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1
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0028675028
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A DNA enzyme that cleaves RNA
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Landmark paper on DNAzyme discovery
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Breaker RR, Joyce GF. A DNA enzyme that cleaves RNA. Chem Biol 1994;1(4):223-9 • Landmark paper on DNAzyme discovery.
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(1994)
Chem Biol
, vol.1
, Issue.4
, pp. 223-229
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Breaker, R.R.1
Joyce, G.F.2
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2
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0030898510
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A general purpose RNA-cleaving DNA enzyme
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A second paper by same lab further defining DNAzyme cleavage kinetics
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Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 1997;94(9):4262-6 • A second paper by same lab further defining DNAzyme cleavage kinetics.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.9
, pp. 4262-4266
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Santoro, S.W.1
Joyce, G.F.2
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3
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22044447619
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Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis
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Paper describing how the EBV protein, LMP1 may present a potential target for DNAzymes as a possible mechanism towards controlling EBV-associated carcinoma
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Lu ZX, Ye M, Yan GR, et al. Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis. Cancer Gene Ther 2005;12(7):647-54 • Paper describing how the EBV protein, LMP1 may present a potential target for DNAzymes as a possible mechanism towards controlling EBV-associated carcinoma.
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(2005)
Cancer Gene Ther
, vol.12
, Issue.7
, pp. 647-654
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Lu, Z.X.1
Ye, M.2
Yan, G.R.3
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4
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0036811085
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Cellular uptake, distribution and stability of 10-23 deoxyribozymes
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Seminal paper examining the kinetics of uptake of DNAzymes into cultured cells, including distribution and stability in serum
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Dass CR, Saravolac EG, Li Y, et al. Cellular uptake, distribution and stability of 10-23 deoxyribozymes. Antisense Nucleic Acid Drug Dev 2002;12(5):289-99 • Seminal paper examining the kinetics of uptake of DNAzymes into cultured cells, including distribution and stability in serum.
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(2002)
Antisense Nucleic Acid Drug Dev
, vol.12
, Issue.5
, pp. 289-299
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Dass, C.R.1
Saravolac, E.G.2
Li, Y.3
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5
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0032912701
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Target site selection for an RNA-cleaving catalytic DNA
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Landmark paper defining the effect of choosing mRNA targets based on sequence on DNAzyme cleavage activity in silico
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Cairns MJ, Hopkins TM, Witherington C, et al. Target site selection for an RNA-cleaving catalytic DNA. Nat Biotech 1999;17(5):480-6 • Landmark paper defining the effect of choosing mRNA targets based on sequence on DNAzyme cleavage activity in silico.
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(1999)
Nat Biotech
, vol.17
, Issue.5
, pp. 480-486
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Cairns, M.J.1
Hopkins, T.M.2
Witherington, C.3
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6
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0033589752
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Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes)
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Seminal paper describing how DNAzymes can downregulate an oncogene and lead to cancer cell growth inhibition
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Wu Y, Yu L, McMahon R, et al. Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum Gene Ther 1999;10(17):2847-57 • Seminal paper describing how DNAzymes can downregulate an oncogene and lead to cancer cell growth inhibition.
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(1999)
Hum Gene Ther
, vol.10
, Issue.17
, pp. 2847-2857
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Wu, Y.1
Yu, L.2
McMahon, R.3
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7
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22544451538
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Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
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DOI 10.1111/j.1742-4658.2005.04778.x
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de Bock CE, Lin Z, Itoh T, et al. Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. FEBS J 2005;272(14):3572-82 • Paper describing the ability of specific DNAzymes to target the uPAR protein, and lead to reduced cell invasion in culture. (Pubitemid 41021170)
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(2005)
FEBS Journal
, vol.272
, Issue.14
, pp. 3572-3582
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De Bock, C.E.1
Lin, Z.2
Itoh, T.3
Morris, D.4
Murrell, G.5
Wang, Y.6
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8
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0041464740
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Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularisation and tumour growth
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Seminal paper looking at the (indirect) in vivo activity of DNAzymes against cancer angiogenesis
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Fahmy RG, Dass CR, Sun LQ, et al. Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularisation and tumour growth. Nat Med 2003;9(8):1026-32 • Seminal paper looking at the (indirect) in vivo activity of DNAzymes against cancer angiogenesis.
