PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 50, 2009, Pages 21353-21358

  Zhao, Chun Tao ^a,b   Li, Kun ^a,b   Li, Jun Tao ^a,b   Zheng, Wang ^a,b   Liang, Xu Jun ^a,b   Geng, An Qi ^a   Li, Ning ^a,b   Yuan, Xiao Bing ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

BDNF; Neuronal migration; Phosphorylation; Protein stability; Ubiquitin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIN DEPENDENT KINASE 5; PROTEIN KINASE C DELTA; PROTEIN P35; SMALL INTERFERING RNA; NERVE PROTEIN; NEURONAL CDK5 ACTIVATOR (P25 P35); NEURONAL CDK5 ACTIVATOR (P25-P35);

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL CULTURE; CELL MIGRATION; DOWN REGULATION; ELECTROPORATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; WILD TYPE; ANIMAL; BRAIN CORTEX; CELL MOTION; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MOVEMENT; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIN-DEPENDENT KINASE 5; DOWN-REGULATION; NERVE TISSUE PROTEINS; NEURONS; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 75849157143     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812872106     Document Type: Article

References (51)

1. Rakic P (1972) Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol 145:61-83.
2. Hatten ME (1999) Central nervous system neuronal migration. Annu Rev Neurosci 22:511-539.
3. Marin O, Rubenstein JL (2003) Cell migration in the forebrain. Annu Rev Neurosci 26:441-483.
4. Leone DP, Srinivasan K, Chen B, Alcamo E, McConnell SK (2008) The determination of projection neuron identity in the developing cerebral cortex. Curr Opin Neurobiol 18:28-35.
5. Kwan KY, et al. (2008) SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci USA 105:16021-16026.
6. Alcamo EA, et al. (2008) Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57:364-377.
7. Britanova O, et al. (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57:378-392.
8. Dulabon L, et al. (2000) Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron 27:33-44.
9. Goffinet AM (1995) Developmental neurobiology. A real gene for reeler. Nature 374:675-676.
10. Belvindrah R, Graus-Porta D, Goebbels S, Nave KA, Muller U (2007) Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci 27:13854-13865.
11. Elias LA, Wang DD, Kriegstein AR (2007) Gap junction adhesion is necessary for radial migration in the neocortex. Nature 448:901-907.
12. Chen G, et al. (2008) Semaphorin-3A guides radial migration of cortical neurons during development. Nat Neurosci 11:36-44.
13. Borghesani PR, et al. (2002) BDNF stimulates migration of cerebellar granule cells. Development 129:1435-1442.
14. Caric D, et al. (2001) EGFRs mediate chemotactic migration in the developing telencephalon. Development 128:4203-4216.
15. Sheldon M, et al. (1997) Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature 389:730-733.
16. Feng Y, Walsh CA (2001) Protein-protein interactions, cytoskeletal regulation and neuronal migration. Nat Rev Neurosci 2:408-416.
17. Dhavan R, Tsai LH (2001) A decade of CDK5. Nat Rev Mol Cell Biol 2:749-759.
18. Tsai LH, Delalle I, Caviness VS, Jr., Chae T, Harlow E (1994) p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371:419-423.
19. Lew J, et al. (1994) A brain-specific activator of cyclin-dependent kinase 5. Nature 371:423-426.
20. Chae T, et al. (1997) Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18:29-42.
21. Ohshima T et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci USA 93:11173-11178.
22. Takahashi S, et al. (2005) Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci USA 102:1737-1742.
23. Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH (1998) p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J Biol Chem 273:24057-24064.
24. Saito T et al. (2003) Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation. J Neurosci 23:1189-1197.
25. Mackay HJ, Twelves CJ (2007) Targeting the protein kinase C family: Are we there yet? Nat Rev Cancer 7:554-562.
26. Toker A (1998) Signaling through protein kinase C. Front Biosci 3:D1134-D1147.
27. Parker PJ, Murray-Rust J (2004) PKC at a glance. J Cell Sci 117:131-132.
28. Miyamoto A, et al. (2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416:865-869.
29. Ryer EJ, et al. (2005) Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J Biol Chem 280:35310-35317.
30. Gschwendt M, et al. (1994) Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199:93-98.
31. Chu IM, Hengst L, Slingerland JM (2008) The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 8:253-267.
32. Soh JW, Lee EH, Prywes R, Weinstein IB (1999) Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Mol Cell Biol 19:1313-1324.
33. Saito T, Nakatsuji N (2001) Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol 240:237-246.
34. Medina DL, et al. (2004) TrkB regulates neocortex formation through the Shc/ PLCgamma-mediated control of neuronal migration. EMBO J 23:3803-3814.
35. Ringstedt T, et al. (1998) BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex. Neuron 21:305-315.
36. Rankin SL, Guy CS, Rahimtula M, Mearow KM (2008) Neurotrophin-induced upregulation of p75NTR via a protein kinase C-delta-dependent mechanism. Brain Res 1217:10-24.
37. Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A (2004) Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem 279:14551-14560.
38. Steinberg SF (2004) Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J 384:449-459.
39. Rybin VO, et al. (2004) Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem 279:19350-19361.
40. Luo W, et al. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci USA 104:9511-9516.
41. Lee SJ, Kim DC, Choi BH, Ha H, Kim KT (2006) Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death. J Biol Chem 281:2215-2224.
42. Vervoorts J, Luscher-Firzlaff J, Luscher B (2006) The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem 281:34725-34729.
43. Hunter T (2007) The age of crosstalk: Phosphorylation, ubiquitination, and beyond. Mol Cell 28:730-738.
44. Suh KS, et al. (2003) Genomic structure and promoter analysis of PKC-delta. Genomics 82:57-67.
45. Brenner W, et al. (2008) Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase. Int J Oncol 32:1125-1131.
46. Xie Z, Samuels BA, Tsai LH (2006) Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling-a hypothesis on neuronal migration. Cereb Cortex 16(Suppl 1):i64-i68.
47. Sahin B, Hawasli AH, Greene RW,Molkentin JD, Bibb JA (2008) Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Eur J Pharmacol 581:270-275.
48. Ino H, Ishizuka T, Chiba T, Tatibana M (1994) Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems. Brain Res 661:196-206.
49. Cheung ZH, Fu AK, Ip NY (2006) Synaptic roles of Cdk5: Implications in higher cognitive functions and neurodegenerative diseases. Neuron 50:13-18.
50. Gopalakrishna R, Jaken S (2000) Protein kinase C signaling and oxidative stress. Free Radic Biol Med 28:1349-1361.
51. Azadi S, Paquet-Durand F, Medstrand P, van Veen T, Ekstrom PA (2006) Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31:759-773.