Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 96 B, Issue 1, 2011, Pages 152-191

  Uskoković, Vuk ^a   Uskoković, Dragan P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE OF TECHNICAL SCIENCES   (Serbia)

Author keywords

bone; calcium phosphate; drug delivery; hydroxyapatite; precipitation; soft chemistry; theranostics

Indexed keywords

AQUEOUS SOLUTIONS; BONE INFECTION; CALCIUM PHOSPHATE NANOPARTICLES; CELL SEPARATION; CONTROLLED DELIVERY; CONTROLLED DRUG RELEASE; DIAGNOSTIC AGENTS; FLUORESCENT MOLECULES; FUNCTIONALIZED; FUNDAMENTAL PROPERTIES; GENE DELIVERY AGENTS; GENE TRANSFECTION; HARD TISSUES; IN-VITRO; IN-VIVO; MAGNETIC IONS; METHODS OF SYNTHESIS; MODERN MEDICINE; NANO-SIZED HYDROXYAPATITE; NANO-SIZED PARTICLES; PHASE TRANSFORMATION; PHOSPHATE CARRIER; PHYSICOCHEMICAL FEATURES; PRECIPITATION; SMART MATERIALS; SOFT CHEMISTRY; THERANOSTICS; THERAPEUTIC AGENTS; ULTRAFINE; ULTRASENSITIVE DETECTION;

APATITE; BIOMATERIALS; BONE; CALCIUM; CHROMATOGRAPHY; DETOXIFICATION; DRUG DELIVERY; GENE THERAPY; GENE TRANSFER; GRAFTS; HYDROXYAPATITE; HYPERTHERMIA THERAPY; MAGNETIC RESONANCE IMAGING; MAMMALS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PEPTIDES; QUALITY CONTROL; RESONANCE;

CALCIUM PHOSPHATE;

AMPHOPHILE; CALCIUM PHOSPHATE; HYDROXYAPATITE; NANOPARTICLE; NUCLEIC ACID; PEPTIDE; PROTEIN;

AQUEOUS SOLUTION; BONE; CELL SEPARATION; DRUG DELIVERY SYSTEM; ENCAPSULATION; GENETIC TRANSFECTION; HUMAN; HYPERTHERMIC THERAPY; NANOMEDICINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL CHEMISTRY; PRECIPITATION; REVIEW; SYNTHESIS; X RAY POWDER DIFFRACTION;

ANIMALS; DRUG DELIVERY SYSTEMS; DURAPATITE; GENE TRANSFER TECHNIQUES; HUMANS; NANOPARTICLES;

EID: 78650019490     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31746     Document Type: Review

References (433)

1. Temenoff JS, Mikos AG,. Biomaterials: the Intersection of Biology and Materials Science. Upper Saddle River, NJ: Prentice Hall; 2008.
2. Park J, Lakes RS,. Biomaterials: An Introduction. Berlin: Springer; 2007.
3. Hench LL,. Science, Faith and Ethics. London: Imperial College Press; 2001.
4. Balać I, Uskoković PS, Aleksić R, Uskoković D,. Predictive modeling of the mechanical properties of particulate hydroxyapatite reinforced polymer composites, J Biomed Mater Res B: Appl Biomater 2002; 63: 793-799.
5. Fratzl P, Weinkamer R,. Nature's Hierarchical Materials, Prog Mater Sci 2007; 52: 1263-1334.
6. Ratner BD, Hoffman AS, Schoen FJ, Lemons JE,. Biomaterials Science: An Introduction to Materials in Medicine, 2nd ed. San Diego, CA: Elsevier Academic Press; 2004.
7. Onuma K,. Recent research on pseudobiological hydroxyapatite crystal growth and phase transition mechanisms. Prog Cryst Growth Charact Mater 2006; 52: 223-245.
8. Hartgerink JD, Beniash E, Stupp SI,. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 2001; 294: 1684-1687.
9. Boyce BF, Xing L,. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008; 473: 139-146.
10. Boyce BF, Xing L,. Biology of RANK, RANKL, and Osteoprotegerin. Arthritis Res Ther 2007; 9 (Suppl 1): S1; 1- 7.
11. Wolff J,. The Law of Bone Remodeling. Berlin: Springer; 1892.
12. Barrere F, Mahmood TA, de Groot K, van Blitterswijk CA,. Advanced biomaterials for skeletal tissue regeneration: instructive and smart functions. Mater Sci Eng R 2008; 59: 38-71.
13. Asefa T, Yoshina-Ishii C, MacLachlan MJ, Ozin GA,. New nanocomposites: putting organic function inside the channel walls of periodic mesoporous silica. J Mater Chem 2000; 10: 1751-1755.
14. Fantner GE, Hassenkam T, Kindt JH, Weaver JC, Birkedal H, Pechenik L, Cutroni JA, Cidade G, AG, Stucky GD, Morse DE, Hansma PK,. Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater 2005; 4: 612-616.
15. Cui F-Z, Ge J,. New observations of the hierarchical structure of human enamel, from nanoscale to microscale. J Tissue Eng Regen Med 2007; 1: 185-191.
16. Fantner GE, Oroudjev E, Schitter G, Golde LS, Thurner P, Finch MM, Turner P, Gutsmann T, Morse DE, Hansma H, Hansma PK,. Sacrificial bonds and hidden length: unraveling molecular mesostructures in tough materials. Biophys J 2006; 90: 1411-1418.
17. Uskoković V,. Nanomaterials and nanotechnologies: approaching the crest of this big wave. Curr Nanosci 2008; 4: 119-129.
18. Nudelman F, Bomans P, Pieterse K, Brylka L, de With G, Sommerdijk N,. Early Stages of Collagen Mineralization Studied by Cryo-TEM: Starting at the Overlap Region? Presented at the Materials Research Society Spring Meeting, San Francisco, CA; 2009.
19. Landis WJ,. Mineral characterization in calcifying tissues: atomic, molecular and macromolecular perspectives. Connective Tissue Res 1996; 34: 239-246.
20. Uskoković V, Bertassoni LE,. Nanotechnology in dental sciences: moving towards a finer way of doing dentistry. Materials 2010; 3: 1674-1691.
21. Ball P,. Water as an active constituent in cell biology. Chem Rev 2008; 108: 74-108.
22. Bertassoni L, Habelitz S, Kinney J, Marshall S, Marshall G,. Biomechanistic perspective on the remineralization of dentin. Caries Res 2009; 43: 70-77.
23. Hoffler CE, Guo XE, Zysset PK, Goldstein SA,. An application of nanoindentation technique to measure bone tissue lamellae properties. J Biomech Eng 2005; 127: 1046-1053.
24. Bembey AK, Bushby AJ, Boyde A, Ferguson VL, Oyen L,. Hydration effects on the micro-mechanical properties of bone. J Mater Res 2006; 21: 1962-1968.
25. Kishen A, Vedantam S,. Hydromechanics in dentine: role of dentinal tubules and hydrostatic pressures on mechanical stress-strain distribution. Dental Mater 2007; 23: 1296-1306.
26. Fawzy AS, Farghaly AM,. Probing nano-scale adhesion force between AFM and acid demineralized intertubular dentin: Moist versus dry dentin. J Dentistry 2009; 37: 963-969.
27. Cooper A,. Thermodynamics of protein folding and stability. In:, Allen G, editor. Protein: A Comprehensive Treatise, Vol. 2, Stamford, CN: JAI Press; 1999. pp 217-270.
28. Shen ZL, Dodge MR, Kahn H, Ballarini R, Eppel SJ,. In Vitro Mechanical Testing of Collagen Nanofibrils, Society for Biomaterials 2010 Annual Meeting and Exposition, Seattle, WA; 2010, presentation #220.
29. Dorozhkin SV,. Calcium Orthophosphates. J Mater Sci 2007; 42: 1061-1095.
30. Uskoković V, Drofenik M,. Synthesis of lanthanum-strontium manganites by oxalate-precursor co-precipitation methods in solution and in reverse micellar microemulsion. J Magn Magn Mater 2006; 303: 214-220.
31. Uskoković V,. Theoretical and practical aspects of colloid science and self-assembly phenomena revisited. Rev Chem Eng 2007; 23: 301-372.
32. Onuma K, Ito A,. Cluster growth model for hydroxyapatite. Chem Mater 1998; 10: 3346-3351.
33. Onuma K,. Recent research on pseudobiological hydroxyapatite crystal growth and phase transition mechanisms. Prog Cryst Growth Charact Mater 2006; 52: 223-245.
34. White TJ, Dong ZL,. Structural derivation and crystal chemistry of apatites. Acta Crystallographia B 2003; 59: 1-16.
35. De Leeuw NH,. Local ordering of hydroxyl groups in hydroxyapatite. Chem Commun 2001; 17: 1646-1647.
36. LeGeros RZ,. Calcium phosphate-based osteoinductive materials. Chem Soc Rev 2008; 108: 4742-4753.
37. Featherstone JD,. Modeling the caries-inhibitory effects of dental materials. Dental Mater 1996; 12: 194-197.
38. Isaacson RL, Varner JA, Jensen KF,. Toxin-induced blood vessel inclusions caused by the chronic administration of aluminum and sodium fluoride and their implications for dementia. Ann NY Acad Sci 1997; 15: 152-166.
39. Garant PR,. Oral Cells and Tissues. Carol Stream, IL: Quintessence; 2003).
40. Yao F, LeGeros J, LeGeros RZ,. Simultaneous incorporation of carbonate and fluoride in synthetic apatites: effect on crystallographic and physico-chemical properties. Acta Biomater 2009; 5: 2169-2184.
41. Porter A, Patel N, Brooks R, Best S, Rushton N, Bonfield W,. Effect of carbonate substitution on the ultrastructural characteristics of hydroxyapatite implants. J Mater Sci: Mater Med 2005; 16: 899-907.
42. Kanno T, Horiuchi JI, Kobayashi M, Motogami Y, Akazawa T,. Characteristics of the carbonate ions incorporated into calcium-partially- strontium-substituted and strontium apatites. J Mater Sci Lett 1999; 18: 1343-1345.
43. Driessens FCM, Verbeeck RMH, Kiekens LP,. Mechanism of substittution in carbonated apatites. Z Anorg Allg Chem 1983; 504: 195-200.
44. Somasundaran P,. Encyclopedia of Surface and Colloid Science. Boca Raton, FL: CRC Press; 2004, pp 567.
45. Barralet J, Best S, Bonfield W,. Carbonate substitution in precipitated hydroxyapatite: An investigation into the effects of reaction temperature and bicarbonate ion concentration. J Biomed Mater Res 1998; 41: 79-86.
46. Rey C, Collins B, Goehl T, Dickson IR, Glimcher MJ,. The Carbonate environment in bone mineral: A resolution-enhanced Fourier transform infrared spectroscopic study. Calcif Tissue Int 1989; 45: 157-164.
47. Emerson WH, Fischer ED,. The infrared absorption spectra of carbonate in calcified tissue. Arch Oral Biol 1962; 7: 671-683.
