Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

Molecular and Cellular Biology

Volumn 22, Issue 7, 2002, Pages 1998-2010

  Buckley, Deirdre A ^a   Cheng, Alan ^a   Kiely, Patrick A ^a   Tremblay, Michel L ^a   O'Connor, Rosemary ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CLONING, MOLECULAR; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; FIBROBLASTS; GENE DELETION; INSULIN-LIKE GROWTH FACTOR I; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN SUBUNITS; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, IGF TYPE 1; SCHIZOSACCHAROMYCES; TIME FACTORS; WOUND HEALING;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE; SIMIAE; SIMIAN VIRUS 40;

EID: 0036121371     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.7.1998-2010.2002     Document Type: Article

References (62)

1. Structure and function of the type 1 insulin-like growth factor receptor
2. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I
3. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
4. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts
5. The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
6. The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage
7. Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent
8. Differentiation and malignant transformation: Two roads diverged in a wood
9. Oncogenic kinase signalling
10. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
11. Identification of an IGF-IR regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP-tagged IGF-IR
12. Attenuation of adhesion dependent signalling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B
13. PTEN, a unique tumor suppressor gene
14. Cellular survival: A play in three Akts
15. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
16. Proliferation, cell cycle and apoptosis in cancer
17. Association of insulin receptor substrate 1 with simian virus 40 large T antigen
18. Insulin-like growth factors regulate neuronal differentiation and survival
19. Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
20. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
21. Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis
22. The hallmarks of cancer
23. Proteintyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-1-stimulated signaling
24. Clinical review 125: The insulin receptor and its cellular targets
25. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
26. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
27. Transient activation of jun n-terminal kinases and protection from apoptosis by the insulin-like growth factor i receptor can be suppressed by dicumarol
28. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells
29. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways
30. Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis
31. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
32. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1
33. Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9
34. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
35. The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to tumor progression from angiogenic progenitors
36. Survival factors and apoptosis
37. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis
38. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe
39. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
40. Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src
41. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
42. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor
43. High efficiency transformation of Schizosaccharomyces pombe by electroporation
44. Role of insulin receptors and IGF receptors in growth and development
45. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
46. The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis
47. Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity
48. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts
49. A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases
50. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
51. Combinatorial control of the specificity of protein tyrosine phosphatases
52. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
53. Comparison of anti-apoptotic signalling by the insulin receptor and IGF-1 receptor in preadipocytes and adipocytes
54. Insulin-like growth factor I receptor signaling in transformation by src oncogenes
55. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways
56. Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substratetrapping" mutants
57. The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis
58. PTEN controls tumor-induced angiogenesis
59. Regulation of C. elegans life-span by insulinlike signaling in the nervous system
60. Role of the insulin-like growth factor family in cancer development and progression
61. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance
62. Schizosaccharomyces pombe: A model for molecular studies of eukaryotic genes