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(2003)
Nat Med
, vol.9
, Issue.8
, pp. 1026-1032
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Fahmy, R.G.1
Dass, C.R.2
Sun, L.Q.3
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9
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2942642252
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Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1
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DOI 10.1093/nar/gkh626
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Mitchell A, Dass CR, Sun LQ, et al. Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor Egr-1. Nucleic Acids Res 2004;32(10):3065-9 • Seminal paper looking at the direct in vivo activity of DNAzymes against tumour growth. (Pubitemid 39022997)
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(2004)
Nucleic Acids Research
, vol.32
, Issue.10
, pp. 3065-3069
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Mitchell, A.1
Dass, C.R.2
Sun, L.-Q.3
Khachigian, L.M.4
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10
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0037151008
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c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun
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Original paper describing the discovery of Dz13, one of the most potent DNAzymes reported to date with anticancer activity
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Khachigian LM, Fahmy RG, Zhang G, et al. c-Jun regulates vascular smooth muscle cell growth and neointima formation after arterial injury. Inhibition by a novel DNA enzyme targeting c-Jun. J Biol Chem 2002;277(25):22985-91 • Original paper describing the discovery of Dz13, one of the most potent DNAzymes reported to date with anticancer activity.
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(2002)
J Biol Chem
, vol.277
, Issue.25
, pp. 22985-22991
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Khachigian, L.M.1
Fahmy, R.G.2
Zhang, G.3
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11
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0036510605
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3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel
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DOI 10.1074/jbc.M102325200
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Cieslak M, Niewiarowska J, Nawrot M, et al. DNAzymes to beta 1 and beta 3 mRNA downregulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel. J Biol Chem 2002;277(9):6779-87 • Another paper looking at the potential of DNAzymes to inhibit angiogenesis in cultured endothelial cells. (Pubitemid 34953059)
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(2002)
Journal of Biological Chemistry
, vol.277
, Issue.9
, pp. 6779-6787
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Cieslak, M.1
Niewiarowska, J.2
Nawrot, M.3
Koziolkiewicz, M.4
Stec, W.J.5
Cierniewski, C.S.6
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12
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0034625010
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Potent and non-toxic antisense oligonucleotides containing locked nucleic acids
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Paper showing that in contrast to PO oligonucleotides, LNA analogues do not cause detectable toxic reactions in rat brain
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Wahlestedt C, Salmi P, Good L, et al. Potent and non-toxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci USA 2000;97(10):5633-8 • Paper showing that in contrast to PO oligonucleotides, LNA analogues do not cause detectable toxic reactions in rat brain.
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(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.10
, pp. 5633-5638
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Wahlestedt, C.1
Salmi, P.2
Good, L.3
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13
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0037326836
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In vivo tumour growth inhibition and biodistribution studies of locked nucleic acid(LNA) antisense oligonucleotides
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An early paper describing the use of LNAs for tumour growth inhibition
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Fluiter K, ten Asbroek AL, de Wissel MB, et al. In vivo tumour growth inhibition and biodistribution studies of locked nucleic acid(LNA) antisense oligonucleotides. Nucleic Acids Res 2003;31(3):953-62 • An early paper describing the use of LNAs for tumour growth inhibition.
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(2003)
Nucleic Acids Res
, vol.31
, Issue.3
, pp. 953-962
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Fluiter, K.1
Ten Asbroek, A.L.2
De Wissel, M.B.3
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14
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0030987371
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Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides
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One of several papers describing off-target effects(OTEs) due to PO oligonucleotides
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Rockwell P, O'Connor WJ, King K, et al. Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides. Proc Natl Acad Sci USA 1997;94(12):6523-8 • One of several papers describing off-target effects(OTEs) due to PO oligonucleotides.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.12
, pp. 6523-6528
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Rockwell, P.1
O'Connor, W.J.2
King, K.3
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15
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2342459633
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Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth
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Seminal paper applying the LNA concept to DNAzymes and showing activity in cultured cells
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Fahmy RG, Khachigian LM. Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth. Nucleic Acids Res 2004;32(7):2281-5 • Seminal paper applying the LNA concept to DNAzymes and showing activity in cultured cells.
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(2004)
Nucleic Acids Res
, vol.32
, Issue.7
, pp. 2281-2285
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Fahmy, R.G.1
Khachigian, L.M.2
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16
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0344442416
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RNA cleaving '10-23' DNAzymes with enhanced stability and activity
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Interesting paper showing how sequence rearrangments in DNAzyme structure may lead to enhanced activity
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Schubert S, Gul DS, Grunert HP, et al. RNA cleaving '10-23' DNAzymes with enhanced stability and activity. Nucleic Acids Res 2003;31(20):5982-92 • Interesting paper showing how sequence rearrangments in DNAzyme structure may lead to enhanced activity.
