler, S.S. Watowich, D. Neumann, D. Langosch and U. Klingmuller, Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor, Current Biol 11 (2001), 110-115.
36. S. Gadd and C.V. Clevenger, Ligand-independent complex formation of the prolactin receptor, Proceedings of the 85th Meeting of the Endocrine Society 85 (2003), 502.
37. B.C. Cunningham, M. Ultsch, A.M. DeVoss, M.G. Mulkerrin, K.R. Clauser and J.A. Wells, Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule, Science 254 (1991), 821-825.
38. W-P. Chang and C.V. Clevenger, Modulation of growth factor receptor function by isoform heterodimerization, Proc Natl Acad Sci USA 93 (1996), 5947-5952.
39. O. Goupille, N. Daniel, C. Bignon, J. Jolivet and J. Djiane, Prolactin signal transduction to milk protein genes, carboxy-terminal part of the prolactin receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation, Mol Endocrinol 127 (1997), 155-169.
40. C.V. Clevenger, T. Torigoe and J.C. Reed, Prolactin induces rapid phosphorylation and activation of prolactin receptor associated Raf-1 kinase in a T-cell line, J Biol Chem 269 (1994), 5559-5565.
41. R.A. Erwin, R.A. Kirken, M.G. Malbarba, W.L. Farrar and H. Rui, Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless, Endocrinology 136 (1995), 3512-3518.
42. R. Das and B.K. Vonderhaar, Activation of raf-1, MEK, and MAP kinase in prolactin responsive mammary cells, Breast Cancer Res Treat 40 (1996), 141-149.
43. J.B. Kline, D.J. Moore and C.V. Clevenger, Activation and association of the Tec tyrosine kinase with the human prolactin receptor, Mapping of a Tec/Vav1 - receptor binding site, Mol Endocrinol 15 (2001), 832-841.
44. J.A. Fresno Vara, M.A. Caceres, A. Silva and J. Martin-Perez, Src family kinases are required for prolactin induction of cell proliferation, Mol Biol Cell 12 (2001), 2171-2183.
45. P. Sorensen and L.G. Sheffield, Involvement of c-src in beta-casein expression by mammary epithelial cells, Biochem Biophys Res Commun 241 (1997), 710-713.
46. C.V. Clevenger and M.V. Medaglia, The protein tyrosine kinase p59fyn is associated with prolactin receptor and is activated by prolactin stimulation of T-lymphocytes, Mol Endocrinol 8 (1994), 674-681.
47. C.V. Clevenger, A.L. Sillman, J. Hanley-Hyde and M.B. Prystowsky, Requirement for prolactin during cell cycle regulated gene expression in cloned T-lymphocytes, Endocrinology 130 (1992), 3216-3222.
48. L-Y. Yu-Lee, Prolactin stimulates transcription of growth-related genes in Nb2 T lymphoma cells, Mol Cell Endocrinol 68 (1990), 21-28.
49. K.F. Lee, S.H. Atiee and J.M. Rosen, Differential regulation of rat b-casein-chloramphenical acetyltransferase fusion gene expression in transgenic mice, Mol Cell Biol 9 (1989), 560-565.
50. R.C. Muise-Helmericks, H.L. Grimes, A. Bellacosa, S.E. Malstrom, P.N. Tsichlis and N. Rosen, Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway, J Biol Chem 273 (1998), 29864-29872.
51. S.L. Wysomierski and J.M. Rosen, Cooperative effects of STAT5 and C/EBP b on b-casein gene transcription are mediated by the glucocorticoid receptor, Mol Endo 15 (2001), 228-240.
52. W-P. Chang, Y. Ye and C.V. Clevenger, Stoichiometric structure/function analysis of the prolactin receptor signaling domains by receptor chimeras, Mol Cell Biol 18 (1998), 896-905.
53. B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura and J.N. Ihle, JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin, Cell 74 (1993), 227-236.
54. L.S. Argetsinger, G.S. Campbell, X. Yang, B.A. Witthuhn, O. Silvennoinen, J.N. Ihle and C. Carter-Su, Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase, Cell 74 (1993), 237-244.