48. Suetsugu Y, Takanashi Y, Okamura FP, Tanaka J,. Structure analysis of A-type carbonate apatite by a single-crystal X-ray diffraction method. J Solid State Chem 2000; 155: 292-304.
49. Corno M, Rimola A, Bolis V, Ugliengo P,. Hydroxyapatite as a key biomaterial: quantum-mechanical simulation of its surfaces in interaction with biomolecules. Phys Chem Chem Phys 2010; 12: 6309-6329.
50. Tonegawa T, Ikoma T, Yoshioka T, Hanagata N, Tanaka J,. Crystal structure refinement of A-type carbonate apatite by X-ray powder diffraction. J Mater Sci 2010; 45: 2419-2426.
51. Fleet ME, Lui X, King P,. Accommodation of the carbonate ion in apatite: An FTIR and X-Ray structure study of crystals synthesized at 2-4 GPa. Am Mineral 2004; 89: 1422-1434.
52. Shi D,. Introduction to Biomaterials. Singapore: World Scientific Press; 2006.
53. Brown S, Clarke I, Williams P,. Synthesis and characterization of hydroxyapatite and fluoroapatite. Key Eng Mater 2002; 218-2: 35-38.
54. Ignjatović N, Suljovrujić E, Stojanović Z, Uskoković D,. Structure and characteristics of the hot pressed hydroxyapatite/poly- L -lactide composite. Sci Sintering 2002; 34: 79-93.
55. Fang Y, Agrawal DK, Roy DM,. Thermal Stability of Synthetic Hydroxyapatite, In:, Brown PW, Constantz B, editors. Hydroxyapatite and Related Materials. Boca Raton, FL: CRC Press; 1994, pp 269-282.
56. Ignjatović N, Suljovrujić E, Budinski J, Krakovsky I, Uskoković D,. Evaluation of hot pressed hydroxyapatite/poly- L -lactide composite biomaterial characteristics. J Biomed Mater Res Part B: Appl Biomater B 2004; 71: 284-294.
57. Welzel T, Meyer-Zaika W, Epple M,. Continuous preparation of functionalised calcium phosphate nanoparticles with adjustable crystallinity. Chem Commun 2004: 1204-1205.
58. Pretto M, Costa AL, Landi E, Tampieri A, Galassi C,. Dispersing behavior of hydroxyapatite powders produced by wet-chemical synthesis. J Am Ceram Soc 2003; 86: 1534-1539.
59. Gomez-Morales J, Torrent-Burgues J, Boix T, Fraile J, Rodriguez-Clemente R,. Precipitation of stoichiometric hydroxyapatite by a continuous method. Crystal Res Technol 2001; 36: 15-26.
60. Tas AC, Korkusuz F, Timucin M, Akkas N,. An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics. J Mater Sci: Mater Med 1997; 8: 91-96.
61. Ashok M, Kalkura SN, Sundaram NM, Arivuoli D,. Growth and characterization of hydroxyapatite crystals by hydrothermal method. J Mater Sci: Mater Med 2007; 18: 895-898.
62. Janaćković Dj, Janković I, Petrović R, Kostić-Gvozdenović Lj, Milonjić S, Uskoković D,. Surface properties of HAP particles obtained by hydrothermal decomposition of urea and calcium-edta chelates. Key Eng Mater 2003; 240-242: 437-440.
63. Thian ES, Ahmad Z, Huang J, Edirisinghe MJ, Jayasinghe SN, Ireland DC, Brooks RA, Rushton N, Bonfield W, Best SM,. The role of electrosprayed apatite nanocrystals in guiding osteoblast behavior. Biomaterials 2008; 29: 1833-1843.
64. Wu Y, Hench LL, Du J, Choy K-L, Guo J,. Preparation of hydroxyapatite fibers by electrospinning technique. J Am Ceram Soc 2005; 87: 1988-1991.
65. Teshima K, Lee S, Sakurai M, Kameno Y, Yubuta K, Suzuki T, Shishido T, Endo M, Oishi S,. Well-formed one-dimensional hydroxyapatite crystals grown by an environmentally friendly flux method. Crystal Growth Design 2009; 9: 2937-2940.
66. Jokanović V, Uskoković D,. Calcium hydroxyapatite thin films on titanium substrates prepared by ultrasonic spray pyrolysis. Mater Trans 2005; 46: 228-235.
67. Fang Y, Agrawal DK, Roy DM, Roy R, Brown PW,. Ultrasonically accelerated synthesis of hydroxyapatite. J Mater Res 1992; 7: 2294-2298.
68. I. Nikčević, Jokanović V, Mitrić M, Nedić Z, Makovec D, Uskoković D,. Mechanochemical synthesis of nanostructured fluorapatite/ fluorhydroxyapatite and carbonated fluorapatite/fluorhydroxyapa tite. J Solid State Chem 2004; 177: 2565-2574.
69. Rhee S-H,. Synthesis of hydroxyapatite via mechanochemical treatment. Biomaterials 2002; 23: 1147-1152.
70. Lak A, Mazloumi M, Mohajerani MS, Zanganeh S, Shayegh MR, Kajbafvala A, Arami H, Sadrnezhaad SK,. Rapid formation of mono-dispersed hydroxyapatite nanorods with narrow-size distribution via microwave irradiation. J Am Ceram Soc 2008; 91: 3580-3584.
71. Liu J, Li K, Wang H, Zhu M, Yan H,. Rapid formation of hydroxyapatite nanostructures by microwave irradiation. Chem Phys Lett 2004; 396: 429-432.
72. Zhang HG, Zhu Q,. Surfactant-assisted preparation of fluoride-substituted hydroxyapatite nanorods. Mater Lett 2005; 59: 3054-3058.
73. Bose S, Saha SK,. Synthesis and characterization of hydroxyapatite nanopowders by emulsion technique. Chem Mater 2003; 15: 4464-4469.
74. Liu JZ, Gou BD, Xu SJ, Wang K,. Formation of calcium phosphate mineral material controlled by microemulsion. Prog Nat Sci 2002; 12: 615-617.
75. Sarda S, Heughebaert M, Lebugle A,. Influence of the type of surfactant on the formation of calcium phosphate in organized molecular systems. Chem Mater 1999; 11: 2722-2727.
76. Banerjee A, Bandyopadhyay A, Bose S,. Hydroxyapatite nanopowders: Synthesis, densification and cell-materials interaction. Mater Sci Eng C 2007; 27: 729-735.
77. Cheng K, Weng W, Han G, Du P, Shen G, Yang J, Ferreira JMF,. The effect of triethanolamine on the formation of sol-gel derived fluoroapatite/ hydroxyapatite solid solution. Mater Chem Phys 2003; 78: 767-771.
78. Chu CL, Lin PH, Dong S, Guo DY,. Influences of citric acid as a chelating reagent on the characteristics of nanophase hydroxyapatite powders fabricated by a sol-gel method. J Mater Sci Lett 2002; 21: 1793-1795.
79. Gao Y,. Synthesis and Characterization of Calcium Phosphate Coatings by metalorganic Chemical vapor Deposition, Presented at the Materials Research Society Meeting, Boston, MA; 1998.
80. Xu S, Long J, Sim L, Diong CH, Ostrikov K,. RF plasma sputtering deposition of hydroxyapatite bioceramics: Synthesis, performance, and biocompatibility. Plasma Process Polym 2005; 2: 373-390.
81. Watari F, Yokoyama A, Gelinsky M, Pompe W,. Conversion of functions by nanosizing-From osteoconductivity to bone substitutional properties in apatite. In: Interface Oral Health Science 2007, Proceedings of the 2nd International Symposium for Interface Oral Health Science, Sendai, Japan. Berlin: Springer; 2007. pp 139-148.
82. Uskoković V,. Challenges for the modern science in its descend towards nano scale. Curr Nanosci 2009; 5: 372-389.
83. Cai Y, Tang R,. Calcium phosphate nanoparticles in biomineralization and biomaterials. J Mater Chem 2008; 18: 3775-3787.
84. Cai Y, Liu Y, Yan W, Hu Q, Tao J, Zhang M, Shi Z, Tang R,. Role of hydroxyapatite nanoparticle size in bone cell proliferation. J Mater Chem 2007; 17: 3780-3787.
85. Perkin KK, Turner JL, Wooley KL, Mann S,. Fabrication of hybrid nanocapsules by calcium phosphate mineralization of shell cross-linked polymer micelles and nanocages. Nano Lett 2005; 5: 1457-1461.
86. Shchukin DG, Sukhorukov GB, Mohwald H,. Biomimetic fabrication of nanoengineered hydroxyapatite/polyelectrolyte composite shell. Chem Mater 2003; 15: 3947-3950.
87. Kirkham J, Brookes SJ, Shore RC, Wood SR, Smith DA, Zhang J, Chen H, Robinson C,. Physico-chemical properties of crystal surfaces in matrix-mineral interactions during mammalian biomineralisation. Curr Opin Colloid Interface Sci 2002; 7: 124-132.
88. Müller B,. Tailoring biocompatibility: Benefitting patients. Mater Today 2010; 13: 58-58.
89. Rimola A, Corno M, Zicovich CM, -Wilson, Ugliengo P,. Ab Initio modeling of protein/biomaterial interactions: Glycine adsorption at hydroxyapatite surfaces. J Am Chem Soc 2008; 130: 16181-16183.
90. Tamerler C, Sarikaya M,. Molecular Biomimetics-Peptide-Based Materials for Nanotechnology and Medicine, Society for Biomaterials 2010 Annual Meeting & Exposition, Seattle, WA; 2010, Presentation #182.
91. Uskoković V, Kim M-K, Li W, Habelitz S,. Enzymatic processing of amelogenin during continuous crystallization of apatite. J Mater Res 2008; 32: 3184-3195.
92. Ahmad G, Dickerson MB, Church BC, Cai Y, Jones SE, Naik RR, King JS, Summers CJ, Kröger N, Sandhage KH,. Rapid, room-temperature formation of crystalline calcium molybdate phosphor microparticles via peptide-induced precipitation. Adv Mater 2006; 18: 1759-1763.
93. Dickerson MB, Naik RN, Stone MO, Cai Y, Sandhage KH,. Identification of peptides that promote the rapid precipitation of germania nanoparticle networks via use of a peptide display library. Chem Commun (Camb) 2004; 15: 1776-1777.
94. Zhan J, Tseng Y-H, Chan JCC, Mou C-Y,. Biomimetic formation of hydroxyapatite nanorods by a single-crystal-to-single-crystal transformation. Adv Funct Mater 2005; 15: 2005-2010.
95. Huang F, Shen Y, Xie A, Zhu J, Zhang C, Li S, Zhu J,. Study on synthesis and properties of hydroxyapatite nanorods and its complex containing biopolymer. J Mater Sci 2007; 42: 8599-8605.
96. Zhang F, Zhou Z-H, Yang S-P, Mao L-H, Chen H-M, Yu X-B,. Hydrothermal synthesis of hydroxyapatite nanorods in the presence of anionic starburst dendrimer. Mater Lett 2005; 59: 1422-1425.
