Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O2 sensor?

Respiratory Physiology and Neurobiology

Volumn 174, Issue 3, 2010, Pages 201-211

  Waypa, Gregory B ^a   Schumacker, Paul T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Mitochondria; Oxidants; Pulmonary arteries; Reactive oxygen species; Redox signaling; Vascular

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RYANODINE RECEPTOR;

ELECTRON TRANSPORT; HYPOXIA; LUNG ARTERY; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN SENSING; OXYGEN TENSION; POTASSIUM CURRENT; PRIORITY JOURNAL; REVIEW; SENSOR; SIGNAL TRANSDUCTION; SYSTEMIC VASCULAR RESISTANCE; TISSUE SPECIFICITY;

ANIMALS; BLOOD VESSELS; CELL HYPOXIA; HUMANS; MITOCHONDRIA; MUSCLE, SMOOTH; OXYGEN; PULMONARY ARTERY; REACTIVE OXYGEN SPECIES; VASCULAR RESISTANCE; VASODILATION;

EID: 78449289850     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.08.007     Document Type: Review

References (155)

1. Aaronson P.I., Robertson T.P., Ward J.P. Endothelium-derived mediators and hypoxic pulmonary vasoconstriction. Respir. Physiol. Neurobiol. 2002, 132:107-120.
2. Ali M.H., Pearlstein D.P., Mathieu C.E., Schumacker P.T. Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction. Am. J. Physiol. Lung Cell Mol. Physiol. 2004.
3. Archer S., Michelakis E. The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. News Physiol. Sci. 2002, 17:131-137.
4. Archer S.L., Huang J., Henry T., Peterson D., Weir E.K. A redox-based O2 sensor in rat pulmonary vasculature. Circ. Res. 1993, 73:1100-1112.
5. Archer S.L., London B., Hampl V., Wu X., Nsair A., Puttagunta L., Hashimoto K., Waite R.E., Michelakis E.D. Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. Faseb J. 2001, 15:1801-1803.
6. 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:7944-7949.
7. Archer S.L., Souil E., Dinh-Xuan A.T., Schremmer B., Mercier J.C., El Yaagoubi A., Nguyen-Huu L., Reeve H.L., Hampl V. Molecular identification of the role of voltage-gated K+ channels, Kv1. 5 and Kv2. 1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J. Clin. Invest. 1998, 101:2319-2330.
8. Archer S.L., Weir E.K., Reeve H.L., Michelakis E. Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation. Adv. Exp. Med. Biol. 2000, 475:219-240.
9. Archer S.L., Will J.A., Weir E.K. Redox status in the control of pulmonary vascular tone. Herz 1986, 11:127-141.
10. Barbirz S., Jakob U., Glocker M.O. Mass spectrometry unravels disulfide bond formation as the mechanism that activates a molecular chaperone. J. Biol. Chem. 2000, 275:18759-18766.
11. Barman S.A. Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293:L472-479.
12. Bodi I., Bishopric N.H., Discher D.J., Wu X., Webster K.A. Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia. Cardiovasc. Res. 1995, 30:975-984.
13. Buescher P.C., Pearse D.B., Pillai R.P., Litt M.C., Mitchell M.C., Sylvester J.T. Energy state and vasomotor tone in hypoxic pig lungs. J. Appl. Physiol. 1991, 70:1874-1881.
14. Cannon M.B., Remington J.S. Redox-sensitive green fluorescent protein: probes for dynamic intracellular redox responses. A review. Methods Mol. Biol. 2009, 476:50-64.
15. Cha C.Y., Earm K.H., Youm J.B., Baek E.B., Kim S.J., Earm Y.E. Electrophysiological modelling of pulmonary artery smooth muscle cells in the rabbits-special consideration to the generation of hypoxic pulmonary vasoconstriction. Prog. Biophys. Mol. Biol. 2008, 96:399-420.
16. Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., Schumacker P.T. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:11715-11720.
17. Chandel N.S., McClintock D.S., Feliciano C.E., Wood T.M., Melendez J.A., Rodriguez A.M., Schumacker P.T. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J. Biol. Chem. 2000, 275:25130-25138.
