Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression

Molecular Endocrinology

Volumn 18, Issue 6, 2004, Pages 1333-1345

  Lam, Ni T ^a   Lewis, Jamie T ^a   Cheung, Anthony T ^a   Luk, Cynthia T ^a   Tse, Jeshurun ^a   Wang, Junfeng ^b   Bryer Ash, Michael ^c   Kolls, Jay K ^d   Kieffer, Timothy J ^a,e  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; GLUCOSE; INSULIN; INSULIN RECEPTOR; LEPTIN; PROTEIN TYROSINE PHOSPHATASE 1B;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL STRAIN HEPG2; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN METABOLISM; INSULIN SENSITIVITY; LIVER; LIVER CELL; MALE; MOUSE; MUSCLE LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TISSUE LEVEL;

ADENOVIRIDAE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CELL LINE; CHO CELLS; CRICETINAE; GLUCOSE; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HUMANS; IMMUNOBLOTTING; INSULIN; LEPTIN; LIVER; MICE; MICE, OBESE; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

ANIMALIA;

EID: 2542499538     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0193     Document Type: Article

References (54)

1. Ahima RS, Flier JS 2000 Leptin. Annu Rev Physiol 62:413-437
2. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
5. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
6. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
7. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC 1996 Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93:6231-6235
8. Cohen B, Novick D, Rubinstein M 1996 Modulation of insulin activities by leptin. Science 274:1185-1188
9. Szanto I, Kahn CR 2000 Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proc Natl Acad Sci USA 97:2355-2360
10. Anderwald C, Muller G, Koca G, Furnsinn C, Waldhausl W, Roden M 2002 Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol Endocrlnol 16:1612-1628
11. Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bornfeldt KE 2000 Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 275:11348-11354
12. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB 2000 In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141:2328-2339
13. Elchebly M, Cheng A, Tremblay ML 2000 Modulation of insulin signaling by protein tyrosine phosphatases. J Mol Med 78:473-482
14. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE 1995 Protein-tyrosine- phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci USA 92:664-668
15. Tang TL, Freeman Jr RM, O'Reilly AM, Neel BG, Sokol SY 1995 The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80:473-483
16. Ahmad F, Considine RV, Goldstein BJ 1995 Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. J Clin Invest 95:2806-2812
17. McGuire MC, Fields RM, Nyomba BL, Raz I, Bogardus C, Tonks NK, Sommercorn J 1991 Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans. Diabetes 40:939-942
18. Ahmad F, Azevedo JL, Cortright R, Dohm GL, Goldstein BJ 1997 Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J Clin Invest 100:449-458
19. Worm D, Handberg A, Hoppe E, Vinten J, Beck-Nielsen H 1996 Decreased skeletal muscle phosphotyrosine phosphatase (PTPase) activity towards insulin receptors in insulin-resistant Zucker rats measured by delayed Europium fluorescence. Diabetologia 39:142-148
20. Cheung A, Kusari J, Jansen D, Bandyopadhyay D, Kusari A, Bryer-Ash M 1999 Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus. J Lab Clin Med 134:115-123
21. Kusari J, Kenner KA, Suh KI, Hill DE, Henry RR 1994 Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance. J Clin Invest 93:1156-1162
22. Worm D, Vinten J, Staehr P, Henriksen JE, Handberg A, Beck-Nielsen H 1996 Altered basal and insulin-stimulated phosphotyrosine phosphatase (PTPase) activity in skeletal muscle from NIDDM patients compared with control subjects. Diabetologia 39:1208-1214
23. Worm D, Vinten J, Beck-Nielsen H 1999 The significance of phosphotyrosine phosphatase (PTPase) 1B in insulin signalling. Diabetologia 42:1146-1149
24. Byon JC, Kusari AB, Kusari J 1998 Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol Cell Biochem 182:101-108
25. Kennedy BP, Ramachandran C 2000 Protein tyrosine phosphatase-1B in diabetes. Biochem Pharmacol 60:877-883
26. Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR 2002 PTP-1B anti-sense oligonucleotide lowers PTP-1B protein normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc Natl Acad Sci USA 99:11357-11362
27. Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM 2003 Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52:21-28
28. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan C-C, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP 1999 Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544-1548
29. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB 2000 Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479-5489
30. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252
31. Bjorntorp P 1991 Metabolic implications of body fat distribution. Diabetes Care 14:1132-1143
32. Kissebah AH 1991 Insulin resistance in visceral obesity, Int J Obes 15(Suppl 2):109-115
33. Seufert J, Kieffer TJ, Habener JF 1999 Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci USA 96:674-679
34. Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L 1997 Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100:3105-3110
35. Wang JL, Chinookoswong N, Scully S, Qi M, Shi ZQ 1999 Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 140:2117-2124
36. Levin N, Nelson C, Gurney A, Vandlen R, de Sauvage F 1996 Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93:1726-1730
37. Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J, Wang J 1997 Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272:27758-27763
38. Liu L, Karkanias GB, Morales JC, Hawkins M, Barzilai N, Wang J, Rossetti L 1998 Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J Biol Chem 273:31160-31167
39. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ 1997 Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377
40. Haque MS, Minokoshi Y, Hamai M, Iwai M, Horiuchi M, Shimazu T 1999 Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes 48:1706-1712
41. Hidaka S, Yoshimatsu H, Kondou S, Tsuruta Y, Oka K, Noguchi H, Okamoto K, Sakino H, Teshima Y, Okeda T, Sakata T 2002 Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J 16:509-518
42. Lin CY, Higginbotham DA, Judd RL, White BD 2002 Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am J Physiol 282:E1084-E1091
43. Kieffer T, Habener J 2000 The adipoinsular axis: effects of leptin on pancreatic β-cells. Am J Physiol 278:E1-E14
44. Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ 2003 Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 384:151-159
45. Wang Y, Kuropatwinski KK, White DW, Hawley TS, Hawley RG, Tartaglia LA, Baumann H 1997 Leptin receptor action in hepatic cells. J Biol Chem 272:16216-16223
46. Kenner KA, Hill DE, Olefsky JM, Kusari J 1993 Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. J Biol Chem 268:25455-25462
47. Cheatham B, Kahn CR1995 Insulin action and the insulin signaling network. Endocr Rev 16:117-142
48. White MF 1997 The insulin signalling system and the IRS proteins. Diabetologia 40(Suppl 2):S2-S17
49. Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP, Tremblay ML 2002 Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell 2:497-503
50. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG 2002 PTP1B regulates leptin signal transduction in vivo. Dev Cell 2:489-495.
51. Fraser DC, Srivastava J, Woodward CJ, Simpson AE, Jones RB 1998 A molecular investigation of the obese phenotype in the Aston University strain of ob/ob mice and the Japanese Kuo Kondo mice. Int J Obes Relat Metab Disord 22:193-194
52. Murakami T, Yamashita T, Iida M, Kuwajima M, Shima K 1997 A short form of leptin receptor performs signal transduction. Biochem Biophys Res Commun 231:26-29
53. Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Bryer-Ash M, Cheung AT, Kolls JK, Kikkawa R, Kashiwagi A 2001 Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in 16 myocytes and Fao hepatoma cells. J Biol Chem 276:10207-10211
54. Wang J, Cheung AT, Kolls JK, Starks WW, Martinez-Hernandez A, Dietzen D, Bryer-Ash M 2001 Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo. Diabetes Obes Metab 3:367-380