55. E. Parganas, D. Wang, D. Stravopodis, D.J. Topham, J-C. Marine, S. Teglund, E.F. Vanin, S. Bodner, O.R. Calamonici, J.M. van Deursen, G. Grosveld and J.N. Ihle, Jak2 is essential for signaling through a variety of cytokine receptors, Cell 93 (1998), 385-395.
56. Y. Zhao, F. Wagner, S.J. Frank and A.S. Kraft, The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulated factor receptor bc chain, J Biol Chem 270 (1995), 13814-13818.
57. H. Rui, R.A. Kirken and W.L. Farrar, Activation of receptor-associated tyrosine kinase JAK2 by prolactin, J Biol Chem 269 (1994), 5364-5368.
58. G.S. Campbell, L.S. Argetsinger, J.N. Ihle, P.A. Kelly, J.A. Rillema and C. Carter-Su, Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants, Proc Natl Acad Sci USA 91 (1994), 5232-5236.
59. I. Dusanter-Fourt, O. Muller, A. Ziemicki, P. Mayeux, B. Drucker, J. Dijane, A. Wilks, A.G. Harpur, S. Fischer and S. Gisselbrecht, Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphod cells, EMBO J 13 (1994), 2583-2591.
60. J. Xie, M.J. LeBaron, M.T. Nevalainen and H. Rui, Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells, J Biol Chem 277 (2002), 14020-14030.
61. J.L. Brockman, M.D. Schroeder and L.A. Schuler, PRL activates the cyclin d1 promoter via the jak2/stat pathway, Mol Endocrinol 16 (2002), 774-784.
62. J.N. Ihle and I.M. Kerr, Jaks and Stats in signaling by the cytokine receptor superfamily, Trends Genet 11 (1995), 69-74.
63. P. Saharinen, M. Vihinen and O. Silvennoinen, Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in tis pseudokinase domain, Molecular Biology of the Cell 14 (2003), 1448-1459.
64. K. He, X. Wang, J. Jiang, R. Guan, K.E. Bernstein, P.P. Sayeski and S.J. Frank, Jak2 determinants for growth hormone receptor association, surface assembly, and signaling, Mol Endocrinol (2003), in Press.
65. J.J. Lebrun, S. Ali, L. Sofer, A. Ullrich and P.A. Kelly, Prolactin-induced proliferation Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2, J Biol Chem 269 (1994), 14021-14026.
66. J-J. Lebrun, S. Ali, A. Ullrich and P.A. Kelly, Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction, J Biol Chem 270 (1995), 10664-10670.
67. A. Pezet, F. Ferrag, P.A. Kelly and M. Edery, Tyrosine docking sites of the rat prolactin receptor required for association and activation Stat5, J Biol Chem 272 (1997), 25043-25050.
68. L. DaSilva, H. Rui, R.A. Erwin, O.M.Z. Howard, R.A. Kirken, M.G. Malabarba, R.H. Hackett, A.C. Larner and W.L. Farrar, Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515, and TYR580, Mol Cell Endocrinol 117 (1996), 131-140.
69. S. Ali, Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways, J Biol Chem 273 (1998), 7709-7716.
70. T. Yin, R. Shen, G-S. Feng and Y-C. Yang, Molecular characterization of specific interactions between SHP-2 phosphatase and Jak tyrosine kinases, J Biol Chem 272 (1997), 1032-1037.
71. Y. Yamashita, S. Watanabe, A. Miyazato, K. Ohya, U. Ikeda, K. Shimada, N. Komatsu, K. Hatake, K. Miura, K. Ozawa and H. Mano, Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription, Blood 91 (1998), 1496-1507.
72. F. Dif, E. Saunier, B. Demeneix, P.A. Kelly and M. Edery, Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor, Endocrinology 142 (2001), 5286-5293.
73. S. Tomic, N. Chugtai and S. Ali, SOCS-1, -2, -3 selective targets and functions downstream of the prolactin receptor, Mol Cell Endocrinol 158 (1999), 45-54.
74. A. Pezet, H. Favre, P.A. Kelly and M. Edery, Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling, J Biol Chem 274 (1999), 24497-24502.
75. J.J. Berlanga, J.A. Fresno Vara, J. Martin-Perez and J.P. Garcia-Ruiz, Prolactin receptor is associated with c-Src in rat liver, Mol Endocrinol 9 (1995), 1461-1467.
