Methotrexate loaded self stabilized calcium phosphate nanoparticles: A novel inorganic carrier for intracellular drug delivery

Journal of Biomedical Nanotechnology

Volumn 5, Issue 1, 2009, Pages 99-105

  Mukesh, Ukawala ^a   Kulkarni, Vijay ^a   Tushar, Rajyaguru ^a   Murthy, R S R ^a  

^a Faculty of Technology and Engineering   (India)

Author keywords

Calcium phosphate; Hydroxyapatite; Intracellular localization; Methotrexate; Reverse micelle

Indexed keywords

ANTICANCER DRUG; AVERAGE SIZE; CALCIUM PHOSPHATE NANOPARTICLES; CHO CELL; COMPOSITE FORMATION; ENDOSOMAL PH; ENTRAPMENT EFFICIENCY; GENE DELIVERY; IN-VITRO; INTRACELLULAR DRUG DELIVERY; INTRACELLULAR LOCALIZATION; IR SPECTRUM; METHOTREXATE; PHYSIOLOGICAL PH; REVERSE MICELLE; REVERSE MICELLES; SLOW RELEASE; TEM;

APATITE; BIOLOGICAL MATERIALS; BIOMATERIALS; CALCIUM; CALCIUM ALLOYS; CELL CULTURE; CONFOCAL MICROSCOPY; DRUG DELIVERY; GENE TRANSFER; GLUCOSE; HYDROXYAPATITE; MICELLES; NANOPARTICLES; PH EFFECTS;

CALCIUM PHOSPHATE;

CALCIUM PHOSPHATE; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HYDROXYAPATITE; METHOTREXATE; NANOPARTICLE;

ANIMAL CELL; ARTICLE; CELL PH; CELLULAR DISTRIBUTION; CHO CELL; COMPOSITE MATERIAL; CONFOCAL MICROSCOPY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENDOSOME; FEMALE; INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; REVERSE MICELLE; X RAY DIFFRACTION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BODY FLUIDS; CALCIUM PHOSPHATES; CHO CELLS; CRICETINAE; CRICETULUS; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; INORGANIC CHEMICALS; MATERIALS TESTING; METHOTREXATE; NANOPARTICLES;

EID: 67649764421     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.026     Document Type: Article

References (31)