18. Chandel N.S., Trzyna W.C., McClintock D.S., Schumacker P.T. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 2000, 165:1013-1021.
19. Chen Q., Vazquez E.J., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 2003, 278:36027-36031.
20. Chi A.Y., Waypa G.B., Mungai P.T., Schumacker P.T. Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells. Antioxid. Redox Signal. 2010, 12:603-610.
21. Coburn R.F. Oxygen tension sensors in vascular smooth muscle. Adv. Exp. Med. Biol. 1977, 78:101-115.
22. Coburn R.F., Grubb B., Aronson R.D. Effect of cyanide on oxygen tension-dependent mechanical tension in rabbit aorta. Circ. Res. 1979, 44:368-378.
23. Cowan D.B., Jones M., Garcia L.M., Noria S., del Nido P.J., McGowan F.X. Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler. Thromb. Vasc. Biol. 2003, 23:1754-1760.
24. Desireddi J.R., Farrow K.N., Marks J.D., Waypa G.B., Schumacker P.T. Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices. Antioxid. Redox Signal. 2010, 12:595-602.
25. Detar R. Mechanism of physiological hypoxia-induced depression of vascular smooth muscle contraction. Am. J. Physiol. 1980, 238:H761-769.
26. Dipp M., Evans A.M. Cyclic ADP-ribose is the primary trigger for hypoxic pulmonary vasoconstriction in the rat lung in situ. Circ. Res. 2001, 89:77-83.
27. Dipp M., Nye P.C., Evans A.M. Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 2001, 281:L318-325.
28. Dooley C.T., Dore T.M., Hanson G.T., Jackson W.C., Remington S.J., Tsien R.Y. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J. Biol. Chem. 2004, 279:22284-22293.
29. Duranteau J., Chandel N.S., Kulisz A., Shao Z., Schumacker P.T. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J. Biol. Chem. 1998, 273:11619-11624.
30. Eu J.P., Xu L., Stamler J.S., Meissner G. Regulation of ryanodine receptors by reactive nitrogen species. Biochem. Pharmacol. 1999, 57:1079-1084.
31. Evans A.M. The role of intracellular ion channels in regulating cytoplasmic calciumin pulmonary arterial mmooth muscle: which store and where?. Adv. Exp. Med. Biol. 2010, 661:57-76.
32. Evans A.M., Dipp M. Hypoxic pulmonary vasoconstriction: cyclic adenosine diphosphate-ribose, smooth muscle Ca(2+) stores and the endothelium. Respir. Physiol. Neurobiol. 2002, 132:3-15.
33. Evans A.M., Ward J.P. Hypoxic pulmonary vasoconstriction-invited article. Adv. Exp. Med. Biol. 2009, 648:351-360.
34. Fabian M., Palmer G. Hydrogen peroxide is not released following reaction of cyanide with several catalytically important derivatives of cytochrome c oxidase. FEBS Lett. 1998, 422:1-4.
35. Franco-Obregon A., Urena J., Lopez-Barneo J. Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:4715-4719.
36. Furchgott R.F. Metabolic factors that influence contractility of vascular smooth muscle. Bull. N. Y. Acad. Med. 1966, 42:996-1006.
37. Garcia-Ruiz C., Colell A., Mari M., Morales A., Fernandez-Checa J.C. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 1997, 272:11369-11377.
38. Gilbert H.F. Molecular and cellular aspects of thiol-disulfide exchange. Adv. Enzymol. Relat. Areas Mol. Biol. 1990, 63:69-172.
39. Gonzalez-Pacheco F.R., Caramelo C., Castilla M.A., Deudero J.J., Arias J., Yague S., Jimenez S., Bragado R., Alvarez-Arroyo M.V. Mechanism of vascular smooth muscle cells activation by hydrogen peroxide: role of phospholipase C gamma. Nephrol. Dial. Transplant. 2002, 17:392-398.
40. Grimminger F., Weissmann N., Spriestersbach R., Becker E., Rosseau S., Seeger W. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs. Am. J. Physiol. 1995, 268:L747-752.
41. Gupte S.A., Wolin M.S. Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH. Am. J. Physiol. Heart Circ. Physiol. 2006, 290:H2228-H2238.