97. Yan L, Li Y, Deng Z-X, Zhuang J, Sun X,. Surfactant-assisted hydrothermal synthesis of hydroxyapatite nanorods. Int J Inorganic Mater 2001; 3: 633-637.
98. Wang A, Liu D, Yin H, Wu H, Wada Y, Ren M, Jiang T, Cheng X, Xu Y,. Size-controlled synthesis of hydroxyapatite nanorods by chemical precipitation in the presence of organic modifiers. Mater Sci Eng C 2007; 27: 865-869.
99. Walsh D, Kingston JL, Heywood BR, Mann S,. Influence of monosaccharides and related molecules on the morphology of hydroxyapatite. J Crystal Growth 1993; 133: 1-12.
100. Stupp SI, Braun PV,. Molecular manipulation of microstructures: Biomaterials, ceramics, and semiconductors. Science 1997; 277: 1242-1248.
101. Zangi R, Berne BJ,. Aggregation and dispersion of small hydrophobic particles in aqueous electrolyte solutions. J Phys Chem B 2006; 110: 22736-22741.
102. Mann S,. Biomineralization: Principles and concepts in bioinorganic materials chemistry. Oxford, UK: Oxford University Press; 2001.
103. Motskin M, Wright DM, Muller K, Kyle N, Gard TG, Porter AE, Skepper JN,. Hydroxyapatite nano and microparticles: Correlation of particle properties with cytotoxicity and biostability. Biomaterials 2009; 30: 3307-3317.
104. Fan Y, Sun Z, Moradian-Oldak J,. Controlled remineralization of enamel in the presence of amelogenin and fluoride. Biomaterials 2009; 30: 478-483.
105. Uskoković DP,. Fine Particles in Advanced Technology, International Symposium on Advanced Dielectric Materials and Electronic Devices, MS&T 2006 Conference Proceedings, Warrendale, PA. Mater Syst 1; 2006: 599-610.
106. Tanaka Y, Hirata Y, Yoshinaka R,. Synthesis and characterization of ultrafine hydroxyapatite particles. J Ceram Process Res 2003; 4: 197-201.
107. Uskoković V, Drofenik M,. Synthesis of materials within reverse micelles. Surface Rev Lett 2005; 12: 239-277.
108. Uskoković V, Drofenik M,. Reverse micelles: Inert nano-reactors or physico-chemically active guides of the capped reactions. Adv Colloid Interface Sci 2007; 133: 23-34.
109. Ye F, Guo H, Zhang H,. Biomimetic synthesis of oriented hydroxyapatite mediated by nonionic surfactants. Nanotechnology 2008; 19: 245605.
110. Santos C, Rovath CF, Franke R-P, Almeida MM, Costa MEV,. Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system. Ceram Int 2009; 35: 509-513.
111. Chen H, Clarkson BH, Sun K, Mansfield JF,. Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure. J Colloid Interface Sci 2005; 288: 423-431.
112. Cai Y, Pan H, Xu X, Hu Q, Li L, Tang R,. Ultrasonic controlled morphology transformation of hollow calcium phosphate nanospheres. A smart and biocompatible drug release system. Chem Mater 2007; 19: 3081-3083.
113. Ignjatović N, Ninkov P, Ajduković Z, Vasiljević- Radović D, Uskoković D,. Biphasic calcium phosphate coated with poly-d,l-lactide-co-glycolide biomaterial as a bone substitute, J Eur Ceram Soc 2007; 27: 1589-1594.
114. Hornez JC, Chai F, Monchau F, Blanchemain N, Descamps M, Hilderbrand HF,. Biological and physico-chemical assessment of hydroxyapatite (HA) with different porosity. Biomol Eng 2007; 24: 505-509.
115. Hesaraki S, Nemati R,. Caphalexin-loaded injectable macroporous calcium phosphate bone cement. J Biomed Mater Res Part B: Appl Biomater B 2009; 89: 342-352.
116. Ignjatović NL, Ajduković ZR, Savić VP, Uskoković DP,. Size effect of calcium phosphate coated with poly-DL-lactide-co-glycolide on healing processes in bone reconstruction. J Biomed Mater Res Part B: Appl Biomater 2010; 94: 108-117.
117. Watari F, Takashi N, Yokoyama A, Uo M, Akasaka T, Sato Y, Abe A, Totsuoka Y, Tohji K,. Material nanosizing effect on living organisms: non-specific, biointeractive, physical size effects. J Royal Soc Interface 2009; 6: S371-S388.
118. Šupova M, Problem of hydroxyapatite dispersion in polymer matrices: A review. J Mater Sci: Mater in Med 2009; 20: 1201-1213.
119. Jevtić M, Radulović A, Ignjatović N, Mitrić M, Uskoković D,. Controlled assembly of poly(D,L-lactide-co-glycolide)/ hydroxyapatite core-shell nanospheres under ultrasonic irradiation. Acta Biomater 2009; 5: 208-218.
120. Jevtić M, Uskoković D,. Influence of urea as a homogenous precipitation agent on sonochemical hydroxyapatite synthesis. Mater Sci Forum 2007; 555: 285-290.
121. Aizawa M, Porter AE, Best SM, Bonfield W,. Ultrastructural observation of single-crystal apatite fibres. Biomaterials 2005; 26: 3427-3433.
122. Chung SY, Kim YM, Kim JG, Kim YJ,. Multiphase transformation and ostwald's rule of stages during crystallization of a metal phosphate. Nat Phys 2009; 5: 68-73.
123. Beniash E, Metzler RA, Lam RSK, Gilbert PUPA,. Transient amorphous calcium phosphate in forming enamel. J Struct Biol 2009: 166; 133-143.
124. George A,. Protein Template is Required for Nucleation and Orientation of Hydroxyapatite in Bones and Teeth, Presented at the 12th Annual Conference of the Institute of Science and Technology of Ceramics ISTEC-CNR, Faenza; 2009.
125. He G, Dahl T, Veis A, George A, Nucleation of Apatite Crystals in vitro by Self-Assembled Dentin Matrix Protein 1. Nat Mater 2003; 2: 552-558.
126. Gower LB,. Biomimetic model systems for investigating the amorphous precursor pathway and its role in biomineralization. Chem Rev 2008; 108: 4551-4627.
127. Tao J, Pan H, Zeng Y, Xu X, Tang R,. Roles of amorphous calcium phosphate and biological additives in the assembly of hydroxyapatite nanoparticles. J Phys Chem B 2007; 111: 13410-13418.
128. Thompson DW,. On Growth and Form. London, UK: Dover; 1917.
129. Chien YC, Masica DL, Gray JJ, Nguyen S, Vali H, McKee MD,. Modulation of calcium oxalate dihydrate growth by selective crystal-face binding of phosphorylated osteopontin and polyaspartate peptide showing occlusion by sectoral (compositional) zoning. J Biol Chem 2009; 284: 23491-23501.
130. He LH, Swain MV,. Understanding the mechanical behaviour of human enamel from its structural and compositional characteristics. J Mech Behav Biomed Mater 2008; 1: 18-29.
131. Beniash E, Metzler RA, Lam RS, Gilbert PU,. Transient amorphous calcium phosphate in forming enamel. J Struct Biol 166; 2009: 133-143.
132. Cao M, Wang Y, Guo C, Qi Y, Hu C,. Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions. Langmuir 2004; 20: 4784-4786.
133. Smith CE,. Cellular and chemical events during enamel maturation. Critical Rev Oral Biol Med 1998; 9: 128-161.
134. Viney C,. Self-assembly as a route to fibrous materials: Concepts, opportunities and challenges. Curr Opin Solid State Mater Sci 2004; 8: 95-101.
135. Viney C, Bell FI,. Inspiration versus duplication with biomolecular fibrous materials: learning nature's lessons without copying nature's limitations. Curr Opin Solid State Mater Sci 2004; 8: 165-171.
136. Bateson G,. Mind and Nature. Cresskill, NJ: Hampton Presss; 1979.
137. Xu A-W, Ma Y, Cölfen H,. Biomimetic Mineralization. J Mater Chem 2007; 17: 415-449.
138. Orme CA, Giocondi JL,. Model Systems for Formation and Dissolution of Calcium Phosphate Minerals. In:, Behrens P, Bäuerlein E, editors. Handbook of Biomineralization, Vol. 2. Weinheim: Wiley; 2007.
139. Harding IS, Rashid N, Hing KA,. Surface charge and the effect of excess calcium ions on the hydroxyapatite surface. Biomaterials 2005; 26: 6818-6826.
140. Somasundaran P, Wang YHC,. Surface Chemical Characteristics and Adsorption Properties of Apatite. In:, Misra DN, editor. Adsorption on and Surface Chemistry of Apatite. Berlin: Springer; 1984.
141. Bengtsson A, Shchukarev A, Persson P, Sjoberg S,. Phase tranformations, ion-exchange, adsorption, and dissolution processes in aquatic fluoroapatite systems. Langmuir 2009; 25: 2355-2362.
142. Cazalbou S, Combes C, Eichert D, Rey C,. Adaptative physico-chemistry of bio-related calcium phosphates. J Mater Chem 2004; 14: 2148-2153.
143. Campbell AA, LoRe M, Nancollas GH,. The influence of carbonate and magnesium ions on the growth of hydroxyapatite, carbonated apatite and human powdered enamel. Colloids Surf 1991; 54: 25-31.
144. Kanzaki N, Onuma K, Ito A, Teraoka K, Tateishi T, Tsutsumi S,. Direct growth rate measurement of hydroxyapatite single crystal by moire phase shift interferometry. J Phys Chem 1998; 102: 6471-6476.
145. Rouahi M, Champion E, Gallet O, Jada A, Anselme K,. Physico-chemical characteristics and protein adsorption potential of hydroxyapatite particles: Influence on in vitro biocompatibility of ceramics after sintering. Colloids Surf B: Biointerfaces 2006; 47: 10-19.
146. Kim H-M, Himeno T, Kokubo T, Nakamura T,. Process and kinetics of bonelike apatite formation on sintered hydroxyapatite in a simulated body fluid. Biomaterials 2005; 26: 4366-4373.
147. Roseeva EV, Golovanova OA, Frank-Kamenetskaya OV,. The influence of amino acids on the formation of nanocrystalline hydroxyapatite. Glass Phys Chem 33: 283-286.
148. Barroug A, Lemaitre J, Rouxhet PG,. Influence of crystallite size on the surface-properties of calcium-deficient hydroxyapatites. J Alloys Compounds 1992; 188: 152-156.
149. Kosmulski M,. Surface Charging and Points of Zero Charge, Surfactant Science Series 145. Boca Raton, FL: CRC Press, Francis & Taylor; 2009.
150. Zhang Y, Yokogawa Y,. Effect of drying conditions during synthesis on the properties of hydroxyapatite powders. J Mater Sci: Mater Med 2008; 19: 623-628.
