Inhibition of hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries by diphengleneiodonium (DPI)

Pulmonary Pharmacology and Therapeutics

Volumn 11, Issue 1, 1998, Pages 71-75

  Thompson, J S ^a   Jones, R D ^a   Rogers, T K ^a   Hancock, J ^b   Morice, A H ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

DPI; Hypoxic pulmonary vasoconstriction; Myography; NADPH oxidase; Oxygen radicals

Indexed keywords

DIMETHYL SULFOXIDE; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; PROSTAGLANDIN F2 ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; HYPOXIC LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT;

EID: 0032004069     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1998.0118     Document Type: Article

References (32)

1. 1. von Euler U S, Liljestrand G. Observation on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 1946; 12: 301-320.
2. 2. Archer S L, Tolins J P, Raij L, Weir E K. Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun 1989; 164: 1198-1205.
3. 3. Ogata M, Ohe M, Katayose D, Takishima T. Modulatory role of EDRF in hypoxic contraction of isolated porcine pulmonary arteries. Am J Physiol 1992; 262: H691-H697.
4. 4. Ohe M, Ogata M, Katayose D, Takishima T. Hypoxic contraction of prestretched human pulmonary artery. Respir Physiol 1992; 87: 105-114.
5. 450 on hypoxic pulmonary vasoconstriction. Circ Res 1978; 43: 429-437.
6. 6. Archer S L, Will J A, Weir E K. Redox status in the control of pulmonary vascular tone. Herz 1986; 11: 127-141.
7. 7. Archer S L, Weir E K. Mechanisms of acute hypoxic and hyperoxic changes in pulmonary vascular reactivity. In: Weir E K, Reeves J T, eds. Pulmonary vascular physiology and pathophysiology. New York: Marcel Dekker Inc., 1989: 241-289.
8. 8. Thomas H M, Carson R C, Fried E D, Novitch R S. Inhibition of hypoxic pulmonary vasoconstriction by diphenyleneiodonium. Biochem Pharmacol 1991; 42: R9-12.
9. 9. Jones O T, Cross A R, Hancock J T, Henderson L M, O'Donnell V B. Inhibitors of NADPH oxidase as guides to its mechanism. Biochem Soc Trans 1991; 19: 70-72.
10. 10. Grimminger F, Weissmann N, Spriestersbach R, Becker E, Rosseau S, Seeger W. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs. Am J Physiol: Lung Cell Mol Physiol 1995; 268: L747-752.
11. 11. Bhattacharya J, Nanjo S, Staub N C. Micropuncture measurement of lung microvascular pressure during 5-HT infusion. J Appl Physiol 1982; 52: 634-637.
12. 12. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper M A, Staub N C. Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats. Circ Res 1984; 54: 90-95.
13. 13. Shirai M, Ninomiya I, Sada K. Constrictor response of small pulmonary arteries to acute pulmonary hypertension during left atrial pressure elevation. Jap J Physiol 1991; 41: 129-142.
14. 14. Barer G R, Cai Y N, Russell P C, Emery C J. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. Am Rev Respir Dis 1989; 140: 1483-1485.
15. 15. Peake M D, Harabin A L, Brennan N J, Sylvester J T. Steady-state vascular responses to graded hypoxia in isolated lungs of five species. J Appl Physiol 1981; 51: 1214-1219.
16. 16. Bennie R E, Packer C S, Powell D R, Jin N, Rhoades R A. Biphasic contractile response of pulmonary artery to hypoxia. Am J Physiol 1991; 261: L156-L163.
17. 17. Wiener C M, Sylvester J T. Effect of glucose on hypoxic vasoconstriction in isolated ferret lungs. J Appl Physiol 1991; 70: 439-446.
18. 18. Woodmansey P A, Zhang F, Channer K S, Morice A H. Variation in the sensitivity of hypoxic pulmonary vasoconstriction to amlodipine according to phase and vessel. Thorax 1993; 48: 465-466.
19. 19. Rogers T K, Morice A H. Inhibition of hypoxic vasoconstriction in isolated small pulmonary arteries by ANP. Am Rev Respir Dis 1993; 147: A724.
20. 20. Rogers T K, Stewart A G, Morice A H. Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide. Clin Sci 1992; 83: 723-729.
21. 21. Teng G Q, Barer G R. In vitro responses of lung arteries to acute hypoxia after NO synthase blockade or chronic hypoxia. J Appl Physiol 1995; 79: 763-770.
22. 22. Leach R M, Robertson T P, Twort C H C, Ward J P T. Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries. Am J Physiol 1994; 266: L223-L231.
23. 23. Teng G Q, Barer G R. In vitro responses of lung arteries to acute hypoxia after NO synthase blockade or chronic hypoxia. J Appl Physiol 1995; 79: 763-770.
24. 2α-induced contractions in isolated rat pulmonary arteries. J Pharmacol Exp Ther 1994; 271: 326-333.
25. 25. Zhang F, Woodmansey P A, Morice A H. Acute hypoxic pulmonary vasoconstriction in isolated rat small and large pulmonary arteries. Physiol Res 1995; 44: 7-18.
26. 2+ currents in isolated pulmonary artery smooth muscle cells. J Appl Physiol 1994; 76: 2611-2615.
27. 27. Wang Y X, Poon C I, Poon K S, Pang CC-Y Inhibitory actions of DPI on endothelial-dependent vasodilatations in vitro and in vivo. Br J Pharmacol 1993; 110: 1232-1238.
28. 2 sensor protein in the rat carotid body. Biochem J 1990; 272: 743-747.
29. 29. Marshall C, Mamary A J, Verhoeven A J, Marshall B E. Pulmonary artery NADPH oxidase is activated in HPV. Am J Respir Cell Mol Biol 1996; 15: 633-644.
30. 2α and KCl induced contractions in isolated rat pulmonary arteries. Pulm Pharmacol Ther 1997; 10: 37-42.
31. 2-induced contractions of pulmonary arteries. Am J Physiol 1993; 264: H1542-1547.
32. 32. Jin N, Packer C S, Rhoades R A. Reactive oxygen mediated contractions in pulmonary artery smooth muscle: cellular mechanisms. Can J Physiol Pharmacol 1990; 69: 383-388.