76. Y. Ito, H. Kawakatsu, T. Takeda, N. Tani, N. Kawaguchi, S. Noguchi, T. Sakai and N. Matsuura, Activation of c-Src is inversely correlated with biological aggressiveness of breast cancer, Breast Ca Res Treat 76 (2002), 261-267.
77. P. Kefalas, T.P. Brown and P.M. Brickell, Signalling by the pp60c-src family of protein-tyrosine kinases, Internanational Journal of Biochemistry and Cell Biology 27 (1995), 551-563.
78. S.A. Courtneidge, Protein tyrosine kinases, with emphasis on the Src family, Cancer Biology 5 (1994), 239-246.
79. M.A. Olayioye, I. Beuvink, K. Horsch, J.M. Daly and N.E. Hynes, ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases, J Biol Chem 274 (1999), 17209-17218.
80. J.A. Fresno Vara, M.V. Carretero, H. Geronimo, K. Ballmer-Hofer and J. Martin-Perez, Stimulation of c-Src by prolactin is independent of Jak2, Biochem J 345 (2000), 17-24.
81. A.B. Kazansky, E.B. Kabotyanski, S.L. Wyszomierski, M.A. Mancini and J.M. Rosen, Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A, J Biol Chem 274 (1999), 22484-22492.
82. J.B. Kline, H. Roehrs and C.V. Clevenger, Functional characterization of the intermediate isoform of the human prolactin receptor, J Biol Chem 274 (1999), 35461-35468.
83. S.D. Heyeck, H.M. Wilcox, S.C. Bunnel and L.J. Berg, Lck phosphorylates the activaiton loop tyrosine of the Itk kinase domain and activates Itk kinase activity, J Biol Chem 272 (1997), 25401-25408.
84. F. Michel, L. Grimaud, L. Tuosto and O. Acuto, Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells, J Biol Chem 273 (1998), 31932-31938.
85. K.A. Al-Sakkaf, P.R.M. Dobson and B.L. Brown, Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidyinositol 3-kinase activation in Nb2 cells, J Mol Endocrinol 19 (1997), 347-350.
86. S. Hunter, E.A. Burton, S.C. Wu and S.M. Anderson, Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase, J Biol Chem 274 (1999), 2097-2106.
87. A. Takesono, L.D. Finkelstein and P.L. Schwartzberg, Beyond calcium, new signaling pathways for Tec family kinases, J Cell Sci 115 (2002), 3039-3048.
88. M. Machide, H. Mano and K. Todokoro, Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain, Oncogene 11 (1995), 619-625.
89. M. Takahashi, M. Hibi, M. Fujitani, T. Fukada, T. Yamaguchi and T. Hirano, Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through Jak, Oncogene 14 (1997), 2273-2282.
90. A. Miyazato, Y. Yamashita, K. Hatake, Y. Miura, K. Ozawa and H. Mano, Tec protein kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor, Cell Growth and Differentiation 7 (1996), 1135-1139.
91. J. Mao, W. Xie, H. Yuan, M. Simon, H. Mano and D. Wu, Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Ga12/13, EMBO J 17 (1998), 5638-5646.
92. R. Bagheri-Yarmand, M. Mandal, A.H. Taludker, R.A. Wang, R.K. Vadlamundi, H.J. Kung and R. Kumar, Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorgenecity of breast cancer cells, J Biol Chem 276 (2001), 29403-29409.
93. C.V. Clevenger, W. Ngo, S.M. Luger and A.M. Gewirtz, Vav is necessary for prolactin-stimutated proliferation and is translocated into the nucleus of a T-cell line, J Biol Chem 270 (1995), 13246-13253.
94. H. Mano, K. Sato, Y. Yazuki and H. Hirai, Tec protein kinase directly associates with Lyn protein tyrosine kinase through its N-terminal unique domain, Oncogene 9 (1994), 3205-3211.
95. D.J. Rawlings, A.M. Scharenberg, H. Park, M.I. Wahl, S. Lin, R.M. Kato, A.-C. Fluckiger, O.N. Witte and J-P. Kinet, Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases, Science 271 (1996), 822-825.
96. K-I. Ohya, S. Kajigaya, Y. Yamashita, A. Miyazato, K. Hatake, Y. Miura, U. Ikeda, K. Shimada, K. Ozawa and H. Mano, SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase, J Biol Chem 272 (1997), 27178-27182.