151. Yao X, Tan S, Jiang D,. Fabrication of hydroxyapatite ceramics with controlled pore characteristics by slip casting. J Mater Sci: Mater Med 2005; 16: 161-165.
152. Ma J, Liang CH, Kong LB, Wang C,. Colloidal characterization and electrophoretic deposition of hydroxyapatite on titanium substrate. J Mater Sci: Mater Med 2003; 14: 797-801.
153. Sadeghian Z, Heinrich JG, Moztarzadeh F,. Preparation of highly concentrated aqueous hydroxyapatite suspensions for slip casting. J Mater Sci 2005; 40: 4619-4623.
154. Kawasaki T, Niikura M, Kobayashi Y,. Fundamental study of hydroxyapatite high-performance liquid chromatography: II. Experimental analysis on the basis of the general theory of gradient chromatography. J Chromatogr 1990; 515: 91-123.
155. Kandori A, Oda S, Fukusumi M, Morisada Y,. Synthesis of positively charged calcium hydroxyapatite nano-crystals and their adsorption behavior of proteins. Colloids Surfaces B: Biointerfaces 2009; 73: 140-145.
156. Boghak S, Bose S, Bandyopadhyay A,. Electro-Thermally Polarized Hydroxyapatite (HAp) Ceramics: Influence of MgO, SrO, and ZnO Dopants, Society for Biomaterials 2010 Annual Meeting & Exposition, Seattle, WA; 2010, presentation #474.
157. Cai Y, Yao J,. Effect of proteins on the synthesis and assembly of calcium phosphate nanomaterials. Nanoscale 2010; 2: 1842-1848.
158. Shaw DJ,. Introduction to Colloid and Surface Chemistry, Oxford, UK: Butterworth Heinemann; 1992.
159. Dorozhkin SV,. Calcium orthophosphates in nature, biology and medicine, Materials 2009; 2: 399-498.
160. Giocondi JL, Nancollas GH, Chernov AA, Orme C,. Does the Incorporation of Calcium or Phosphate Control the Rate of Brushite Mineralization? Presented at the Materials Research Society Spring Meeting, San Francisco, CA; 2009.
161. Leontidis E,. Hofmeister anion effects on surfactant self-assembly and the formation of mesoporous solids. Curr Opin Colloid Interface Sci 2002; 7: 81-91.
162. Filankembo A, Giorgio S, Lisiecki I, Pileni MP,. Is the anion the major parameter in the shape control of nanocrystals. J Phys Chem B 2003; 107: 7492-7500.
163. Orme CA, Giocondi JL,. The Use of Scanning Probe Microscopy to Investigate Crystal-Fluid Interfaces, In:, Skowronski M, DeYoreo JJ, Wang CA, editors. Perspectives on Inorganic, Organic, and Biological Crystal Growth: From Fundamentals to Applications. Berlin: Springer; 2007.
164. Riddick TM,. Control of Colloid Stability through Zeta Potential and its Relationship to Cardiovascular Disease. Wynnewood, PA: Livingston Publishing; 1968.
165. Ngankam P, Lavalle Ph, Voegel JC, Szyk L, Decher G, Schaaf P, Cuisinier FJG,. Influence of polyelectrolyte multilayer films on calcium phosphate nucleation. J Am Chem Soc 2000; 122: 8998-9005.
166. Qiu SR, Orme CA,. Dynamics of biomineral formation at the near-molecular level. Chem Review 2008; 108: 4784-4822.
167. Bengtsson A, Shchukarev A, Persson P, Sjoberg S,. A solubility and surface complexation study of a non-stoichiometric hydroxyapatite. Geochim Cosmochim Acta 2009; 73: 257-267.
168. Lu X, Leng Y,. Theoretical analysis of calcium phosphate precipitation in simulated body fluid. Biomaterials 2005; 26: 1097-1108.
169. Harding JH, Duffy DM, Sushko ML, Rodger PM, Quigley D, Elliott JA,. Computational techniques at the organic-inorganic interface in biomineralization. Chem Rev 2008; 108: 4823-4854.
170. Pan H, Tao J, Yu X, Fu L, Zhang J, Zeng X, Xu G, Tang R,. Anisotropic demineralization and oriented assembly of hydroxyapatite crystals in enamel: smart structures of biominerals. J Physical Chem B 2008; 112: 7162-7165.
171. van Kemenade MJJM, de Bruyn PL,. A kinetic study of precipitation from supersaturated calcium phosphate solutions. J Colloid Interface Sci 2001; 118: 564-585.
172. Szczes A, Holysz L, Chibowski E,. Influence of magnetic field on the properties of freshly precipitated calcium phosphate: implication in adhesion to glass surface. J Adhes Sci Technol 2006; 20: 345-358.
173. 3 using permanent magnets. Chem Eng Sci 2008; 63: 5606-5612.
174. Tai CY, Chang MC, Shieh RJ, Chen TG,. Magnetic effects on crystal growth rate of calcite in a constant-composition environment. J Crystal Growth 2008; 310: 3690-3697.
175. Gavira JA, Garca-Ruiz Jma,. Effects of a magnetic field on lysozome crystal nucleation and growth in a diffusive environment. Crystal Growth Design 2009; 9: 2610-2615.
176. Sikirić MD, Furedi-Milhofer H,. The influence of surface active molecules on the crystallization of biominerals in solution. Adv Colloid Interface Sci 2006; 128-130: 135-158.
177. Posner AS, Betts F, Blumenthal NC,. Formation and structure of synthetic and bone hydroxyapatite. Prog Crystal Growth Character Mater 1980; 3: 49-64.
178. Brecević Lj, Hlady V, Furedi-Milhofer H,. Influence of gelatin on the precipitation of amorphous calcium phosphate. Colloids Surf 1987; 28: 301-313.
179. Melikhov IV,. Crystallization Behavior of Nanodisperse Phases. Inorg Mater 2000; 36: 278-286.
180. Lazić S,. Microcrystalline hydroxyapatite formation from alkaline solutions. J Crystal Growth 1995; 147: 147-154.
181. Privman V, Goia DV, Park J, Matijević E,. Mechanism of formation of monodispersed colloids by aggregation of nanosize precursors. J Colloid Interface Sci 1999; 213: 36-45.
182. Privman V,. Growth of nanosize and colloid particles by controlled addition of singlets. Mater Res Soc Symp Proc 2002; 703: 577-585.
183. Privman V,. Mechanisms of diffusional nucleation of nanocrystals and their self-assembly into uniform colloids. Ann NY Acad Sci 2009; 1161: 508-526.
184. Matijević E,. Nanosize precursors as building blocks for monodispersed colloids. Colloid J 2007; 69: 29-38.
185. Oh M, Mirkin CA,. Chemically tailorable colloidal particles from infinite coordination polymers. Nature 2005; 438: 651-654.
186. Robb DT, Halaciuga I, Privman V, Goia DV,. Computational model for the formation of uniform silver spheres by aggregation of nanosize precursors. J Chem Phys 2008; 129: 184705.
187. Cho K-S, Talapin DV, Gaschler W, Murray CB,. Designing PbSe nanowires and
188. Alivisatos P,. Chemical Transformations in Nanocrystals, Presented at the Materials Research Society Spring Meeting, San Francisco, CA; 2009.
189. Jokanović V, Nikčević I, Dačić B, Uskoković D,. Synthesis of nanostructured carbonated calcium hydroxyapatite by ultrasonic spray pyrolysis. J Ceram Process Res 2004; 5: 157-162.
190. Chow LC, Sun L,. Properties of nanostructured hydroxyapatite prepared by a spray drying technique. J Res Natl Inst Stand Techol 2004; 109: 543-551.
191. Liu C, Huang Y, Shen W, Cui J,. Kinetics of hydroxyapatite precipitation at pH 10 to 11. Biomaterials 2001; 22: 301-306.
192. Lazić S, Katanić-Popović J, Zec S, Miljević N,. Properties of hydroxyapatite crystallized from high temperature alkaline solutions. J Crystal Growth 1996; 165: 124-128.
193. Lazić S, Zec S, Miljević N, Milonjić S,. The effect of temperature on the properties of hydroxyapatite precipitated from calcium hydroxide and phosphoric acid. Thermochim Acta 2001; 374: 13-22.
194. Larsen MJ,. Ion products and solubility of calcium phosphates. Denmark: Royal Dental College; 2001.
195. Kibalczyc W, Zielenkiewicz A, Zielenkiewicz W,. Calorimetric investigations of calcium phosphate precipitation in relation to solution composition and temperature. Thermochim Acta 1988; 131: 47-55.
196. Termine JD, Eanes ED,. Comparative chemistry of amorphous and apatitic calcium phosphate preparation. Calcified Tissue Res 1972; 10: 171-197.
197. Meyer JL, Weatherall CC,. Amorphous to crystalline calcium phosphate transformation at elevated pH. J Colloid Interface Sci 1982; 89: 257-267.
198. Marshall AF, Lawless KR,. TEM study of the central dark line in enamel crystallites. J Dental Res 1981; 60: 1773-1782.
199. Fernandez ME, Reyes-Gasga J,. A model for human tooth enamel central dark line its HRTEM images contrast transfer function analysis. Microsc Microanal 2003; 9 (Suppl 2): 1290-1291.
200. Reyes-Gasga J, Alcantara-Rodriguez CM,. Structural analysis of the human tooth enamel by transmission electron microscopy. In:, Brown PW, Constantz B, editors. Hydroxyapatite and Related Materials. Boca Raton, FL: CRC Press; 1994. pp 295-304.
201. Brown WE, Mathew M, Chow LC,. Roles of OCP in surface chemistry of apatites. In:, Dwarika Misra N, editor. Adsorption on and Surface Chemistry of Apatites. Berlin: Springer; 1984.
202. Chaari K, Baklouti S, Bouaziz J, Bouzouita K,. Optimizing the dispersion of a fluoroapatite suspension using penta sodium triphosphate. Ann Chimie Sci Materiaux 2004; 29: 1-13.
203. Yin G, Liu Z, Zhan J, Ding F, Yuan N,. Impacts of the surface charge property on protein adsorption on hydroxyapatite. Chem Eng J 2002; 87: 181-186.
204. Smith IO, Baumann MJ, McCabe LR,. Electrostatic interactions as a predictor for osteoblast attachment to biomaterials. J Biomed Mater Res A 2004; 70: 436-441.
205. Feenstra TP, de Bruyn PL,. The Ostwald rule of stages in precipitation from highly supersaturated solutions: A model and its application to the formation of the nonstoichiometric amorphous calcium phosphate precursor phase. J Colloid Interface Sci 1981; 84: 66-72.
206. Boskey AL, Posner AS,. Conversion of amorphous calcium phosphate to microcrystalline hydroxyapatite. A pH-dependent, solution-mediated, solid-solid conversion. J Phys Chem 1973; 77: 2313-2317.
