메뉴 건너뛰기




Volumn 39, Issue 6, 2009, Pages 1480-1493

The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells

Author keywords

Cell differentiation; Cytokines; Th cells; Transcription factors

Indexed keywords

CD161 ANTIGEN; CHEMOKINE RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 6; LENTIVIRUS VECTOR; RETINOIC ACID RELATED ORPHAN RECEPTOR VARIANT 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RORC2; UNCLASSIFIED DRUG; CD28 ANTIGEN; CD3 ANTIGEN; CYTOKINE; GRANZYME; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; ORPHAN NUCLEAR RECEPTOR ROR GAMMA; ORPHAN NUCLEAR RECEPTOR ROR-GAMMA; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR;

EID: 67649525188     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838908     Document Type: Article
Times cited : (61)

References (64)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0034661356 scopus 로고    scopus 로고
    • Lineage commitment in the immune system: The T helper lymphocyte grows up
    • Glimcher, L. H. and Murphy, K. M., Lineage commitment in the immune system: The T helper lymphocyte grows up. Genes Dev. 2000. 14: 1693-1711.
    • (2000) Genes Dev , vol.14 , pp. 1693-1711
    • Glimcher, L.H.1    Murphy, K.M.2
  • 3
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli, E., Korn, T., Oukka, M. and Kuchroo, V. K., Induction and effector functions of T(H)17 cells. Nature 2008. 453: 1051-1057.
    • (2008) Nature , vol.453 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 4
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong, C., TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 2008. 8: 337-348.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 337-348
    • Dong, C.1
  • 5
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: The long and winding road
    • McGeachy, M. J. and Cua, D. J., Th17 cell differentiation: The long and winding road. Immunity 2008. 28: 445-453.
    • (2008) Immunity , vol.28 , pp. 445-453
    • McGeachy, M.J.1    Cua, D.J.2
  • 7
    • 0034541221 scopus 로고    scopus 로고
    • Microbial lipopeptides induce the production of IL-17 in Th cells
    • Infante-Duarte, C., Horton, H. F., Byrne, M. C. and Kamradt, T., Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 2000. 165: 6107-6115.
    • (2000) J. Immunol , vol.165 , pp. 6107-6115
    • Infante-Duarte, C.1    Horton, H.F.2    Byrne, M.C.3    Kamradt, T.4
  • 8
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver, C. T., Hatton, R. D., Mangan, P. R. and Harrington, L. E., IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 2007. 25: 821-852.
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 9
    • 15844402155 scopus 로고    scopus 로고
    • T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    • Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J. et al., T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 1996. 183: 2593-2603.
    • (1996) J. Exp. Med , vol.183 , pp. 2593-2603
    • Fossiez, F.1    Djossou, O.2    Chomarat, P.3    Flores-Romo, L.4    Ait-Yahia, S.5    Maat, C.6    Pin, J.J.7
  • 10
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang, S. C., Tan, X. Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M. and Fouser, L. A., Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 2006. 203: 2271-2279.
    • (2006) J. Exp. Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 11
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang, W., Kolls, J. K. and Zheng, Y., The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008. 28: 454-467.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 12
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud, M., Durand, J. M., Buchs, N., Fossiez, F., Page, G., Frappart, L. and Miossec, P., Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 1999. 42: 963-970.
    • (1999) Arthritis Rheum , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5    Frappart, L.6    Miossec, P.7
  • 14
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A. et al., Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002. 8: 500-508.
    • (2002) Nat. Med , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3    Brendolan, A.4    Schadt, E.5    Garren, H.6    Langer-Gould, A.7
  • 17
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng, Y., Danilenko, D. M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J. and Ouyang, W., Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007. 445: 648-651.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6    Ouyang, W.7
  • 18
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J. et al., Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 2006. 7: 929-936.
    • (2006) Nat. Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6    Lee, J.7
  • 20
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006. 24: 179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 21
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T. and Cua, D. J., TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 2007. 8: 1390-1397.