42. Gupte S.A., Wolin M.S. Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension. Antioxid. Redox Signal. 2008, 10:1137-1152.
43. Gusarova G.A., Dada L.A., Kelly A.M., Brodie C., Witters L.A., Chandel N.S., Sznajder J.I. Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol. Cell Biol. 2009, 29:3455-3464.
44. Guyton A.C., Carrier O., Walker J.R. Evidence for tissue oxygen demand as the major factor causing autoregulation. Circ. Res. 1964, 15(Suppl.):60-69.
45. Guzy R.D., Hoyos B., Robin E., Chen H., Liu L., Mansfield K.D., Simon M.C., Hammerling U., Schumacker P.T. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 2005, 1:401-408.
46. Guzy R.D., Mack M.M., Schumacker P.T. Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast. Antioxid. Redox Signal. 2007, 9:1317-1328.
47. Guzy R.D., Sharma B., Bell E., Chandel N.S., Schumacker P.T. Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol. Cell Biol. 2008, 28:718-731.
48. Hanson G.T., Aggeler R., Oglesbee D., Cannon M., Capaldi R.A., Tsien R.Y., Remington S.J. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J. Biol. Chem. 2004, 279:13044-13053.
49. Hasunuma K., Rodman D.M., McMurtry I.F. Effects of K+ channel blockers on vascular tone in the perfused rat lung. Am. Rev. Respir. Dis. 1991, 144:884-887.
50. Hewavitharana T., Deng X., Soboloff J., Gill D.L. Role of STIM and Orai proteins in the store-operated calcium signaling pathway. Cell Calcium 2007, 42:173-182.
51. Holland P.C., Clark M.G., Bloxham D.P., Lardy H.A. Mechanism of action of the hypoglycemic agent diphenyleneiodonium. J. Biol. Chem. 1973, 248:6050-6056.
52. Homma N., Nagaoka T., Morio Y., Ota H., Gebb S.A., Karoor V., McMurtry I.F., Oka M. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J. Cardiovasc. Pharmacol. 2007, 50:697-702.
53. Hu J., Discher D.J., Bishopric N.H., Webster K.A. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 1998, 245:894-899.
54. Janda I., Devedjiev Y., Derewenda U., Dauter Z., Bielnicki J., Cooper D.R., Graf P.C., Joachimiak A., Jakob U., Derewenda Z.S. The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism. Structure (Camb.) 2004, 12:1901-1907.
55. Jiang K., Schwarzer C., Lally E., Zhang S., Ruzin S., Machen T., Remington S.J., Feldman L. Expression and characterization of a redox-sensing green fluorescent protein (reduction-oxidation-sensitive green fluorescent protein) in Arabidopsis. Plant Physiol. 2006, 141:397-403.
56. Jin N., Packer C.S., Rhoades R.A. Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms. Can. J. Physiol. Pharmacol. 1991, 69:383-388.
57. Jones D.P., Kennedy F.G. Intracellular oxygen supply during hypoxia. Am. J. Physiol. 1982, 243:C247-C253.
58. Jones D.P., Kennedy F.G. Analysis of intracellular oxygenation of isolated adult cardiac myocytes. Am. J. Physiol. 1986, 250:C384-390.
59. Jones R.D., Thompson J.S., Morice A.H. The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries. Physiol. Res. 2000, 49:587-596.
60. Jung H.J., Shim J.S., Lee J., Song Y.M., Park K.C., Choi S.H., Kim N.D., Yoon J.H., Mungai P.T., Schumacker P.T., Kwon H.J. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J. Biol. Chem. 2010, 285:11584-11595.
61. i rise in rabbit pulmonary arterial smooth muscle cells. Life Sci. 2002, 70:2321-2333.
62. Kang T.M., Park M.K., Uhm D.Y. Effects of hypoxia and mitochondrial inhibition on the capacitative calcium entry in rabbit pulmonary arterial smooth muscle cells. Life Sci. 2003, 72:1467-1479.
63. Killilea D.W., Hester R., Balczon R., Babal P., Gillespie M.N. Free radical production in hypoxic pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 279:L408-L412.
64. Lassegue B., Sorescu D., Szocs K., Yin Q., Akers M., Zhang Y., Grant S.L., Lambeth J.D., Griendling K.K. Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ. Res. 2001, 88:888-894.
