p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

Journal of Neuroscience

Volumn 21, Issue 17, 2001, Pages 6758-6771

  Ko, Jane ^a   Humbert, Sandrine ^b   Bronson, Roderick T ^c   Takahashi, Satoru ^d   Kulkarni, Ashok B ^d   Li, En ^e   Tsai, Li Huei ^a,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CNRS   (France)

^c TUFTS UNIVERSITY   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Cdk5; Development; Lamination; Neurofilaments; Neuronal migration; Nudel; p35; p39

Indexed keywords

CYCLIN DEPENDENT KINASE 5; PROTEIN; PROTEIN P35; PROTEIN P39; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CELL MIGRATION; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE LOCUS; HIPPOCAMPUS; MOUSE; NERVE CELL DIFFERENTIATION; NEUROFILAMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0035448915     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-17-06758.2001     Document Type: Article

References (64)

1. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
2. Prenatal development of the cerebellar system in the rat. II. Cytogenesis and histogenesis of the inferior olive, pontine gray, and the precerebellar reticular nuclei
3. Development of the precerebellar nuclei in the rat. II. The intramural olivary migratory stream and the neurogenetic organization of the inferior olive
4. The ascent and settling of Purkinje cells in relation to their time and site of origin
5. Selective disruption of "late onset" sagittal banding patterns by ectopic expression of engrailed-2 in cerebellar Purkinje cells
6. Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cells
7. Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS
8. Development of the hippocampal region in the rat. I. Neurogenesis examined with 3H-thymidine autoradiography
9. The development of the primordial plexiform layer and its subsequent partitioning into layer I and the subplate (layer VII)
10. Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development
11. Altering the genome by homologous recombination
12. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
13. Sonic hedgehog regulates the growth and patterning of the cerebellum
14. Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse
15. A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function
16. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
17. Development of calretinin immunoreactivity in the neocortex of the rat
18. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex
19. Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5
20. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton
21. Synaptic localization of p39, a neuronal activator of cdk5
22. Discriminable excitotoxic effects of ibotenic acid, AMPA, NMDA and quinolinic acid in the rat laterodorsal tegmental nucleus
23. Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
24. Neurofilament functions in health and disease
25. A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule
26. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
27. A novel disruption of cortical development in p35(-/-) mice distinct from reeler
28. Callosal axon guidance defects in p35(-/-) mice
29. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase
30. Neurotoxicity induces cleavage of p35 to p25 by calpain
31. A brain specific activator of cyclin-dependent kinase 5
32. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells
33. Deregulation of cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
34. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
35. Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5) activator
36. Neurofilament phosphorylation: A new look at regulation and function
37. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
38. Migration defects of cdk5(-/-) neurons in the developing cerebellum are cell autonomous
39. Evidence for the participation of the neuron-specific Cdk5 activator p35 during laminin-enhanced axonal growth
40. Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)
41. Efficacy of tribromoethanol anesthesia in mice
42. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
43. Extracellular matrix in early cortical development
44. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats
45. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
46. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin
47. Changes in the distribution of extracellular matrix components accompany early morphogenetic events of mammalian cortical development
48. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1
49. A cdc2-like kinase distinct from cdk5 is associated with neurofilaments
50. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35
51. Neuronal cyclin-dependent kinase 5 activity is critical for survival
52. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator
53. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
54. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
55. Selective solubilization of high-molecular-mass neurofilament subunit during nerve regeneration
56. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
57. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
58. Purkinje-cell-derived sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
59. Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
60. Localization of calretinin in cells of layer I (Cajal-Retzius cells) of the developing cortex of the rat
61. The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains
62. Role of cyclins in neuronal differentiation of immortalized hippocampal cells
63. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice
64. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system