1. J. Kingsley, H. Dou, J. Morehead, B. Rabinow, H. Gendelman, and C. Destache, Nanotechnology: A focus on nanoparticles as a drug delivery system. J. Neuroimmune Pharmacol. 1, 340 (2006).
2. M. Youssef, E. Fattal, M. Alonso, L. Roblot, J. Sauzieres, C. Tancredo, A. Omnes, P. Couvreur, and A. Andremont, Effectiveness of nanoparticle-bound ampicillin in the treatment of listeria monocytogenes infection in athymic nude mice. Antimicrob. Agents Chemother. 32, 1204 (1988).
3. S. Kim, Y. Lee, H. Shin, and J. Kang, Indomethacin-loaded methoxy poly(ethylene glycol)/poly(e-caprolactone) diblock copolymeric nanosphere: pharmacokinetic characteristics of indomethacin in the normal Sprague Dawley rats. Biomaterials 22, 2049 (2001).
4. L. Harivardhan, K. Vivek, B. Nishant, and R. S. R. Murthy, Tamoxifen citrate loaded solid lipid nanoparticles (SLN): preparation, characterization, in vitro drug release, and pharmacokinetic evaluation. Pharm Dev. Technol. 11, 167 (2006).
5. L. Harivardhan and R. S. R. Murthy, Etoposide loaded nanoparticles made from glyceride lipids: formulation, characterization, in vitro drug release, and stability evaluation. AAPS Pharm Sci. Tech. 6, 158 (2005).
6. L. Harivardhan and R. S. R. Murthy, Pharmacokinetics and biodistribution studies of doxorubicin loaded Poly(butyl cyanoacrylate) nanoparticles synthesized by two different techniques. Biomed. Papers 148, 161 (2004).
7. N. Subramanian, Y. Archit, and R. S. R. Murthy, Artificial neural network as an alternative to multiple regression analysis in optimizing formulation parameters of cytarabine liposomes. AAPS Pharm Sci. Tech. 5, 1 (2004).
8. P. Zhi, H. Qing, G. Qing, and A. Bing, Inorganic nanoparticles as carriers for efficient cellular delivery. Chem. Eng. Sci. 61, 1027 (2006).
9. V. Kulkarni, V. Shenoy, S. Dodiya, T. Rajyaguru, and R. S. R. Murthy, Role of calcium in gene delivery. Exp. Opi Drug Del. 3, 235 (2006).
10. L. Tse-Ying, C. San-Yuan, L. Dean-Mo, and L. Sz-Chian, On the study of BSA-loaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery. J. Control Rel. 107, 112 (2005).
11. M. Yutaka, I. Toshiyuki, T. Jyunzo, H. Keiko, I. Tsutomu, O. Yasuaki, and U. Akinori, Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. J. Control Rel. 110, 260 (2006).
12. V. Viktoriya, R. Ina, H. Rolf, and E. Matthias, Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 27, 3147 (2006).
13. A. Barroug, L. T. Kuhn, L. C. Gerstenfeld, and M. J. Glimcher, Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release. J. Orthop. Res. 22, 703 (2004).
14. K. Kandori, M. Saito, H. Saito, A. Yasukawa, and T. Ishikawa, Adsorption of protein on non-stoichiometric calcium-strontium hydroxyapatite. Colloids Surf. A Physicochem. Eng. Asp. 94, 225 (1995).
15. S. C. Liou, S. Y. Chen, and D. M. Liu, Synthesis and characterization of needlelike apatitic nanocomposite with controlled aspect ratios. Biomaterials 24, 3981 (2003).
16. T. Hartley, L. Ben, A. Philip, and E. Agnes, Assembly of aqueous-cored calcium phosphate nanoparticles for drug delivery. Chem. Mater. 16, 4942 (2004).
17. M. R. T. Filgueirasa, D. Mkhonto, and N. Leeuw, Computer simulations of the adsorption of citric acid at hydroxyapatite surfaces. J. Cryst. Growth 15, 60 (2006).
18. D. Rautaray, S. Mandal, and M. Sastry, Synthesis of hydroxyapatite crystals using amino acid-capped gold nanoparticles as a scaffold. Langmuir 21, 5185 (2005).
19. K. Yoshinori and K. Kazunori, Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxy-nucleotide and si-RNA delivery. J. Control Rel. 97, 345 (2004).
20. E. Boanini, T. Paola, G. Massimo, G. Roberto, and B. Adriana, Nanocomposites of hydroxyapatite with aspartic acid and glutamic acid and their interaction with osteoblast-like cells. Biomaterials 27, 4428 (2006).
21. A. Maitra, R. Indrajit, M. Susmita, and M. Subho, Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int. J. Pharm. 250, 25 (2003).
22. B. Savita, B. Gajadhar, M. Susmita, and M. Amarnath, pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. Int. J. Pharm. 288, 157 (2005).
23. E. Bertoni, B. Adriana, F. Giuseppe, P. Silvia, and R. Norberto, Hydroxyapatite/polyacrylic acid nanocrystals. J. Mat. Chem. 9, 779 (1999).
24. A. Bigi, B. Elisa, G. Massimo, A. M. Kojdecki, and R. Kata, Microstructural investigation of hydroxyapatite-polyelectrolyte composites. J. Mat. Chem. 14, 274 (2004).
25. A. Bigi, E. Boanini, and K. Rubini, Hydroxyapatite gels and nanocrystals prepared through a sol-gel process. J. Solid State Chem. 177, 3092 (2004).
26. Powder Diffraction File: inorganic phases, joint committee on powder diffraction standards, Swarthmore Card No. 9-432 (1986).
27. Y. Wang, J. Chen, K. Wei, S. Zhang, and X. Wang, Surfactant-assisted synthesis of hydroxyapatite particles. Mater. Lett. 60, 3227 (2006).
28. I. Mobasherpour, M. Heshaji, A. Kazemzadeha, and M. Zakeri, Synthesis of nanocrystalline hydroxyapatite by using precipitation method. J. Alloys and Compd. 430, 330 (2007).
29. N. Al-Qasas and S. Rohani, Synthesis of pure hydroxyapatite and the effect of synthesis conditions on its yield, crystallinity, morphology and mean particle size. Sep. Sci. Technol. 40, 3187 (2005).
30. C. Lai, S. Tang, Y. Wang, and K. Wei, Formation of calcium phosphate nanoparticles in reverse microemulsions. Mater. Lett. 59, 210 (2005).
31. S. Koutsopoulos and E. Dalas, The effect of acidic amino acids on hydroxyapatite crystallization. J. Cryst. Growth 217, 410 (2000).