65. 2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury. Crit. Care Med. 2007, 35:1709-1716.
66. Lazor R., Feihl F., Waeber B., Kucera P., Perret C. Endothelin-1 does not mediate the endothelium-dependent hypoxic contractions of small pulmonary arteries in rats. Chest 1996, 110:189-197.
67. Leach R.M., Hill H.M., Snetkov V.A., Robertson T.P., Ward J.P. Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor. J. Physiol. London 2001, 536:211-224.
68. Leach R.M., Robertson T.P., Twort C.H., Ward J.P. Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries. Am. J. Physiol. 1994, 266:L223-L231.
69. Leach R.M., Sheehan D.W., Chacko V.P., Sylvester J.T. Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 278:L294-L304.
70. Li X.Q., Zheng Y.M., Rathore R., Ma J., Takeshima H., Wang Y.X. Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009, 457:771-783.
71. Lin M.J., Yang X.R., Cao Y.N., Sham J.S. Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 292:L1598-1608.
72. Liu J.Q., Sham J.S., Shimoda L.A., Kuppusamy P., Sylvester J.T. Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am. J. Physiol. Lung Cell Mol. Physiol. 2003, 285:L322-333.
73. Liu Q., Sham J.S., Shimoda L.A., Sylvester J.T. Hypoxic constriction of porcine distal pulmonary arteries: endothelium and endothelin dependence. Am. J. Physiol. Lung Cell Mol. Physiol. 2001, 280:L856-L865.
74. Lohman J.R., Remington S.J. Development of a family of redox-sensitive green fluorescent protein indicators for use in relatively oxidizing subcellular environments. Biochemistry 2008, 47:8678-8688.
75. Lopez-Barneo J., Pardal R., Montoro R.J., Smani T., Garcia-Hirschfeld J., Urena J. K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues. Respir. Physiol. 1999, 115:215-227.
76. Lu W., Wang J., Peng G., Shimoda L.A., Sylvester J.T. Knockdown of stromal interaction molecule 1 attenuates store-operated Ca2+ entry and Ca2+ responses to acute hypoxia in pulmonary arterial smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 2009.
77. Lu W., Wang J., Shimoda L.A., Sylvester J.T. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 295:L104-L113.
78. Majander A., Finel M., Wikstrom M. Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I). J. Biol. Chem. 1994, 269:21037-21042.
79. Mansfield K.D., Guzy R.D., Pan Y., Young R.M., Cash T.P., Schumacker P.T., Simon M.C. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005, 1:393-399.
80. Marshall C., Mamary A.J., Verhoeven A.J., Marshall B.E. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am. J. Respir. Cell Mol. Biol. 1996, 15:633-644.
81. McDaniel S.S., Platoshyn O., Wang J., Yu Y., Sweeney M., Krick S., Rubin L.J., Yuan J.X. Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction. Am. J. Physiol. Lung Cell Mol. Physiol. 2001, 280:L870-L880.
82. McMurtry I.F. Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs. J. Appl. Physiol. 1984, 56:375-380.
83. Mehta J.P., Campian J.L., Guardiola J., Cabrera J.A., Weir E.K., Eaton J.W. Generation of oxidants by hypoxic human pulmonary and coronary smooth-muscle cells. Chest 2008, 133:1410-1414.
84. Michelakis E.D., Hampl V., Nsair A., Wu X., Harry G., Haromy A., Gurtu R., Archer S.L. Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ. Res. 2002, 90:1307-1315.
85. Mohazzab K.M., Wolin M.S. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am. J. Physiol. 1994, 267:L815-L822.
86. Morio Y., McMurtry I.F. Ca(2+) release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J. Appl. Physiol. 2002, 92:527-534.
87. Olschewski A., Hong Z., Linden B.C., Porter V.A., Weir E.K., Cornfield D.N. Contribution of the K(Ca) channel to membrane potential and O2 sensitivity is decreased in an ovine PPHN model. Am. J. Physiol. Lung Cell Mol. Physiol. 2002, 283:L1103-L1109.