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(2003)
Nucleic Acids Res
, vol.31
, Issue.20
, pp. 5982-5992
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Schubert, S.1
Gul, D.S.2
Grunert, H.P.3
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17
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0035113736
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Locked nucleic acid(LNA): Fine-tuning the recognition of DNA and RNA
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Review article on LNA technology
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Braasch DA, Corey DR. Locked nucleic acid(LNA): fine-tuning the recognition of DNA and RNA. Chem Biol 2001;8(1):1-7 • Review article on LNA technology.
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(2001)
Chem Biol
, vol.8
, Issue.1
, pp. 1-7
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Braasch, D.A.1
Corey, D.R.2
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18
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0032544134
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The first analogues of LNA (locked nucleic acids): Phsophorothioate-LNA and 2′-thio-LNA
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Chemical paper describing the synthesis of the first chemically modified LNA analogues
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Kumar R, Singh SK, Koshkin AA, et al. The first analogues of LNA (locked nucleic acids): phsophorothioate-LNA and 2′-thio-LNA. Bioorg Med Chem Lett 1998;8(16):2219-22 • Chemical paper describing the synthesis of the first chemically modified LNA analogues.
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(1998)
Bioorg Med Chem Lett
, vol.8
, Issue.16
, pp. 2219-2222
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Kumar, R.1
Singh, S.K.2
Koshkin, A.A.3
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19
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34548103208
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Hairpin DNAzymes: A new tool for efficient cellular gene silencing
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DOI 10.1002/jgm.1061
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Abdelgany A, Wood M, Beeson D. Hairpin DNAzymes: a new tool for efficient cellular gene silencing. J Gene Med 2007;9(8):727-38 • Paper describing the introduction of hairpin technology to the field of DNAzyme research. (Pubitemid 47288830)
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(2007)
Journal of Gene Medicine
, vol.9
, Issue.8
, pp. 727-738
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Abdelgany, A.1
Wood, M.2
Beeson, D.3
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20
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1842588051
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Gene silencing nucleic acids designed by scanning arrays: Anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system
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DOI 10.1080/1061186042000207039
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Beale G, Hollins AJ, Benboubetra M, et al. Gene silencing nucleic acids designed by scanning arrays: anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridisation-accessible region using the same delivery system. J Drug Target 2003;11:449-56 • A head-to-head comparison of siRNA, ribozyme and DNAzyme in cultured cells. (Pubitemid 38455831)
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(2003)
Journal of Drug Targeting
, vol.11
, Issue.7
, pp. 449-456
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Beale, G.1
Hollins, A.J.2
Benboubetra, M.3
Sohail, M.4
Fox, S.P.5
Benter, I.6
Akhtar, S.7
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21
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5444269937
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Targeting PML/RAR alpha transcript with DNAzymes results in reduction of proliferation and induction of apoptosis in APL cells
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DOI 10.1038/sj.thj.6200535
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Kabuli M, Yin JA, Tobal K. Targeting PML/RAR alpha transcript with DNAzymes results in reduction of proliferation and induction of apoptosis in APL cells. Hematol J 2004;5:426-33 • Another study looking at in vitro anticancer activity of DNAzymes. (Pubitemid 39359279)
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(2004)
Hematology Journal
, vol.5
, Issue.5
, pp. 426-433
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Kabuli, M.1
Yin, J.A.L.2
Tobal, K.3
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22
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33644700405
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DNAzyme-mediated cleavage of survivin mRNA and inhibition of the growth of PANC-1 cells
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Another study looking at in vitro anticancer activity of DNAzymes
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Liang Z, Wei S, Guan J, et al. DNAzyme-mediated cleavage of survivin mRNA and inhibition of the growth of PANC-1 cells. J Gastroenterol Hepatol 2005;20:1595-602 • Another study looking at in vitro anticancer activity of DNAzymes.
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(2005)
J Gastroenterol Hepatol
, Issue.20
, pp. 1595-1602
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Liang, Z.1
Wei, S.2
Guan, J.3
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23
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52449131065
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c-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasising model
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Study showing anti-metastasis activity of a c-jun DNAzyme
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Dass CR, Khachigian LM, Choong PFM. c-Jun is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasising model. Mol Cancer Res 2008;6(8):1289-92 • Study showing anti-metastasis activity of a c-jun DNAzyme.