207. Martin RI, Brown PW,. Aqueous formation of hydroxyapatite. J Biomed Mater Res 1997; 35: 299-308.
208. Meier W,. Nanostructure synthesis using surfactants and copolymers. Curr Opin Colloid Interface Sci 1999; 4: 6-14.
209. oC. J Biomed Mater Res B: Appl Biomater B 2003; 67: 632-637.
210. 2O. J Biomed Mater Res 1997; 36: 233-241.
211. Uskoković V, Drofenik M,. Synthesis of nanocrystalline nickel-zinc ferrites via a microemulsion route. Mater Sci Forum 2004; 453-454: 225-230.
212. Uskoković V, Drofenik M,. A mechanism for the formation of nanostructured nizn ferrites via a microemulsion-assisted precipitation method. Colloids Surf A: Physicochem Eng Aspects 2005; 266: 168-174.
213. Robbins H,. The preparation of Mn-Zn ferrites by co-precipitation. In: Watanabe H, Iida S, Sugimoto M, editors. Proceedings of the 3rd International Conference on Ferrites. Tokyo: Reidel; 1982. pp 7-10.
214. Grier DG,. When like-charges attract: Interactions and dynamics in charge-stabilized colloidal suspensions. J Phys Condens Matter 2000; 12: A85-A94.
215. Grier DG,. Colloids: A surprisingly attractive couple. Nature 1998; 393: 621.
216. Kunz W, Lo Nostro P, Ninham BW,. The present state of affairs with Hofmeister effects. Curr Opin Colloid Interface Sci 2004; 9: 1-18.
217. Edwards SA, Williams DRM,. Hofmeister effects in colloid science and biology explained by dispersion forces: Analytic results for the double layer interaction. Curr Opin Colloid Interface Sci 2004; 9: 139-144.
218. Ninham B,. Self-Assembly-Some Thoughts, In:, Robinson BH, editor. Self-Assembly. Amsterdam: IOS Press; 2003.
219. Cölfen H, Mann S,. Higher-order organization by mesoscale self-assembly and transformation of hybrid nanostructures. Angew Chem Int Ed Engl 2003; 42: 2350-2365.
220. Uskoković V,. Trends in Practical Colloid Science., Hauppauge, NY,: Nova Science Publishers; 2009.
221. De Aza PN, Guitian F, Merlos A, Lora-Tamayo E, De Aza S,. Bioceramics-Simulated body fluid interfaces: pH and its influence of hydroxypatite formation. J Mater Sci: Mater Med 1996; 7: 399-402.
222. Canham LT, Reeves CL, Loni A, Houlton MR, Newey JP, Simons AJ, Cox TI,. Calcium phosphate nucleation on porous silicon: Factors influencing kinetics in acellular simulated body fluids. Thin Solid Films 1997; 297: 304-307.
223. Kokubo T, Takadama H,. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 2006; 27: 2907-2915.
224. Melikhov IV, Lazić S, Vuković Ž,. The effect of dissolved impurity on calcium phosphate nucleation in supersaturated medium. J Colloid Interface Sci 1989; 127: 317-327.
225. Budz JA, LoRe M, Nancollas GH,. Hydroxyapatite and carbonated apatite as models for the dissolution behavior of human dental enamel. Adv Dental Res 1987; 1: 314-321.
226. Wang L, Guan X, Du C, Moradian-Oldak J, Nancollas GH,. Amelogenin promotes the formation of elongated apatite microstructures in a controlled crystallization system, J Phys Chem C 2007; 111: 6398-6404.
227. Tarasevich BJ, Howard CJ, Larson JL, Snead ML, Simmer JP, Paine M, Shaw WJ,. The nucleation and growth of calcium phosphate by amelogenin. J Crystal Growth 2007; 304: 407-415.
228. Wu W, Nancollas GH,. Kinetics of nucleation and crystal growth of hydroxyapatite and fluoroapatite on titanium oxide surfaces. Colloids Surf B: Biointerfaces 1997; 10: 87-94.
229. Koutsopoulos S, Dalas E,. Hydroxyapatite crystallization in the presence of serine, tyrosine and hydroxyproline amino acids with polar side groups. J Crystal Growth 2000; 216: 443-449.
230. Wagner RS, Ellis WC,. Vapor-liquid-solid mechanism of single crystal growth. Appl Phys Lett 1964; 4: 89-90.
231. Sivakov VA, Scholz R, Syrowatka F, Falk F, Gosele U, Christiansen SH,. Silicon nanowire oxidation: The influence of sidewall structure and gold distribution. Nanotechnology 2009; 20(40): 5607.
232. Zhang JW, Nancollas GH,. Mechanisms of growth and dissolution of sparingly soluble salts. In:, Hochella MF, Jr., White AF, editors. Mineral-Water Interface Geochemistry, Reviews in Mineralogy, 1990; Vol. 23, Washington D.C.: Mineralogical Society of America. pp 365-396.
233. Moradian-Oldak J,. Amelogenins: Assembly, processing and control of crystal morphology. Matrix Biol 2001; 20: 293-305.
234. De Yoreo JJ, Vekilov PG,. Principles of crystal nucleation and growth. Rev Mineral Geochem 2003; 54: 57-93.
235. Uskoković V,. Isn't self-assembly a misnomer? Multi-disciplinary arguments in favor of co-assembly. Adv Colloid Interface Sci 2008; 141: 37-47.
236. Mutaftschiev B,. The Atomistic Nature of Crystal Growth. Berlin: Springer; 2001.
237. A Saenz, Montero ML, Mondragon G, Rodriguez-Lugo V, Castano VM,. Effect of pH on the precipitation of hydroxyapatite on silica gels. Mater Res Innovation 2003; 7: 68-73.
238. Hayakawa S, Li Y, Tsuru K, Osaka A, Fujii E, Kawabata K,. Preparation of nanometer-scale rod array of hydroxyapatite crystal. Acta Biomater 2009; 5: 2152-2160.
239. Tomoda K, Ariizumi H, Nakaji T, Makino K,. Hydroxyapatite particles as drug carriers for proteins. Colloids Surf B: Biointerfaces 2010; 76: 226-235.
240. Koutsopoulos S,. Synthesis and characterization of hydroxyapatite crystals: A review study on the analytical methods. Int J Biomed Mater Res 2002; 62: 600-612.
241. Barth A, Zscherp C,. What vibrations tell us about proteins. Quart Rev Biophys 2002; 35: 369-430.
242. Tsuda H, Arends J,. Raman spectra of human dental calculus. J Dental Res 1993; 72: 1609-1613.
243. Tsuda H, Arends J,. Raman spectroscopy in dental research: A short review of recent studies. Adv Dental Res 1997; 11: 539-547.
244. 3 vibrational modes in synthetic and biological apatites. Calcif Tissue Int 1998; 63: 475-481.
245. Awonusi A, Morris DM, Tecklenburg MJ,. Carbonate assignment and calibration in the Raman spectrum of apatite. Calcif Tissue Int 2007; 81: 46-52.
246. Gibson IR, Bonfield W,. Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite. J Biomed Mater Res 2002; 59: 697-708.
247. LeGeros RZ, Trautz OR, Klein E, LeGeros JP,. Two types of carbonate substitution in the apatite structure. Experimentia 1969; 25: 5-7.
248. Rey C, Renugopalakrishnan V, Collins B, Glimcher MV,. Fourier transform infrared spectroscopic study of the carbonate ions in bone mineral during aging. Calcif Tissue Int 1991: 49; 251-258.
249. Wopenka B, Pasteris JD,. A mineralogical perspective on the apatite in bone. Mater Sci Eng C 2005; 25: 131-143.
250. Schroder E, Jonsson T, Poole L,. Hydroxyapatite chromatography: Altering the phosphate-dependent elution profile of protein as a function of pH. Anal Biochem 2003; 313: 176-178.
251. Giovannini R, Freitag R,. Comparison of different types of ceramic hydroxyapatite for the chromatographic separation of plasmid DNA and a recombinant anti-rhesus D antibody. Bioseparation 2000; 9: 359-368.
252. Fujii S, Okada M, Furuzono T,. Hydroxyapatite nanoparticles as stimulus-responsive particulate emulsifiers and building block for porous materials. J Colloid Interface Sci 2007; 315: 287-296.
253. Phandugath C,. Casein micelle structure: A concise review. Songklanakarin J Sci Technol 2005; 27: 201-212.
254. Sas L, Tang C, Rengel Z,. Suitability of hydroxyapatite and iron phosphate as P sources for Lupinus albus grown in nutrient solution. Plant Soil 2001; 235: 159-166.
255. Reichert J, Binner JGP,. An evaluation of hydroxyapatite-based filters for removal of heavy metal ions from aqueous solutions. J Mater Sci 2004; 31: 1231-1241.
256. Uskoković V,. Nanotechnologies: What we do not know. Technol Soc 2007; 29: 43-61.
257. Yang L, Sheldon BW, Webber TJ,. Nanophase ceramics for improved drug delivery. Am Ceram Soc Bull 2010; 89: 24-31.
258. Duncan R,. Nanomedicine gets clinical. Materials Today 2005; 8 (Suppl1): 16-17.
259. Bawa R,. Nanoparticles-based therapeutics in humans. Nanotechnol Law Business 2008; 5: 135-155.
260. Caruthers SD, Wickline SA, Lanza GM,. Nanotechnological applications in medicine. Curr Opin Biotechnol 2007; 18: 26-30.
261. Zhang J-Y, Shen Z-G, Zhong J, Hu T-T, Chen J-F, Ma Z-Q, Yun J,. Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants. Int J Pharm 2006; 323: 153-160.
262. Branco MC, Schneider JP,. Self-assembling materials for therapeutic delivery. Acta Biomater 2009; 5: 817-831.
263. Korenstein R,. Targeted drug delivery by nanoparticles and theranostics, Presentation retrieved from; 2009.
264. Bisht S, Bhakta G, Mitra S, Maitra A,. DNA loaded calcium phosphate nanoparticles: Highly efficient non-viral vector for gene delivery. Int J Pharm 2005; 288: 157-168.
265. Zhang M, Kataoka K,. Nano-structured composites based on calcium phosphate for cellular delivery of therapeutic and diagnostic agents. Nano Today 2009; 4: 508-517.
266. Epple M, Ganesan K, Heumann R, Klesing J, Kovtun A, Neumann S, Sokolova V,. Application of calcium phosphate nanoparticles in biomedicine. J Mater Chem 2010; 20: 18-23.
267. Wiethoff CM, Middaugh CR,. Barriers to nonviral gene delivery. J Pharm Sci 2003; 92: 203-217.
268. Roszek B, de Jong WH, Geertsma RE,. Nanotechnology in medical applications: State-of-the-art in materials and devices. RIVM Report 265001001; 2005.
269. Zhang Q, Zhao D, Zhang X-Z, Cheng S-X, Zhuo R-X,. Calcium phosphate/DNA co-precipitates encapsulated fast-degrading polymer films for substrate-mediated gene delivery. Int J Biomed Mater Res Part B: Appl Biomater B 2009; 91: 172-180.
270. Watson A, Latchman D,. Gene delivery into neuronal cells by calcium phosphate-mediated transfection. Methods 1996; 10: 289-291.