88. Olschewski A., Hong Z., Nelson D.P., Weir E.K. Graded response of K(+) current, membrane potential, and [Ca(2+)](i) to hypoxia in pulmonary arterial smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 2002, 283:L1143-L1150.
89. Olschewski A., Hong Z., Peterson D.A., Nelson D.P., Porter V.A., Weir E.K. Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 286:L15-L22.
90. Paddenberg R., Ishaq B., Goldenberg A., Faulhammer P., Rose F., Weissmann N., Braun-Dullaeus R.C., Kummer W. Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am. J. Physiol. Lung Cell Mol. Physiol. 2003, 284:L710-L719.
91. Pastukh V., Ruchko M., Gorodnya O., Wilson G.L., Gillespie M.N. Sequence-specific oxidative base modifications in hypoxia-inducible genes. Free Radic. Biol. Med. 2007, 43:1616-1626.
92. Post J.M., Gelband C.H., Hume J.R. [Ca2+]i inhibition of K+ channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization. Circ. Res. 1995, 77:131-139.
93. Post J.M., Hume J.R., Archer S.L., Weir E.K. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 1992, 262:C882-C890.
94. Pourmahram G.E., Snetkov V.A., Shaifta Y., Drndarski S., Knock G.A., Aaronson P.I., Ward J.P. Constriction of pulmonary artery by peroxide: role of Ca2+ release and PKC. Free Radic. Biol. Med. 2008, 45:1468-1476.
95. Quintero M., Colombo S.L., Godfrey A., Moncada S. Mitochondria as signaling organelles in the vascular endothelium. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:5379-5384.
96. Rathore R., Zheng Y.M., Niu C.F., Liu Q.H., Korde A., Ho Y.S., Wang Y.X. Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic. Biol. Med. 2008, 45:1223-1231.
97. Reeve H.L., Michelakis E., Nelson D.P., Weir E.K., Archer S.L. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J. Appl. Physiol. 2001, 90:2249-2256.
98. Reeve H.L., Weir E.K., Nelson D.P., Peterson D.A., Archer S.L. Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp. Physiol. 1995, 80:825-834.
99. Rettig J., Heinemann S.H., Wunder F., Lorra C., Parcej D.N., Dolly J.O., Pongs O. Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature 1994, 369:289-294.
100. Rhoades R.A., Packer C.S., Roepke D.A., Jin N., Meiss R.A. Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle. Can. J. Physiol. Pharmacol. 1990, 68:1581-1589.
101. Richter C., Gogvadze V., Laffranchi R., Schlapbach R., Schweizer M., Suter M., Walter P., Yaffee M. Oxidants in mitochondria: from physiology to diseases. Biochim. Biophys. Acta 1995, 1271:67-74.
102. Robertson T.P., Aaronson P.I., Ward J.P. Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: evidence for PKC-independent Ca2+ sensitization. Am. J. Physiol. 1995, 268:H301-H307.
103. Robertson T.P., Aaronson P.I., Ward J.P. Ca2+-sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium-dependent. Am. J. Physiol. Lung Cell Mol. Physiol. 2003, 284:L1121-L1126.
104. Robertson T.P., Dipp M., Ward J.P., Aaronson P.I., Evans A.M. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br. J. Pharmacol. 2000, 131:5-9.
105. Robertson T.P., Hague D., Aaronson P.I., Ward J.P. Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. J. Physiol. London 2000, 525(Pt 3):669-680.
106. Robertson T.P., Ward J.P., Aaronson P.I. Hypoxia induces the release of a pulmonary-selective, Ca(2+)-sensitising, vasoconstrictor from the perfused rat lung. Cardiovasc. Res. 2001, 50:145-150.
107. Rounds S., McMurtry I.F. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circ. Res. 1981, 48:393-400.
108. Saitoh S., Zhang C., Tune J.D., Potter B., Kiyooka T., Rogers P.A., Knudson J.D., Dick G.M., Swafford A., Chilian W.M. Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler. Thromb. Vasc. Biol. 2006, 26:2614-2621.
109. Salvaterra C.G., Goldman W.F. Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes. Am. J. Physiol. 1993, 264:L323-L328.
110. Sato K., Morio Y., Morris K.G., Rodman D.M., McMurtry I.F. Mechanism of hypoxic pulmonary vasoconstriction involves ET(A) receptor-mediated inhibition of K(ATP) channel. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 278:L434-L442.