    • (2007) Nat. Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6    Cua, D.J.7
  • 22
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E. et al., IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007. 8: 967-974.
    • (2007) Nat. Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6    Levy, D.E.7
  • 24
    • 59849121375 scopus 로고    scopus 로고
    • Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome
    • Tangye, S. G., Cook, M. C. and Fulcher, D. A., Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome. J. Immunol. 2009. 182: 21-28.
    • (2009) J. Immunol , vol.182 , pp. 21-28
    • Tangye, S.G.1    Cook, M.C.2    Fulcher, D.A.3
  • 26
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel, N., Unutmaz, D. and Littman, D. R., The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 2008. 9: 641-649.
    • (2008) Nat. Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 27
    • 37849048599 scopus 로고    scopus 로고
    • T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors ROR[alpha] and ROR[gamma]
    • Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L. et al., T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors ROR[alpha] and ROR[gamma]. Immunity 2008. 28: 29-39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6    Ma, L.7
  • 28
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang, F., Meng, G. and Strober, W., Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 2008. 9: 1297-1306.
    • (2008) Nat. Immunol , vol.9 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 29
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • Brustle, A., Heink, S., Huber, M., Rosenplanter, C., Stadelmann, C., Yu, P., Arpaia, E. et al., The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 2007. 8: 958-966.
    • (2007) Nat. Immunol , vol.8 , pp. 958-966
    • Brustle, A.1    Heink, S.2    Huber, M.3    Rosenplanter, C.4    Stadelmann, C.5    Yu, P.6    Arpaia, E.7
  • 33
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupe, P., Barillot, E. and Soumelis, V., A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 2008. 9: 650-657.
    • (2008) Nat. Immunol , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupe, P.5    Barillot, E.6    Soumelis, V.7
  • 34
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated th17 lymphocytes
    • Pene, J., Chevalier, S., Preisser, L., Venereau, E., Guilleux, M. H., Ghannam, S., Moles, J. P. et al., Chronically inflamed human tissues are infiltrated by highly differentiated th17 lymphocytes. J. Immunol. 2008. 180: 7423-7430.
    • (2008) J. Immunol , vol.180 , pp. 7423-7430
    • Pene, J.1    Chevalier, S.2    Preisser, L.3    Venereau, E.4    Guilleux, M.H.5    Ghannam, S.6    Moles, J.P.7
  • 35
    • 50949116632 scopus 로고    scopus 로고
    • Regulation of IL-17 in human CCR6(1) effector memory T cells
    • Liu, H. and Rohowsky-Kochan, C., Regulation of IL-17 in human CCR6(1) effector memory T cells. J. Immunol. 2008. 180: 7948-7957.
    • (2008) J. Immunol , vol.180 , pp. 7948-7957
    • Liu, H.1    Rohowsky-Kochan, C.2
  • 39
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. and Sallusto, F., Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 2007. 8: 942-949.
    • (2007) Nat. Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 40
    • 36749081557 scopus 로고    scopus 로고
    • Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
    • Evans, H. G., Suddason, T., Jackson, I., Taams, L. S. and Lord, G. M., Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl. Acad. Sci. USA 2007. 104: 17034-17039.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17034-17039
    • Evans, H.G.1    Suddason, T.2    Jackson, I.3    Taams, L.S.4    Lord, G.M.5
  • 41
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • Chen, Z., Tato, C. M., Muul, L., Laurence, A. and O'Shea, J. J., Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007. 56: 2936-2946.
    • (2007) Arthritis Rheum , vol.56 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 46
    • 15244351083 scopus 로고    scopus 로고
    • Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
    • Amendola, M., Venneri, M. A., Biffi, A., Vigna, E. and Naldini, L., Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat. Biotechnol. 2005. 23: 108-116.
    • (2005) Nat. Biotechnol , vol.23 , pp. 108-116
    • Amendola, M.1    Venneri, M.A.2    Biffi, A.3    Vigna, E.4    Naldini, L.5
  • 47
    • 40449141770 scopus 로고    scopus 로고
    • Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
    • Singh, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N. and Farber, J. M., Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 2008. 180: 214-221.
    • (2008) J. Immunol , vol.180 , pp. 214-221
    • Singh, S.P.1    Zhang, H.H.2    Foley, J.F.3    Hedrick, M.N.4    Farber, J.M.5
  • 48
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F. et al., Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. 2007. 13: 1173-1175.
    • (2007) Nat Med , vol.13 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3    Dodelet-Devillers, A.4    Cayrol, R.5    Bernard, M.6    Giuliani, F.7