271. Chowdhury EH, Akaike T,. Fibronectin-coated nano-precipitates of calcium-magnesium phosphate for integrin-targeted gene delivery. J Control Release 2006; 116: e68-e69.
272. Okazaki M, Yoshida Y, Yamaguchi S, Kaneno M, Elliott JC,. Affinity binding phenomena of DNA onto apatite crystals. Biomaterials 2001; 22: 2459-2464.
273. Olton D, Li J, Wilson ME, Rogers T, Close J, Huang L, Kumta PN, Sfeir C,. Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: Influence of the synthesis parameters on transfection efficiency. Biomaterials 2007; 28: 1267-1279.
274. Faraji AH, Wipf P,. Nanoparticles in cellular drug delivery. Bioorg Med Chem 2009; 17: 2950-2963.
275. Kester M, Heakal Y, Fox T, Sharma A, Robertson GP, Morgan TT, Altinoglu EI, Tabakovic A, Parette MR, Rouse SM, Ruiz-Velasco V, Adair JH,. Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells. Nano Lett 2008; 8: 4116-4121.
276. Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TGG, Wright CJ, Doak SH,. NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials. Biomaterials 2009; 30: 3891-3914.
277. Cölfen H, Mann S,. Higher-order organization by mesoscale self-assembly and transformation of hybrid nanostructures. Angew Chemie Int Ed: Engl 2003; 42: 2350-2365.
278. Dorozhkin SV,. A hierarchical structure for apatite crystals. J Mater Sci: Mater Med 2007; 18: 363-366.
279. Lim GK, Wang J, Ng SC, Gan LM,. Processing of fine hydroxyapatite powders via an inverse microemulsion route. Mater Lett 1996; 28: 431-436.
280. Ball V, Planeix J-M, Flix O, Hemmerl J, Schaaf P, Hosseini MW, Voegel JC,. Molecular tectonics: Abiotic control of hydroxyapatite crystals morphology. Crystal Growth Design 2002; 2: 489-492.
281. Jevtić M, Mitrić M, Škapin S, Jančar B, Ignjatović N, Uskoković D,. Crystal structure of hydroxyapatite nano-rods synthesized by sonochemical homogenous precipitation. Crystal Growth Design 2008; 8: 2217-2222.
282. Fowler CE, Li M, Mann S, Margolis HC,. Influence of surfactant assembly on the formation of calcium phosphate materials-A model for dental enamel formation. J Mater Chem 2005; 15: 3317-3325.
283. Wang P, Li C, Gong H, Jiang X, Wang H, Li K,. Effects of synthesis conditions on the morphology of hydroxyapatite nanoparticles produced by wet chemical process. Powder Technol 2010; 203: 315-321.
284. Uskoković V,. Insights into morphological nature of precipitation of cholesterol. Steroids 2008; 73: 356-369.
285. Fischer EK, Aleman BJ, Tao SL, Hugh Daniels R, Li EM, Bunger MD, Nagaraj G, Singh P, Zettl A, Desai TA,. Biomimetic nanowire coatings for next generation adhesive drug delivery systems. Nano Lett 2009; 9: 716-720.
286. Ducheyne P, Radin S, King L,. The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. J Biomed Mater Res 1993; 27: 25-34.
287. Yamada S, Heymann D, Bouler JM, Daculsi G,. OSteoclastic resorption of calcium phosphate ceramic with different hydroxyapatite/β-tricalcium phosphate ratios. Biomaterials 1997; 18: 1037-1041.
288. Melville AJ, Rodriguez-Lorenzo LM, Forsythe JS,. Effects of calcination temperature on the drug delivery behaviour of ibuprofen from hydroxyapatite powders. J Mater Sci: Mater Med 2008; 19: 1187-1195.
289. Raynaud S, Champion E, Bernache-Assollant D,. Characterization of hydroxyapatite-tricalcium phosphate bioceramics issued from Ca-deficient hydroxyapatite powders: Influence of Ca/P ratio. Phosphorus Res Bull 1999; 10: 214-218.
290. Raynaud S, Champion E, Bernache-Assollant D, Thomas P,. Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders. Biomaterials 2002; 23: 1065-1072.
291. Gamble W,. Atherosclerosis: The carbonic anhydrase, carbon dioxide, calcium concerted theory. J Theor Biol 2006; 239: 16-21.
292. Uskoković V,. Surface charge effects involved in the control of stability of sols comprising uniform cholesterol particles. Mater Manuf Process 2008; 23: 620-623.
293. Craven BM,. Crystal structure of cholesterol monohydrate. Nature 1976; 260: 727-729.
294. Dorozhkin SV, Epple M,. Biological and medical significance of calcium phosphates. Angew Chem Int Ed 2002; 41: 3130-3146.
295. Sumer B, Gao J,. Theranostic nanomedicine for cancer. Nanomedicine 2008; 3: 137-140.
296. Boccaccini AR, Blaker JJ,. Bioactive composite materials for tissue Engineering Scaffolds. Expert Rev Med Dev 2005; 2: 303-317.
297. Wahl DA, Sachlos E, Liu C, Czernuszka JT,. Controlling the processing of collagen-hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci: Mater Med 2007; 18: 201-209.
298. Best S,. Nanostructured Apatites: The Next Generation of Bioactive Materials, Presented at the 10th YUCOMAT Conference in Herceg-Novi, Montenegro (2008).
299. Yan W-Q, Nakamura T, Kobayashi M, Kim H-M, Miyaji F, Kokubo T,. Bonding of chemically treated titanium implants to bone. J Biomed Mater Res A 1998; 37: 267-275.
300. Cui F-Z, Jiang T-F,. Tissue-Engineered Bone. In: Wiley Encyclopedia of Biomedical Engineering. New York, NY: Wiley; 2009.
301. Best SM, Porter AE, Thian ES, Huang J,. Bioceramics: Past, present and for the future. J Eur Ceram Soc 2008; 28: 1319-1327.
302. Ignjatović N, Liu C, Czernuszka J, Uskoković D,. Micro and nano/injectable composite biomaterials containing calcium phosphate coated with poly(dl-lactide-co-glycolide). Acta Biomater 2007; 3: 927-935.
303. Daculsi G, Uzel AP, Weiss P, Goyenvalle E, Aguado E,. Developments in injectable multiphasic biomaterials. The performance of microporous biphasic calcium phosphate granules and hydrogels. J Mater Sci: Mater Med 2010; 21: 855-861.
304. Doty H, Haggard W, Courtney H, Bumgardner J,. Effectiveness of a dual drug delivery calcium sulfate, chitosan-calcium phosphate bone scaffold, Society for Biomaterials 2010 Annual Meeting & Exposition, Seattle, WA; 2010, presentation #677.
305. Combes C, Rey C,. Amorphous calcium phosphates: synthesis, properties and uses in biomaterials. Acta Biomater 2010; 6: 3362-3378.
306. Huang J, Lin YW, Fu XW, Best SM, Brooks RA, Rushton N, Bonfield W,. Development of nano-sized hydroxyapatite reinforced composites for tissue engineering scaffolds. J Mater Sci: Mater Med 2007; 18: 2151-2157.
307. Zheng X, Zhou S, Xiao Y, Yu X, Feng B,. In situ preparation and characterization of a novel gelatin/poly(D, L-Lactide)/hydroxyapatite nanocomposite. J Biomed Mater Res Part B: Appl Biomater B 2009; 91: 181-190.
308. Ignjatović N, Tomić S, Dakić M, Miljković M, Plavšić M, Uskoković D,. Synthesis and properties of hydroxyapatite/poly- L -lactide composite biomaterials. Biomaterials 1999; 20: 809-816.
309. Ignjatović N, Ninkov P, Kojić V, Bokurov M, Srdić V, Krnojelac D, Selaković S, Uskoković D,. Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphate/poly-dl-lactide-co-glycolide biocomposites and different phosphate materials. Microsc Res Tech 2006; 69: 976-982.
310. Vukomanović M, Mitrić M, Šapin SD, Žagar E, Plavec J, Ignjatović N, Uskoković D,. Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide -co-glycolide) alone and in its biocomposite with hydroxyapatite. Ultrasonics Sono Chem 2010; 17: 902-908.
311. Stevanović M, Maksin T, Petković J, Filipič M, Uskoković D,. An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. Nanotechnology 2009; 20: 335102.
312. Uskoković V, Ignjatović N, Petranović N,. Synthesis and characterization of hydroxyapatite-collagen biocomposite materials. Mater Sci Forum 2003; 413: 269-274.
313. Kretlow JD, Young S, Klouda L, Wong M, Mikos AG,. Injectable biomaterials for regenerating complex craniofacial tissues. Adv Mater 2009; 21: 1-26.
314. Miyai T, Ito A, Tamazawa G, Matsuno T, Sogo Y, Nakamura C, Yamazaki A, Satoh T,. Antibiotic-loaded poly-e-caprolactone and porous b-tricalcium phosphate composite for treating osteomyelitis. Biomaterials 2008; 29: 350-358.
315. Martins VCA, Goissis G, Ribeiro AC, Marcantonio E, Jr., Bet MR,. The controlled release of antibiotic by hydroxyapatite: Anionic collagen composites. Artif Organs 1998; 22: 215-221.
316. Rauchmann MA, Wichelhaus TA, Stirnal V, Dingeldein E, Zichner L, Schnettler R, Alt V,. Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections. Biomaterials 2005; 26: 2677-2684.
317. El-Kamel A, Baddour M,. Gatifloxacin biodegradable implant for treatment of experimental osteomyelitis: In vitro and in vivo evaluation. Drug Deliv 2007; 14: 349-356.
318. Ignjatović NL, Ninkov P, Sabetrasekh R, Uskoković DP,. A novel nano drug delivery system based on tigecycline-loaded calcium phosphate coated with poly-DL-lactide-co-glycolide. J Mater Sci: Mater Med 2010; 21: 231-239.
319. Hylands J,. Tigecycline: A new antibiotic. Intensive Critic Care Nurs 2008; 24: 260-263.
320. Nandi SK, Kundu B, Ghosh SK, Mandal TK, Datta S, De DK, Basu D,. Cefuroxime-impregnated calcium phosphates as an implantable delivery system in experimental osteomyelitis. Ceram Int 2009; 35: 1367-1376.
321. Xu QG, Czernuszka JI,. Controlled release of amoxicillin from hydroxyapatite-coated poly(lactic-co-glycolic acid) microspheres. J Control Release 2008; 127: 146-153.
322. Xu QG, Tanaka Y, Czernuszka JT,. Encapsulation and release of a hydrophobic drug from hydroxyapatite coated liposomes. Biomaterials 2007; 28: 2687-2694.
323. Victor SP, Kumar TSS,. Tailoring calcium-deficient hydroxyapatite nanocarriers for enhanced release of antibiotics. J Biomed Nanotechnol 2008; 4: 203-209.