111. Sham J.S., Crenshaw B.R., Deng L.H., Shimoda L.A., Sylvester J.T. Effects of hypoxia in porcine pulmonary arterial myocytes: roles of K(V) channel and endothelin-1. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 279:L262-272.
112. Sheehan D.W., Giese E.C., Gugino S.F., Russell J.A. Characterization and mechanisms of H2O2-induced contractions of pulmonary arteries. Am. J. Physiol. 1993, 264:H1542-H1547.
113. Shimoda L.A., Luke T., Sylvester J.T., Shih H.W., Jain A., Swenson E.R. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 292:L1002-L1012.
114. Smani T., Hernandez A., Urena J., Castellano A.G., Franco-Obregon A., Ordonez A., Lopez-Barneo J. Reduction of Ca(2+) channel activity by hypoxia in human and porcine coronary myocytes. Cardiovasc. Res. 2002, 53:97-104.
115. Snetkov V.A., Aaronson P.I., Ward J.P., Knock G.A., Robertson T.P. Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat. Br. J. Pharmacol. 2003, 140:97-106.
116. Sommer N., Dietrich A., Schermuly R.T., Ghofrani H.A., Gudermann T., Schulz R., Seeger W., Grimminger F., Weissmann N. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur. Respir. J. 2008, 32:1639-1651.
117. Spasojevic I., Liochev S.I., Fridovich I. Lucigenin: redox potential in aqueous media and redox cycling with O-(2) production. Arch. Biochem. Biophys. 2000, 373:447-450.
118. Sweeney M., Yuan J.X. Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels. Respir. Res. 2000, 1:40-48.
119. Taggart M.J., Wray S. Hypoxia and smooth muscle function: key regulatory events during metabolic stress. J. Physiol. 1998, 509(Pt 2):315-325.
120. Thannickal V.J., Fanburg B.L. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 279:L1005-L1028.
121. Thompson J.S., Jones R.D., Rogers T.K., Hancock J., Morice A.H. Inhibition of hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries by diphenyleneiodonium (DPI). Pulm. Pharmacol. Ther. 1998, 11:71-75.
122. Turrens J.F., Alexandre A., Lehninger A.L. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 1985, 237:408-414.
123. Vanden Hoek T.L., Becker L.B., Shao Z., Li C., Schumacker P.T. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J. Biol. Chem. 1998, 273:18092-18098.
124. Verkhovsky M.I., Morgan J.E., Puustein A., Wikstrom M. Kinetic trapping of oxygen in cell respiration. Nature 1996, 380:268-270.
125. von Euler U., Liljestrand G. Observations on the pulmonary arterial blood pressure of the cat. Acta Physiol. Scand. 1946, 12:301-320.
126. Wang J., Shimoda L.A., Sylvester J.T. Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 286:L848-L858.
127. Wang Q.S., Zheng Y.M., Dong L., Ho Y.S., Guo Z., Wang Y.X. Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes. Free Radic. Biol. Med. 2007, 42:642-653.
128. Wang Y.X., Zheng Y.M., Abdullaev I., Kotlikoff M.I. Metabolic inhibition with cyanide induces calcium release in pulmonary artery myocytes and Xenopus oocytes. Am. J. Physiol. Cell Physiol. 2003, 284:C378-C388.
129. Wang Z., Jin N., Ganguli S., Swartz D.R., Li L., Rhoades R.A. Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction. Am. J. Respir. Cell Mol. Biol. 2001, 25:628-635.
130. Ward J.P., McMurtry I.F. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr. Opin. Pharmacol. 2009, 9:287-296.
131. Ward J.P., Robertson T.P. The role of the endothelium in hypoxic pulmonary vasoconstriction. Exp. Physiol. 1995, 80:793-801.
132. Waypa G.B., Chandel N.S., Schumacker P.T. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ. Res. 2001, 88:1259-1266.
133. Waypa G.B., Guzy R., Mungai P.T., Mack M.M., Marks J.D., Roe M.W., Schumacker P.T. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circ. Res. 2006, 99:970-978.
