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Volumn 6, Issue 2, 2009, Pages 127-138

DNAzyme delivery systems: Getting past first base

Author keywords

Chitosan; DNAzyme; Drug delivery system; Gene therapy; Liposome; Oligonucleotide

Indexed keywords

ADAMANTANE DERIVATIVE; ADAMANTANE DIGLUTAMATE POLY(ETHYLENE GLYCOL)GALACTOSE; ADAMANTANE DIGLUTAMATE POLY(ETHYLENE GLYCOL)TRANSFERRIN; ANTISENSE OLIGONUCLEOTIDE; BCR ABL PROTEIN; BETA1 INTEGRIN; BETA3 INTEGRIN; CHITOSAN; CYCLODEXTRIN DERIVATIVE; DEOXYRIBOZYME; DRUG CARRIER; EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; FUGENE 6; IMIDAZOLE; LATENT MEMBRANE PROTEIN 1; LEUCINE ZIPPER PROTEIN; LOCKED NUCLEIC ACID; MACROGOL; MICROSPHERE; POLY(PROPYLENE IMINE); POLYETHYLENEIMINE; POLYGLYCOLIC ACID; POLYLACTIC ACID; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN C JUN; SMALL INTERFERING RNA; SURVIVIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; MESSENGER RNA; POLYMER;

EID: 66949132992     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425240902751605     Document Type: Review
Times cited : (40)

References (44)
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    • DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats
    • The egr-1 DNAzyme is shown to have activity against heart disease caused by ischemia
    • Bhindi R, Khachigian LM, Lowe HC. DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats. J Thromb Haemost 2006;4:1479-83 • The egr-1 DNAzyme is shown to have activity against heart disease caused by ischemia.
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    • DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
    • A DNAzyme targeting TNF-alpha shows improvement of rats that underwent heart failure
    • Iversen PO, Nicolaysen G, Sioud M. DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure. Am J Physiol Heart Circ Physiol 2001;281:H2211-7 • A DNAzyme targeting TNF-alpha shows improvement of rats that underwent heart failure.
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    • Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction
    • DOI 10.1016/j.jacc.2005.04.047, PII S0735109705010387
    • Xiang G, Schuster MD, Seki T, et al. Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularisation and reduces cardiomyocyte apoptosis after acute myocardial infarction. J Am Coll Cardiol 2005;46:536-41 • PAI-1 downregulation by a specific DNAzyme assists in damaged tissue repair following acute infarction. (Pubitemid 41040299)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.3 , pp. 536-541
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    • Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia
    • DOI 10.1074/jbc.M502966200
    • Xiang G, Seki T, Schuster MD, et al. Catalytic degradation of vitamin D up-regulated protein-1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodelling after myocardial ischemia. J Biol Chem 2005;280:39394-402 • Another study showing benefits to animals suffering from induced heart disease treated with DNAzymes. (Pubitemid 41713897)
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    • Xiang, G.1    Seki, T.2    Schuster, M.D.3    Witkowski, P.4    Boyle, A.J.5    See, F.6    Martens, T.P.7    Kocher, A.8    Sondermeijer, H.9    Krum, H.10    Itescu, S.11
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    • Sustained polymeric delivery of gene solcening antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies
    • Classic and interesting study comparing the performance of DNAzymes alongside antisense, siRNA and ribozymes
    • Khan A, Benboubetra M, Sayyed PZ, et al. Sustained polymeric delivery of gene solcening antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. J Drug Target 2004;12(6):393-404 • Classic and interesting study comparing the performance of DNAzymes alongside antisense, siRNA and ribozymes.
    • (2004) J Drug Target , vol.12 , Issue.6 , pp. 393-404
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    • Targeted delivery of RNA-cleaving DNA enzyme(DNAzyme) to tumour tissue by transferring-modified, cyclodextrin-based particles
    • The use of cyclodextrin-modified particles for transfer of DNAzymes to tumours
    • Pun SH, Tack F, Bellocq NC, et al. Targeted delivery of RNA-cleaving DNA enzyme(DNAzyme) to tumour tissue by transferring-modified, cyclodextrin-based particles. Cancer Biol Ther 2004;3(7):641-50 • The use of cyclodextrin-modified particles for transfer of DNAzymes to tumours.
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    • A second study showing beneficial effects of a transferrin-mediated targeting of DNAzyme-loaded particles to tumours
    • Bellocq NC, Pun SH, Jensen GS, et al. Transferrin-containing, cyclodextrin polymer-based particles for tumour-targeted gene delivery. Bioconjug Chem 2003;14(6):1122-32 • A second study showing beneficial effects of a transferrin-mediated targeting of DNAzyme-loaded particles to tumours.
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    • Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes(DNAzymes)
    • PEI shown to be efficient in transfecting cells with DNAzymes
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