324. Stevanović M, Radulović A, Jordović B, Uskoković D,. Poly(DL-lactide-co-glycolide) nanospheres for the sustained release of folic acid. J Biomed Nanotechnol 2008; 4: 349-358.
325. Stevanović MM, Jordović B, Uskoković DP,. Preparation and characterization of poly(D,L-lactide-co-glycolide) microparticles containing ascorbic acid. J BioMed Biotechnol 2007: 1-9. Article ID 84965; 2007.
326. Stevanović M, Savić J, Jordović B, Uskoković D,. Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid. Colloids Surf B: Biointerfaces 2007; 59: 215-223.
327. Stevanović M, Uskoković D,. Influence of different degradation medium on release of ascorbic acid from poly(D,L-lactide-co- glycolide) nano- and microspheres. Russian J Phys Chem A 2009; 83: 1457-1460.
328. Nehilla BJ, Bergkvist M, Popat KC, Desai TA,. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. Int J Pharm 2008; 348: 107-114.
329. Schmidt HT, Gray BL, Wingert PA, Ostafin AE,. Assembly of aqueous-cored calcium phosphate nanoparticles for drug delivery. Chem Mater 16: 4942-4947.
330. Ma MY, Zhu YJ, Li L, Cao SW,. Nanostructured porous hollow ellipsoidal capsules of hydroxyapatite and calcium silicate: Preparation and aplication in drug delivery. J Mater Chem 2008; 18: 2722-2727.
331. Akasha AA, Sotiriadou I, Doss MX, Halbach M, Winkler J, Baunach JJS, Katsen-Glob A, Zimmermann H, Chood Y, Hescheler J, Sachinidis A,. Entrapment of embryonic stem cells-derived cardiomyocytes in macroporous biodegradable microspheres: Preparation and characterization. Cell Physiol Biochem 2008; 22: 665-672.
332. Tielens S, Declercq H, Gorski T, Lippens E, Schacht E, Cornelissen M,. Gelatin-based microcarriers as embryonic stem cell delivery system in bone tissue engineering: An in-vitro study. Biomacromolecules 2007; 8: 825-832.
333. Ashton RS, Banerjee A, Punyani S, Schaffer DV, Kane RS,. Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials 2007; 28: 5518-5525.
334. Liao S, Chan CK, Ramakrishna S,. Stem cells and biomimetic materials strategies for tissue engineering. Mater Sci Eng C 2008; 28: 1189-1202.
335. Yanga Y, Rossib FMV, Putninsa EE,. Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture. Biomaterials 2007; 28: 3110-3120.
336. Matsusaki M, Kadowaki K, Tateishi K, Higuchi C, Ando W, Hart DA, Tanaka Y, Take Y, Akashi M, Yoshikawa H, Nakamura N,. Scaffold-free tissue-engineered construct-hydroxyapatite composites generated by an alternate soaking process: Potential for repair of bone defects. Tissue Eng A 2009; 15: 55-63.
337. Gonzales-McQuire R, Chane-Ching J-Y, Vignaud E, Lebugle A, Mann S,. Synthesis and characterization of amino acid-functionalized hydroxyapatite nanorods. J Mater Chem 2004; 14: 2277-2281.
338. Wormuth K,. Superparamagnetic latex via inverse emulsion polymerization. J Colloid Interface Sci 2001; 241: 366-377.
339. El-Backly RM, Massoud AG, El-Badry AM, Sherif RA, Marei MK,. Regeneration of dentine/pulp-like tissue using a dental pulp stem cell/poly(lactic-co- glycolic) acid scaffold construct in New Zealand white rabbits. Australian Endodontic J 2008; 34: 52-67.
340. Chevalier J, Gremillard L,. Ceramics for medical applications: A picture for the next 20 years. J Eur Ceram Soc 2009; 29: 1245-1255.
341. Kokubo T, Matsushita T, Takadama H, Kizuki T,. Development of bioactive materials based on surface chemistry. J Eur Ceram Soc 2009; 29: 1245-1255.
342. Teller M, Gopp U, Neumann HG, Kuhn KD,. Release of gentamicin from bone regenerative materials: An in vitro study. J Biomed Mater Res Part B: Appl Biomater B 2007; 81: 23-29.
343. Grasset F, Labhsetwar N, Li D, Park DC, Saito N, Haneda H, Cador O, Roisnel T, Mornet S, Duguet E, Portier J, Etourneau J,. Synthesis and magnetic characterization of zinc ferrite nanoparticles with different environments: Powder, colloidal solution, and zinc ferrite-silica core-shell nanoparticles. Langmuir 2002; 18: 8209-8216.
344. Tago T, Hatsuta T, Miyajima K, Kishida M, Tashiro S, Wakabayashi K,. Novel synthesis of silica-coated ferrite nanoparticles prepared using water-in-oil microemulsion. J Am Ceram Soc 2002; 85: 2188-2194.
345. Arriagada FJ, Osseo-Asare K,. Controlled hydrolysis of tetraethoxysilane in a nonionic water-in-oil microemulsion: A statistical model of silica nucleation. Colloids Surf A: Physicochem Eng Aspects 1999; 154: 311-326.
346. Uskoković V, Košak A, Drofenik M,. Silica-coated lanthanum-strontium manganites for hyperthermia treatments. Mater Lett 2006; 60: 2620-2622.
347. V. Uskoković, Matijević E,. Uniform particles of pure and silica coated cholesterol. J Colloid Interface Sci 2007; 315: 500-511.
348. Park K, Lee S, Kang E, Kim K, Choi K, Kwon IC,. New generation of multifunctional nanoparticles for cancer imaging and therapy. Adv Funct Mater 2009; 19: 1-14.
349. Jongpaiboonkit L, Franklin-Ford T, Murphy WL,. Mineral-coated polymer microspheres for controlled protein binding and release. Adv Mater 2009; 21: 1-4.
350. Vukomanović M, Škapin S, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D,. Poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. Colloids Surf B: Biointerfaces. Forthcoming.
351. Fischer S, Foerg C, Merkle HP, Gander B,. Chitosan coated PLGA-microspheres-A modular system for targeted drug delivery. Euro Cells Mater 2004; 7 (Suppl 2): 11-12.
352. Stevanović MM, Uskoković DP,. Poly(lactide-co-glycolide)- based micro and nanoparticles for the controlled drug delivery of vitamins. Curr Nanosci 2009; 5: 1-14.
353. Ong HT, Loo JSC, F. Boey YC, Russell SJ, Ma J, Peng KW,. Exploiting the high-affinity phosphonate-hydroxyapatite nanoparticle interaction for delivery of radiation and drugs. J Nanoparticle Res 2008; 10: 141-150.
354. Morgan TT, Muddana HS, Altinoglu EI, Rouse SM, Tabakovic A, Tabouillot T, Russin TJ, Shanmugavelandy SS, Butler PJ, Eklund PC, Yun JK, Kester M, Adair JH,. Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery. Nano Lett 2008; 8: 4108-4115.
355. Yang PP, Quan ZW, Li CX, Kang XJ, Lian HZ, Lin J,. Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier. Biomaterials 2008; 29: 4341-4347.
356. 3+ ions. Biomaterials 2010; 31: 4259-4267.
357. Mondejar SP, Kovtun A, Epple M,. Lanthanide-doped calcium phosphate nanoparticles with high internal crystallinity and with a shell of DNA as fluorescent probes in cell experiments. J Mater Chem 2007; 17: 4153-4159.
358. Doat A, Fanjul M, Pelle F, Hollande E, Lebugle A,. Europium-doped bioapatite: A new photostable biological probe, internalizable by human cells. Biomaterials 2003; 24: 3365-3371.
359. Kovtun A, Heumann R, Epple M,. Calcium phosphate nanoparticles for the transfection of cells. J Biomed Eng Mater 2009; 19: 241-247.
360. Nehilla BJ, Allen PG, Desai TA,. Surfactant-free, drug-quantum-dot coloaded poly(lactide-co-glycolide) nanoparticles: Towards multifunctional nanoparticles. ACS Nano 2008; 2: 528-544.
361. Guo Y, Shi DL, Lian J, Dong ZY, Wang W, Cho HS, Liu GK, Wang LM, Ewing RC,. Quantum dot conjugated hydroxylapatite nanoparticles for in vivo imaging. Nanotechnology 2008; 19: 175102.
362. Sokolova V, Kovtun A, Heumann R, Epple M,. Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. J Biol Inorg Chem 2007; 12: 174-179.
363. LeGeros RZ,. Biological and synthetic apatites. In:, Brown PW, Constantz B, editors. Hydroxyapatite and Related Materials. Boca Raton, FL: CRC Press; 1994. pp 3-28.
364. Banerjee SS, Tarafder MS, Bandyaopadhyay A, Bose S,. Tricalcium Phosphate Based Resorbable Ceramics: Influence of MgO and SrO Addition on Mechanical Properties and Biocompatibility, Society for Biomaterials 2010 Annual Meeting & Exposition, Seattle, WA; 2010, presentation #435.
365. Bohner M,. Silicon-substituted calcium phosphates-A critical view. Biomaterials 2009; 30: 6403-6406.
366. Xynos ID, Edgar AJ, Buttery LDK, Hench LL, Polak JM,. Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass (R) 45S5 dissolution. J Biomed Mater Res 2001; 55: 151-157.
367. Hench LL,. Genetic design of bioactive glasses. J Eur Ceram Soc 2009; 29: 1257-1265.
368. Hench LL, Polak JM,. Third-generation biomedical materials. Science 2002; 295: 1014-1017.
369. Veselinović Lj, Karanović Lj, Stojanović Z, Bračko I, Marković S, Ignjatović N, Uskoković D,. Crystal structure of cobalt-substituted calcium hydroxyapatite nanopowders prepared by hydrothermal processing. J Appl Crystallogr 2010; 43: 320-327.
370. Stojanović Z, Veselinović Lj, Marković S, Ignjatović N, Uskoković D,. Hydrothermal synthesis of nanosize pure and cobalt-exchanged hydroxyapatite. Mater Manuf Process 2009; 24: 1096-1103.
371. Wu H-C, Wang T-W, Sun J-S, Wang W-H, Lin F-H,. A novel biomagnetic nanoparticle based on hydroxyapatite. Nanotechnology 2007; 18: 165601-165610.
372. Low HR, Phonthammachai N, Maignan A, Stewart GA, Bastow TJ, Ma LL, White TJ,. The crystal chemistry of ferric oxyhydroxyapatite. Inorg Chem 2008; 47: 11774-11782.
373. Liu X, Kaminski MD, Chen H, Torno M, Taylor L, Rosengart AJ,. Synthesis and characterization of highly-magnetic biodegradable poly(D,L-lactide-co- glycolide) nanospheres. J Control Release 2007; 119: 52-58.
374. Tarafder MS, Bandyopadhyay A, Bose S,. Osteoblast Interactions on Electrically Polarized Biphasic Calcium Phosphate, Society for Biomaterials 2010 Annual Meeting & Exposition, Seattle, WA; 2010, presentation #234.
