Effects of hypoxia in porcine pulmonary arterial myocytes: Roles of K(v) channel and endothelin-1

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 2 23-2, 2000, Pages

  Sham, James S K ^a,b   Crenshaw Jr , Benjamin R ^a   Deng, Li Hua ^a   Shimoda, Larissa A ^a   Sylvester, J T ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Pulmonary arterial smooth muscle cell; Vasoconstriction; Voltage dependent potassium channel

Indexed keywords

4 AMINOPYRIDINE; CALCIUM ION; ENDOTHELIN 1; OXYGEN; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HYPOXIA; HYPOXIC CELL; MALE; NONHUMAN; OXYGEN TENSION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN INTERACTION; PULMONARY ARTERY; SMOOTH MUSCLE FIBER; VASOCONSTRICTION;

EID: 0033848092     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.2.l262     Document Type: Article

References (66)

1. Differential K+ channel distribution in smooth muscle cells isolated from the pulmonary arterial tree of the rat
2. A redox-based O2 sensor in rat pulmonary vasculature
3. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia
4. Biphasic contractile response of pulmonary artery to hypoxia
5. Increased sensitization of the myofilaments in rat neonatal portal vein: A potential mechanism
6. 2 sensor in the pulmonary artery
7. Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats
8. The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats
9. Outward currents in rabbit pulmonary artery cells dissociated with a new technique
10. Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells
11. Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells
12. Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: Effect of BQ-123
13. Hypoxia on the pulmonary circulation. How and where it acts
14. Hypoxic pulmonary endothelial cells release a diffusible contractile factor distinct from endothelin
15. Ca2+ release from intracellular stores is an initial step in hypoxic pulmonary vasoconstriction of rat pulmonary artery resistance vessels
16. [Ca2+]i Inhibition of K+ channels in canine renal artery. Novel mechanism for agonist-induced membrane depolarization
17. Intracellular divalent cations block smooth muscle K+ channels
18. A new generation of Ca2+ indicators with greatly improved fluorescence properties
19. 2+-dependent action potentials in small pulmonary arteries of the cat
20. Effects of K+ channel blockers on vascular tone in the perfused rat lung
21. Acute effects of increased intravascular volume and hypoxia on the pulmonary circulation: Assessment with high-resolution CT
22. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium
23. The endothelin antagonist bosentan: Hemodynamic effects during normoxia and hypoxic pulmonary hypertension in pigs
24. The ETA receptor antagonist, BMS-182874, reduces acute hypoxic pulmonary hypertension in pigs in vivo
25. Effect of hypoxia on plasma immunoreactive endothelin-1 concentration in anesthetized rats
26. Prominent role of intracellular Ca2+ release in hypoxic vasoconstriction of canine pulmonary artery
27. Pulmonary arterial hypoxic contraction: Signal transduction
28. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium
29. Endothelium-derived contracting and relaxing factors contribute to hypoxic responses of pulmonary arteries
30. Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries
31. Hypoxic contraction of isolated porcine pulmonary arterioles: Role of endothelin-1
32. Hypoxia-induced activation in small isolated pulmonary arteries from the cat
33. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells
34. Role of peptidoleukotrienes in hypoxic pulmonary vasoconstriction in rats
35. Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs
36. BAY K 8644 potentiates and A23187 inhibits hypoxic vasoconstriction in rat lungs
37. Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs
38. Hypoxic contraction of cultured pulmonary vascular smooth muscle cells
39. Endothelin increases myofilament Ca2+ sensitivity in alpha-toxin-permeabilized rabbit mesenteric artery
40. Modulatory role of EDRF in hypoxic contraction of isolated porcine pulmonary arteries
41. Biosynthesis and modulation of endothelin from bovine pulmonary arterial endothelial cells
42. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat
43. [Ca2+]i Inhibition of K+ channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization
44. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
45. 2+ sensitization
46. Hypoxic contraction of isolated rat pulmonary artery
47. Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes
48. Effects of hypoxia on leukotriene activity and vasomotor tone in isolated sheep lungs
49. + current in rat intrapulmonary arterial myocytes by endothelin-1
50. Endothelium-dependent hypoxic contraction of pig proximal intrapulmonary arteries: Role of endothelin
51. Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential
52. Vasodilator and constrictor responses to hypoxia in isolated pig lungs
53. Pulmonary vascular tone is increased by a voltage-dependent calcium channel potentiator
54. Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude
55. Relationship between membrane potential, delayed rectifier K+ currents and hypoxia in rat pulmonary arterial myocytes
56. 2+ in pulmonary and cerebral arterial myocytes
57. Involvement of endothelin-1 in hypoxic pulmonary vasoconstriction in the lamb
58. The role of the endothelium in hypoxic pulmonary vasoconstriction
59. The mechanism of acute hypoxic pulmonary vasoconstriction: The tale of two channels
60. Local control of excitation-contraction coupling in rat heart cells
61. Nonpeptide endothelin receptor antagonists. VIII: Attenuation of acute hypoxia-induced pulmonary hypertension in the dog
62. Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?
63. Voltage-gated K+ currents regulate resting membrane potential and [Ca2+]i in pulmonary arterial myocytes
64. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes
65. Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries
66. 2+](i) and contraction: Responses to diphenyleneiodonium and hypoxia