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(2008)
Mol Cancer Res
, vol.6
, Issue.8
, pp. 1289-1292
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Dass, C.R.1
Khachigian, L.M.2
Choong, P.F.M.3
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24
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2442429588
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Effect of deoxyribozymes targeting c-Jun on solid tumour growth and angiogenesis in rodents
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Study showing the antiangiogenic activity of a c-jun DNAzyme
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Zhang G, Dass CR, Sun LQ, et al. Effect of deoxyribozymes targeting c-Jun on solid tumour growth and angiogenesis in rodents. J Natl Cancer Inst 2004;96:683-96 • Study showing the antiangiogenic activity of a c-jun DNAzyme.
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(2004)
J Natl Cancer Inst
, vol.96
, pp. 683-696
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Zhang, G.1
Dass, C.R.2
Sun, L.Q.3
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25
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33751309568
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Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression
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DOI 10.1038/sj.onc.1209726, PII 1209726
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Zhang G, Luo X, Sumithran E, et al. Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression. Oncogene 2006;25:7260-6 • Paper describing the direct anticancer effect of a c-jun DNAzyme. (Pubitemid 44809091)
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(2006)
Oncogene
, vol.25
, Issue.55
, pp. 7260-7266
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Zhang, G.1
Luo, X.2
Sumithran, E.3
Pua, V.S.C.4
Barnetson, R.S.C.5
Halliday, G.M.6
Khachigian, L.M.7
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26
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47949089587
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Downregulation of c-Jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model
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A further paper showing antiosteosarcoma activity of Dz13, the c-jun DNAzyme
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Dass CR, Freidhuber AM, Khachigian LM, et al. Downregulation of c-Jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. Cancer Biol Ther 2008;7(7):1033-6 • A further paper showing antiosteosarcoma activity of Dz13, the c-jun DNAzyme.
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(2008)
Cancer Biol Ther
, vol.7
, Issue.7
, pp. 1033-1036
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Dass, C.R.1
Freidhuber, A.M.2
Khachigian, L.M.3
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27
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0032886118
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Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent
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Santiago FS, Atkins DG, Khachigian LM. Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent. Am J Pathol 1999;155:897-905 • Cell culture proof that an egr-1 DNAzyme has activity against cultured vascular smooth muscle cells. (Pubitemid 29426836)
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(1999)
American Journal of Pathology
, vol.155
, Issue.3
, pp. 897-905
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Santiago, F.S.1
Atkins, D.G.2
Khachigian, L.M.3
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28
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0032996518
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Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
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Santiago FS, Lowe HC, Day FL, et al. Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am J Pathol 1999;154:937-44 • DNAzyme was used as a molecular dissecting tool showing link between egr-1 and FGF-2. (Pubitemid 29122613)
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(1999)
American Journal of Pathology
, vol.154
, Issue.3
, pp. 937-944
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Santiago, F.S.1
Lowe, H.C.2
Day, F.L.3
Chesterman, C.N.4
Khachigian, L.M.5
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29
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0032717640
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New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury
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DOI 10.1038/15215
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Santiago FS, Lowe HC, Kavurma MM, et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat Med 1999;5:1264-9 • Seminal paper showing link between egr-1 and vascular smooth muscle growth in vitro and in vivo. (Pubitemid 29535603)
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(1999)
Nature Medicine
, vol.5
, Issue.11
, pp. 1264-1269
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Santiago, F.S.1
Lowe, H.C.2
Kavurma, M.M.3
Chesterman, C.N.4
Baker, A.5
Atkins, D.G.6
Khachigian, L.M.7
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30
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33745268460
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DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats
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The egr-1 DNAzyme is shown to have activity against heart disease caused by ischemia
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Bhindi R, Khachigian LM, Lowe HC. DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats. J Thromb Haemost 2006;4:1479-83 • The egr-1 DNAzyme is shown to have activity against heart disease caused by ischemia.
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(2006)
J Thromb Haemost
, vol.4
, pp. 1479-1483
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Bhindi, R.1
Khachigian, L.M.2
Lowe, H.C.3
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31
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0035200041
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DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
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A DNAzyme targeting TNF-alpha shows improvement of rats that underwent heart failure
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Iversen PO, Nicolaysen G, Sioud M. DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure. Am J Physiol Heart Circ Physiol 2001;281:H2211-7 • A DNAzyme targeting TNF-alpha shows improvement of rats that underwent heart failure.
