Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells

Molecular and Cellular Neuroscience

Volumn 24, Issue 3, 2003, Pages 632-645

  Cheng, Qi ^a   Sasaki, Yukio ^a,d   Shoji, Masayuki ^a   Sugiyama, Yoshinobu ^a   Tanaka, Hideaki ^b   Nakayama, Takashi ^a   Mizuki, Nobuhisa ^a   Nakamura, Fumio ^a   Takei, Kohtaro ^a,c   Goshima, Yoshio ^a,c  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALANINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; EPHRIN A5; EPHRIN RECEPTOR; MUTANT PROTEIN; OLOMOUCINE; PROTEIN P35; PROTEIN TYROSINE KINASE; RHO KINASE; TAU PROTEIN; TYROSINE KINASE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; DOWNSTREAM PROCESSING; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSFECTION; GROWTH CONE; HERPES SIMPLEX VIRUS; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; VIRUS RECOMBINANT;

SIMPLEXVIRUS;

EID: 10744223248     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-7431(03)00220-3     Document Type: Article

References (37)

1. Aizawa H., Wakatsuki S., Ishii A., Moriyama K., Sasaki Y., Ohashi K., Sekine-Aizawa Y., Sehara-Fujisawa A., Mizuno K., Goshima Y., Yahara I. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat. Neurosci. 4:2001;367-373.
2. Arimura N., Inagaki N., Chihara K., Menager C., Nakamura N., Amano M., Iwamatsu A., Goshima Y., Kaibuchi K. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase evidence for two separate signaling pathways for growth cone collapse . J. Biol. Chem. 275:2000;23973-23980.
3. Chae T., Kwon Y.T., Bronson R., Dikkes P., Li E., Tsai L.H. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 18:1997;29-42.
4. Davy A., Gale N.W., Murray E.W., Klinghoffer R.A., Soriano P., Feuerstein C., Robbins S.M. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 13:1999;3125-3135.
5. Devies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:2000;95-105.
6. Dhavan R., Tsai L.-H. A decade of CDK5. Nat. Rev. Mol. Cell. Biol. 2:2001;749-759.
7. Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
8. Edwards D.C., Sanders L.C., Bokoch G.M., Gill G.N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1:1999;253-259.
9. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell. 90:1997;403-404.
10. Flanagan J.G., Pierre Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21:1998;309-345.
11. Goshima Y., Kawakami T., Hori H., Sugiyama Y., Takasawa S., Hashimoto Y., Kagoshima-Maezono M., Takenaka T., Misu Y., Strittmatter S.M. A novel action of collapsin collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse . J. Neurobiol. 33:1997;316-328.
12. Kempf M., Clement A., Faissner A., Lee G., Brandt R. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J. Neurosci. 16:1996;5583-5592.
13. Knoll B., Drescher U. Ephrin-As as receptors in topographic projections. Trends Neurosci. 25:2002;145-149.
14. Kullander K., Klein R. Mechanisms and functions of Eph and ephrins signaling. Nat. Rev. Mol. Cell Biol. 3:2002;475-486.
15. Lew J., Wang J.H. Neuronal cdc2-like kinase. Trends Biochem. Sci. 20:1995;33-37.
16. Liu C.W., Lee G., Jay D.G. Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons. Cell Motil. Cytoskel. 43:1999;232-242.
17. Meijer L., Borgne A., Mulner O., Chong J.P., Blow J.J., Inagaki N., Inagaki M., Delcros J.G., Moulinoux J.P. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243:1997;527-536.
18. Meima L., Kljavin I.J., Moran P., Shih A., Winslow J.W., Caras I.W. AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton. Eur. J. Neurosci. 9:1997;177-188.
19. Meima L., Moran P., Matthews W., Caras I.W. Lerk2 (ephrin-B1) is a collapsing factor for a subset of cortical growth cones and acts by a mechanism different from AL-1 (ephrin-A5). Mol. Cell Neurosci. 9:1997;314-328. doi:10.1006/mcne.1997.0621.
20. Miao H., Burnett E., Kinch M., Simon E., Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2:2000;62-69.
21. Michel G., Mercken M., Murayama M., Noguchi K., Ishiguro K., Imahori K., Takashima A. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim. Biophys. Acta. 1380:1998;177-182.
22. Mueller B.K. Growth cone guidance first steps towards a deeper understanding . Annu. Rev. Neurosci. 22:1999;351-388.
23. Nakamoto M., Cheng H.J., Friedman G.C., McLaughlin T., Hansen M.J., Yoon C.H., O'Leary D.D., Flanagan J.G. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 86:1996;755-766.
24. Nakayama T., Goshima Y., Misu Y., Kato T. Role of cdk5 and tau phosphorylation in heterotrimeric G protein-mediated retinal growth cone collapse. J. Neurobiol. 41:1999;326-339.
25. Nikolic M., Chou M.M., Lu W., Mayer B.J., Tsai L.H. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature. 395:1998;194-198.
26. Ohshima, T., Ward, J.M., Huh, C.G., Longenecker, G., Veeranna, Pant, H.C., Brady, R.O., Martin, L.J., Kulkarni, A.B., 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA 93, 11173-11178.
27. Patrick G.N., Zhou P., Kwon Y.T., Howley P.M., Tsai L.H. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 273:1998;24057-24064.
28. Sasaki Y., Cheng C., Uchida Y., Nakajima O., Ohshima T., Yagi T., Taniguchi M., Nakayama T., Kishida R., Kudo Y., Ohno S., Nakamura F., Goshima Y. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron. 35:2002;907-920.
29. Shamah S.M., Lin M.Z., Goldberg J.L., Estrach S., Sahin M., Hu L., Bazalakova M., Neve R.L., Corfas G., Debant A., Greenberg M.E. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 105:2001;233-244.
30. Tessier-Lavigne M., Goodman C.S. The molecular biology of axon guidance. Science. 274:1996;1123-1133.
31. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., Tamakawa H., Yamagami K., Inui J., Maekawa M., Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 389:1997;990-994.
32. Vesely J., Havlicek L., Strnad M., Blow J.J., Donella-Deana A., Pinna L., Letham D.S., Kato J., Detivaud L., Leclerc S. Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224:1994;771-786.
33. Wahl S., Barth H., Ciossek T., Aktories K., Mueller B.K. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J. Cell Biol. 149:2000;263-270.
34. Wang H.U., Anderson D.J. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron. 18:1997;383-396.
35. Yu H.H., Zisch A.H., Dodelet V.C., Pasqual E.B. Multiple signal interactions of Ab1 and Arg kinase with EphB2 receptor. Oncogene. 20:2001;3995-4006.
36. Zhong T.P., Childs S., Leu J.P., Fishman M.C. Gridlock signaling pathway fashions the first embryonic artery. Nature. 414:2001;216-220.
37. Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.H. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 26:2000;633-646.