Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system

Ceramics International

Volumn 35, Issue 1, 2009, Pages 509-513

  Santos, C ^a,b   Rovath, C F ^a   Franke, R P ^c   Almeida, M M ^a   Costa, M E V ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

A Drug delivery; A Spray drying; D 5 Fluorouracil; D Hydroxyapatite

Indexed keywords

APATITE; CURING; DEWATERING; DRUG DELIVERY; DRYING; HYDROXYAPATITE; PESTICIDES; SPRAY DRYING;

[A] DRUG DELIVERY; [A] SPRAY DRYING; [D] 5-FLUOROURACIL; [D] HYDROXYAPATITE; ARE SPRAYS; BONE REGENERATIONS; DELIVERY SYSTEMS; DRUG DELIVERY SYSTEMS; DRYING TEMPERATURES; FLUOROURACIL; FLUOROURACIL (5FU); OPTIMIZED CONDITIONS; PHOSPHATE SOLUTIONS; PHYSIOLOGICAL TEMPERATURES; POTENTIAL APPLICATIONS; SECONDARY PHASES;

GRANULATION;

EID: 55949121867     PISSN: 02728842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceramint.2008.01.012     Document Type: Article

References (16)

1. Siddharthan A., Seshadri S.K., and Sampath Kumar T.S. Microwave accelerated synthesis of nanosized calcium deficient hydroxyapatite. Journal of Materials Science: Materials in Medicine 15 (2004) 1279-1284
2. Oktar F.N. Microstructure and mechanical properties of sintered enamel hydroxyapatite. Ceramics International 33 7 (2007) 1309-1314
3. Szymura-Oleksiak J., Lósarczyk A., Cios A., Mycek B., Paszkiewicz Z., Szklarczyk S., and Stankiewicz D. The kinetics of pentoxifylline release in vivo from drug-loaded hydroxyapatite implants. Ceramics International 27 7 (2001) 767-772
4. Stahl K., Claesson M., Lilliehorn P., Lindén H., and Backstrom K. The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation. International Journal of Pharmaceutics 233 (2002) 227-237
5. Freitas C., and Müller R.H. Spray-drying of solid lipid nanoparticles (SLN™). European Journal of Pharmaceutics and Biopharmaceutics 46 (1998) 145-151
6. Luo P., and Nieh T.G. Synthesis of ultrafine hydroxyapatite particles by a spray dry method. Materials Science and Engineering C3 (1995) 75-78
7. Martins M.A., Santos C., Costa M.E.V., and Almeida M.M. Preparation of porous hydroxyapatite particles to be used as drug delivery systems. Advanced Materials Forum II II 455 (2004) 353-357
8. Chen X., Deng C., Tang S., and Zhang M. Mitochondria-dependent apoptosis induced by nanoscale hydroxyapatite in human gastric cancer SGC-7901 cells. Biological and Pharmaceutical Bulletin 30 (2007) 128-132
9. Hu J., Liu Z.-S., Tang S.-L., and He Y.-M. Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection. World Journal of Gastroenterology 13 20 (2007) 2798-2802 28
10. Kaiser N., Kimpfler A., Massing U., Burger A.M., Fiebig H.H., Brandl M., and Schubert R. 5-Fluorouracil in vesicular phospholipic gels for anticancer treatment: entrapment and release properties. International Journal of Pharmaceutics 256 (2003) 123-131
11. Sun Y., Guo G., Wang Z., and Guo H. Synthesis of single-crystal HAP nanorods. Ceramics International 32 8 (2006) 951-954
12. Elliott J.C. Structure and Chemistry of the Apatites and Other Calcium Orthophosphates vol. 18 (1994), Elsevier pp. 111-116
13. Rastogi V.K., Singh C., Jain V., and Alcolea Palafox M. FTIR and FT-Raman spectra of 5-methyluracil (thymine). Journal of Raman Spectroscopy 31 (2000) 1005-1012
14. Koutsopoulos S. Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods. Journal of Biomedical Materials Research 62 4 (2002) 600-612
15. Fu Y.-J., Shyu S.-S., Su F.-H., and Yu P.-C. Development of biodegradable co-poly(d,l-lactic/glycolic acid) microspheres for the controlled release of 5FU by the spray drying method. Colloids and Surfaces B: Biointerfaces 25 (2002) 269-279
16. 2Al layered double hydroxides containing 5-Fluorouracil. Journal of Solid State Chemistry 178 (2005) 736-741