97. J.E. Darnell, I.M. Kerr and G.R. Stark, JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science 264 (1994), 1415-1421.
98. C.J. Watson, Stat transcription factors in mammary gland development and tumorigenesis, J Mammary Gland Biol Neoplasia 6 (2001), 115-127.
99. C. Bole-Feysot, V. Goffin, M. Edery, N. Binart and P.A. Kelly, Prolactin (PRL) and its receptor, Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice, Endocrine Rev 19 (1998), 225-268.
100. R.S. Chapman, P.C. Lourenco, E. Tonner, D.J. Flint, S. Selbert, K. Takeda, S. Akira, R. Clarke and C.J. Watson, Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3, Genes Dev 13 (1999), 2604-2616.
101. R. Garcia, T.L. Bowman, G. Niu, H. Yu, S. Minton, C.A. Muo-Cacho, C.E. Cox, R. Falcone, R. Fairclough, S. Parsons, A. Laudano, A. Gazit, A. Levitzki, A. Kraker and R. Jove, Constitutive activation of Stat3 by the Src and Jak tryosine kinases participates in growth regulation of human breast cancer cells, Oncogene 20 (2001), 2499-2513.
102. C.J. Watson and W.R. Miller, Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts, Br J Cancer 71 (1995), 840-844.
103. L. Li and P.E. Shaw, Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines, J Biol Chem 277 (2002), 17397-17405.
104. W.M. Burke, X. Jin, H.J. Lin, M. Huang, R. Liu, R.K. Reynolds and J. Lin, Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells, Oncogene 20 (2001), 7925-7934.
105. I. Cotarla, S. Ren, Y. Zhang, E. Gehan, B. Singh and P.A. Furth, Stat5a is activated and nuclear localizaed in a high proportion of human breast cancers, Int J Cancer (2003), in press.
106. M. Onishi, T. Nosaka, K. Misawa, A.L.F. Mui, D.M. Gorman, M. McMahon, A. Miyajima and T. Kitamura, Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation, Mol Cell Biol 18 (1998), 3871-3879.
107. A.V. Kazansky and J.M. Rosen, Signal transducers and activators of transcription 5B potentiates v-Src mediated transformation of NIH-3T3 cells, Cell Growth and Differentiation 12 (2001), 1-7.
108. S. Ren, H.R. Cai, M. Li and P.A. Furth, Loss of Stat5a delays mammary cancer progression in a mouse model, Oncogene 21 (2002), 4355-4339.
109. X. Chen, U. Vinkemeier, Y. Zhao, D. Jerzalmi, J.E. Darnell and J. Kuriyan, Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA, Cell 93 (1998), 827-839.
110. J.E. Darnell, The JAK-STAT pathway, Summary of initial studies and recent advances, Rec Prog Horm Res 51 (1996), 391-404.
111. S.A. Qureshi, S. Leung, I.M. Kerr, G.R. Stark and J.E. Darnell, Function of Stat2 protein in transcriptional activation alpha interferon, Mol Cell Biol 16 (1996), 288-293.
112. T. Decker and P. Kovarik, Serine phosphorylation of STATs, Oncogene 19 (2000), 2628-2637.
113. Z. Wen, Z. Zhong and J.E. Darnell, Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation, Cell 82 (1995), 241-250.
114. H. Yamashita, J. Xu, R.A. Erwin, W.L. Farrar, R.A. Kirken and H. Rui, Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells, J Biol Chem 273 (1998), 30218-30224.
115. C.V. Clevenger, Nuclear localization and function of polypeptide ligands and their receptors, A new paradigm for hormone specificity within the mammary gland? Breast Cancer Research 5 (2003), 181-187.
116. M.A. Rycyzyn, S.C. Reilly, K. O'Malley and C.V. Clevenger, Role of cyclophilin B in PRL signal transduction and nuclear retrotranslocation, Mol Endocrinol 14 (2000), 1175-1186.
117. C.V. Clevenger, A.L. Sillman and M.B. Prystowsky, Interleukin-2 driven nuclear translocation of prolactin in cloned T-lymphocytes, Endocrinology 127 (1990), 3151-3159.
118. M.A. Rycyzyn and C.V. Clevenger, The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer, Proc Natl Acad Sci USA 99 (2002), 6790-6795.