134. Waypa G.B., Marks J.D., Guzy R., Mungai P.T., Schriewer J., Dokic D., Schumacker P.T. Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ. Res. 2010, 106:526-535.
135. Waypa G.B., Marks J.D., Mack M.M., Boriboun C., Mungai P.T., Schumacker P.T. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ. Res. 2002, 91:719-726.
136. Waypa G.B., Morton C.A., Vincent P.A., Mahoney J.R., Johnston W.K., Minnear F.L. Oxidant-increased endothelial permeability: prevention with phosphodiesterase inhibition vs. cAMP production. J. Appl. Physiol. 2000, 88:835-842.
137. Waypa G.B., Schumacker P.T. Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question. Exp. Physiol. 2008, 93:133-138.
138. Weigand L., Foxson J., Wang J., Shimoda L.A., Sylvester J.T. Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels. Am. J. Physiol. Lung Cell Mol. Physiol. 2005, 289:L5-L13.
139. Weigand L., Sylvester J.T., Shimoda L.A. Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Am. J. Physiol. Lung Cell Mol. Physiol. 2006, 290:L284-L290.
140. Weir E.K., Archer S.L. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. Faseb J. 1995, 9:183-189.
141. Weir E.K., Eaton J.W., Chesler E. Redox status and pulmonary vascular reactivity. Chest 1985, 88:249S-252S.
142. Weir E.K., Obreztchikova M., Vargese A., Cabrera J.A., Peterson D.A., Hong Z. Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus. Br. J. Pharmacol. 2008, 155:300-307.
143. Weir E.K., Reeve H.L., Cornfield D.N., Tristani-Firouzi M., Peterson D.A., Archer S.L. Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Kidney Int. 1997, 51:462-466.
144. Weissmann N., Dietrich A., Fuchs B., Kalwa H., Ay M., Dumitrascu R., Olschewski A., Storch U., Mederos y Schnitzler M., Ghofrani H.A., Schermuly R.T., Pinkenburg O., Seeger W., Grimminger F., Gudermann T. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:19093-19098.
145. Weissmann N., Ebert N., Ahrens M., Ghofrani H.A., Schermuly R.T., Hanze J., Fink L., Rose F., Conzen J., Seeger W., Grimminger F. Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs. Am. J. Respir. Cell Mol. Biol. 2003, 29:721-732.
146. Weissmann N., Grimminger F., Voswinckel R., Conzen J., Seeger W. Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am. J. Physiol. 1998, 274:L721-727.
147. Weissmann N., Grimminger F., Walmrath D., Seeger W. Hypoxic vasoconstriction in buffer-perfused rabbit lungs. Respir. Physiol. 1995, 100:159-169.
148. Weissmann N., Tadic A., Hanze J., Rose F., Winterhalder S., Nollen M., Schermuly R.T., Ghofrani H.A., Seeger W., Grimminger F. Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?. Am. J. Physiol. Lung Cell Mol. Physiol. 2000, 279:L683-L690.
149. Weissmann N., Zeller S., Schafer R.U., Turowski C., Ay M., Quanz K., Ghofrani H.A., Schermuly R.T., Fink L., Seeger W., Grimminger F. Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction. Am. J. Respir. Cell Mol. Biol. 2006, 34:505-513.
150. Wolin M.S. Reactive oxygen species and the control of vascular function. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H539-H549.
151. Yamashita K., Discher D.J., Hu J., Bishopric N.H., Webster K.A. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J. Biol. Chem. 2001, 276:12645-12653.
152. Yuan J.P., Zeng W., Huang G.N., Worley P.F., Muallem S. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat. Cell Biol. 2007, 9:636-645.
153. Yuan X.J., Goldman W.F., Tod M.L., Rubin L.J., Blaustein M.P. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 1993, 264:L116-L123.
154. Zhang F., Carson R.C., Zhang H., Gibson G., Thomas H.M. Pulmonary artery smooth muscle cell [Ca2+]i and contraction: responses to diphenyleneiodonium and hypoxia. Am. J. Physiol. 1997, 273:L603-611.
155. Zhao Y., Rhoades R.A., Packer C.S. Hypoxia-induced pulmonary arterial contraction appears to be dependent on myosin light chain phosphorylation. Am. J. Physiol. 1996, 271:L768-774.