  • 49
    • 58749105841 scopus 로고    scopus 로고
    • IL-23 promotes maintenance but not commitment to the Th17 lineage
    • Stritesky, G. L., Yeh, N. and Kaplan, M. H., IL-23 promotes maintenance but not commitment to the Th17 lineage. J. Immunol. 2008. 181: 5948-5955.
    • (2008) J. Immunol , vol.181 , pp. 5948-5955
    • Stritesky, G.L.1    Yeh, N.2    Kaplan, M.H.3
  • 50
    • 58849112222 scopus 로고    scopus 로고
    • Cutting Edge: Antigen-specific TGFbeta-induced regulatory T cells suppress Th17-mediated autoimmune disease
    • Huter, E. N., Stummvoll, G. H., DiPaolo, R. J., Glass, D. D. and Shevach, E. M., Cutting Edge: Antigen-specific TGFbeta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J. Immunol. 2008. 181: 8209-8213.
    • (2008) J. Immunol , vol.181 , pp. 8209-8213
    • Huter, E.N.1    Stummvoll, G.H.2    DiPaolo, R.J.3    Glass, D.D.4    Shevach, E.M.5
  • 51
    • 49649101595 scopus 로고    scopus 로고
    • Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    • Stummvoll, G.H., DiPaolo, R. J., Huter, E.N., Davidson, T. S., Glass, D., Ward, J. M. and Shevach, E. M., Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J. Immunol. 2008. 181: 1908-1916.
    • (2008) J. Immunol , vol.181 , pp. 1908-1916
    • Stummvoll, G.H.1    DiPaolo, R.J.2    Huter, E.N.3    Davidson, T.S.4    Glass, D.5    Ward, J.M.6    Shevach, E.M.7
  • 52
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T-cells differentiate into IL-17 producing cells
    • Koenen, H. J., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. and Joosten, I., Human CD25highFoxp3pos regulatory T-cells differentiate into IL-17 producing cells. Blood 2008. 112: 2340-2352.
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 53
    • 51549097819 scopus 로고    scopus 로고
    • + T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J. Immunol. 2008. 181: 3137-3147.
    • + T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J. Immunol. 2008. 181: 3137-3147.
  • 54
    • 34249799285 scopus 로고    scopus 로고
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 2007. 178: 6725-6729.
    • (2007) J. Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 55
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang, X. O., Nurieva, R., Martinez, G. J., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B. et al., Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008. 29: 44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6    Shah, B.7
  • 56
    • 47249166438 scopus 로고    scopus 로고
    • + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    • + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 2008. 180: 7112-7116.
    • (2008) J. Immunol , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 57
    • 54949139265 scopus 로고    scopus 로고
    • The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
    • Annunziato, F., Cosmi, L., Liotta, F., Maggi, E. and Romagnani, S., The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int. Immunol. 2008. 20: 1361-1368.
    • (2008) Int. Immunol , vol.20 , pp. 1361-1368
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3    Maggi, E.4    Romagnani, S.5
  • 58
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F. et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000. 13: 715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7
  • 59
    • 34250005444 scopus 로고    scopus 로고
    • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/ STAT1
    • Amadi-Obi, A., Yu, C. R., Liu, X., Mahdi, R. M., Clarke, G. L., Nussenblatt, R. B., Gery, I. et al., TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/ STAT1. Nat. Med. 2007. 13: 711-718.
    • (2007) Nat. Med , vol.13 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6    Gery, I.7
  • 60
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B. et al., Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007. 26: 371-381.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6    Blank, R.B.7
  • 62
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 2003. 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 63
    • 33845910939 scopus 로고    scopus 로고
    • Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
    • Lohr, J., Knoechel, B., Wang, J. J., Villarino, A. V. and Abbas, A. K., Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 2006. 203: 2785-2791.
    • (2006) J. Exp. Med , vol.203 , pp. 2785-2791
    • Lohr, J.1    Knoechel, B.2    Wang, J.J.3    Villarino, A.V.4    Abbas, A.K.5
  • 64
    • 8544277272 scopus 로고    scopus 로고
    • Biology of recently discovered cytokines: Interleukin-17-a unique inflammatory cytokine with roles in bone biology and arthritis
    • Gaffen, S. L., Biology of recently discovered cytokines: interleukin-17-a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis Res. Ther. 2004. 6: 240-247.
    • (2004) Arthritis Res. Ther , vol.6 , pp. 240-247
    • Gaffen, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.