Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 292, Issue 4, 2007, Pages

  Shimoda, Larissa A ^a   Luke, Trevor ^a   Sylvester, J T ^a   Shih, Hui Wen ^b   Jain, Ahamindra ^b   Swenson, Erik R ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intracellular Ca2+; Pulmonary vascular smooth muscle

Indexed keywords

ACETAZOLAMIDE; BENZOLAMIDE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CARBONATE DEHYDRATASE; ETHOXZOLAMIDE; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CELL PH; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FLUORESCENCE MICROSCOPY; HYPOXIA; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PULMONARY ARTERY; SMOOTH MUSCLE;

ACETAZOLAMIDE; ANOXIA; BENZOLAMIDE; CALCIUM; CALCIUM SIGNALING; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; ETHOXZOLAMIDE; HYDROGEN-ION CONCENTRATION; METHAZOLAMIDE; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY;

EID: 34247260402     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00161.2006     Document Type: Article

References (55)

1. 2+ concentration of myocytes isolated from different regions of the rat pulmonary arterial tree. Exp Physiol 83: 337-347, 1998.
2. Bartsch P, Mairbaurl H, Maggiorini M, Swenson ER. Physiological aspects of high-altitude pulmonary edema. J Appl Physiol 98: 1101-1110, 2005.
3. Berg JT, Ramanathan S, Gabrielli MG, Swenson ER. Carbonic anhydrase in mammalian vascular smooth muscle. J Histochem Cytochem 52: 1101-1106, 2004.
4. Bonanno JA, Srinivas SP, Brown M. Effect of acetazolamide on intracellular pH and bicarbonate transport in bovine corneal endothelium. Exp Eye Res 60: 425-434, 1995.
5. Chipperfield AR, Davis JP, Harper AA. An acetazolamide-sensitive inward chloride pump in vascular smooth muscle. Biochem Biophys Res Commun 194: 407-412, 1993.
6. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 266: L469-L475, 1994.
7. Deem S, Hedges RG, Kerr ME, Swenson ER. Acetazolamide reduces hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs. Respir Physiol 123: 109-119, 2000.
8. Emery CJ, Sloan PJ, Mohammed FH, Barer GR. The action of hypercapnia during hypoxia on pulmonary vessels. Bull Eur Physiopath Respir 13: 763-776, 1977.
9. Farrukh IS, Hoidal JR, Barry WH. Effect of intracellular pH on ferret pulmonary arterial smooth muscle cell calcium homeostasis and pressure. J Appl Physiol 80: 496-505, 1996.
10. i in porcine coronary artery endothelium and smooth muscle. A novel method for measurements in endothelial cells in situ. Circ Res 80: 21-27, 1997.
11. Garcia L, Boue-Grabot E, Garret M, Sartor P. Regulation of intracellular pH in rat lactotrophs: involvement of anionic exchangers. Endocrinology 138: 4191-4198, 1997.
12. + channels in cat cerebral arterial muscle cell membranes. Pflügers Arch 428: 621-630, 1994.
13. Gottfried JA, Chesler M. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons. J Neurophysiol 74: 2774-2777, 1995.
14. Henderson RM, Bell PB, Cohen RD, Browning C, Iles RA. Measurement of intracellular pH with microelectrodes in rat kidney in vivo. Am J Physiol Renal Fluid Electrolyte Physiol 250: F203-F209, 1986.
15. Hohne C, Krebs MO, Seiferheld M, Boemke W, Kaczmarczyk G, Swenson ER. Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs. J Appl Physiol 97: 515-521, 2004.
16. Iturriaga R, Lahiri S, Mokashi A. Carbonic anhydrase and chemoreception in the cat carotid body. Am J Physiol Cell Physiol 261: C565-C573, 1991.
17. Jahromi SS, Pelletier MR, McDonald PJ, Khosravani H, Carlen PL. Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models. Brain Res 872: 20-28, 2000.
18. Krampetz IK, Rhoades RA. Intracellular pH: effect on pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 260: L516-L521, 1991.
19. Lamsa K, Kaila K. Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine. J Neurophysiol 78: 2582-2591, 1997.
20. Leniger T, Wiemann M, Bingmann D, Widman G, Hufnagel A, Bonnet U. Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons. Epilepsia 43: 469-474, 2002.
21. Loeppky JA, Scotto P, Riedel CE, Roach RC, Chick TW. Effects of acid-base status on acute hypoxic pulmonary vasoconstriction and gas exchange. J Appl Physiol 72: 1787-1797, 1992.
22. Madden JA, Ray DE, Keller PA, Kleinman JG. Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia. Am J Physiol Lung Cell Mol Physiol 280: L264-L271, 2001.
