Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 6, 2010, Pages 1242-1251

  Mcmurchy, Alicia N ^a   Gillies, Jana ^a   Allan, Sarah E ^a   Passerini, Laura ^b   Gambineri, Eleonora ^c   Roncarolo, Maria Grazia ^b,d   Bacchetta, Rosa ^b   Levings, Megan K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

autoimmunity; FOXP3; IL 17; IPEX; T regulatory cells; tolerance

Indexed keywords

CELL SURFACE MARKER; CHEMOKINE RECEPTOR CCR4; CYCLOSPORIN A; INTERLEUKIN 17; MEPREDNISONE; PREDNISONE; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOSUPPRESSIVE TREATMENT; IPEX SYNDROME; MUTATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; TH17 CELL; WILD TYPE;

ADOLESCENT; ANTIGENS, CD4; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; CHILD; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOSUPPRESSION; MUTANT PROTEINS; POINT MUTATION; POLYENDOCRINOPATHIES, AUTOIMMUNE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSGENES; YOUNG ADULT;

EID: 78649902529     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.09.001     Document Type: Article

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