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(2001)
Am J Physiol Heart Circ Physiol
, vol.281
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Iversen, P.O.1
Nicolaysen, G.2
Sioud, M.3
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32
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22844440907
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Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction
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DOI 10.1016/j.jacc.2005.04.047, PII S0735109705010387
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Xiang G, Schuster MD, Seki T, et al. Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularisation and reduces cardiomyocyte apoptosis after acute myocardial infarction. J Am Coll Cardiol 2005;46:536-41 • PAI-1 downregulation by a specific DNAzyme assists in damaged tissue repair following acute infarction. (Pubitemid 41040299)
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(2005)
Journal of the American College of Cardiology
, vol.46
, Issue.3
, pp. 536-541
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Xiang, G.1
Schuster, M.D.2
Seki, T.3
Witkowski, P.4
Eshghi, S.5
Itescu, S.6
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33
-
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28244473007
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Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia
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DOI 10.1074/jbc.M502966200
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Xiang G, Seki T, Schuster MD, et al. Catalytic degradation of vitamin D up-regulated protein-1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodelling after myocardial ischemia. J Biol Chem 2005;280:39394-402 • Another study showing benefits to animals suffering from induced heart disease treated with DNAzymes. (Pubitemid 41713897)
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(2005)
Journal of Biological Chemistry
, vol.280
, Issue.47
, pp. 39394-39402
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Xiang, G.1
Seki, T.2
Schuster, M.D.3
Witkowski, P.4
Boyle, A.J.5
See, F.6
Martens, T.P.7
Kocher, A.8
Sondermeijer, H.9
Krum, H.10
Itescu, S.11
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34
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4644293047
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Sustained polymeric delivery of gene solcening antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies
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Classic and interesting study comparing the performance of DNAzymes alongside antisense, siRNA and ribozymes
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Khan A, Benboubetra M, Sayyed PZ, et al. Sustained polymeric delivery of gene solcening antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. J Drug Target 2004;12(6):393-404 • Classic and interesting study comparing the performance of DNAzymes alongside antisense, siRNA and ribozymes.
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(2004)
J Drug Target
, vol.12
, Issue.6
, pp. 393-404
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Khan, A.1
Benboubetra, M.2
Sayyed, P.Z.3
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35
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10444239845
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Targeted delivery of RNA-cleaving DNA enzyme(DNAzyme) to tumour tissue by transferring-modified, cyclodextrin-based particles
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The use of cyclodextrin-modified particles for transfer of DNAzymes to tumours
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Pun SH, Tack F, Bellocq NC, et al. Targeted delivery of RNA-cleaving DNA enzyme(DNAzyme) to tumour tissue by transferring-modified, cyclodextrin-based particles. Cancer Biol Ther 2004;3(7):641-50 • The use of cyclodextrin-modified particles for transfer of DNAzymes to tumours.
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(2004)
Cancer Biol Ther
, vol.3
, Issue.7
, pp. 641-650
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Pun, S.H.1
Tack, F.2
Bellocq, N.C.3
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36
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0345357073
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Transferrin-containing, cyclodextrin polymer-based particles for tumour-targeted gene delivery
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A second study showing beneficial effects of a transferrin-mediated targeting of DNAzyme-loaded particles to tumours
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Bellocq NC, Pun SH, Jensen GS, et al. Transferrin-containing, cyclodextrin polymer-based particles for tumour-targeted gene delivery. Bioconjug Chem 2003;14(6):1122-32 • A second study showing beneficial effects of a transferrin-mediated targeting of DNAzyme-loaded particles to tumours.
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(2003)
Bioconjug Chem
, vol.14
, Issue.6
, pp. 1122-1132
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Bellocq, N.C.1
Pun, S.H.2
Jensen, G.S.3
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37
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33645863164
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Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes(DNAzymes)
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PEI shown to be efficient in transfecting cells with DNAzymes
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Tack F, Bakker A, Maes S, et al. Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes(DNAzymes). J Drug Target 2006;14(2):69-86 • PEI shown to be efficient in transfecting cells with DNAzymes.
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(2006)
J Drug Target
, vol.14
, Issue.2
, pp. 69-86
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Tack, F.1
Bakker, A.2
Maes, S.3
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38
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0034991899
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Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity
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DOI 10.1006/mthe.2001.0311
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