23. Maren TH. Carbonic anhydrase inhibition. V. N5-substituted 2-acetylamino-1,3,4-thiadiazole-5-sulfonamides: metabolic conversion and use as control substances. J Pharmacol Exp Ther 117: 385-401, 1956.
24. Maren TH. Use of inhibitors in physiological studies of carbonic anhydrase. Am J Physiol Renal Fluid Electrolyte Physiol 232: F291-F297, 1977.
25. McMurtry IF, Davidson AB, Reeves JT, Grover RF. Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs. Circ Res 38: 99-104, 1976.
26. 2+ channels by carbonic anhydrase inhibitors. J Pharm Sci 95: 240-247, 2004.
27. Naeije R, Melot C, Mols P, Hallemans R. Effects of vasodilators on hypoxic pulmonary vasoconstriction in normal man. Chest 82: 404-410, 1982.
28. Pickkers P, Garcha RS, Schachter M, Smits P, Hughes AD. Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. Hypertension 33: 1043-1048, 1999.
29. Pickkers P, Hughes AD, Russel FG, Thien T, Smits P. In vivo evidence for K(Ca) channel opening properties of acetazolamide in the human vasculature. Br J Pharmacol 132: 443-450, 2001.
30. + channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization. Circ Res 77: 131-139, 1995.
31. Post JM, Hume JR, Archer SL, Weir EK. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol Cell Physiol 262: C882-C890, 1992.
32. + exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 5: 586-591, 1991.
33. Raffestin B, McMurtry IF. Effects of intracellular pH on hypoxic vasoconstriction in rat lungs. J Appl Physiol 63: 2524-2531, 1987.
34. Redding GJ, Tuck R, Escourrou P. Nifedipine attenuates acute hypoxic pulmonary vasoconstriction in awake piglets. Am Rev Respir Dis 129: 785-789, 1984.
35. Relman AS, Porter R, Tobias JF, Schwartz WB. The diuretic effects of large doses of acetazolamide and an analog lacking carbonic anhydrase inhibiting activity. J Clin Invest 39: 1551-1559, 1960.
36. Rothe KF, Heisler N. Correction of metabolic alkalosis by HCl and acetazolamide: effects on extracellular and intracellular acid-base status in rats in vivo. Acta Anaesthesiol Scand 30: 566-570, 1986.
37. 2+, pH, and energetics in porcine coronary artery. Circ Res 86: 862-870, 2000.
38. i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 279: L884-L894, 2000.
39. + current in rat intrapulmonary arterial myocytes by endothelin-1. Am J Physiol Lung Cell Mol Physiol 274: L842-L853, 1998.
40. Simonneau G, Escourrou P, Duroux P, Lockhart A. Inhibition of hypoxic pulmonary vasoconstriction by nifedipine. N Engl J Med 304: 1582-1585, 1981.
41. Stanbrook HS, Morris KG, McMurtry IF. Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. Am Rev Respir Dis 130: 81-85, 1984.
42. Suggett AJ, Mohammed FH, Barer GR. Angiotensin, hypoxia, verapamil and pulmonary vessels. Clin Exp Pharmacol Physiol 7: 263-274, 1980.
43. Swenson ER. Carbonic anhydrase inhibitors and hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol 151: 209-216, 2006.
44. Swenson ER. Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression. Eur Respir J 12: 1242-1247, 1998.
45. Swenson ER, Robertson HT, Hlastala MP. Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the dog lung. J Clin Invest 92: 702-709, 1993.
46. Ca2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Ann Neurol 48: 304-312, 2000.
47. +-deficient rats. FASEB J 18: 760-761, 2004.
48. Tucker A, McMurtry IF, Grover RF, Reeves JT. Attenuation of hypoxic pulmonary vasoconstriction by verapamil in intact dogs. Proc Soc Exp Biol Med 151: 611-614, 1976.
49. + currents and hypoxia in rat pulmonary arterial myocytes. Exp Physiol 82: 629-645, 1997.
50. 2+ spikes in conduit and resistance myocytes of the rabbit pulmonary artery. J Physiol 496: 103-109, 1996.
51. 2+ entry. Am J Physiol Lung Cell Mol Physiol 288: L1059-L1069, 2005.
52. Wu Q, Pierce WM Jr, Delamere NA. Cytoplasmic pH responses to carbonic anhydrase inhibitors in cultured rabbit nonpigmented ciliary epithelium. J Membr Biol 162: 31-38, 1998.
53. Yuan XJ, Goldman WF, Tod ML, Rubin LJ, Blaustein MP. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am J Physiol Lung Cell Mol Physiol 264: L116-L123, 1993.
54. 2+ conductances in pulmonary artery cells. Am J Physiol Lung Cell Mol Physiol 267: L52-L63, 1994.
55. Zhang X, Velumian AA, Jones OT, Carlen PL. Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia 41, Suppl 1: S52-S60, 2000.