375. Bock N, Riminucci A, Dionigi C, Russo A, Tampieri A, Landi E, Goranov VA,. A novel route in bone tissue engineering: Magnetic biomimetic scaffolds. Acta Biomater 2010; 6: 786-796.
376. Misono M, Hall WK,. Oxidation-reduction properties of copper- and nickel-substituted hydroxyapatites. J Phys Chem 1973; 77: 791-800.
377. Wakamura M, Kandori K, Ishikawa T,. Surface structure and composition of calcium hydroxyapatites substituted with Al(III), La(III) and Fe(III) ions. Colloids Surf A 2000; 164: 297-305.
378. Uskoković V, Košak A, Drofenik M,. Preparation of silica-coated lanthanum-strontium manganite particles with designable curie point, for application in hyperthermia treatments. Int J Appl Ceram Technol 2006; 3: 134-143.
379. Hou C-H, Hou S-M, Hsueh Y-S, Lin J, Wu H-C, Lin F-H,. The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy. Biomaterials 2009; 30: 3956-3960.
380. Uskoković V, Drofenik M, Ban I,. The characterization of nanosized nickel-zinc ferrites synthesized within reverse micelles of CTAB/1-hexanol/water microemulsion. J Magn Magn Mater 2004; 284: 294-302.
381. Wu H-C, Wang T-W, Bohn MC, Lin F-H, Spector M,. Novel magnetic hydroxyapatite nanoparticles as non-viral vectors for the glial cell line-derived neurotrophic factor gene. Adv Funct Mater 2010; 20: 67-77.
382. Chen H, Kaminski MD, Liu X, Mertz CJ, Xie Y, Torno MD, Rosengart AJ,. A novel human detoxification system based on nanoscale bioengineering and magnetic separation techniques. Med Hypotheses 2007; 68: 1071-1079.
383. Silva GA,. Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS. BMC Neurosci 2008; 10 (9 Suppl 3): S4: 1- 4.
384. Bawa R,. NanoBiotech 2008: Exploring global advances in nanomedicine. Nanomedicine 2009; 5: 5-7.
385. Patel LN, Zaro JL, Shen WC,. Cell penetrating peptides: Intracellular pathways and pharmaceutical perspectives. Pharm Res 2007; 24: 1977-1992.
386. Gratton SE, Ropp PA, Pohlhaus PD, Luft JC, Madden VJ, Napier ME,. The effect of particle design on cellular internalization pathways. Proc Nat Acad Sci USA 2008; 105: 11613-11618.
387. Chithrani BD, Chan WC,. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 2007; 7: 1542-1550.
388. Lubbe AS, Bergemann C, Brock J, McClure DG,. Physiological aspects in magnetic drug-targeting. J Magn Magn Mater 1999: 194; 149-155.
389. Pankhurst QA, Connolly J, Jones SK, Dobson J,. Applications of magnetic nanoparticles in biomedicine. J Phys D 2003; 36: R167-R181.
390. Mistry AS, Mikos AG,. Tissue engineering strategies for bone regeneration. Adv Biochem Eng/Biotechnol 2005; 94: 1-22.
391. Harush-Frenkel O, Debotton N, Benita S, Altschuler Y,. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochem Biophys Res Commun 2007; 353: 26-32.
392. Klesing J, Wiehe A, Gitter B, Grafe S, Epple M,. Positively charged calcium phosphate/polymer nanoparticles fro photodynamic therapy. J Mater Sci: Mater Med 2010; 21: 887-892.
393. Mrksich M,. Using self-assembled monolayers to model the extracellular matrix. Acta Biomater 2009; 5: 832-841.
394. Tang S, Jin A, Wang Y,. Preparation of plastic nano-hydroxyapatite/poly (3-hydroyybutyrate-hydroxyvalerate)-polyethy lene glycol gentamicin drug delivery system. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006; 20: 758-761.
395. Ho ML, Fu YC, Wang GJ, Chen HT, Chang JK, Tsai TH, Wang CK,. Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite. J Control Release 2008; 128: 142-148.
396. Wilson OC, Jr, Hull JR,. Surface modification of nanophase hydroxyapatite with chitosan. Mater Sci Eng C 2008; 28: 434-437.
397. Zhou G, Li Y, Zhang L, Zuo Y, Jansen JA,. Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite. J Biomed Mater Res Part A 2007; 83: 931-939.
398. Tan ML, Choong PF, Dass CR,. DNAzyme delivery systems: getting past first base. Expert Opin Drug Deliv 2009; 6: 127-138.
399. Dass CR, Choong PFM,. The use of chitosan formulations in cancer therapy. J Microencapsul 2003; 25: 275-279.
400. Reves BT, Bumgardner JD, Cole JA, Yang Y, Haggard WO,. Lyophilization to improve drug delivery for chitosan-calcium phosphate bone scaffold construct: A preliminary investigation. J Biomed Mater Res B 2009; 90: 1-10.
401. Adair J,. Nano Delivery of Cancer Therapeutics & siRNA, Presentation retrieved from; 2009.
402. Mukesh U, Kulkarni V, Tushar R, Murthy RSR,. Methotrexate loaded self stabilized calcium phosphate nanoparticles: A novel inorganic carrier for intracellular drug delivery. J Biomed Nanotechnol 2009; 5: 99-105.
403. Cheng X, Kuhn L,. Chemotherapy drug delivery from calcium phosphate nanoparticles. Int J Nanomed 2007; 2: 667-674.
404. Oh J-M, Choi S-J, Lee G-E, Han S-H, Choy J-H,. Inorganic drug-delivery nanovehicle conjugated with cancer-cell-specific ligand. Adv Funct Mater 2009; 19: 1-8.
405. Baba K, Pudavar HE, Roy I, Ohulchanskyy TY, Chen Y, Pandey RK, Prasad PN,. New method for delivering a hydrophobic drug for photodynamic therapy using pure nanocrystal form of the drug. Mol Pharm 2007; 4: 289-297.
406. Koh AL, Shachaf CM, Elchuri S, Nolan GP, Sinclair R,. Electron microscopy localization and characterization of functionalized composite organic-inorganic SERS nanoparticles on leukemia cells. Ultramicroscopy 2008; 109: 111-121.
407. Cheng S-H, Lee C-H, Yang C-S, Tseng F-G, Mou C-Y, Lo L-W,. Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: Potential cancer theranostics. J Mater Chem 2009; 19: 1252-1257.
408. Sokolova VV, Radtke I, Heumann R, Epple M,. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 2006; 27: 3147-3153.
409. Mazin AL,. Hydroxyapatite thin-layer chromatography of nucleic acid. Mol Biol 1977; 11: 477-498.
410. Gagnon P,. Improved antibody aggregate removal by hydroxyapatite chromatography in the presence of polyethylene glycol. J Immunol Methods 2008; 336: 222-228.
411. Fargues C, Bailly M, Grevillot G,. Adsorption of BSA and hemoglobin on hydroxyapatite support: Equilibria and multicomponent dynamic adsorption. Adsorption-J Int Adsorption Soc 1998; 4: 5-16.
412. Sokolova V, Epple M,. Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed 2008; 47: 1382-1395.
413. Nguyen DN, Green JJ, Chan JM, Langer R, Anderson DG,. Polymeric materials for gene delivery and DNA vaccination. Adv Mater 2009; 21: 847-867.
414. Graham FL, van der Eb AJ,. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 63: 456-467.
415. Dass CR, Choong PFM,. The use of chitosan formulations in cancer therapy. J Microencapsul 2008; 25: 275-279.
416. Zhu S, Zhou K, Huang B, Huang S, Liu F, Li Y, Xue Z, Long Z,. Hydroxyapatite nanoparticles: A novel material of gene carrier. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2005; 22: 980-984.
417. Sokolova V, Prymak O, Meyer-Zaika W, Cölfen H, Rehage H, Shukla A, Epple M,. Synthesis and characterization of DNA-functionalized calcium phosphate nanoparticles. Mat Werkstofftech 2006; 37: 441-445.
418. Schwiertz J, Meyer-Zaika W, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M, Epple M,. Calcium phosphate nanoparticles as templates for nanocapsules prepared by the layer-by-layer technique. J Mater Chem 2008; 18: 152.
419. Bai X, More K, Rouleau CM, Rabiei A,. Functionally graded hydroxyapatite coatings doped with antibacterial components. Acta Biomater 2010; 6: 2264-2273.
420. Gopalakrishnan B, Wolff J,. siRNA and DNA transfer to cultured cells. Methods Mol Biol 2009; 480: 31-52.
421. Zhang M, Ishii A, Nishiyama N, Matsumoto S, Ishii T, Yamasaki Y, Kataoka K,. PEGylated Calcium Phosphate Nanocomposites as Smart Environment-Sensitive Carriers for siRNA Delivery. Adv Mater 2009; 21: 1-6.
422. Seferos DS, Prigodich AE, Giljohann DA, Patel PC, Mirkin CA,. Polyvalent DNA nanoparticle conjugates stabilize nucleic acids. Nano Lett 2009; 9: 308-311.
423. Ren J, Zhao P, Ren T, Gu S, Pan K,. Poly (D,L-lactide)/nano- hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation. J Mater Sci: Mater Med 2008; 19: 1075-1082.
424. Wang M, Li Y, Wu J, Xu F, Zuo Y, Jansen JA,. In vitro and in vivo study to the biocompatibility and biodegradation of hydroxyapatite/poly(vinyl alcohol)/gelatin composite. J Biomed Mater Part A 2008; 85: 418-426.
425. Najman S, Savić V, Djordjević Lj, Ignjatović N, Uskoković D,. Biological evaluation of hydroxyapatite/poly- L -lactide (HAp/PLLA) composite biomaterials with poly- L -lactide of different molecular weights intraperitoneally implanted into mice. Biomed Mater Eng 2004; 14: 61-70.
426. Ignjatović N, Savić V, Najman S, Plavšić M, Uskoković D,. Study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. Biomaterials 2001; 22: 571-575.
427. Service RF,. Nanomaterials show signs of toxicity. Science 2003; 300: 243.
428. Oberdörster G, Oberdörster E, Oberdörster J,. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005; 113: 823-839.
429. Stellacci F,. On the Role of Interfacial Energy in Bio-interfaces, Presentation at the Materials Research Society Conference, San Francisco, CA, April 2010.
430. 4 composite nanospheres for in vivo imaging and hyperthermia. Adv Mater 2009; 21: 1-4.
431. Lee J-H, Lee K, Moon SH, Lee Y, Park TG, Cheon J,. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. Angew Chem Int Ed: Engl 2009; 48: 4174-4179.
432. Ashokan A, Menon D, Nair S, Koyakutty M,. A molecular receptor targeted, hydroxyapatite nanocrystal based multi-modal contrast agent. Biomaterials 2010; 31: 2606-1616.
433. Kim J, Park S, Lee JE, Jin SM, Lee JH, Lee IS, Yang I, Kim JS, Kim SK, Cho MH, Hyeon T,. Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. Angew Chem Int Ed 2006; 45: 7754-7758.